CN113966231B - 用于调节t细胞介导的免疫力的材料和方法 - Google Patents

用于调节t细胞介导的免疫力的材料和方法 Download PDF

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CN113966231B
CN113966231B CN202080043002.2A CN202080043002A CN113966231B CN 113966231 B CN113966231 B CN 113966231B CN 202080043002 A CN202080043002 A CN 202080043002A CN 113966231 B CN113966231 B CN 113966231B
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seq
amino acid
acid sequence
antigen
antibody
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CN113966231A (zh
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R·贾内桑
I·S·格鲁瓦尔
S·辛赫
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Janssen Biotech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202080043002.2A 2019-05-08 2020-05-07 用于调节t细胞介导的免疫力的材料和方法 Active CN113966231B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962844959P 2019-05-08 2019-05-08
US201962844966P 2019-05-08 2019-05-08
US201962844970P 2019-05-08 2019-05-08
US201962844976P 2019-05-08 2019-05-08
US201962844995P 2019-05-08 2019-05-08
US62/844976 2019-05-08
US62/844966 2019-05-08
US62/844995 2019-05-08
US62/844959 2019-05-08
US62/844970 2019-05-08
PCT/US2020/031749 WO2020227457A1 (en) 2019-05-08 2020-05-07 Materials and methods for modulating t cell mediated immunity

Publications (2)

Publication Number Publication Date
CN113966231A CN113966231A (zh) 2022-01-21
CN113966231B true CN113966231B (zh) 2025-04-01

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US (2) US11667712B2 (https=)
EP (1) EP3965818A4 (https=)
JP (2) JP7686571B2 (https=)
KR (1) KR20220017892A (https=)
CN (1) CN113966231B (https=)
AU (1) AU2020267504A1 (https=)
BR (1) BR112021022089A2 (https=)
CA (1) CA3139508A1 (https=)
CL (1) CL2021002905A1 (https=)
CO (1) CO2021015998A2 (https=)
CR (1) CR20210548A (https=)
DO (1) DOP2021000229A (https=)
EC (1) ECSP21087921A (https=)
IL (1) IL287817A (https=)
JO (1) JOP20210297A1 (https=)
MA (1) MA55903A (https=)
MX (1) MX2021013532A (https=)
PE (1) PE20220763A1 (https=)
PH (1) PH12021552790A1 (https=)
SG (1) SG11202112021QA (https=)
TW (1) TW202108618A (https=)
WO (1) WO2020227457A1 (https=)

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KR20230042035A (ko) 2020-07-08 2023-03-27 라바 테라퓨틱스 엔.브이. Psma와 감마-델타 t 세포 수용체에 결합할 수 있는 항체
EP4237003A4 (en) 2020-10-28 2025-07-09 Janssen Biotech Inc COMPOSITIONS AND METHODS FOR MODULATING GAMMA DELTA CHAIN-MEDIATED IMMUNITY
BR112023016360A2 (pt) * 2021-02-16 2024-01-23 Janssen Biotech Inc Materiais e métodos para determinação aprimorada de ligante alvo
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TW202537974A (zh) * 2023-11-15 2025-10-01 大陸商上海盛迪醫藥有限公司 Ｔｒｇｖ９結合蛋白及其醫藥用途

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Publication number Publication date
EP3965818A4 (en) 2023-05-31
US11667712B2 (en) 2023-06-06
US20210032338A1 (en) 2021-02-04
CR20210548A (es) 2022-02-11
EP3965818A1 (en) 2022-03-16
ECSP21087921A (es) 2022-01-31
JP2022533538A (ja) 2022-07-25
CN113966231A (zh) 2022-01-21
PH12021552790A1 (en) 2022-09-05
KR20220017892A (ko) 2022-02-14
CO2021015998A2 (es) 2021-12-10
JOP20210297A1 (ar) 2023-01-30
AU2020267504A1 (en) 2021-12-02
DOP2021000229A (es) 2022-07-31
CA3139508A1 (en) 2020-11-12
MX2021013532A (es) 2022-02-11
US20240150464A1 (en) 2024-05-09
PE20220763A1 (es) 2022-05-16
BR112021022089A2 (pt) 2022-02-08
IL287817A (en) 2022-01-01
WO2020227457A1 (en) 2020-11-12
JP7686571B2 (ja) 2025-06-02
MA55903A (fr) 2022-03-16
CL2021002905A1 (es) 2022-06-17
JP2024170410A (ja) 2024-12-10
TW202108618A (zh) 2021-03-01
SG11202112021QA (en) 2021-11-29

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