CN204564062U - A kind of facility for granulating of microgel particle - Google Patents
A kind of facility for granulating of microgel particle Download PDFInfo
- Publication number
- CN204564062U CN204564062U CN201420750189.1U CN201420750189U CN204564062U CN 204564062 U CN204564062 U CN 204564062U CN 201420750189 U CN201420750189 U CN 201420750189U CN 204564062 U CN204564062 U CN 204564062U
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- Prior art keywords
- granulating
- facility
- screen cloth
- cartridge
- cutter
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- Expired - Fee Related
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- 229910001220 stainless steel Inorganic materials 0.000 claims description 20
- 239000010935 stainless steel Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 229920005479 Lucite® Polymers 0.000 claims description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims description 4
- 229920002521 macromolecule Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- 235000009566 rice Nutrition 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 238000011022 operating instruction Methods 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
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- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 239000000853 adhesive Substances 0.000 abstract description 4
- 238000005469 granulation Methods 0.000 abstract description 4
- 230000003179 granulation Effects 0.000 abstract description 4
- 230000011218 segmentation Effects 0.000 abstract description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 29
- 229920002674 hyaluronan Polymers 0.000 description 23
- 229960003160 hyaluronic acid Drugs 0.000 description 23
- 238000009826 distribution Methods 0.000 description 12
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- 238000002347 injection Methods 0.000 description 3
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- 238000007906 compression Methods 0.000 description 2
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- 102000008186 Collagen Human genes 0.000 description 1
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- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
Landscapes
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Abstract
The utility model relates to a kind of facility for granulating of microgel particle.This equipment is made up of transmission device, push-rod piston, cartridge, screen cloth, cutter, quadrupod, fixing base and digital control system.Described quadrupod fix forming device vertical with fixing base supports; Described transmission device is connected with push-rod piston, drives push-rod piston up and down in cartridge inside, pushes gel and make it by the screen cloth of cartridge one end; Transmission device is chimeric with cutting ring inner annular recess by conveyer belt, drives cutter to rotate around cylindric fixed axis, realizes the cutting to gel.Facility for granulating of the present utility model can improve cutting efficiency and granulation efficiency; Strengthen pressure-bearing and the stress-bearing capability of screen cloth, segmentation gel effect is better simultaneously; In addition, avoid once cutting after formed gel slice between inter-adhesive, can effectively control diameter of particle size, and effectively ensure that the effect that secondary rotating cuts.
Description
Technical field
The utility model relates to a kind of facility for granulating of microgel particle.
Background technology
Hyaluronic acid is a kind of natural macromolecular material, is extensively present in skin and hypodermis, has viscosity and collagen and elastic fibers can be made to be fitted together to closely.Hyaluronic acid derivatives after crosslinked modification can, at intermolecular formation covalent cross-linking network, make hyaluronic mechanical strength strengthen, and degradation time increases, and expands its range of application, becomes one effectively clinical soft tissue filling material.
The injection hyaluronic acid derivatives used clinically mostly at present is microgranular, namely by equipment, cross-linked hyaluronic acid gel is prepared into the microgel particle with certain particle size.The validity of microgel particle and particle size uniformity, particle size are relevant, and uniformity and particle size are respectively with the design of screen cloth, cutting and coordinate relevant.
Patent CN202427635U discloses a kind of particle grading device of hyaluronic acid sodium gel, and this device is by cylindrical container, and annulus pushes mould and cylindric screen cloth is formed.By pushing mould to the hyaluronic acid derivatives applied thrust in cylindrical vessel, hyaluronic acid derivatives is through screen cloth, and screen cloth cuts to reach gradation effect to it.This device is only provided with screen cloth, and its cut direction is single, and screen cloth is cylindrical design, require that pushing mould applies larger pressure to cross-linked hyaluronic acid gel, be easy to inter-adhesive by the hyaluronic acid derivatives of screen cloth, cause cutting effect poor, the particle size heterogeneity formed.
Patent CN102716704A provides a kind of facility for granulating of injectable cross-linked hyaluronic acid gel particulate, and this equipment comprises the cartridge with variable-diameter structure, and exit is provided with screen device.The hyaluronic acid derivatives of crosslinked modification is put into cartridge, and by push rod to cross-linked hyaluronic acid gel applied thrust, the reaction force making cross-linked hyaluronic acid gel be subject to taper barrel through reducing section is extruded compression; When cross-linked hyaluronic acid gel passes through the screen cloth in exit, be cut into slice, and rely on the unexpected release of the potential energy stored by extruding compression when discharging outlet, hyaluronic acid derivatives is cracked into cross-linked hyaluronic acid gel particulate.But screen cloth only has unidirectional cutting to cross-linked-hyaluronic acid, the abrupt release of deformation potential has randomness, and restive deformation potential size, made diameter of particle size is restive, microgel particle skewness.In addition, the granulation screen cloth mentioned in patent is latticed design, and the pressure that therefore can bear is very limited, and spacing between mesh is less, easily inter-adhesive by the cross-linked hyaluronic acid gel slice of screen cloth, affects the cutting efficiency of cutter.
Patent CN102728290A provides a kind of facility for granulating of injectable cross-linked hyaluronic acid gel particulate, this equipment comprises cartridge and push-rod piston, advance on route at hyaluronic acid and be provided with screen cloth, be provided with after screen cloth the blade of being arranged by grizzly bar shape form, can reciprocating cutter.The hyaluronic acid derivatives of crosslinked modification is put into cartridge, and by push-rod piston to cross-linked hyaluronic acid gel applied thrust, cross-linked hyaluronic acid gel is when by screen cloth, and be cut into slice, slice is cut into microgel particle by reciprocating cutter further.The blade of this equipment cutter is the arrangement of grizzly bar shape, causes the gel slice skewness in grizzly bar after screen cloth; The reciprocating motion design of cutter, gel slice may be caused to pile up on cutter blade, thus make the effect of transverse cuts poor, the microgel particle heterogeneity cut out, and microgel particle particle size is restive.The screen cloth used in this patent has above-mentioned defect equally.
In sum, the facility for granulating of existing cross-linked hyaluronic acid gel particulate, its cutting mode is single, and many adopt the unidirectional cutting of screen cloth or are equipped with the reciprocating cutting of cutter, and cutting efficiency is poor; Latticed screen cloth makes it bear limited pressure, and causes the easy adhesion of gel because the mesh spacing of screen cloth is too small, and prepared particle size differs, particle size is restive.Therefore, in the control of cross-linked hyaluronic acid gel diameter of particle, still simple and reliable equipment is lacked at present.
Summary of the invention
For the defect of existing equipment, the purpose of this utility model is the facility for granulating providing a kind of screen cloth and cutter Double Directional Cutting, and its structure is simple, and cost is low, and prepared gel uniform particle diameter, size are controlled.
The utility model forms by by transmission device, push-rod piston, cartridge, screen cloth, cutter, quadrupod, fixing base and digital control system; Quadrupod fix forming device vertical with fixing base supports; Transmission device is connected with push-rod piston, drives push-rod piston up and down in cartridge inside, pushes gel and make it by the screen cloth of cartridge one end; Transmission device is chimeric with cutting ring inner annular recess by conveyer belt, drives cutter to rotate around cylindric fixed axis, realizes the cutting to gel.
Described transmission device is fixed on the fixing base of quadrupod upper end, can select any one transmission of belt transmission, Chain conveyer, gear drive, worm drive or worm and gear.
Described cartridge is hollow cylinder, its open top, and the screen cloth of coupling is fixed by draw-in groove in bottom.
Described push-rod piston and cartridge diameter matches.
Described screen cloth diameter is consistent with cartridge, and detachably, screen cloth has the circular mesh of concentric circles, radial, arc-shaped, helical form or grid-like arrangement, and mesh diameter is consistent, between 50 ~ 1000 μm.
Described cutter is fixed on the fixing base central authorities of quadrupod lower end, and cutter centre bit is equipped with cylindric fixed axis, and cutter can horizontally rotate around cylindric fixed axis; Cutter is made up of cutting ring and stainless steel wire, cutting ring inner ring is evenly distributed with installing hole, connect the installing hole of arbitrary diameter, any one in " one " type, in " ten " type, " X " type, " rice " font structure of stainless steel wire, stainless steel wire diameter 0.2 ~ 2.0 mm.
Described digital control system, comprises electric rotating machine, motor driver, touch-screen and Programmable Logic Controller; Touch-screen is connected with electric rotating machine with Programmable Logic Controller, for arranging and show the rotating speed of electric rotating machine; Programmable Logic Controller, issue operating instruction for program storage running, signal input part is connected with touch-screen and accepts its signal, output is connected with motor driver; Electric rotating machine signal input part is connected with motor driver, and signal output part is connected with transmission device, drives transmission device to run.
Described cartridge is prepared from by any one of stainless steel, lucite, poly terephthalic acid class plastics or macromolecule material.
Described screen cloth is processed by stainless steel.
Described quadrupod and fixing base are stainless steel.
Gel granulating equipment of the present utility model, preferably, for the preparation of cross-linked hyaluronic acid gel.
The microgel particle preparation method of the utility model and step, as described below:
1. gel is placed in cartridge, adjustment push-rod piston, makes it fall into cartridge.
2. open device power supply (DPS), by the Programmable Logic Controller setting electric rotating machine rotating speed of control section.
3. press touch-screen and run button, transmission device runs, and push-rod piston extruding gel passes through screen cloth, cutter circumgyration incision.
4. when push-rod piston runs to bottom cartridge, out of service.Pull-out push-rod piston, inserts gel again in cartridge, adjustment push-rod piston, can carry out second time and granulate.
Compared to the facility for granulating of existing microgel particle, the utility model has the following advantages:
First, facility for granulating of the present utility model adopts longitudinal screen cloth to coordinate transverse rotation cutter cuts, overcomes the shortcoming that unidirectional cutting is uneven, improves cutting efficiency.
Secondly, the cutter of facility for granulating of the present utility model is made up of the wall scroll horizontally rotated or many steel wires, adds the scope of transverse cuts, avoids the accumulation of gel slice on cutter simultaneously, improves granulation efficiency.
Finally, the screen cloth mesh of facility for granulating of the present utility model is regular distribution, the spacing-controllable of mesh, compared with designing, increases pressure-bearing and the stress-bearing capability of screen cloth with the grid type of traditional screen cloth, and segmentation gel effect is better; In addition, mesh of the present utility model design, inter-adhesive between the gel slice formed after avoiding once cutting, meanwhile, push-rod piston is pushed evenly, and diameter of particle size is effectively controlled, and effectively ensure that the effect that secondary rotating cuts.
Accompanying drawing explanation
Fig. 1 is the structural representation of facility for granulating of the present utility model.
Fig. 2 is the schematic diagram of cutter of the present utility model.
In figure: 1, transmission device, 2, push-rod piston, 3, cartridge, 4, screen cloth, 5, cutter, 6, quadrupod, 7, fixing base, 8, stainless steel wire, 9, cutting ring.
Fig. 3 is domain size distribution interval graph after embodiment 1 injection cross-linked hyaluronic acid gel is granulated, and abscissa represents particle size interval, and unit is μm; Ordinate represents distribution percentage composition; Series 1 be the domain size distribution that embodiment 1 obtains particulate, serial 2 provide equipment to obtain the domain size distribution of particulate for patent CN102716704A, and the distribution of the size of particulate prepared by the two comparative descriptions the present embodiment is little, has higher uniformity consistency.
Detailed description of the invention
The key fitment model that the present embodiment adopts is as follows: electric rotating machine and necessary electromotor driver: Panasonic servo A4 series MHMD022P1U motor and supporting MADDT1207003 driver; Touch-screen: Mitsubishi GT1155-QSBD-C; Programmable Logic Controller: Mitsubishi FX1N-24MR-001.
Fig. 1 shows the main-body structure of the present embodiment: the microgel particle facility for granulating of the present embodiment, is made up of transmission device (1), push-rod piston (2), cartridge (3), screen cloth (4), cutter (5), quadrupod (6), fixing base (7) and digital control system.Quadrupod (6) fixing forming device vertical with fixing base (7) supports; Transmission device (1) is connected with push-rod piston (2), drives push-rod piston (2) to operate up and down in cartridge (3) inside, pushes gel and make it by the screen cloth of cartridge one end.Meanwhile, transmission device (1) is chimeric with cutting ring (9) inner annular recess by conveyer belt, drives cutter (5) to horizontally rotate around cylindric fixed axis, realizes the cutting to gel.
Described transmission device (1) is fixed on the fixing base (7) of quadrupod (6) upper end, can select any one transmission of belt transmission, Chain conveyer, gear drive, worm drive or Worm Wheel System.
Described cartridge (3) is hollow cylinder, its open top, and the screen cloth (4) of coupling is fixed by draw-in groove in bottom.
Described push-rod piston (2) and cartridge (3) diameter matches.
Described digital control system, comprises electric rotating machine, motor driver, touch-screen and Programmable Logic Controller; Touch-screen is connected with electric rotating machine with Programmable Logic Controller, for arranging and show the rotating speed of electric rotating machine; Programmable Logic Controller, issue operating instruction for program storage running, signal input part is connected with touch-screen and accepts its signal, output is connected with motor driver; Electric rotating machine signal input part is connected with motor driver, and signal output part is connected with transmission device (1), drives transmission device (1) to run.
Described cartridge (3) is prepared from by any one of stainless steel, lucite, poly terephthalic acid class plastics or macromolecule material.
Described screen cloth (4) is processed by stainless steel.
Described quadrupod (6) and fixing base (7) are stainless steel.
Fig. 2 shows the structure of the present embodiment cutter (5): described cutter (5) is fixed on fixing base (7) central authorities of quadrupod (6) lower end, cutter (5) centre bit is equipped with cylindric fixed axis, and cutter (5) can horizontally rotate around cylindric fixed axis; Cutter (5) is made up of cutting ring (9) and stainless steel wire (8), cutting ring (9) inner ring is evenly distributed with installing hole, connect the installing hole of arbitrary diameter, stainless steel wire (8) in " one " type, " ten " type, " X " type, any one in " rice " font structure, stainless steel wire (8) diameter 0.2 ~ 2.0 mm.
embodiment 1
Employing such as Fig. 1 gel granulating equipment prepares the particle of cross-linked hyaluronic acid gel.Transmission device selects rotary drive and belt transmission to coordinate; Cartridge is stainless steel; The mesh radial distribution of screen cloth, diameter 200 μm; Cutter steel wire diameter 0.5mm, the arrangement in " ten " font; Electric rotating machine rotating speed 2000 revs/min.The domain size distribution that 1000g cross-linked hyaluronic acid gel obtains particulate by this equipment is as follows: the particle of particle diameter between 100 ~ 200 μm accounts for 13.4%, the particle of particle diameter between 200 ~ 300 μm accounts for 25.5%, the particle of particle diameter between 300 ~ 400 μm accounts for 36.2%, the particle of particle diameter between 400 ~ 500 μm accounts for 23.2%, it is 352.7 μm that the particle of particle diameter between 500 ~ 600 μm accounts for 1.8%, D50.The present embodiment obtains comparatively satisfied granulation result, uniform particle diameter, can be used as injection cross-linked-hyaluronic acid particulate and uses (Fig. 3).
embodiment 2
Employing such as Fig. 1 gel granulating equipment prepares the particle of cross-linked hyaluronic acid gel.Transmission device selects gear drive and belt transmission to coordinate, and cartridge is lucite material; The mesh concentric circles distribution of screen cloth, diameter 250 μm; Cutter steel wire diameter 1.0mm, the arrangement in " X " font; Electric rotating machine rotating speed 2000 revs/min.The domain size distribution of obtained microgel particle is as follows: the particle of particle diameter between 100 ~ 200 μm accounts for 8.2%, the particle of particle diameter between 200 ~ 300 μm accounts for 11.3%, the particle of particle diameter between 300 ~ 400 μm accounts for 14.7%, the particle of particle diameter between 400 ~ 500 μm accounts for 25.7%, the particle of particle diameter between 500 ~ 600 μm accounts for 13.4%, the particle of particle diameter between 600 ~ 700 μm accounts for 10.2%, the particle of particle diameter between 700 ~ 800 μm accounts for 8.0%, the particle of particle diameter between 800 ~ 900 μm accounts for 4.1%, the particle of particle diameter between 900 ~ 1000 μm accounts for 2.5%, the particle of particle diameter between 1000 ~ 1100 μm accounts for 1.9%, D50 is 432.4 μm.
embodiment 3
Employing such as Fig. 1 gel granulating equipment prepares the particle of cross-linked hyaluronic acid gel.Transmission device selects gear drive and belt transmission to coordinate, and cartridge is macromolecule material; The mesh concentric circles distribution of screen cloth, diameter 300 μm; Cutter steel wire diameter 1.5mm, the arrangement in " rice " font; Electric rotating machine rotating speed 2000 revs/min.The domain size distribution of obtained microgel particle is as follows: the particle of particle diameter between 100 ~ 200 μm accounts for 6.8%, the particle of particle diameter between 200 ~ 300 μm accounts for 10.6%, the particle of particle diameter between 300 ~ 400 μm accounts for 22.4%, the particle of particle diameter between 400 ~ 500 μm accounts for 25.2%, the particle of particle diameter between 500 ~ 600 μm accounts for 18.7%, the particle of particle diameter between 600 ~ 700 μm accounts for 10.3%, and it is 515.6 μm that the particle of particle diameter between 700 ~ 800 μm accounts for 6.0%, D50.
Claims (10)
1. a facility for granulating for microgel particle, is made up of transmission device (1), push-rod piston (2), cartridge (3), screen cloth (4), cutter (5), quadrupod (6), fixing base (7) and digital control system;
It is characterized in that, quadrupod (6) fixing forming device vertical with fixing base (7) supports; Transmission device (1) is connected with push-rod piston (2), drives push-rod piston (2) inner up and down at cartridge (3), pushes gel and make it by the screen cloth of cartridge one end; Transmission device (1) is chimeric with cutting ring (9) inner annular recess by conveyer belt, drives cutter (5) to rotate around cylindric fixed axis, realizes the cutting to gel.
2. facility for granulating as claimed in claim 1, it is characterized in that, described transmission device (1) is fixed on the fixing base (7) of quadrupod (6) upper end, can select any one transmission of belt transmission, Chain conveyer, gear drive, worm drive or worm and gear.
3. facility for granulating as claimed in claim 1, it is characterized in that, described cartridge (3) is hollow cylinder, its open top, and the screen cloth (4) of coupling is fixed by draw-in groove in bottom.
4. facility for granulating as claimed in claim 1, is characterized in that, described push-rod piston (2) and cartridge (3) diameter matches.
5. facility for granulating as claimed in claim 1, it is characterized in that, described screen cloth (4) diameter is consistent with cartridge (3), detachably, screen cloth (4) has the circular mesh of concentric circles, radial, arc-shaped, helical form or grid-like arrangement, mesh diameter is consistent, between 50 ~ 1000 μm.
6. facility for granulating as claimed in claim 1, it is characterized in that, described cutter (5) is fixed on fixing base (7) central authorities of quadrupod (6) lower end, and cutter (5) centre bit is equipped with cylindric fixed axis, and cutter (5) can horizontally rotate around cylindric fixed axis; Cutter (5) is made up of cutting ring (9) and stainless steel wire (8), cutting ring (9) inner ring is evenly distributed with installing hole, connect the installing hole of arbitrary diameter, stainless steel wire (8) in " one " type, " ten " type, " X " type, any one in " rice " font structure, stainless steel wire (8) diameter 0.2 ~ 2.0 mm.
7. facility for granulating as claimed in claim 1, is characterized in that described digital control system comprises electric rotating machine, motor driver, touch-screen and Programmable Logic Controller; Touch-screen is connected with electric rotating machine with Programmable Logic Controller, for arranging and show the rotating speed of electric rotating machine; Programmable Logic Controller, issue operating instruction for program storage running, signal input part is connected with touch-screen and accepts its signal, output is connected with motor driver; Electric rotating machine signal input part is connected with motor driver, and signal output part is connected with transmission device (1), drives transmission device (1) to run.
8. facility for granulating as claimed in claim 1, is characterized in that, described cartridge (3) is prepared from by any one of stainless steel, lucite, poly terephthalic acid class plastics or macromolecule material.
9. facility for granulating as claimed in claim 1, it is characterized in that, described screen cloth (4) is processed by stainless steel.
10. facility for granulating as claimed in claim 1, it is characterized in that, described quadrupod (6) and fixing base (7) are stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420750189.1U CN204564062U (en) | 2014-12-04 | 2014-12-04 | A kind of facility for granulating of microgel particle |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420750189.1U CN204564062U (en) | 2014-12-04 | 2014-12-04 | A kind of facility for granulating of microgel particle |
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| CN204564062U true CN204564062U (en) | 2015-08-19 |
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| CN201420750189.1U Expired - Fee Related CN204564062U (en) | 2014-12-04 | 2014-12-04 | A kind of facility for granulating of microgel particle |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105413584A (en) * | 2015-12-24 | 2016-03-23 | 太仓市微贯机电有限公司 | Moulding and granulating apparatus having management and control assembly and operation method thereof |
| CN110326791A (en) * | 2019-06-27 | 2019-10-15 | 中山大学附属第三医院 | A kind of preparation method and device of semisolid gel nutrition carrier |
| CN113959198A (en) * | 2021-11-15 | 2022-01-21 | 德州德药制药有限公司 | Nifedipine sustained-release tablet particle drying equipment and preparation process thereof |
-
2014
- 2014-12-04 CN CN201420750189.1U patent/CN204564062U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105413584A (en) * | 2015-12-24 | 2016-03-23 | 太仓市微贯机电有限公司 | Moulding and granulating apparatus having management and control assembly and operation method thereof |
| CN110326791A (en) * | 2019-06-27 | 2019-10-15 | 中山大学附属第三医院 | A kind of preparation method and device of semisolid gel nutrition carrier |
| CN113959198A (en) * | 2021-11-15 | 2022-01-21 | 德州德药制药有限公司 | Nifedipine sustained-release tablet particle drying equipment and preparation process thereof |
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