CN113967931A

CN113967931A - Umbilical cord tissue cutting machine

Info

Publication number: CN113967931A
Application number: CN202111222548.7A
Authority: CN
Inventors: 张斌; 别庆丽; 何宝玉; 吴佩佩; 赵柔; 魏利; 梁敬; 董海新; 钱晖; 许文荣; 李莹澳
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-10-20
Filing date: 2021-10-20
Publication date: 2022-01-25
Anticipated expiration: 2041-10-20
Also published as: CN113967931B

Abstract

The invention discloses an umbilical cord tissue cutting machine, which relates to the technical field of medical scientific research and medical instruments and comprises a bracket, an operating mechanism, a cutting knife and a sample table, wherein the bracket is arranged on the operating mechanism; the operating mechanism is arranged at the upper part of the bracket, the cutting knife is arranged at the bottom of the operating mechanism, and the operating mechanism is used for controlling the vertical position of the cutting knife; the sample table is arranged on the lower portion of the support, and the sample table is located right below the cutting knife. The umbilical cord tissue on the sample table is cut by pressing the operating mechanism with two hands to enable the cutting knife to move downwards, and then the sample table is rotated by 90 degrees to perform secondary cutting, so that the blocky umbilical cord tissue can be obtained; the interval between the blades can be adjusted by setting different gasket quantities, so that the umbilical cord tissue blocks with set sizes are cut out, and different culture requirements are met.

Description

Umbilical cord tissue cutting machine

Technical Field

The invention relates to the technical field of medical scientific research and medical instruments, in particular to an umbilical cord tissue cutting machine.

Background

The mesenchymal stem cell is an adult stem cell, exists in tissues such as umbilical cord, bone marrow, fat, umbilical cord blood and the like, and has strong self-renewal and multi-embryo layer differentiation capacity. Research shows that the medicine has obvious curative effect on immunoregulation and promoting tissue repair, and is widely used for clinical research and treatment of various major diseases such as rheumatoid arthritis, lupus erythematosus, graft-versus-host disease, hepatic fibrosis and the like.

The umbilical cord mesenchymal stem cells are extracted from the umbilical cord tissue of the newborn after full-term delivery and umbilical cord rupture, have the advantages of rich sources, no harm to the body, strong proliferation capacity, multi-embryo layer differentiation capacity, low immunogenicity and the like, and are accepted and applied by more and more professionals.

Before extracting the mesenchymal stem cells in the umbilical cord tissue, the umbilical cord tissue needs to be cut into 1mm²The tissue blocks are cultured, at present, the tissue blocks are trimmed manually, but the tissue blocks are time-consuming, labor-consuming and difficult to achieve with the thickness of 1mm²Standardized culture of (2), existing cuttingThe machine structure is complicated, is difficult to disinfect, therefore, needs a simple structure's slabbing machine urgently.

Disclosure of Invention

In order to solve the technical problems, the invention provides the umbilical cord tissue cutting machine with a simple structure, which is used for cutting umbilical cord tissues.

In order to achieve the purpose, the invention provides the following scheme:

the invention provides an umbilical cord tissue cutting machine, which comprises a bracket, an operating mechanism, a cutting knife and a sample table, wherein the bracket is fixedly connected with the operating mechanism; the operating mechanism is arranged at the upper part of the bracket, the cutting knife is arranged at the bottom of the operating mechanism, and the operating mechanism is used for controlling the vertical position of the cutting knife; the sample table is arranged on the lower portion of the support, and the sample table is located right below the cutting knife.

Optionally, the operating mechanism comprises a support rod, a guide rod, a connecting frame and a handle; the bottom of the supporting rod is connected with the bracket, the guide rod is arranged in parallel with the supporting rod, the top of the supporting rod and the top of the guide rod are both connected with the connecting frame, and the handles are arranged on two sides of the connecting frame; the cutting knife is arranged at the bottom of the guide rod.

Optionally, the connecting frame is of a T-shaped structure.

Optionally, the cutting knife comprises a knife rest and a plurality of knife sets; the plurality of knife groups are arranged at the bottom of the knife rest, and the top of the knife rest is connected with the operating mechanism.

Optionally, the cutter set includes a cutter seat, a baffle, a cutter shaft, a plurality of blades and a plurality of gaskets; the tool apron is of an L-shaped structure, the top end of the horizontal part of the tool apron is connected with the bottom of the tool rest, and the baffle is arranged on one side, away from the vertical part of the tool apron, of the horizontal part of the tool apron; the cutter shaft penetrates through the cutter holder and the baffle; the plurality of blades are arranged on the cutter shaft, and at least one gasket is arranged between every two adjacent blades.

Optionally, the bottom of the tool rest is provided with four tool sets.

Optionally, the sample stage comprises a hollow plate, a silica gel plate and a horizontal rotating plate which are sequentially arranged from top to bottom; the hollowed-out plate, the silica gel plate and the horizontal rotating plate are detachably connected.

Optionally, a turnover table is arranged on the support, and the horizontal rotating plate is arranged on the turnover table.

Optionally, the top of the bracket is further provided with a shell.

Compared with the prior art, the invention has the following technical effects:

according to the umbilical cord tissue cutting machine, the operating mechanism is pressed by two hands, the cutting knife moves downwards to cut umbilical cord tissues on the sample table, then the sample table is rotated by 90 degrees to perform secondary cutting, and then blocky umbilical cord tissues can be obtained, the umbilical cord tissue cutting machine is simple in structure and convenient to operate, and the cutting knife and the sample table can be quickly disassembled so as to be convenient to disinfect and clean; the interval between the blades can be adjusted by setting different gasket quantities, so that the umbilical cord tissue blocks with set sizes are cut out, and different culture requirements are met.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

FIG. 1 is a schematic structural view of an umbilical cord tissue cutting machine according to the present invention;

FIG. 2 is a schematic structural view of the umbilical cord tissue cutting machine according to the present invention in a use state;

FIG. 3 is a schematic view of the structure of the umbilical cord tissue cutting machine with the casing removed;

FIG. 4 is a schematic side view of the umbilical cord tissue cutting machine of the present invention;

FIG. 5 is a schematic structural diagram of a cutting knife in the umbilical cord tissue cutting machine of the present invention;

FIG. 6 is a schematic structural view of a knife set in the umbilical cord tissue cutting machine according to the present invention;

FIG. 7 is a schematic side view of the knife set of the umbilical cord tissue cutting machine of the present invention.

Description of reference numerals: 1. an operating mechanism; 2. a housing; 3. a sample stage; 4. a turning table; 5. a support; 6. a cutting knife;

11. a handle; 12. a connecting frame; 13. a support bar; 14. a guide bar;

31. a hollowed-out plate; 32. a silica gel plate; 33. horizontally rotating the plate;

41. positioning a plate; 42. a front support; 43. a rotating shaft; 44. a first reset-type index pin; 45. a rear support;

51. a top plate; 52. a main support; 53. a base plate; 54. a sub-mount; 55. a second reset-type index pin;

61. a tool holder; 62. a knife group;

621. a tool apron; 622. a baffle plate; 623. a cutter shaft; 624. a B-type cotter pin; 625. a blade; 626. a silica gel gasket; 627. and (7) a gasket.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in fig. 1 to 7, the present embodiment provides an umbilical cord tissue cutting machine, which includes a bracket 5, an operating mechanism 1, a cutting knife 6 and a sample stage 3; the operating mechanism 1 is arranged at the upper part of the bracket 5, the cutting knife 6 is arranged at the bottom of the operating mechanism 1, and the operating mechanism 1 is used for controlling the vertical position of the cutting knife 6; the sample table 3 is arranged at the lower part of the bracket 5, and the sample table 3 is positioned right below the cutting knife 6.

In the present embodiment, the support 5 includes a bottom plate 53, a main support 52, a sub-support 54, and a top plate 51; one end of the bottom plate 53 is fixedly provided with a main bracket 52 through a screw, the auxiliary bracket 54 is fixedly arranged at the other end of the bottom plate 53 through a screw, and one end of the top plate 51 is fixedly connected with the top of the main bracket 52 through a screw. The top plate 51 is provided with three through holes, and the support rod 13 and the guide rod 14 of the operating mechanism 1 respectively penetrate through one through hole.

The two sides of the shell 2 are provided with long holes, and the shell 2 is connected with the side walls of the top plate 51 and the main bracket 52 through screws.

The operating mechanism 1 comprises a support rod 13, a guide rod 14, a connecting frame 12 and a handle 11; the bottom of the supporting rod 13 is connected with the bracket 5, the guide rod 14 is arranged in parallel with the supporting rod 13, the top of the supporting rod 13 and the top of the guide rod 14 are both connected with the connecting frame 12, and the handles 11 are arranged on two sides of the connecting frame 12; the cutting knife 6 is arranged at the bottom of the guide rod 14. The connecting frame 12 is of a T-shaped structure.

Through threaded connection between handle 11 and the link 12, it is concrete, the one end of handle 11 sets up the external screw thread, and the both sides of link 12 all set up the internal thread, make external screw thread and internal thread fit connection through passing handle 11 the slot hole on the shell 2, accomplish the assembly of handle 11 and link 12.

The bottom of the support rod 13 is connected with the vertical end surface of the main bracket 52 through a support seat; specifically, the supporting seat is fixedly connected with the main support 52 through screws, a supporting hole is formed in one side, facing the sample stage 3, of the supporting seat, a connecting hole is formed in the bottom of the supporting rod 13, and the connecting hole and the supporting hole are rotatably connected through bolts and nuts. More specifically, the support rod 13 may be a hydraulic rod or a pneumatic rod.

The tops of the supporting rod 13 and the guide rod 14 are connected with the connecting frame 12 through screws, so that when the handle 11 is pressed, the handle 11, the connecting frame 12, the supporting rod 13 and the guide rod 14 can synchronously move downwards, and after hands are loosened, the original height can be restored under the restoring action of the supporting rod 13.

The cutting knife 6 comprises a knife rest 61 and four knife groups 62; the plurality of knife sets 62 are all arranged at the bottom of the knife rest 61, and the top of the knife rest 61 is connected with the operating mechanism 1.

The knife group 62 comprises a knife holder 621, a baffle 622, a knife shaft 623, a plurality of blades 625 and a plurality of gaskets 627; the tool apron 621 is of an L-shaped structure, the top end of the horizontal part of the tool apron 621 is connected with the bottom of the tool holder 61, and the baffle 622 is arranged on one side of the horizontal part of the tool apron 621, which is far away from the vertical part of the tool apron 621; the cutter shaft 623 penetrates through the cutter holder 621 and the baffle 622; the plurality of blades 625 are disposed on the cutter shaft 623, and at least one spacer 627 is disposed between adjacent blades 625. More specifically, in order to keep the cutting edges of the plurality of blades 625 in the same blade group 62 parallel, a silicone gasket 626 is provided at the bottom of the horizontal portion of the tool holder 621, the cutting edges of the plurality of blades 625 are in close contact with the silicone gasket 626, and the cutting edges of the plurality of blades 625 are kept parallel by the plane of the silicone gasket 626. One end of the knife shaft 623 is provided with an end cap and the other end is provided with a B-shaped cotter pin 624. Further, a vertical connecting hole is formed in the top of the tool rest 61, a horizontal pin hole is formed in the top of the tool rest and penetrates through the connecting hole, the connecting hole is used for being connected with the guide rod 14, and a quick-pull pin is inserted into the pin hole to fix the tool rest 61 and the guide rod 14; the tool holder 621 and the tool holder 61 are fixed by two screws, so that the single tool holder 621 can be detached conveniently. The tool holder 621 and the baffle 622 are fixed by two screws so as to replace the blade 625 by detaching the baffle 622.

A single spacer 627 of thickness 0.7mm, two spacers 627 in the adjacent blades 625 so far, allows the cut umbilical cord to be a 1.5mm block.

The sample table 3 comprises a hollow plate 31, a silica gel plate 32 and a horizontal rotating plate 33 which are sequentially arranged from top to bottom; the hollow plate 31, the silica gel plate 32 and the horizontal rotating plate 33 are detachably connected through screws, so that the silica gel plate 32 can be conveniently replaced and the hollow plate 31 can be sterilized. Four first locating holes are evenly arranged at the bottom of the horizontal rotating plate 33, the center of the bottom of the horizontal rotating plate 33 is rotatably connected with the middle part of the overturning platform 4, and the horizontal rotating plate 33 can rotate relative to the overturning platform 4.

The support 5 is provided with a turnover table 4, and the horizontal rotating plate 33 is arranged on the turnover table 4. More specifically, the flipping table 4 includes a positioning plate 41, a front support 42, a rotating shaft 43, a first reset-type index pin 44, a rear support 45, and a second reset-type index pin 55; main support 52 and auxiliary support 54 are run through to pivot 43, preceding support 42 and rear support 45 set up on pivot 43, locating plate 41 sets up in the top of preceding support 42 and rear support 45, preceding support 42 is provided with the second locating hole towards the one end of auxiliary support 54, the angle between the adjacent second locating hole is 90 degrees, second reset type index pin 55 runs through auxiliary support 54 and the cooperation of second locating hole, the completion is to the location of preceding support 42, thereby make roll-over table 4 can keep level or vertical state, and then make sample platform 3 keep level or vertical, so that carry out sample cutting or clearance sample platform 3. The first reset type index pin 44 is disposed at the bottom of the positioning plate 41, and penetrates through the positioning plate 41 to be matched with the first positioning hole, so that the rotation or positioning of the sample table 3 can be controlled by the first reset type index pin 44.

When the sample table is used, the sample table 3 is kept in a horizontal state by adjusting the second reset type indexing pin 55, the cutting knife 6 is placed on the sample table 3, the handle 11 is pressed to enable the bottom of the guide rod 14 to be inserted into a connecting hole in the top of the knife rest 61, and the guide rod 14 and the knife rest 61 are connected through the quick-pull pin; the handle 11 is loosened, so that the operating mechanism 1 drives the cutting knife 6 to rise to the maximum height; placing the umbilical cord tissue on the sample table 3, pressing the handle 11 to enable the cutting knife 6 to move downwards to cut the umbilical cord tissue; then, the handle 11 is loosened, the cutting knife 6 is reset, the second reset type indexing pin 55 is pulled, the second reset type indexing pin 55 is loosened after the sample table 3 rotates, the handle 11 is pressed again, the cutting knife 6 cuts the umbilical cord tissue again, and the massive umbilical cord tissue can be obtained.

Through experiments, two persons respectively use the umbilical cord tissue cutting machine provided by the invention to cut 9 dishes of tissue blocks, the sharing time is 20 minutes for one hour, the average time is 40 minutes when no person is used, and after 7 days, all cells in 18 dishes of tissue blocks grow.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not intended to be construed as limiting the claim concerned.

The principle and the implementation mode of the present invention are explained by applying specific examples in the present specification, and the above descriptions of the examples are only used to help understanding the method and the core idea of the present invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.

Claims

1. An umbilical cord tissue cutting machine is characterized by comprising a bracket, an operating mechanism, a cutting knife and a sample table; the operating mechanism is arranged at the upper part of the bracket, the cutting knife is arranged at the bottom of the operating mechanism, and the operating mechanism is used for controlling the vertical position of the cutting knife; the sample table is arranged on the lower portion of the support, and the sample table is located right below the cutting knife.

2. The umbilical cord tissue cutting machine according to claim 1, wherein the operating mechanism includes a support bar, a guide bar, a connecting frame, and a handle; the bottom of the supporting rod is connected with the bracket, the guide rod is arranged in parallel with the supporting rod, the top of the supporting rod and the top of the guide rod are both connected with the connecting frame, and the handles are arranged on two sides of the connecting frame; the cutting knife is arranged at the bottom of the guide rod.

3. The umbilical cord tissue cutting machine according to claim 2, wherein the connection frame is of a T-shaped configuration.

4. The umbilical cord tissue cutting machine of claim 1, wherein the cutting knife comprises a knife holder and a plurality of knife sets; the plurality of knife groups are arranged at the bottom of the knife rest, and the top of the knife rest is connected with the operating mechanism.

5. The umbilical cord tissue cutting machine of claim 4, wherein the knife assembly includes a knife holder, a baffle, a knife shaft, a plurality of blades, and a plurality of shims; the tool apron is of an L-shaped structure, the top end of the horizontal part of the tool apron is connected with the bottom of the tool rest, and the baffle is arranged on one side, away from the vertical part of the tool apron, of the horizontal part of the tool apron; the cutter shaft penetrates through the cutter holder and the baffle; the plurality of blades are arranged on the cutter shaft, and at least one gasket is arranged between every two adjacent blades.

6. The umbilical cord tissue cutting machine according to claim 4, wherein the bottom of the tool holder is provided with four of the sets of tools.

7. The umbilical cord tissue cutting machine according to claim 1, wherein the sample stage comprises a hollow plate, a silica gel plate and a horizontal rotating plate which are arranged from top to bottom in sequence; the hollowed-out plate, the silica gel plate and the horizontal rotating plate are detachably connected.

8. The umbilical cord tissue cutting machine according to claim 7, wherein the bracket is provided with a turnover table, and the horizontal rotating plate is arranged on the turnover table.

9. The umbilical cord tissue cutting machine according to claim 1, wherein the stent top is further provided with a housing.