CN115363811A - Rat tail breaking device - Google Patents

Rat tail breaking device Download PDF

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Publication number
CN115363811A
CN115363811A CN202211193964.3A CN202211193964A CN115363811A CN 115363811 A CN115363811 A CN 115363811A CN 202211193964 A CN202211193964 A CN 202211193964A CN 115363811 A CN115363811 A CN 115363811A
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CN
China
Prior art keywords
cutter
groove
limiting
rotating
rat tail
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Pending
Application number
CN202211193964.3A
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Chinese (zh)
Inventor
冯宇霞
张素才
管倩倩
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Beijing Zhaoyan New Drug Research Center Co ltd
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Beijing Zhaoyan New Drug Research Center Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Beijing Zhaoyan New Drug Research Center Co ltd filed Critical Beijing Zhaoyan New Drug Research Center Co ltd
Priority to CN202211193964.3A priority Critical patent/CN115363811A/en
Publication of CN115363811A publication Critical patent/CN115363811A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00Surgical instruments for veterinary use
    • A61D1/04Cropping devices for tails or ears

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention provides a special device for rat tail breaking, which comprises an operation table and a cutter, wherein the cutter is arranged on the operation table through a support frame; a tail limiting mechanism is further arranged on the workbench and is arranged right below the cutter; the limiting mechanism is arranged, so that the angle for cutting the tail of the rat can be controlled, the height consistency of the wound surface of the tail of each rat is kept, and the error of experimental comparison can be reduced; the knife rest is arranged, so that the cutting is more convenient, the labor is saved when the knife is used for cutting by force vertically compared with the prior art that the knife is used for cutting by force on the side surface, and the error in bleeding caused by manually pressing the tail part of a mouse in the cutting process can be prevented; in addition, the cutter is rotatably arranged on the cutter rest, so that the cutter can be conveniently disinfected by experimenters, and meanwhile, the cutter can be conveniently replaced.

Description

Rat tail breaking device
Technical Field
The invention relates to the technical field of animal clinical experimental tools for new hemophilia medicines, in particular to a tail breaking device which can conveniently cut off a rat tail and can keep high consistency.
Background
Hemophilia is a bleeding disease of blood coagulation dysfunction, and in the development of new drugs, hemophilia construction is generally performed on a mouse or a rat, then pharmacological clinical experiments of new hemophilia drugs are performed on the rat with hemophilia, and when drug effects are detected, the rat tail front end is cut at a position of about 5mm, and then, the amount of bleeding is collected to be used as one of detection bases of the drug effects of the new drugs.
In the prior art, a rat tail is usually directly cut off by using a rat tail clamp or a scalpel, and the skin tissue of a rat is usually connected after a tail bone is cut off under the condition of using the rat tail clamp, so that the operation efficiency is low, and the traumatic damage to the rat tail is obviously different; the physical requirement of an operator is high by using a scalpel for direct cutting, hundreds of or even more rat tails are cut in one day, the workload is high, and in the cutting process, the wound surfaces are different due to different placement angles of the rat tails, so that the final result is in error. Therefore, there is a need for a rat tail-severing device that facilitates cutting and maintains a high degree of consistency.
Disclosure of Invention
Aiming at the technical problems, the technical scheme of the invention provides a special device for rat tail breaking, which can control the angle of a cut rat tail by arranging a limiting mechanism and keep the high consistency of the wound surface of each rat tail, thereby reducing the error of experimental comparison; the knife rest is arranged, so that the cutting is more convenient, the labor is saved when the knife is used for cutting by force vertically compared with the prior art that the knife is used for cutting by force on the side surface, and the error in bleeding caused by manually pressing the tail part of a mouse in the cutting process can be prevented; in addition, the cutter can be rotatably arranged on the cutter rest, so that the cutter can be conveniently sterilized by experimenters, and meanwhile, the cutter can be conveniently replaced.
The invention provides a tail breaking device for a rat, which comprises: the cutting knife is arranged on the operation platform through a support frame; still be provided with mouse tail stop gear on the workstation, just mouse tail stop gear sets up under the cutter.
According to the further optimization of the technical scheme, the cutter is mounted on the support frame through a cutter bar, and a support device for supporting the cutter bar is arranged in the support frame; the cutter bar is provided with a holding part.
According to the technical scheme, the cutter bar is vertically and slidably arranged on the support frame, and sliding grooves for the cutter bar to slide in the vertical direction are respectively formed in the opposite side surfaces of the two support rods of the support frame; the two ends of the cutter bar are respectively provided with a cuboid-shaped sliding block matched with the sliding groove; the support rod is further internally provided with an accommodating cavity for installing the support device, and the accommodating cavity is communicated with the sliding groove.
In a further optimization of the technical scheme of the invention, the supporting device is an elastic device or a telescopic device arranged in the accommodating frame, and in an initial state, the elastic device or the telescopic device is used for enabling the cutter bar to be positioned at the top of the supporting frame.
According to the technical scheme, the cutter bar is connected with the support frame through a rotating mechanism, and the rotating mechanism is arranged at the top end of the accommodating cavity.
According to the further optimization of the technical scheme, the rotating mechanism comprises a rotating cavity formed in the top of the supporting rod and a rotating rod arranged in the rotating cavity, the rotating rod comprises a fixed head, a rotating body and a fixed groove, the fixed groove is formed in the rotating body and communicated with the sliding groove in an initial state, and the fixed groove is matched with the sliding block; the fixed head is connected with the supporting rod through a bearing, and the rotating body is located in the rotating cavity.
According to further optimization of the technical scheme, a clamping mechanism is arranged between the inner wall of the rotating cavity and the outer side wall of the rotating body, and comprises an elastic bulge arranged on the side wall of the rotating body and a clamping groove arranged on the inner wall of the rotating cavity.
According to the further optimization of the technical scheme, the limiting mechanism comprises two limiting blocks symmetrically arranged on the workbench, and the upper side surfaces of the limiting blocks and the operation area of the workbench are respectively provided with scale marks.
According to the technical scheme, the limiting block comprises a vertical limiting plate, a horizontal limiting plate and a glass slide limiting groove which are integrally arranged, and the glass slide limiting groove consists of the vertical limiting plate and the horizontal limiting plate; and a through groove for the cutter to pass through is formed in the horizontal limiting plate, and one side of the through groove is a starting point of the scale marks on the upper surface of the limiting block.
According to the technical scheme, the bevel edge is arranged on one side of each of the two limiting blocks; the limiting block is arranged on the workbench in a sliding mode through the vertical limiting plate, and the bottom of the vertical limiting plate is connected with the workbench through a limiting sliding groove structure.
Drawings
The invention will be described in more detail hereinafter on the basis of embodiments and with reference to the accompanying drawings.
FIG. 1 is a schematic view of the overall structure of the rat tail-severing device of the present invention;
FIG. 2 is a schematic view of the structure of the cutter bar of the rat tail-cutting device of the present invention;
FIG. 3 isbase:Sub>A schematic view of the rat tail-severing device of FIG. 1 according to the present invention, taken along line A-A' in partial cross-section;
FIG. 4 is a schematic structural view of a rotating rod in the tail breaking device for rats of the present invention;
fig. 5 is a schematic structural diagram of a limiting mechanism in the rat tail breaking device.
In the drawings, like parts are provided with like reference numerals. The figures are not drawn to scale.
Description of the reference symbols: 1-a working platform; 2-a support rod; 21-a chute; 22-a containment chamber; 23-a rotation cavity; 3, cutting a tool bar; 31-a grip portion; 32-a slide block; 4-cutting knife; 5, limiting a block; 51-slide limiting groove; 52-through groove; 53-vertical fiberboard; 54-horizontal limiting plate; 6-scale line; 7-a limiting chute; 8-rotating the body; 81-fixed head; 82-elastic protrusions; 83-fixed slot; 9-spring.
Detailed Description
The invention will be further illustrated with reference to fig. 1-5.
Hemophilia is classified as one of ten rare diseases, patients of the hemophilia are mainly diseases caused by blood coagulation dysfunction, have a tendency of bleeding after slight trauma for life, and are easy to cause disability or death due to untimely treatment. Therefore, research and development of new hemophilia medicines are highly concerned in the medical field at home and abroad, clinical experiments in research and development of new hemophilia medicines are a necessary process for verifying medicine effect, a rat is generally used as an experimental object, hemophilia is constructed on the rat, then the new hemophilia medicines are used for the rat, the recovery condition of blood coagulation of the rat during trauma is observed, the trauma experiment is mainly that the tail of the rat is broken at a position 5mm away from the tail end of the rat, the bleeding amount of the rat tail part after the tail breaking is collected, and meanwhile, a contrast experiment is matched to comprehensively analyze the treatment effect of the new medicines. In the prior art, a special tail breaking device is not provided, so that an experimental operator usually adopts a rat tail clamp to break a rat tail or adopts a scalpel to directly press and cut, and both the tail breaking effect and the working efficiency are unsatisfactory, so that the special device for rat tail breaking comprises an operation table 1 and a cutter 4, wherein the cutter 4 is arranged on the operation table 1 through a support frame, so that the relative stability between the operation table 1 and the cutter 4 is ensured; set up the stop gear who is used for fixed mouse tail simultaneously under cutter 4, can fix the mouse tail in the cutting to set up scale mark 6 respectively in stop gear and the workstation position that corresponds, the position that can accurate control cut, thereby keep the uniformity of experimental processing, the effectual experimental error that has reduced.
Specifically, the cutter 4 is mounted on the support frame through the cutter bar 3, the support frame may be a single-side support frame, i.e., a structure similar to a guillotine, except for the structure shown in fig. 1, and one side of the cutter bar 3 is hinged to the support frame. In order to more stably and preferably adopt the support frame with the double support rods 2 in the technical scheme of the invention, a support device for supporting the cutter rod 3 is arranged in the support frame, and the support device mainly supports the cutter 4 to be kept at the upper part of the support frame in an unused state; as shown in fig. 2, the cutter bar 3 is provided with a holding portion 31, so that the operator can hold the holding portion 31 by hand and directly press the cutter bar to realize the operation of the cutter 4 in the vertical direction.
The cutter bar 3 is arranged on the support frame in a vertically sliding manner, and the opposite side surfaces of the two support rods 2 of the support frame are respectively provided with a sliding groove 21 for the cutter bar 3 to slide in the vertical direction; the two ends of the cutter bar 3 are respectively provided with a cuboid-shaped sliding block 32 matched with the sliding groove 21, the sliding blocks 32 can stably limit the cutter bar 3 in the support frame, the cutter bar cannot swing left and right when in use, and the sliding groove 21 limits the motion track; the support rod 2 is also internally provided with an accommodating cavity 22 for installing the support device, and the accommodating cavity 22 is communicated with the sliding groove 21, so that the support device can directly act on the cutter bar 3 and move up and down along with the cutter bar 3. The supporting device is an elastic device or a telescopic device arranged in the accommodating frame, and in an initial state, the elastic device or the telescopic device is used for enabling the cutter bar 3 to be positioned at the top of the supporting frame; the elastic device is preferably a spring 9, the accommodating cavity 22 is a cylindrical cavity, the lower part of the cutter bar 3 can be directly supported after the spring 9 is placed in the accommodating cavity, the elasticity of the spring 9 is not too large, and the weight of the cutter bar 3 and the weight of the cutter 4 can be properly supported, so that too much elasticity of the spring 9 is not needed to be overcome when the cutter bar is used; in another embodiment, a telescopic device is arranged in the accommodating cavity 22, preferably a telescopic rod arranged in the accommodating cavity 22, the minimum vertical height of the top end of the telescopic rod from the surface of the workbench 1 in a compressed state is equal to the height of the cutter 4 plus the thickness of the upper glass slide plus 0.1-0.4mm (the thickness of the filter paper), the telescopic rod is of a hard support structure, and through the design of the height, an operator can place a piece of filter paper on the glass slide when cutting a mouse tail, so that the filter paper can keep certain integrity without influencing the cutting of the mouse tail, blood cannot flow onto the glass slide, the design is mainly used for collecting blood flowing out from the wound surface of the mouse tail at the first time, the filter paper is directly used for collecting the blood, secondary collection from the glass slide is not needed, the workload of the operator can be reduced while the accuracy of blood flow collection is improved, and the use is more efficient.
As shown in fig. 1 and 3, in order to facilitate the sterilization of the cutting knife 4 and the replacement of the blade, the knife bar 3 is connected to the support frame through a rotating mechanism, the rotating mechanism is disposed at the top end of the accommodating cavity 22, and specifically includes a rotating cavity 23 formed at the top of the support bar 2 and a rotating rod disposed in the rotating cavity 23, as shown in fig. 4, the rotating rod includes a fixing head 81, a rotating body 8 and a fixing groove 83, the fixing groove 83 is formed on the rotating body 8, and in an initial state, the fixing groove 83 is communicated with the sliding groove 21, and the fixing groove 83 is matched with the sliding block 32, preferably, spherical protrusions are disposed on two side walls of the sliding block 32, a groove is disposed in the fixing groove 83 corresponding to the spherical protrusion on the sliding block 32, and when the knife bar 3 is located on the fixing groove, the height of the knife bar can be kept consistent with the rotation of the rotating body 8 through the cooperation between the spherical protrusion and the groove, and the sliding block 32 cannot be rotated together with the knife bar because the rotating rod does not enter the fixing groove 83; the fixed head 81 is connected with the support rod 2 through a bearing, and the rotating body 8 is positioned in the rotating cavity 23. The rotating body 8 is fixed in the support rod 2 through the fixing head 81, and the friction force during rotation can be reduced through the bearing. Rotate the inner wall of chamber 23 with be provided with screens mechanism between the lateral wall of rotating body 8, screens mechanism is including setting up rotate elastic bulge 82 on the 8 lateral walls of body and set up rotate draw-in groove on the 23 inner walls of chamber, and preferred bellied number is 1, sets up on the 8 lateral walls of rotating body that the fixed slot 83 opening is relative, and the draw-in groove sets up 3, is located respectively and holds the top of chamber 22 and the corresponding left and right sides lateral wall of horizontal diameter, can guarantee like this that rotating body 8 rotates 90 degrees and fixes, conveniently disinfects or changes cutter 4.
As shown in fig. 1 and 5, the limiting mechanism includes two limiting blocks 5 symmetrically disposed on the worktable. The single limiting block 5 comprises a vertical limiting plate 53, a horizontal limiting plate 54 and a glass slide limiting groove 51 which are integrally arranged, the glass slide limiting groove 51 consists of the vertical limiting plate 53 and the horizontal limiting plate 54 (namely, the glass slide limiting groove 51 is arranged on one side of the limiting block 5), and the glass slide limiting grooves 51 on the two limiting blocks 5 are oppositely arranged, so that a glass slide can be just fixed when the glass slide limiting groove is used; offer the confession on the horizontal limiting plate 54 the logical groove 52 that cutter 4 passed, just one side that leads to groove 52 does the starting point of 5 upper surface scale marks of stopper 6, cutter 4 can pass logical groove 52 and cut the rat tail when cutting from upper portion, can control the accurate nature of cutting like this, the position of measurement rat tail cutting that also can be accurate, preferred stopper 5 is made by transparent resin material, and the position of scale and observation rat tail is conveniently observed to transparent material. One side of each of the two limiting blocks 5 is provided with a bevel edge, the side faces, opposite to each other, of the two limiting blocks 5 can directly clamp the mouse tail when the mouse is used, a triangular space is formed by the bevel edges of the two limiting blocks 5, the mouse tail can be fixed by being close to the glass slide, or mouse tail placing grooves can be formed in the opposite side faces of the limiting blocks 5; stopper 5 passes through perpendicular limiting plate 53 slides and sets up on the operation panel 1, just perpendicular limiting plate 53's bottom through 7 structures of spacing spout with the workstation is connected, alternative technical scheme connects through the strong magnet between perpendicular limiting plate 53 and the workstation, and magnet sets up into the strip moreover, forms the slip track, also sets up strip magnet on stopper 5, can keep stopper 5 during operation like this to fix in a particular position, can not produce the error because of injecing.
The use method of the rat tail breaking device comprises the following steps: the operation table 1, the cutter bar 3, the cutter 4, the support frame and the limiting mechanism are respectively disinfected, then a mouse after anesthesia is placed on the operation table 1 and is placed on a glass slide below the cutter 4 corresponding to the mouse tail, and then the mouse tail is limited through the limiting mechanism, firstly, the size of the tail end of the rat from the cutting position is aligned, and measurement is carried out according to scales on the operation table 1 or the limiting block 5; secondly, the tail of the mouse is fixed through the inclined plane on the limiting block 5 and is close to the glass slide, and the cutting angle change wound surface is increased when the tail of the mouse tilts. After the position is limited, the cutter 4 can be cut off the rat tail by grasping the holding part 31 on the cutter rod 3 and pressing downwards. After cutting, the cutter rod 3 is reset to the top of the support frame, then the cutter rod 3 is rotated, the cutter 4 is in a horizontal state, the cutter can be disinfected, and then next cutting is prepared.
While the invention has been described with reference to a preferred embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the technical features mentioned in the embodiments can be combined in any way as long as there is no structural conflict. It is intended that the invention not be limited to the particular embodiments disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims (10)

1. A rat tail-severing device, comprising: the cutting knife is arranged on the operation platform through a support frame; still be provided with mouse tail stop gear on the workstation, just mouse tail stop gear sets up under the cutter.
2. The rat tail breaking device according to claim 1, wherein the cutter is mounted on the support frame through a cutter bar, and a support device for supporting the cutter bar is arranged in the support frame; the cutter bar is provided with a holding part.
3. The rat tail breaking device according to claim 2, wherein the cutter bar is vertically slidably disposed on the support frame, and sliding grooves for the cutter bar to slide in the vertical direction are respectively disposed on opposite side surfaces of two support rods of the support frame; the two ends of the cutter bar are respectively provided with a cuboid-shaped sliding block matched with the sliding groove; the support rod is further internally provided with an accommodating cavity for installing the support device, and the accommodating cavity is communicated with the sliding groove.
4. A rat tail-breaking device according to claim 3, wherein the supporting means is an elastic means or a telescopic means arranged inside the receiving means, and in an initial state, the elastic means or the telescopic means is used for enabling the knife bar to be located at the top of the supporting frame.
5. A rat tail breaking device according to claim 3, wherein the knife bar is connected with the support frame through a rotating mechanism, and the rotating mechanism is arranged at the top end of the accommodating cavity.
6. A rat tail breaking device according to claim 5, wherein the rotating mechanism comprises a rotating cavity arranged at the top of the supporting rod and a rotating rod arranged in the rotating cavity, the rotating rod comprises a fixed head, a rotating body and a fixed groove, the fixed groove is arranged on the rotating body and communicated with the sliding groove in an initial state, and the fixed groove is matched with the sliding block; the fixed head is connected with the supporting rod through a bearing, and the rotating body is located in the rotating cavity.
7. A rat tail breaking device according to claim 6, wherein a clamping mechanism is arranged between the inner wall of the rotating cavity and the outer side wall of the rotating body, and the clamping mechanism comprises an elastic bulge arranged on the side wall of the rotating body and a clamping groove arranged on the inner wall of the rotating cavity.
8. The device according to any one of claims 1-7, characterized in that the limiting mechanism comprises two limiting blocks symmetrically arranged on the workbench, and the upper side surfaces of the limiting blocks and the working area of the workbench are respectively provided with scale marks.
9. The rat tail breaking device according to claim 8, wherein the limiting block comprises a vertical limiting plate, a horizontal limiting plate and a slide glass limiting groove which are integrally arranged, and the slide glass limiting groove consists of the vertical limiting plate and the horizontal limiting plate; and a through groove for the cutter to pass through is formed in the horizontal limiting plate, and one side of the through groove is a starting point of the scale marks on the upper surface of the limiting block.
10. A rat tail breaking device according to claim 8, wherein one side of the two limiting blocks is provided with a bevel edge; the limiting block is arranged on the workbench in a sliding mode through the vertical limiting plate, and the bottom of the vertical limiting plate is connected with the workbench through a limiting sliding groove structure.
CN202211193964.3A 2022-09-28 2022-09-28 Rat tail breaking device Pending CN115363811A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211193964.3A CN115363811A (en) 2022-09-28 2022-09-28 Rat tail breaking device

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Application Number Priority Date Filing Date Title
CN202211193964.3A CN115363811A (en) 2022-09-28 2022-09-28 Rat tail breaking device

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CN115363811A true CN115363811A (en) 2022-11-22

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CN202211193964.3A Pending CN115363811A (en) 2022-09-28 2022-09-28 Rat tail breaking device

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117091932A (en) * 2023-10-18 2023-11-21 北京昭衍新药研究中心股份有限公司 Automatic embedding system

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201213076A (en) * 2010-09-16 2012-04-01 Guo-Hong Luo Structure of vegetable and fruit slicing tool
KR20160042307A (en) * 2014-10-08 2016-04-19 울산대학교 산학협력단 Assistant equipment for Intravenous injection and blood collecting of Rat
CN206880756U (en) * 2017-11-03 2018-01-16 郝颖 White mouse cuts cercoids
CN211388922U (en) * 2019-11-01 2020-09-01 卢相均 A novel hand hay cutter for chinese herbal medicine processing
CN112674767A (en) * 2020-12-28 2021-04-20 四川大学 Blood system is got to mouse tail vein
CN213249950U (en) * 2020-08-06 2021-05-25 苏州市中医医院 Rat intervertebral disc cutting device
KR20210117502A (en) * 2020-03-19 2021-09-29 주식회사 바이탈스 Mouse holder
CN220124875U (en) * 2022-09-28 2023-12-05 北京昭衍新药研究中心股份有限公司 Rat tail-breaking frame

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201213076A (en) * 2010-09-16 2012-04-01 Guo-Hong Luo Structure of vegetable and fruit slicing tool
KR20160042307A (en) * 2014-10-08 2016-04-19 울산대학교 산학협력단 Assistant equipment for Intravenous injection and blood collecting of Rat
CN206880756U (en) * 2017-11-03 2018-01-16 郝颖 White mouse cuts cercoids
CN211388922U (en) * 2019-11-01 2020-09-01 卢相均 A novel hand hay cutter for chinese herbal medicine processing
KR20210117502A (en) * 2020-03-19 2021-09-29 주식회사 바이탈스 Mouse holder
CN213249950U (en) * 2020-08-06 2021-05-25 苏州市中医医院 Rat intervertebral disc cutting device
CN112674767A (en) * 2020-12-28 2021-04-20 四川大学 Blood system is got to mouse tail vein
CN220124875U (en) * 2022-09-28 2023-12-05 北京昭衍新药研究中心股份有限公司 Rat tail-breaking frame

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117091932A (en) * 2023-10-18 2023-11-21 北京昭衍新药研究中心股份有限公司 Automatic embedding system
CN117091932B (en) * 2023-10-18 2023-12-29 北京昭衍新药研究中心股份有限公司 Automatic embedding system

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