CN113959198A - Nifedipine sustained-release tablet particle drying equipment and preparation process thereof - Google Patents

Nifedipine sustained-release tablet particle drying equipment and preparation process thereof Download PDF

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Publication number
CN113959198A
CN113959198A CN202111349540.7A CN202111349540A CN113959198A CN 113959198 A CN113959198 A CN 113959198A CN 202111349540 A CN202111349540 A CN 202111349540A CN 113959198 A CN113959198 A CN 113959198A
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China
Prior art keywords
sliding
shell
fixedly connected
wall
preparation process
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CN202111349540.7A
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Chinese (zh)
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CN113959198B (en
Inventor
卞建钢
潘秀芝
潘永祥
王延杰
王文波
张华巍
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DEZHOU DEYAO PHARMACEUTICAL CO LTD
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DEZHOU DEYAO PHARMACEUTICAL CO LTD
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B9/00Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
    • F26B9/10Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in the open air; in pans or tables in rooms; Drying stacks of loose material on floors which may be covered, e.g. by a roof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B23/00Heating arrangements
    • F26B23/04Heating arrangements using electric heating
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/001Handling, e.g. loading or unloading arrangements
    • F26B25/003Handling, e.g. loading or unloading arrangements for articles
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/02Applications of driving mechanisms, not covered by another subclass
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/06Chambers, containers, or receptacles

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the technical field of medicine preparation, in particular to nifedipine sustained-release tablet particle drying equipment and a preparation process thereof, and the nifedipine sustained-release tablet particle drying equipment comprises a shell, wherein a drying mechanism is arranged in the shell, the drying mechanism comprises a fixed plate, a fixed sleeve, a sliding cover, fixed columns and a groove, the fixed plate is fixedly connected to the inner wall of the shell, the fixed sleeve is fixedly connected to the fixed plate, the sliding cover is slidably connected to the fixed sleeve, the fixed columns are fixedly connected to the sliding cover, a medicine injection mechanism is connected to the inner wall of the shell, the medicine injection mechanism comprises a sliding rod, a medicine tube and an injection needle, the sliding rod is slidably connected to the inner wall of the shell, the medicine tubes are fixedly connected to the sliding rod, an auxiliary mechanism is connected to the shell, and granular nifedipine can be directly prepared in a drying mode, and the whole preparation process is automatically carried out, and is quick and convenient.

Description

Nifedipine sustained-release tablet particle drying equipment and preparation process thereof
Technical Field
The invention relates to drying equipment, in particular to nifedipine sustained-release tablet particle drying equipment and a preparation process thereof, and belongs to the technical field of medicine preparation.
Background
Nifedipine sustained release tablets are a drug which can be used for treating cardiovascular diseases, such as coronary heart disease, angina pectoris and the like, and also can be used for treating hypertension, and nifedipine is yellow crystal in appearance, solid, odorless and tasteless, unstable when being exposed to light, soluble in acetone or chloroform, slightly soluble in ethanol and hardly soluble in water.
Due to the properties of the nifedipine, such as unstable when exposed to light, easy dissolution in acetone or chloroform, slight dissolution in ethanol and the like, nifedipine medicines are usually required to be prepared into medicinal powder firstly during production, and then the medicinal powder is prepared into granular medicines, while the process of preparing the medicinal powder and then preparing the medicinal powder into granules is complicated, if the granular nifedipine is dried by a direct drying mode, more preparation time can be saved, and therefore, a novel device is required to solve the problem.
Disclosure of Invention
The invention aims to solve the problems and provide a nifedipine sustained-release tablet particle drying device and a preparation process thereof, granular drugs of nifedipine can be directly prepared in a drying mode, and the whole preparation process is automatic, rapid and convenient.
The invention realizes the aim through the following technical scheme, the nifedipine sustained-release tablet particle drying equipment comprises a shell, a drying mechanism is arranged in the shell, the drying mechanism comprises a fixed plate, a fixed sleeve, a sliding cover, fixed columns and a groove, the fixed plate is fixedly connected to the inner wall of the shell, the fixed sleeve is fixedly connected to the fixed plate, the sliding cover is connected to the fixed sleeve in a sliding manner, the fixed columns are fixedly connected to the sliding cover, the groove is formed in each fixed column, a medicine injection mechanism is connected to the inner wall of the shell, the medicine injection mechanism comprises a sliding rod, a medicine tube and an injection needle, the sliding rod is connected to the inner wall of the shell in a sliding manner, the medicine tubes are fixedly connected to the sliding rod, the injection needle is fixedly connected to the medicine tubes, and an auxiliary mechanism is connected to the shell, be connected with actuating mechanism on the inner wall of shell, actuating mechanism includes motor, pivot, baffle, first carousel, second carousel, sprocket and chain, fixedly connected with on the inner wall of shell the baffle, fixedly connected with on the inner wall of shell the motor, swing joint has on the motor the pivot, rotate on the baffle and be connected with first carousel with the second carousel, first carousel with fixed connection in the pivot, the pivot with equal fixedly connected with on the second carousel the sprocket, two the common meshing has on the sprocket the chain, the inside of shell is equipped with link gear.
Preferably, the drying mechanism further comprises a first spring, a vertical rod through hole and a drawer, the sliding cover is fixedly connected with the fixed sleeve, the first spring is connected with the fixed sleeve, the fixed plate is fixedly connected with the vertical rod, the vertical rod is connected with the fixed sleeve in a plurality of sliding modes respectively, the through hole is formed in the fixed plate, and the drawer is arranged on the shell.
Preferably, the medicine injection mechanism further comprises a sliding plate, a plurality of piston sleeves and a plurality of sliding holes, the sliding plate is connected to the inner wall of the shell in a sliding mode, the sliding plate is fixedly connected with the plurality of piston sleeves, and the plurality of piston sleeves are provided with the sliding holes.
Preferably, the injection mechanism further comprises a piston rod and a bottom hole, and is multiple, the piston rod is fixedly connected to the inner wall of the bottom of the medicine tube, the bottom end of the piston rod is provided with the bottom hole, and the piston rod is connected with the piston sleeve in a sliding mode.
Preferably, the auxiliary mechanism comprises a top cylinder, a soft plug, a breathable net and heating rods, the top end of the shell is connected with the soft plug and the breathable net, the top of the sliding plate is fixedly connected with the top cylinder, and the inner wall of the side face of the shell is provided with a plurality of the heating rods.
Preferably, the auxiliary mechanism further comprises a handle, a connecting rod and a second spring, the handle is fixedly connected to one end, located outside the shell, of the sliding rod, the connecting rod is fixedly connected to the inner wall of the shell, and the second spring is fixedly connected between the connecting rod and the sliding rod.
Preferably, the linkage mechanism comprises a sliding seat and a vertical hole, the sliding seat is connected to the plurality of fixing columns in a sliding manner, one side of the sliding seat is connected with the inner wall of the shell in a sliding manner, the vertical hole is formed in the sliding seat, and the plurality of fixing columns are located in the vertical holes respectively.
Preferably, the link gear still includes first horizontal pole, second horizontal pole and round hole, first carousel with all seted up on the second carousel the round hole, sliding connection has on the sliding seat first horizontal pole, sliding connection has on the slide the second horizontal pole, first horizontal pole with the second horizontal pole respectively sliding connection in two the inside of round hole.
Preferably, the preparation process comprises the following steps:
s1: firstly, starting the driving mechanism, and driving the linkage mechanism to move through the driving mechanism;
s2: the drying mechanism is driven to move through the movement of the linkage mechanism, so that the medicines on the drying mechanism are dried, and then the dried medicines can be concentrated;
s3: the medicine injection mechanism is driven by the movement of the linkage mechanism to continuously inject new medicines to be dried into the drying mechanism;
s4: the above process is repeated continuously by the continuous movement of the driving mechanism.
The invention has the beneficial effects that: the output shaft of the motor rotates to drive the rotating shaft and the chain wheel to rotate and further drive the chain to drive and further drive the first rotating disc and the second rotating disc to rotate, the first cross rod and the second cross rod move along with the rotation of the first rotating disc and the second rotating disc, the first cross rod and the second cross rod simultaneously drive the sliding plate and the sliding seat to move up and down due to the movement of the first cross rod and the second cross rod, when the sliding plate moves up and down, the piston sleeve moves up and down relative to the piston rod, when the sliding plate moves down, the medicine in the medicine tube is extruded downwards and discharged downwards from the injection needle, when the piston sleeve moves up, air is sucked into the medicine tube from the injection needle, so that the medicine is discharged downwards along with the up and down movement of the sliding plate, the heating rod is electrically connected with an external power supply, after being electrified, the heating rod can generate heat, the temperature in the shell is increased, thereby being used for drying the medicine, and when the sliding plate moves up and down, the sliding seat also reciprocates with the same cycle, when the sliding seat is located the top, and form a plurality of grooves between a plurality of fixed columns, and the medicine drips into a plurality of grooves respectively, subsequently under the heating of heating rod, the medicine is dried gradually, become hard graininess, the sliding seat moves down afterwards, until supporting the sliding closure, the sliding seat continues to move down afterwards, drive the sliding closure and move down together, along with the sliding closure moves down, the fixed column moves down thereupon, a plurality of montants move up relatively this moment, push up the medicine that has become hard into the granule in a plurality of recesses, make the medicine granule drop, the medicine that drops passes through the through-hole and falls in the drawer, subsequently along with the sliding seat moves up, first spring drives each structure and resets, along with the motor constantly rotates, then above-mentioned process constantly repeats, final medicine granule is collected in the drawer, the drawer can directly take out, thereby take out the medicine that makes.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the internal structure of the present invention;
FIG. 3 is an enlarged view of the portion A shown in FIG. 2 according to the present invention;
FIG. 4 is an enlarged view of the portion B shown in FIG. 2 according to the present invention;
fig. 5 is a schematic view of the connection structure of the driving mechanism of the present invention.
In the figure: 1. a housing; 2. a drying mechanism; 21. a fixing plate; 22. fixing a sleeve; 23. a sliding cover; 24. fixing a column; 25. a groove; 26. a first spring; 27. a vertical rod; 28. a through hole; 29. a drawer; 3. a drug injection mechanism; 31. a slide bar; 32. a medicine tube; 33. a piston rod; 34. a bottom hole; 35. an injection needle; 36. a slide plate; 37. a piston sleeve; 38. a slide hole; 4. an auxiliary mechanism; 41. jacking the cylinder; 42. a grip; 43. a connecting rod; 44. a second spring; 45. a soft plug; 46. a breathable net; 47. a heating rod; 5. a drive mechanism; 51. a motor; 52. a rotating shaft; 53. a partition plate; 54. a first turntable; 55. a second turntable; 56. a sprocket; 57. a chain; 6. a linkage mechanism; 61. a sliding seat; 62. vertical holes; 63. a first cross bar; 64. a second cross bar; 65. a circular hole.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-5, a nifedipine sustained release tablet particle drying apparatus includes a housing 1, a drying mechanism 2 is disposed inside the housing 1, the drying mechanism 2 includes a fixing plate 21, a fixing sleeve 22, a sliding cover 23, fixing posts 24 and a groove 25, the fixing plate 21 is fixedly connected to an inner wall of the housing 1, the fixing sleeve 22 is fixedly connected to the fixing plate 21, the sliding cover 23 is slidably connected to the fixing sleeve 22, the sliding cover 23 is fixedly connected to a plurality of the fixing posts 24, the groove 25 is formed in each of the plurality of the fixing posts 24, a drug injection mechanism 3 is connected to the inner wall of the housing 1, the drug injection mechanism 3 includes a sliding rod 31, a drug tube 32 and an injection needle 35, the sliding rod 31 is slidably connected to the inner wall of the housing 1, the drug tube 32 is fixedly connected to the sliding rod 31, the injection needles 35 are fixedly connected on a plurality of medicine tubes 32, the shell 1 is connected with an auxiliary mechanism 4, the inner wall of the shell 1 is connected with a driving mechanism 5, the driving mechanism 5 comprises a motor 51, a rotating shaft 52, a partition plate 53, a first rotating disc 54, a second rotating disc 55, a chain wheel 56 and a chain 57, the partition plate 53 is fixedly connected to the inner wall of the housing 1, the motor 51 is fixedly connected to the inner wall of the housing 1, the motor 51 is movably connected with the rotating shaft 52, the clapboard 53 is rotatably connected with the first rotating disc 54 and the second rotating disc 55, the first rotating disc 54 is fixedly connected with the rotating shaft 52, the rotating shaft 52 and the second rotating disc 55 are both fixedly connected with the chain wheels 56, the two chain wheels 56 are meshed with the chain 57 together, and the linkage mechanism 6 is arranged inside the shell 1.
As a technical optimization scheme of the present invention, the drying mechanism 2 further includes a first spring 26, a through hole 28 of a vertical rod 27, and a drawer 29, wherein a plurality of first springs 26 are fixedly connected between the sliding cover 23 and the fixing cover 22, a plurality of vertical rods 27 are fixedly connected to the fixing plate 21, the plurality of vertical rods 27 are respectively slidably connected to the inside of the plurality of fixing columns 24, the fixing plate 21 is provided with a plurality of through holes 28, and the drawer 29 is provided on the housing 1.
As a technical optimization scheme of the present invention, the medicine injection mechanism 3 further includes a sliding plate 36, a piston sleeve 37 and a sliding hole 38, the sliding plate 36 is slidably connected to the inner wall of the housing 1, the sliding plate 36 is fixedly connected to a plurality of the piston sleeves 37, and the sliding holes 38 are formed in the plurality of the piston sleeves 37.
As a technical optimization scheme of the present invention, the medicine injection mechanism 3 further includes piston rods 33 and bottom holes 34, the piston rods 33 are fixedly connected to inner walls of the bottoms of the medicine tubes 32, the bottom holes 34 are formed at bottom ends of the piston rods 33, and the piston rods 33 are slidably connected to the piston sleeves 37, respectively.
As a technical optimization scheme of the present invention, the auxiliary mechanism 4 includes a top cylinder 41, a soft plug 45, a ventilation net 46 and heating rods 47, the top end of the housing 1 is connected with the soft plug 45 and the ventilation net 46, the top of the sliding plate 36 is fixedly connected with the top cylinder 41, and the inner wall of the side surface of the housing 1 is provided with a plurality of the heating rods 47.
As a technical optimization scheme of the present invention, the auxiliary mechanism 4 further includes a handle 42, a connecting rod 43 and a second spring 44, the handle 42 is fixedly connected to one end of the sliding rod 31 located outside the housing 1, the connecting rod 43 is fixedly connected to the inner wall of the housing 1, and the second spring 44 is fixedly connected between the connecting rod 43 and the sliding rod 31.
As a technical optimization scheme of the present invention, the linkage mechanism 6 includes a sliding seat 61 and a vertical hole 62, the sliding seat 61 is connected to the plurality of fixing posts 24 in a sliding manner, one side of the sliding seat 61 is connected to an inner wall of the housing 1 in a sliding manner, the sliding seat 61 is provided with the plurality of vertical holes 62, and the plurality of fixing posts 24 are respectively located inside the plurality of vertical holes 62.
As a technical optimization scheme of the present invention, the linkage mechanism 6 further includes a first cross bar 63, a second cross bar 64 and round holes 65, the round holes 65 are respectively formed on the first rotating disk 54 and the second rotating disk 55, the first cross bar 63 is connected to the sliding seat 61 in a sliding manner, the second cross bar 64 is connected to the sliding plate 36 in a sliding manner, and the first cross bar 63 and the second cross bar 64 are respectively connected to the insides of the two round holes 65 in a sliding manner.
As a technical optimization scheme of the invention, the preparation process comprises the following steps:
s1: firstly, starting the driving mechanism 5, and driving the linkage mechanism 6 to move through the driving mechanism 5;
s2: the drying mechanism 2 is driven to move through the movement of the linkage mechanism 6, so that the medicines on the drying mechanism 2 are dried, and then the dried medicines can be concentrated;
s3: the medicine injection mechanism 3 is driven by the movement of the linkage mechanism 6 to continuously inject new medicines to be dried into the drying mechanism 2;
s4: the above process is repeated continuously by the continuous movement of the driving mechanism 5.
When the invention is used, firstly, the motor 51 is electrically connected with an external power supply, the soft plug 45 is taken down, a mixture of nifedipine and ethanol to be dried is poured into the shell 1, and then falls into the top cylinder 41 below, then the handle 42 is held by hands, the sliding rod 31 is pulled down, along with the downward movement of the sliding rod 31, the plurality of medicine tubes 32 move downward, and further the piston rod 33 and the piston sleeve 37 are separated, at the moment, the medicine in the top cylinder 41 can seep into the medicine tube 32 from the sliding hole 38, then the handle 42 is loosened, under the elastic force of the second spring 44, the sliding rod 31 and the medicine tubes 32 are reset, the piston rod 33 and the piston sleeve 37 are contacted again, then the motor 51 is started, the output shaft of the motor 51 rotates, the rotating shaft 52 and the chain wheel 56 are driven to rotate, further the chain 57 is driven, further the first rotating disc 54 and the second rotating disc 55 rotate, along with the first rotating disc 54 and the second rotating disc 55, the first cross bar 63 and the second cross bar 64 move along with the first cross bar 63 and the second cross bar 64, and simultaneously drive the sliding plate 36 and the sliding seat 61 to move up and down, wherein when the sliding plate 36 moves up and down, the piston sleeve 37 moves up and down relative to the piston rod 33, each time the sliding plate moves down, the medicine in the medicine tube 32 is extruded downwards and discharged downwards from the injection needle 35, and when the piston sleeve 37 moves up, air is sucked into the medicine tube 32 from the injection needle 35, so that the injection needle 35 periodically discharges the medicine downwards along with the up and down movement of the sliding plate 36, the heating rod 47 is electrically connected with an external power supply, the temperature in the shell 1 can be increased after the power is on, the medicine is dried, when the sliding plate 36 moves up and down, the sliding seat 61 also moves up and down at the same period, when the sliding seat 61 is positioned at the top, a plurality of grooves are formed between the sliding seat 61 and the plurality of fixed columns 24, the medicines are respectively dripped into the grooves, then the medicines are gradually dried under the heating of the heating rod 47 to become hard granules, then the sliding seat 61 moves downwards until the medicines abut against the sliding cover 23, then the sliding seat 61 continues to move downwards to drive the sliding cover 23 to move downwards together, the fixed column 24 moves downwards along with the sliding cover 23, at the moment, the vertical rods 27 move upwards relatively, the medicines which are hardened into granules in the grooves 25 are pushed upwards, the medicine granules drop, the dropped medicines drop into the drawer 29 through the through holes 28, then the sliding seat 61 moves upwards, the first spring 26 drives the structures to reset, the processes are repeated continuously along with the continuous rotation of the motor 51, finally the medicine granules are collected in the drawer 29, and the drawer 29 can be directly drawn out, so that the prepared medicines are taken out.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (9)

1. The utility model provides a nifedipine slow release tablet granule drying equipment, includes shell (1), its characterized in that: the inside of shell (1) is equipped with stoving mechanism (2), stoving mechanism (2) is including fixed plate (21), fixed cover (22), sliding closure (23), fixed column (24) and recess (25), fixedly connected with on the inner wall of shell (1) fixed plate (21), fixedly connected with on fixed plate (21) fixed cover (22), sliding connection has on fixed cover (22) sliding closure (23), fixedly connected with is a plurality of on sliding closure (23) fixed column (24), a plurality of all seted up on fixed column (24) recess (25), be connected with injection mechanism (3) on the inner wall of shell (1), injection mechanism (3) includes slide bar (31), medicine pipe (32) and syringe needle (35), sliding connection has on the inner wall of shell (1) slide bar (31), fixedly connected with is a plurality of on slide bar (31) pencil (32), a plurality of equal fixedly connected with on pencil (32) syringe needle (35), be connected with complementary unit (4) on shell (1), be connected with actuating mechanism (5) on the inner wall of shell (1), actuating mechanism (5) include motor (51), pivot (52), baffle (53), first carousel (54), second carousel (55), sprocket (56) and chain (57), fixedly connected with on the inner wall of shell (1) baffle (53), fixedly connected with on the inner wall of shell (1) motor (51), swing joint has on motor (51) pivot (52), swing joint has on baffle (53) first carousel (54) with second carousel (55), first carousel (54) with fixedly connected on pivot (52), the rotating shaft (52) and the second rotating disc (55) are fixedly connected with chain wheels (56), the chain wheels (56) are meshed with chains (57), and a linkage mechanism (6) is arranged inside the shell (1).
2. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 1, characterized in that: drying mechanism (2) still include first spring (26), montant (27) through-hole (28) and drawer (29), sliding closure (23) with fixedly connected with is a plurality of between fixed cover (22) first spring (26), fixedly connected with is a plurality of on fixed plate (21) montant (27), it is a plurality of montant (27) sliding connection respectively is in a plurality of the inside of fixed column (24), seted up a plurality ofly on fixed plate (21) through-hole (28), be equipped with on shell (1) drawer (29).
3. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 1, characterized in that: the injection mechanism (3) further comprises a sliding plate (36), a piston sleeve (37) and a sliding hole (38), the sliding plate (36) is connected to the inner wall of the shell (1) in a sliding mode, the sliding plate (36) is fixedly connected with a plurality of piston sleeves (37) and a plurality of sliding holes (38) are formed in the piston sleeves (37).
4. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 3, characterized in that: annotate medicine mechanism (3) still include piston rod (33) and bottom outlet (34), it is a plurality of equal fixedly connected with on the bottom inner wall of pencil (32) piston rod (33), it is a plurality of the bottom of piston rod (33) has all been seted up bottom outlet (34), it is a plurality of piston rod (33) respectively with a plurality of piston sleeve (37) sliding connection.
5. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 3, characterized in that: the auxiliary mechanism (4) comprises a top cylinder (41), a soft plug (45), a breathable net (46) and heating rods (47), the top end of the shell (1) is connected with the soft plug (45) and the breathable net (46), the top of the sliding plate (36) is fixedly connected with the top cylinder (41), and the inner wall of the side face of the shell (1) is provided with the plurality of heating rods (47).
6. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 1, characterized in that: the auxiliary mechanism (4) further comprises a handle (42), a connecting rod (43) and a second spring (44), the sliding rod (31) is located at one end, outside the shell (1), of the handle (42), the connecting rod (43) is fixedly connected to the inner wall of the shell (1), and the second spring (44) is fixedly connected between the connecting rod (43) and the sliding rod (31).
7. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 3, characterized in that: the linkage mechanism (6) comprises a sliding seat (61) and a vertical hole (62), the sliding seat (61) is connected to the plurality of fixing columns (24) in a sliding mode, one side of the sliding seat (61) is connected with the inner wall of the shell (1) in a sliding mode, the sliding seat (61) is provided with the plurality of vertical holes (62), and the plurality of fixing columns (24) are located inside the plurality of vertical holes (62) respectively.
8. The nifedipine sustained-release tablet particle drying equipment and the preparation process thereof according to claim 7 are characterized in that: link gear (6) still include first horizontal pole (63), second horizontal pole (64) and round hole (65), first carousel (54) with all seted up on second carousel (55) round hole (65), sliding connection has on sliding seat (61) first horizontal pole (63), sliding connection has on slide (36) second horizontal pole (64), first horizontal pole (63) with second horizontal pole (64) sliding connection respectively in two the inside of round hole (65).
9. The preparation process of nifedipine sustained release tablet particle drying equipment according to claim 1, characterized in that: the preparation process comprises the following steps:
s1: firstly, the driving mechanism (5) is started, and the linkage mechanism (6) is driven to move by the driving mechanism (5);
s2: the drying mechanism (2) is driven to move through the movement of the linkage mechanism (6), so that the medicines on the drying mechanism (2) are dried, and then the dried medicines can be concentrated;
s3: the medicine injection mechanism (3) is driven to continuously inject new medicines to be dried into the drying mechanism (2) through the movement of the linkage mechanism (6);
s4: the above process is repeated continuously by the continuous movement of the driving mechanism (5).
CN202111349540.7A 2021-11-15 2021-11-15 Nifedipine sustained release tablet particle drying equipment and preparation process thereof Active CN113959198B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114705030A (en) * 2022-04-02 2022-07-05 黑龙江中医药大学 Traditional Chinese medicine storage device for cardiovascular treatment and storage method thereof

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CN112755914A (en) * 2020-12-15 2021-05-07 江西省萍乡市轩品塑胶制品有限公司 High-efficient prilling granulator that biodegradable is modified

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CN204564062U (en) * 2014-12-04 2015-08-19 陕西佰傲再生医学有限公司 A kind of facility for granulating of microgel particle
CN208229860U (en) * 2018-04-18 2018-12-14 安徽中农大丰化肥有限公司 A kind of compound fertilizer's extruding granulation device
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