CN114010535B - Degradable tooth whitening material and preparation and application thereof - Google Patents
Degradable tooth whitening material and preparation and application thereof Download PDFInfo
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- CN114010535B CN114010535B CN202111249487.3A CN202111249487A CN114010535B CN 114010535 B CN114010535 B CN 114010535B CN 202111249487 A CN202111249487 A CN 202111249487A CN 114010535 B CN114010535 B CN 114010535B
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- tooth whitening
- polylactic acid
- whitening material
- tooth
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 116
- 239000000463 material Substances 0.000 title claims abstract description 99
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 57
- 239000004626 polylactic acid Substances 0.000 claims abstract description 57
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 37
- 238000003756 stirring Methods 0.000 claims description 35
- 235000003599 food sweetener Nutrition 0.000 claims description 34
- 239000003765 sweetening agent Substances 0.000 claims description 34
- 239000008367 deionised water Substances 0.000 claims description 31
- 229910021641 deionized water Inorganic materials 0.000 claims description 31
- 239000003945 anionic surfactant Substances 0.000 claims description 30
- 239000003906 humectant Substances 0.000 claims description 22
- 239000002562 thickening agent Substances 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 10
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
- 239000011248 coating agent Substances 0.000 claims description 10
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- 239000008103 glucose Substances 0.000 claims description 10
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- 238000005406 washing Methods 0.000 claims description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 238000005070 sampling Methods 0.000 claims description 6
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 4
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- WSELJKAMVUHMJP-PUZYILPLSA-N (2s,3r,4s,5r)-2,3-dichloro-2,3,4,5,6-pentahydroxyhexanoyl chloride Chemical compound OC[C@@H](O)[C@H](O)[C@@](O)(Cl)[C@](O)(Cl)C(Cl)=O WSELJKAMVUHMJP-PUZYILPLSA-N 0.000 claims description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
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- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 235000014749 Mentha crispa Nutrition 0.000 claims description 2
- 244000078639 Mentha spicata Species 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000003082 abrasive agent Substances 0.000 claims description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 229960001047 methyl salicylate Drugs 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 229920001206 natural gum Polymers 0.000 claims description 2
- 239000002304 perfume Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 1
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- 241000283690 Bos taurus Species 0.000 description 35
- 230000008859 change Effects 0.000 description 13
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 10
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 8
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 8
- 239000000551 dentifrice Substances 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- 238000002386 leaching Methods 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 229910002113 barium titanate Inorganic materials 0.000 description 4
- 229960001631 carbomer Drugs 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- JRPBQTZRNDNNOP-UHFFFAOYSA-N barium titanate Chemical compound [Ba+2].[Ba+2].[O-][Ti]([O-])([O-])[O-] JRPBQTZRNDNNOP-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
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- 210000003298 dental enamel Anatomy 0.000 description 2
- 239000005548 dental material Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- ZBSCCQXBYNSKPV-UHFFFAOYSA-N oxolead;oxomagnesium;2,4,5-trioxa-1$l^{5},3$l^{5}-diniobabicyclo[1.1.1]pentane 1,3-dioxide Chemical compound [Mg]=O.[Pb]=O.[Pb]=O.[Pb]=O.O1[Nb]2(=O)O[Nb]1(=O)O2 ZBSCCQXBYNSKPV-UHFFFAOYSA-N 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
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- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- NKZSPGSOXYXWQA-UHFFFAOYSA-N dioxido(oxo)titanium;lead(2+) Chemical compound [Pb+2].[O-][Ti]([O-])=O NKZSPGSOXYXWQA-UHFFFAOYSA-N 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- HFGPZNIAWCZYJU-UHFFFAOYSA-N lead zirconate titanate Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4].[Pb+2] HFGPZNIAWCZYJU-UHFFFAOYSA-N 0.000 description 1
- 229910052451 lead zirconate titanate Inorganic materials 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0279—Porous; Hollow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Abstract
The invention belongs to the field of tooth whitening, and particularly relates to a degradable tooth whitening material, and preparation and application thereof. The invention provides a tooth whitening material, wherein the whitening component of the material is stereocomplex polylactic acid. The invention provides a biodegradable biocompatible tooth whitening material, which has good whitening effect and no damage to teeth; and has an effect of rapidly whitening teeth under mild conditions.
Description
Technical Field
The invention belongs to the field of tooth whitening, and particularly relates to a degradable tooth whitening material, and preparation and application thereof.
Background
Tooth whitening is a major concern for modern people regarding tooth health, and many people are not satisfied with their own tooth color due to smoking, drinking, drug use, genetic factors, and the like.
At present, the most common whitening agent is peroxide, the main component of the whitening agent is generally acidic agent or strong oxidant, and the acid etching effect or oxidation effect is utilized to remove foreign materials adhered to the surface of the teeth, so that the substances destroy the foreign materials on the surface of the teeth, and the substances have obvious whitening effect but stimulate the oral cavity due to the corrosion effect. In addition, since the dental material itself is an inorganic material, damage to the dental material itself may be caused by corrosion or oxidation. Finally, the existing several whitening materials have larger defects, and the whitening effect of the tooth body cannot be realized on the premise of smaller influence.
In view of the above drawbacks, publication No. CN110464674a discloses a tooth whitening product containing a piezoelectric material, which indicates that the piezoelectric material containing a piezoelectric effect is used as a whitening component of the tooth whitening product, and the piezoelectric property of the piezoelectric material is activated by the tooth whitening product contacting the teeth and applying pressure on the surfaces of the teeth, so that a large number of active groups are generated, stains on the surfaces of the teeth are degraded, and whitening of the teeth is achieved; the product does not harm the tooth structure, but the disclosed material with piezoelectric effect is selected from one or more materials of BaTiO3, gaN, znSnO3, (Na, K) -NbO3, znO, lead zirconate titanate, lead magnesium niobate, polyvinylidene fluoride and polyvinylidene fluoride, such as lead magnesium niobate lead titanate; since the piezoelectric material contains lead and is non-degradable, there is a potential hazard to human health; moreover, the piezoelectric materials need to be polarized to achieve good whitening effect; furthermore, the piezoelectric material is selected so that the tooth color is only significantly whitened under high-power, high-frequency vibration operating conditions (e.g., 40W,1000 Hz); these factors limit the scope of use.
Disclosure of Invention
Aiming at the defects, the invention provides a biodegradable and biocompatible tooth whitening material which has good whitening effect and has no damage to teeth; and has an effect of rapidly whitening teeth under mild conditions.
The technical scheme of the invention is as follows:
the first technical problem to be solved by the invention is to provide a tooth whitening material, wherein the whitening component of the material is a stereocomplex polylactic acid.
Further, the stereocomplex polylactic acid is porous stereocomplex polylactic acid prepared by blending left-handed polylactic acid and right-handed polylactic acid.
The porous stereocomplex polylactic acid of the invention is prepared by a method disclosed in patent with the publication number of CN 103965493B.
Further, the porosity of the stereocomplex polylactic acid is 10% -70%.
Further, the raw materials and the proportions of the tooth whitening material can be as follows: 5 to 50 parts of stereocomplex polylactic acid, 0.1 to 0.2 part of sweetener, 0.1 to 0.3 part of essence, 3 to 5 parts of anionic surfactant, 5 to 10 parts of abrasive material and the balance of deionized water. When the raw materials and the proportion thereof are adopted, the obtained tooth whitening material is dentifrice.
Further, the raw materials and the proportions of the tooth whitening material can be as follows: 5 to 50 parts of stereocomplex polylactic acid, 0.25 to 0.9 part of thickener, 0.1 to 0.2 part of sweetener, 20 to 40 parts of humectant, 0.1 to 0.3 part of essence, 3 to 5 parts of anionic surfactant and the balance of deionized water. When the raw materials and the proportion thereof are adopted, the obtained tooth whitening material is toothpaste, gel or biting gum.
Further, the sweetener is selected from: at least one of glucose, sucrose, maltose, dextrin, stevioside, and trichlorogalactose.
Further, the perfume is selected from: at least one of peppermint essence, methyl salicylate and spearmint.
Further, the anionic surfactant is selected from: at least one of sodium dodecyl sulfate, sodium lauroyl sarcosinate, betaine and PEG-40 hydrogenated castor oil.
Further, the abrasive is selected from: at least one of calcium carbonate, dicalcium phosphate, silica or natural microcrystalline cellulose.
Further, the thickener is selected from: at least one of carbomers, cellulosic polymers, salts thereof, natural gums, polyethylene glycol, triethanolamine, silica, and peptized magnesium aluminum silicate.
Further, the humectant is selected from: at least one of glycerin, sorbitol, and propylene glycol.
Further, the tooth whitening material may be formulated as a toothpaste, a dentifrice, a gel, a toothbrush, a dental tablet, or other known forms.
The second technical problem to be solved by the invention is to provide a preparation method of the tooth whitening material, which comprises the following steps: and uniformly mixing various raw materials of the tooth whitening material, and sampling and detecting the pH value of the mixed system to be 5.5-10.5 to obtain the tooth whitening material.
Further, the tooth whitening material adopts the following method one: firstly, uniformly stirring and mixing a sweetener, an anionic surfactant and essence in a container, then, putting the rest components in the container, and uniformly stirring and mixing to obtain a mixture, and sieving the mixture by a 60-mesh sieve to obtain the under-sieve tooth whitening material (finished dentifrice); wherein the stereocomplex polylactic acid is prepared into powder with granularity not more than 0.045mm (325 mesh), the abrasive is prepared into powder with granularity not more than 0.011mm (1300 mesh), and the anionic surfactant, sweetener and essence are respectively prepared into powder with granularity not more than 0.250mm (60 mesh).
Further, the tooth whitening material adopts the following method II: firstly, adding part of deionized water into a batching pot, then adding a humectant into the batching pot for mixing, then adding a thickener and a stereocomplex polylactic acid, gradually heating to 50 ℃ -75 ℃ (preferably 65 ℃), preserving heat for 10 min-35 min (preferably 20 min), and continuously cooling to 15 ℃ -40 ℃ (preferably 20 ℃) during stirring; then adding an anionic surfactant in the stirring process; adding sweetener, essence and the rest deionized water into a batching pot, and continuously stirring; the pH value of the sampling and detecting mixed system is 5.5-10.5, and the tooth whitening material is prepared.
The third technical problem to be solved by the present invention is to provide a method for using the tooth whitening material, wherein the method for using the tooth whitening material comprises the following steps: coating or spraying a tooth whitening material on the surface of the tooth, and applying pressure on the surface of the tooth; the pressure applied to the tooth surface is applied by vibration or friction.
The fourth technical problem to be solved by the invention is to indicate the application of the stereocomplex polylactic acid in the tooth whitening material, namely to indicate that the stereocomplex polylactic acid can be used as the whitening component of the tooth whitening material.
The invention has the beneficial effects that:
compared with the prior art, the tooth whitening material has the advantages of reduced gum irritation, no damage to oral soft tissues, biocompatibility and biodegradability, and capability of realizing rapid (generally within 15 min) tooth whitening under mild pressure conditions (which can be realized by tooth brushing).
Description of the drawings:
fig. 1 is a graph showing the whitening effect of the tooth whitening material obtained in example 1.
Fig. 2 is a graph showing the whitening effect of the tooth whitening material obtained in example 2.
Fig. 3 is a graph showing the whitening effect of the tooth whitening material obtained in example 3.
Fig. 4 is a graph showing the whitening effect of the tooth whitening material obtained in example 4.
Fig. 5 is a graph showing the whitening effect of the tooth whitening material obtained in example 5.
Fig. 6 is a graph showing the whitening effect of the tooth whitening material obtained in example 6.
Fig. 7 is a graph showing the whitening effect of the tooth whitening material obtained in comparative example 1.
Fig. 8 is a graph showing the whitening effect of the tooth whitening material obtained in comparative example 2.
Fig. 9 is a graph showing whitening effect of the tooth whitening material obtained in comparative example 4.
FIGS. 10a, 10b and 10c are graphs showing cytotoxicity test results of a control material (polytetrafluoroethylene), stereocomplex polylactic acid employed in the examples of the present invention, and whitening gel (comparative example 4) containing 22% hydrogen peroxide, respectively; as can be seen from the figure, the cytotoxicity of the stereocomplex polylactic acid is obviously smaller than that of the whitening gel containing 22% hydrogen peroxide.
Fig. 11a, 11b, 11c and 11d are SEM images of an original tooth (tooth not whitened in example 1), a tooth whitened in comparative example 4, a tooth whitened in comparative example 3 and a tooth whitened in example 1, respectively; as can be seen from fig. 11: the whitening gel containing 22% hydrogen peroxide can cause irreversible damage to tooth surface enamel, and barium titanate can also cause damage to tooth enamel after whitening teeth, and the surface appearance of the whitening gel is almost the same as that of original teeth after the teeth are whitened by the whitening material prepared from the stereocomplex polylactic acid.
The following describes the invention in further detail with reference to examples, which are not intended to limit the invention thereto.
Example 1
A tooth whitening material, comprising the following raw materials:
5 parts of porous stereocomplex polylactic acid, 0.25 part of thickening agent, 0.1 part of sweetener, 20 parts of humectant, 0.1 part of essence, 3 parts of anionic surfactant and the balance of deionized water; wherein, the thickener is carbomer, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method of the stereocomplex polylactic acid comprises the following steps: firstly, the weight ratio is 1:1, mixing the L-polylactic acid and the D-polylactic acid, and then melt-blending the mixture with a proper amount of pore-forming agent at 180 ℃ to obtain the three-dimensional composite polylactic acid powder; the poly Kong Ligou composite polylactic acid can be prepared by washing with deionized water.
The preparation method of the tooth whitening material comprises the following steps: firstly adding part of deionized water into a batching pot, adding a humectant into the batching pot for mixing, adding a thickener and a stereocomplex polylactic acid, stirring for 30min at 30rpm, gradually heating to 65 ℃, preserving heat for 20min, stirring for 5min at 2000rpm, cooling the materials in the batching pot to 20 ℃ after stirring, stirring at a speed of 15rpm, and then adding an anionic surfactant for stirring for 30min; adding sweetener, essence and the rest deionized water into a batching pot, and stirring at 10rpm for 10min; and discharging the material into a storage tank after meeting the standard (the pH value is 5.5-10.5 in a sampling test) to obtain the tooth whitening material.
Immersing isolated bovine teeth into deionized water for cleaning, coating the obtained tooth whitening material on the bovine teeth, brushing the bovine teeth by adopting a conventional brushing mode, brushing for 5min each time, washing with clear water, drying, repeating the brushing steps for 3 times, and finishing brushing, wherein each time the color change of the bovine tooth surface is observed (the specific change result is shown in figure 1), and simultaneously, the structural change of the bovine tooth surface is observed by using a scanning electron microscope (the result is shown in figure 11).
Example 2
A tooth whitening material, comprising the following raw materials:
50 parts of porous stereocomplex polylactic acid, 0.9 part of thickening agent, 0.2 part of sweetener, 40 parts of humectant, 0.3 part of essence, 5 parts of anionic surfactant and the balance of deionized water; wherein, the thickener is carbomer, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method of the tooth whitening material comprises the following steps: firstly adding part of deionized water into a batching pot, adding a humectant into the batching pot for mixing, adding a thickener and a stereocomplex polylactic acid, stirring for 30min at 30rpm, gradually heating to 65 ℃, preserving heat for 20min, stirring for 5min at 2000rpm, cooling the materials in the batching pot to 20 ℃ after stirring, stirring at a speed of 15rpm, and then adding an anionic surfactant for stirring for 30min; adding sweetener, essence and the rest deionized water into a batching pot, and stirring at 10rpm for 10min; and discharging the material into a storage tank after meeting the standard (the pH value is 5.5-10.5 in a sampling test) to obtain the tooth whitening material.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, brushing the bovine teeth by adopting a conventional brushing mode, brushing each time for 5min, washing with clear water, drying, repeating the brushing steps for 3 times, finishing brushing, and observing color change of the surface of the bovine teeth after 3 times of brushing.
Example 3
A tooth whitening material, comprising the following raw materials:
5 parts of porous stereocomplex polylactic acid, 0.25 part of sweetener, 90 parts of abrasive, 0.1 part of essence and 2.5 parts of anionic surfactant; wherein, the sweetener is glucose, the grinding material is calcium carbonate, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method comprises the following steps: preparing the stereocomplex polylactic acid into powder with granularity not more than 0.045mm (325 meshes), preparing the abrasive into powder with granularity not more than 0.011mm (1300 meshes), preparing the surfactant, the sweetener and the essence into powder with granularity not more than 0.250mm (60 meshes), stirring and mixing the sweetener, the surfactant and the essence uniformly in a container, then placing the rest components in the container, stirring and mixing uniformly to obtain a mixture, sieving the mixture with a 60-mesh sieve, and obtaining the finished dentifrice after sieving the mixture, wherein the dentifrice is prepared.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, brushing the bovine teeth by adopting a conventional brushing mode, brushing each time for 5min, washing with clear water, drying, repeating the brushing steps for 3 times, and finishing brushing, wherein the color change of the surface of the bovine teeth is observed each time.
Example 4
A tooth whitening material, comprising the following raw materials:
50 parts of porous stereocomplex lactic acid, 0.25 part of sweetener, 40 parts of abrasive, 0.1 part of essence and 2.5 parts of anionic surfactant; wherein, the sweetener is glucose, the grinding material is calcium carbonate, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate.
The preparation method comprises the following steps: preparing porous three-dimensional composite polylactic acid into powder with granularity not more than 0.045mm (325 meshes), preparing abrasive into powder with granularity not more than 0.011mm (1300 meshes), preparing surfactant, sweetener and essence into powder with granularity not more than 0.250mm (60 meshes), stirring and mixing the sweetener, the surfactant and the essence uniformly in a container, then putting the rest components into the container, stirring and mixing uniformly to obtain a mixture, sieving the mixture with a 60-mesh sieve, and obtaining the finished dentifrice after sieving the mixture, wherein the dentifrice is prepared.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, brushing the bovine teeth by adopting a conventional brushing mode, brushing each time for 5min, washing with clear water, drying, repeating the brushing steps for 3 times, finishing brushing, and observing color change of the surface of the bovine teeth after 3 times of brushing.
Example 5
A tooth whitening material, comprising the following raw materials:
5 parts of porous stereocomplex polylactic acid, 3 parts of thickening agent, 0.2 part of sweetener, 40 parts of humectant, 0.3 part of essence, 5 parts of anionic surfactant, 0.5 part of stabilizer and the balance of deionized water. Wherein, the thickener is sodium carboxymethyl cellulose, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, the anionic surfactant is sodium dodecyl sulfate, and the stabilizer is disodium ethylenediamine tetraacetate.
The preparation method comprises the following steps: adding the thickener into the humectant to form colloid under stirring; dissolving the three-dimensional composite polylactic acid and the stabilizer in deionized water in a small pot, stirring uniformly, and then sucking the mixture into a vacuum paste making machine in a vacuum state to uniformly stir with the glue; finally stirring and degassing for 10min under vacuum state to obtain the tooth whitening material.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, performing ultrasonic vibration for 1 hour at 40W and 0.6-0.8 kHz, and observing the color change of the surface of the bovine teeth.
Example 6
A tooth whitening material, comprising the following raw materials:
50 parts of porous stereocomplex polylactic acid, 0.35 part of thickener, 0.1 part of sweetener, 20 parts of humectant, 0.1 part of essence, 2 parts of anionic surfactant, 0.3 part of stabilizer and the balance of deionized water; wherein, the thickener is sodium carboxymethyl cellulose, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, the anionic surfactant is sodium dodecyl sulfate, and the stabilizer is disodium ethylenediamine tetraacetate.
The preparation method comprises the following steps: adding the thickener into the humectant to form colloid under stirring; dissolving the three-dimensional composite polylactic acid and the stabilizer in deionized water in a small pot, stirring uniformly, and then sucking the mixture into a vacuum paste making machine in a vacuum state to uniformly stir with the glue; finally stirring and degassing for 10min under vacuum state to obtain the tooth whitening material.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, performing ultrasonic vibration for 1 hour at 40W and 0.6-0.8 kHz, finishing brushing, and observing the color change of the surface of the bovine teeth.
Comparative example 1
5 parts of L-polylactic acid, 0.25 part of thickener, 0.1 part of sweetener, 20 parts of humectant, 0.1 part of essence, 3 parts of anionic surfactant and the balance of deionized water; wherein, the thickener is carbomer, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate; a tooth whitening material was prepared in the same manner as in example 1 using the above raw materials.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, brushing the bovine teeth by adopting a conventional brushing mode, brushing each time for 5min, washing with clear water, drying, repeating the brushing steps for 3 times, finishing brushing, and observing color change of the surface of the bovine teeth after 3 times of brushing.
Comparative example 2
5 parts of solid spherical stereocomplex polylactic acid, 0.25 part of thickening agent, 0.1 part of sweetener, 20 parts of humectant, 0.1 part of essence, 3 parts of anionic surfactant and the balance of deionized water. Wherein, the thickener is carbomer, the sweetener is glucose, the humectant is triethanolamine, the essence is peppermint essence, and the anionic surfactant is sodium dodecyl sulfate; a tooth whitening material was prepared in the same manner as in example 1 using the above raw materials.
The preparation method of the solid sphere stereocomplex polylactic acid comprises the following steps: firstly, the weight ratio is 1:1 and the D-polylactic acid are melted and blended at 180 ℃ to obtain the three-dimensional composite polylactic acid powder.
Immersing isolated bovine teeth into deionized water for cleaning, coating tooth whitening materials on the bovine teeth, brushing the bovine teeth by adopting a conventional brushing mode, brushing each time for 5min, washing with clear water, drying, repeating the brushing steps for 3 times, finishing brushing, and observing color change of the surface of the bovine teeth after 3 times of brushing.
Comparative example 3
The isolated bovine teeth were placed in a suspension of barium titanate powder at a concentration of 1mg/ml, and subjected to ultrasonic vibration at 40W for 1 hour at 0.6kHz, with a barium titanate particle diameter of 100nm, and after ultrasonic vibration for 1 hour, the color change of the bovine tooth surface was observed, and at the same time, the structural change of the bovine tooth surface was observed by a scanning electron microscope.
Comparative example 4
The whitening agent containing 22% hydrogen peroxide was used for the same time as in example 1, and the structural change of the bovine tooth surface was observed by a scanning electron microscope.
In addition, the invention carries out cytotoxicity test on the stereocomplex polylactic acid, the control material and the whitening agent containing 22% hydrogen peroxide adopted in the embodiment of the invention; the detailed process is as follows: leaching medium: 89% mem medium +10% fetal bovine serum +1% penicillin-streptomycin solution; cell preparation: mouse fibroblasts (L-929) were cultured at 37℃with 5% CO 2 Culturing under saturated humidity condition; sample preparation: preparing a storage solution with the leaching medium of 0.2g/ml for the stereocomplex polylactic acid; taking storage solutions (100%, 50%,25% and 12.5% concentration groups) respectively; the whitening gel containing 22% hydrogen peroxide is treated by the same method as the stereocomplex polylactic acid; leaching polytetrafluoroethylene with leaching medium, and collecting leaching solution; experimental grouping: l-929 cells were seeded on 96-well plates at a density of 1.5X104 cells/well and cultured for 24 hours. Removing the supernatant, adding 150 mu L of leaching solution culture medium for culturing for 24 hours, lightly washing with PBS for 2 times, adding 110 mu L of 10% CCK-8DMEM culture medium for further incubation in an incubator for 2 hours, and measuring the absorbance density (OD) at the wavelength of 450nm by using an enzyme-labeled instrument; after detection, the sample was washed with PBS for 2 times, and the image was collected under a mirror, and the result is shown in FIG. 10.
Claims (10)
1. A tooth whitening material, characterized in that the raw materials of the tooth whitening material include: 5 to 50 parts by weight of porous three-dimensional composite polylactic acid, 0.1 to 0.2 part by weight of sweetener, 0.1 to 0.3 part by weight of essence, 3 to 5 parts by weight of anionic surfactant, 5 to 10 parts by weight of abrasive material and the balance of deionized water; wherein the porosity of the porous three-dimensional composite polylactic acid is 10% -70%;
the preparation method of the porous stereocomplex polylactic acid comprises the following steps: firstly, the weight ratio is 1:1, mixing the L-polylactic acid and the D-polylactic acid, and then melt-blending the mixture with a proper amount of pore-forming agent at 180 ℃ to obtain the three-dimensional composite polylactic acid powder; the poly Kong Ligou composite polylactic acid can be prepared by washing with deionized water.
2. A tooth whitening material, characterized in that the raw materials of the tooth whitening material include: 5 to 50 parts by weight of porous stereocomplex polylactic acid, 0.25 to 0.9 part by weight of thickener, 0.1 to 0.2 part by weight of sweetener, 20 to 40 parts by weight of humectant, 0.1 to 0.3 part by weight of essence, 3 to 5 parts by weight of anionic surfactant and the balance of deionized water;
wherein the porosity of the porous three-dimensional composite polylactic acid is 10% -70%;
the preparation method of the porous stereocomplex polylactic acid comprises the following steps: firstly, the weight ratio is 1:1, mixing the L-polylactic acid and the D-polylactic acid, and then melt-blending the mixture with a proper amount of pore-forming agent at 180 ℃ to obtain the three-dimensional composite polylactic acid powder; the poly Kong Ligou composite polylactic acid can be prepared by washing with deionized water.
3. The tooth whitening material according to claim 1 or 2, wherein,
the sweetener is selected from: at least one of glucose, sucrose, maltose, dextrin, stevioside or trichlorogalactose;
the perfume is selected from the following components: at least one of peppermint essence, methyl salicylate or spearmint;
the anionic surfactant is selected from: at least one of sodium dodecyl sulfate and sodium lauroyl sarcosinate.
4. The tooth whitening material according to claim 1, wherein,
the abrasive is selected from: at least one of calcium carbonate, dicalcium phosphate, silica or natural microcrystalline cellulose.
5. Tooth whitening material according to claim 2, characterized in that the thickening agent is selected from the group consisting of: at least one of carbomers, cellulosic polymers, salts thereof, natural gums, polyethylene glycol, triethanolamine, silica, or peptized magnesium aluminum silicate;
the humectant is selected from: at least one of glycerin, sorbitol, and propylene glycol.
6. Tooth whitening material according to claim 1 or 2, characterized in that it can be formulated as a toothpaste, a tooth powder, a gel, a toothbrush, a dental tablet or in other known forms.
7. The method for preparing a tooth whitening material according to any one of claims 1 to 6, wherein the method comprises: and uniformly mixing various raw materials of the tooth whitening material, and sampling and detecting the pH value of the mixed system to be 5.5-10.5 to obtain the tooth whitening material.
8. The method for preparing a tooth whitening material according to claim 1, wherein the tooth whitening material is prepared by: firstly, uniformly stirring and mixing a sweetener, an anionic surfactant and essence in a container, then, putting the rest components in the container, and uniformly stirring and mixing to obtain a mixture, and sieving the mixture by a 60-mesh sieve, wherein the sieved material is the tooth whitening material; wherein the porous stereocomplex polylactic acid is prepared into powder with granularity not more than 0.045mm, the abrasive is prepared into powder with granularity not more than 0.011mm, and the anionic surfactant, sweetener and essence are respectively prepared into powder with granularity not more than 0.250 mm.
9. The method for preparing a tooth whitening material according to claim 2, wherein the tooth whitening material is prepared by: firstly adding part of deionized water into a batching pot, then adding a humectant into the batching pot for mixing, then adding a thickening agent and porous three-dimensional composite polylactic acid, gradually heating to 50-75 ℃ under stirring, preserving heat for 10-35 min, and continuously cooling to 15-40 ℃ under stirring; then adding an anionic surfactant in the stirring process; adding sweetener, essence and the rest deionized water into a batching pot, and continuously stirring; the pH value of the sampling detection mixed system is 5.5-10.5, and the tooth whitening material is prepared.
10. The method of using a tooth whitening material according to any one of claims 1 to 6 for non-therapeutic purposes, wherein the method of using is: coating or spraying a tooth whitening material on the surface of the tooth, and applying pressure on the surface of the tooth; the pressure applied to the tooth surface is applied by vibration or friction.
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CN103608445A (en) * | 2011-06-20 | 2014-02-26 | 宝洁公司 | Liquid cleaning and/or cleansing composition |
CN106947228A (en) * | 2017-05-05 | 2017-07-14 | 四川大学 | Multistage porous poly-lactic acid material and preparation method thereof |
CN107670108A (en) * | 2017-09-27 | 2018-02-09 | 四川大学 | A kind of tissue engineering bracket polylactic acid porous material and preparation method thereof |
CN110464674A (en) * | 2019-08-19 | 2019-11-19 | 南京理工大学 | Tooth whitening products containing piezoelectric material |
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CN114058165B (en) * | 2021-11-04 | 2022-10-28 | 泰世德(北京)医药科技有限公司 | Piezoelectric polylactic acid material and preparation method and application thereof |
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CN103608445A (en) * | 2011-06-20 | 2014-02-26 | 宝洁公司 | Liquid cleaning and/or cleansing composition |
CN106947228A (en) * | 2017-05-05 | 2017-07-14 | 四川大学 | Multistage porous poly-lactic acid material and preparation method thereof |
CN107670108A (en) * | 2017-09-27 | 2018-02-09 | 四川大学 | A kind of tissue engineering bracket polylactic acid porous material and preparation method thereof |
CN110464674A (en) * | 2019-08-19 | 2019-11-19 | 南京理工大学 | Tooth whitening products containing piezoelectric material |
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