CN113941027A - Injectable facial filler composition gel for cosmetic and plastic surgery and preparation method thereof - Google Patents
Injectable facial filler composition gel for cosmetic and plastic surgery and preparation method thereof Download PDFInfo
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- CN113941027A CN113941027A CN202111228824.0A CN202111228824A CN113941027A CN 113941027 A CN113941027 A CN 113941027A CN 202111228824 A CN202111228824 A CN 202111228824A CN 113941027 A CN113941027 A CN 113941027A
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- apatite
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 30
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 239000000945 filler Substances 0.000 title claims abstract description 23
- 238000002316 cosmetic surgery Methods 0.000 title claims abstract description 16
- 230000001815 facial effect Effects 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 17
- 238000002347 injection Methods 0.000 claims abstract description 32
- 239000007924 injection Substances 0.000 claims abstract description 32
- 239000002245 particle Substances 0.000 claims abstract description 17
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 15
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 15
- 102000008186 Collagen Human genes 0.000 claims abstract description 13
- 108010035532 Collagen Proteins 0.000 claims abstract description 13
- 239000007864 aqueous solution Substances 0.000 claims abstract description 13
- 229920001436 collagen Polymers 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
- 229930003231 vitamin Natural products 0.000 claims abstract description 13
- 235000013343 vitamin Nutrition 0.000 claims abstract description 13
- 239000011782 vitamin Substances 0.000 claims abstract description 13
- 229940088594 vitamin Drugs 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 9
- 229910052586 apatite Inorganic materials 0.000 claims description 31
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 30
- 239000000463 material Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000003851 corona treatment Methods 0.000 claims description 15
- 239000008367 deionised water Substances 0.000 claims description 15
- 229910021641 deionized water Inorganic materials 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 10
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 5
- 241000132012 Atractylodes Species 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- 241000913745 Spatholobus Species 0.000 claims description 5
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 5
- 229930003761 Vitamin B9 Natural products 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 239000002689 soil Substances 0.000 claims description 5
- 235000019155 vitamin A Nutrition 0.000 claims description 5
- 239000011719 vitamin A Substances 0.000 claims description 5
- 235000019158 vitamin B6 Nutrition 0.000 claims description 5
- 239000011726 vitamin B6 Substances 0.000 claims description 5
- 235000019159 vitamin B9 Nutrition 0.000 claims description 5
- 239000011727 vitamin B9 Substances 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 229940045997 vitamin a Drugs 0.000 claims description 5
- 229940011671 vitamin b6 Drugs 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 206010040954 Skin wrinkling Diseases 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- -1 compound vitamin Chemical class 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- 230000003796 beauty Effects 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- Cosmetics (AREA)
Abstract
The invention discloses an injection type face filler composition gel for cosmetic and plastic surgery, which belongs to the technical field of medical treatment and comprises the following components in parts by weight: 10-20 parts of sodium hyaluronate, 90-100 parts of an aqueous solution for injection, 2-5 parts of collagen powder, 5-8 parts of modified particles, 0.1-0.2 part of an extracting agent and 0.4-0.7 part of a vitamin complex. The composition gel is safe to use, does not cause the problems of red swelling, vascular embolism and the like, and the treated skin is beautiful and natural.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to an injection type facial filler composition gel for cosmetic and plastic and a preparation method thereof.
Background
Over time, the skin naturally relaxes and wrinkles develop, especially facial contour aging becomes increasingly severe, including visible skin wrinkles, deep nasolabial folds, frown lines, puppet lines, buccal junctional lines, perioral wrinkles, temporal collapse, and the like. Also, collapse of the nose bridge due to congenital or trauma, and misalignment of the brow bone and chin all cause annoying pain to people. Beauty is a constant topic and a pursuit target of human beings, and the problem of continuously exploring and solving how to effectively delay skin aging and beautify the appearance of the skin is still solved.
The injection beautifying is a kind of non-operation shaping beautifying method, and the injection method is used to inject biological material or artificially synthesized material with good biocompatibility into dermis or subcutaneous layer, so as to reduce skin wrinkle or plasticity. The sodium hyaluronate is a polysaccharide biomaterial with very good biocompatibility, has clear research on the in-vivo degradation and metabolism process, is safe to human bodies, and is a preferred material for preparing gel products. Nowadays, gel products are well known as important products in the field of micro-plastic, and a plurality of gel products for injection are available on the market, wherein the hyaluronic acid products are widely used by plastic beauty institutions with good biocompatibility, little side effect after injection and relatively long-lasting plastic effect.
However, the existing products usually have the defects that the product duration is not long, the injection needs to be performed again for several months, the phenomena of red and swollen after the operation and the like are easily caused, bad feeling is brought to operators, and great potential safety hazards exist.
Disclosure of Invention
The invention aims to solve the existing problems and provides an injection type face filler composition gel for cosmetic and plastic and a preparation method thereof.
The invention is realized by the following technical scheme:
an injection type face filler composition gel for cosmetic and plastic comprises the following components in parts by weight:
10-20 parts of sodium hyaluronate, 90-100 parts of an aqueous solution for injection, 2-5 parts of collagen powder, 5-8 parts of modified particles, 0.1-0.2 part of an extracting agent and 0.4-0.7 part of a vitamin complex.
Preferably, the composition comprises the following components in parts by weight:
15 parts of sodium hyaluronate, 95 parts of aqueous solution for injection, 4 parts of collagen powder, 7 parts of modified particles, 0.15 part of extractant and 0.6 part of vitamin complex.
Further, the water solution for injection is a sodium chloride solution with a mass concentration of 0.9%.
Further, the preparation method of the modified microparticle comprises the following steps:
(1) soaking apatite with a citric acid solution, filtering, washing with deionized water for 3-5 times for later use;
(2) immersing the apatite treated in the step (1) into a silane coupling agent solution, and filtering out for later use after immersing for 10-15 min;
(3) and (3) performing corona treatment on the apatite treated in the step (2), taking out the apatite after the corona treatment, washing the apatite with deionized water for 3-5 times, and drying the apatite.
Further, the mass concentration of the citric acid solution in the step (1) is 0.5-0.7%.
Further, the volume concentration of the silane coupling agent solution in the step (2) is 5-7%.
Further, the field intensity is controlled to be 500-520 kV/m during the corona treatment in the step (3).
Further, the preparation method of the extracting agent comprises the following steps:
a. firstly, the white atractylodes rhizome and the suberect spatholobus stem are mixed according to the weight ratio of 1: 2, mixing, then putting into an earthen pot filled with yellow core soil, stir-frying for 10-15 min, and taking out and crushing after completion;
b. and (3) putting the crushed materials into deionized water with the total mass being 8-10 times of that of the crushed materials, boiling the materials for 1-1.5 hours with strong fire, filtering the materials after the boiling, and finally concentrating the obtained filtrate to half of the original volume.
Furthermore, the compound vitamin contains vitamin A, vitamin B6, vitamin B9 and vitamin C.
A preparation method of an injectable facial filler composition gel for cosmetic and plastic surgery comprises the following steps:
firstly, adding sodium hyaluronate into an aqueous solution for injection, uniformly stirring at the rotating speed of 800-900 rpm, then adding collagen powder and modified particles, uniformly stirring at the rotating speed of 1200-1500 rpm, finally adding an extracting agent and multivitamins, and uniformly stirring at the rotating speed of 200-300 rpm.
Compared with the prior art, the invention has the following advantages:
the application provides an injection type facial filler composition gel for beauty and plastic, wherein the components are reasonably adjusted and compatible, and the added modified particles are formed by modifying apatite and have special active groups, so that the combination of sodium hyaluronate and tissues can be promoted, the natural filling effect can be improved, the natural filling effect cannot be eliminated by an immune system, and the using effect of the gel is enhanced; the added extractant can promote the hematopoietic function, improve the differentiation and proliferation capacity of cells, improve the natural fineness of the filled skin and further enhance the use effect of the gel. In addition, the method is simple, easy to popularize and apply and extremely high in market competitiveness.
Detailed Description
Example 1
An injection type face filler composition gel for cosmetic and plastic comprises the following components in parts by weight:
10 parts of sodium hyaluronate, 90 parts of aqueous solution for injection, 2 parts of collagen powder, 5 parts of modified particles, 0.1 part of extractant and 0.4 part of vitamin complex.
The water solution for injection is a sodium chloride solution with the mass concentration of 0.9%.
The preparation method of the modified particles comprises the following steps:
(1) firstly, soaking apatite with citric acid solution, then filtering and washing with deionized water for 3 times for later use; the mass concentration of the citric acid solution is 0.5 percent;
(2) immersing the apatite treated in the step (1) into a silane coupling agent solution, and filtering out for later use after immersing for 10 min; the volume concentration of the silane coupling agent solution is 5 percent;
(3) performing corona treatment on the apatite treated in the step (2), taking out the apatite after the corona treatment, washing the apatite for 3 times by using deionized water, and drying the apatite; the field intensity is controlled to be 500kV/m during corona treatment.
The preparation method of the extractant comprises the following steps:
a. firstly, the white atractylodes rhizome and the suberect spatholobus stem are mixed according to the weight ratio of 1: 2, mixing, then putting into a marmite containing yellow core soil, stir-frying for 10min, taking out and crushing after completion;
b. and (3) putting the crushed materials into deionized water with the mass 8 times of the total mass of the materials, boiling the materials for 1 hour with strong fire, filtering the materials after the boiling is finished, and finally concentrating the obtained filtrate to be half of the original volume.
The compound vitamin contains vitamin A, vitamin B6, vitamin B9, and vitamin C.
A preparation method of an injectable facial filler composition gel for cosmetic and plastic surgery comprises the following steps:
firstly, adding sodium hyaluronate into an aqueous solution for injection, uniformly stirring at the rotating speed of 800rpm, then adding collagen powder and modified particles, uniformly stirring at the rotating speed of 1200rpm, finally adding an extracting agent and multivitamins, and uniformly stirring at the rotating speed of 200 rpm.
Example 2
An injection type face filler composition gel for cosmetic and plastic comprises the following components in parts by weight:
15 parts of sodium hyaluronate, 95 parts of aqueous solution for injection, 4 parts of collagen powder, 7 parts of modified particles, 0.15 part of extractant and 0.6 part of vitamin complex.
The water solution for injection is a sodium chloride solution with the mass concentration of 0.9%.
The preparation method of the modified particles comprises the following steps:
(1) firstly, soaking apatite with citric acid solution, and then filtering and washing with deionized water for 4 times for later use; the mass concentration of the citric acid solution is 0.6 percent;
(2) immersing the apatite treated in the step (1) into a silane coupling agent solution, and filtering out for later use after immersion treatment for 13 min; the volume concentration of the silane coupling agent solution is 6 percent;
(3) performing corona treatment on the apatite treated in the step (2), taking out the apatite after the corona treatment, washing the apatite with deionized water for 4 times, and drying the apatite; the field intensity is controlled to be 510kV/m during corona treatment.
The preparation method of the extractant comprises the following steps:
a. firstly, the white atractylodes rhizome and the suberect spatholobus stem are mixed according to the weight ratio of 1: 2, mixing, then putting into a marmite containing yellow core soil, stir-frying for 14min, taking out and crushing after completion;
b. and (3) putting the crushed materials into deionized water with the mass 9 times of the total mass of the materials, boiling the materials for 1.3 hours with strong fire, filtering the materials after the boiling is finished, and finally concentrating the obtained filtrate to half of the original volume.
The compound vitamin contains vitamin A, vitamin B6, vitamin B9, and vitamin C.
A preparation method of an injectable facial filler composition gel for cosmetic and plastic surgery comprises the following steps:
firstly, adding sodium hyaluronate into an injection water solution, uniformly stirring at the rotating speed of 860rpm, then adding collagen powder and modified particles, uniformly stirring at the rotating speed of 1400rpm, finally adding an extracting agent and multivitamins, and uniformly stirring at the rotating speed of 250 rpm.
Example 3
An injection type face filler composition gel for cosmetic and plastic comprises the following components in parts by weight:
20 parts of sodium hyaluronate, 100 parts of aqueous solution for injection, 5 parts of collagen powder, 8 parts of modified particles, 0.2 part of extractant and 0.7 part of vitamin complex.
The water solution for injection is a sodium chloride solution with the mass concentration of 0.9%.
The preparation method of the modified particles comprises the following steps:
(1) firstly, soaking apatite with citric acid solution, then filtering and washing with deionized water for 5 times for later use; the mass concentration of the citric acid solution is 0.7%;
(2) immersing the apatite treated in the step (1) into a silane coupling agent solution, and filtering out for later use after immersion treatment for 15 min; the volume concentration of the silane coupling agent solution is 7 percent;
(3) performing corona treatment on the apatite treated in the step (2), taking out the apatite after the corona treatment, washing the apatite for 5 times by using deionized water, and drying the apatite; the control field intensity during corona treatment is 520 kV/m.
The preparation method of the extractant comprises the following steps:
a. firstly, the white atractylodes rhizome and the suberect spatholobus stem are mixed according to the weight ratio of 1: 2, mixing, then putting into a marmite containing yellow core soil, stir-frying for 15min, taking out and crushing after completion;
b. and (3) putting the crushed materials into deionized water with the weight 10 times of the total weight of the materials, boiling the materials for 1.5 hours with strong fire, filtering the materials after the boiling is finished, and finally concentrating the obtained filtrate to half of the original volume.
The compound vitamin contains vitamin A, vitamin B6, vitamin B9, and vitamin C.
A preparation method of an injectable facial filler composition gel for cosmetic and plastic surgery comprises the following steps:
firstly, adding sodium hyaluronate into an aqueous solution for injection, uniformly stirring at the rotating speed of 900rpm, then adding collagen powder and modified particles, uniformly stirring at the rotating speed of 1500rpm, finally adding an extracting agent and multivitamins, and uniformly stirring at the rotating speed of 300 rpm.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing description, it will be apparent to one skilled in the art that various changes, modifications, equivalents, and improvements may be made without departing from the spirit and scope of the invention.
Claims (10)
1. An injection type face filler composition gel for cosmetic and plastic, which is characterized by comprising the following components in parts by weight:
10-20 parts of sodium hyaluronate, 90-100 parts of an aqueous solution for injection, 2-5 parts of collagen powder, 5-8 parts of modified particles, 0.1-0.2 part of an extracting agent and 0.4-0.7 part of a vitamin complex.
2. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 1, comprising the following components in parts by weight:
15 parts of sodium hyaluronate, 95 parts of aqueous solution for injection, 4 parts of collagen powder, 7 parts of modified particles, 0.15 part of extractant and 0.6 part of vitamin complex.
3. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 1 or 2, wherein the aqueous solution for injection is a sodium chloride solution having a mass concentration of 0.9%.
4. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 1 or 2, wherein the modified fine particles are prepared by a method comprising the steps of:
(1) soaking apatite with a citric acid solution, filtering, washing with deionized water for 3-5 times for later use;
(2) immersing the apatite treated in the step (1) into a silane coupling agent solution, and filtering out for later use after immersing for 10-15 min;
(3) and (3) performing corona treatment on the apatite treated in the step (2), taking out the apatite after the corona treatment, washing the apatite with deionized water for 3-5 times, and drying the apatite.
5. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 4, wherein the citric acid solution in the step (1) has a mass concentration of 0.5 to 0.7%.
6. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 4, wherein the silane coupling agent solution in the step (2) has a volume concentration of 5 to 7%.
7. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 4, wherein the field strength during corona treatment in step (3) is controlled to be 500 to 520 kV/m.
8. The injectable facial filler composition gel for cosmetic and cosmetic use according to claim 1 or 2, wherein the extraction agent is prepared by a method comprising the steps of:
a. firstly, the white atractylodes rhizome and the suberect spatholobus stem are mixed according to the weight ratio of 1: 2, mixing, then putting into an earthen pot filled with yellow core soil, stir-frying for 10-15 min, and taking out and crushing after completion;
b. and (3) putting the crushed materials into deionized water with the total mass being 8-10 times of that of the crushed materials, boiling the materials for 1-1.5 hours with strong fire, filtering the materials after the boiling, and finally concentrating the obtained filtrate to half of the original volume.
9. The injectable gel of a cosmetic pack composition according to claim 1 or 2, wherein the vitamin complex comprises vitamin A, vitamin B6, vitamin B9, and vitamin C.
10. A preparation method of an injectable facial filler composition gel for cosmetic and plastic surgery is characterized by comprising the following steps:
firstly, adding sodium hyaluronate into an aqueous solution for injection, uniformly stirring at the rotating speed of 800-900 rpm, then adding collagen powder and modified particles, uniformly stirring at the rotating speed of 1200-1500 rpm, finally adding an extracting agent and multivitamins, and uniformly stirring at the rotating speed of 200-300 rpm.
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| CN115252896A (en) * | 2022-08-11 | 2022-11-01 | 成都恒美盛生物科技有限公司 | Material mixing method for producing facial filler |
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