CN115252896A

CN115252896A - Material mixing method for producing facial filler

Info

Publication number: CN115252896A
Application number: CN202210963802.7A
Authority: CN
Inventors: 吴庆江
Original assignee: Chengdu Hengmeisheng Biotechnology Co ltd
Current assignee: Chengdu Hengmeisheng Biotechnology Co ltd
Priority date: 2022-08-11
Filing date: 2022-08-11
Publication date: 2022-11-01

Abstract

The invention provides a material mixing method for producing a facial filler, and relates to the technical field of waste gas waste heat recycling. The material mixing method for the production of the facial filler comprises the steps of injecting a proper amount of hyaluronic acid into a sodium hydroxide solution, uniformly stirring to prepare a hyaluronic acid solution, and standing for later use. This facial filler production material mixing method, during the use, through citric acid to nanometer hydroxyl phosphorus lime's processing, can improve filler and facial tissue's combination effect, effectively improve the actual filling effect of filler, simultaneously can effectively improve the actual mobility of filler through water-soluble epoxy, vitamin, xanthan gum and sodium glycerophosphate, and then effectively shorten the actual shaping time of filler, the live time after can effectively prolonging the shaping simultaneously, can be favorable to the renewal of filler use site cell through collagen polypeptide and amino acid, and then ensure elasticity and fine and smooth quality of filling position skin.

Description

Material mixing method for producing facial filler

Technical Field

The invention relates to the technical field of medical treatment, in particular to a material mixing method for producing a facial filler.

Background

The medical cosmetology refers to a cosmetic mode of repairing and remodeling human appearance and human body part morphology by applying medicines, operations, medical instruments and other traumatic or irreversible medical technical methods.

However, in the prior art, the actual medical cosmetology treatment is performed with facial filling injection, due to the limitation of the components of the existing facial filler, the actual use molding effect is long, the actual use duration is short, the injection supplementation needs to be performed frequently, the red and swollen injection part is easy to cause after the actual injection, the inflammation is easy to cause at the injection part due to excessive injection, and great inconvenience is brought to the daily life of users.

Disclosure of Invention

The invention aims to provide a material mixing method for producing a facial filler, which can effectively shorten the use and molding time, effectively prolong the actual use time, reduce the actual use frequency, effectively avoid the occurrence of red swelling or inflammation at an injection part and improve the actual use safety.

In order to achieve the purpose, the invention is realized by the following technical scheme: a mixing method of materials for producing a facial filler comprises the following steps:

s1, preparing a mixed base solution: injecting a proper amount of hyaluronic acid into the sodium hydroxide solution, uniformly stirring to obtain a hyaluronic acid solution, and standing for later use.

S2, adjusting substance preparation: proper amount of nano hydroxyapatite is soaked in citric acid, and then is treated, filtered and washed for later use.

S3, preparing a mixed solution: and (3) stirring and adding the nano-hydroxyapatite treated in the step (S2) into the hyaluronic acid solution in the step (S1), adding a proper amount of water-soluble epoxy resin, stirring and heating, and standing for later use.

S4, fusion preparation: and adding a proper amount of forming agent into the S3 standing solution, mixing and stirring to obtain a secondary finished product.

S5, completing preparation: and (3) adding a proper amount of auxiliary agent into the sodium chloride solution with the concentration of 0.9%, uniformly mixing, adding the secondary finished product of S4 into the mixed solution, standing, and performing dialysis treatment to obtain the finished product.

As a further scheme of the invention: the hyaluronic acid is uronic acid, and the specific gravity of the sodium hydroxide solution and the hyaluronic acid solution is 1:9.

As a further scheme of the invention: and the treatment, filtration and washing are carried out, namely the filtered nano hydroxyl apatite ash is washed by deionized water, meanwhile, the washed nano hydroxyl apatite ash is put into a silane coupling agent for soaking, and then the nano hydroxyl apatite ash soaked by the silane coupling agent is subjected to corona treatment.

As a further scheme of the invention: washing with deionized water for 4-5 times, soaking in silane coupling agent for 15-20min, filtering, and taking out.

As a further scheme of the invention: the specific gravity of the nano hydroxyl phosphorus lime and hyaluronic acid solution to the water-soluble epoxy resin is 2.

As a further scheme of the invention: the heating is water bath heating, the water temperature is 50-60 ℃, and the continuous heating time is 3-5h.

As a further scheme of the invention: the forming agent is glucitol, and the specific gravity of the solution prepared from the glucitol and the S3 is 1:2.

As a further scheme of the invention: the specific gravity of the sodium chloride solution and the auxiliary agent is 3:1.

As a further scheme of the invention: the auxiliary agents are vitamins, collagen polypeptides, amino acids, curdlan, xanthan gum and sodium glycerophosphate, the vitamins are vitamin A, vitamin B6, vitamin B9 and vitamin C, the vitamins have a specific gravity of 2.

As a further scheme of the invention: and the standing temperature is 20-25 ℃, the standing time is 4-5h, and the dialysis is to perform 3-4d dialysis treatment on the solution in the S5 by using deionized water.

The invention provides a material mixing method for producing a facial filler. The method has the following beneficial effects:

the method for mixing the materials for producing the facial filler can improve the combination effect of the filler and facial tissues and effectively improve the actual filling effect of the filler by treating the nano hydroxyl phospholime with citric acid when in use, can effectively improve the actual fluidity of the filler by using the water-soluble epoxy resin, the vitamins, the xanthan gum and the sodium glycerophosphate, further effectively shorten the actual forming time of the filler, and can effectively prolong the using time after forming.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.

Example 1, a method for mixing materials for facial filler production, comprising the steps of: step one, preparing mixed base solution: injecting a proper amount of hyaluronic acid into the sodium hydroxide solution, uniformly stirring to prepare a hyaluronic acid solution, standing for later use, effectively dissolving hyaluronic acid by the sodium hydroxide solution, wherein the hyaluronic acid is uronic acid, effectively adjusting the permeability of a blood vessel wall by the uronic acid, and simultaneously adjusting the diffusion and the transportation of protein and the hyaluronic acid, so as to effectively promote the healing of a wound, the specific gravity of the sodium hydroxide solution and the hyaluronic acid solution is 1:9, and the step two, adjusting the material configuration: soaking a proper amount of nano hydroxyapatite in citric acid, treating, filtering and washing for later use, wherein the use of the citric acid can effectively improve the combination of the filling agent and the tissue of a filling part, treating, filtering and washing, namely washing the filtered nano hydroxyapatite ash by deionized water, simultaneously putting the washed nano hydroxyapatite ash into a silane coupling agent for soaking, then carrying out corona treatment on the nano hydroxyapatite ash soaked by the silane coupling agent, washing for 4-5 times by the deionized water, soaking the silane coupling agent for 15-20min, filtering and taking out for later use, and preparing a mixed solution: stirring and adding the nano hydroxyapatite treated in the step two into the hyaluronic acid solution in the step one, simultaneously adding a proper amount of water-soluble epoxy resin, and then matching an auxiliary agent with the water-soluble epoxy resin to improve the fluidity of the filler in the actual use process and the durability after forming, stirring and heating, standing for later use, wherein the specific gravity of the nano hydroxyapatite and hyaluronic acid solution and the water-soluble epoxy resin is 2; step four, fusing the preparation: adding a proper amount of forming agent into the standing solution obtained in the third step, mixing and stirring to obtain a secondary finished product, wherein the forming agent is glucitol, the actual forming effect of the filler can be improved through the glucitol, the mixing of auxiliary components can be improved, the diffusion effect of other components can be improved, the specific gravity of the glucitol and the prepared solution obtained in the third step is 1:2, and the fifth step is completed: after a proper amount of auxiliary agent is injected into a sodium chloride solution with the concentration of 0.9 percent and is uniformly mixed, the sodium chloride solution can effectively perform the fusion treatment of the auxiliary agent, simultaneously can effectively prevent the injection part of the filling agent from generating edema after injection, can effectively avoid the water absorption and expansion of hyaluronic acid, effectively improve the fluidity during the actual injection process of the filling agent and improve the actual use effect of the filling agent, and then the secondary product of the step four is added into the mixed solution, and is subjected to dialysis treatment after standing to prepare a finished product, wherein the specific gravity of the sodium chloride solution and the auxiliary agent is 3:1, the auxiliary agent is vitamin, collagen polypeptide, amino acid, thermogel polysaccharide, xanthan gum and sodium glycerophosphate, the addition of the vitamin and the amino acid can effectively accelerate the degradation of the filling agent and improve the use aging of the filling agent, and the fluidity of the filling agent during injection can be improved through the collagen polypeptide, the xanthan gum and the sodium glycerophosphate, the preparation method has the advantages that the uniform injection of the filling agent is ensured, the immunostimulation effect can be avoided through the curdlan, the cell proliferation effect can be improved, the breeding of bacteria can be effectively inhibited, the occurrence of inflammation or inflammation at the injection part is effectively prevented, the moisturizing and senescence delaying effects and the cell proliferation promoting effects are effectively achieved, the specific gravity of the vitamin, the collagen polypeptide, the amino acid, the curdlan, the xanthan gum and the sodium glycerophosphate is (2).

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the inventive concept of the present invention, and these changes and modifications are all within the scope of the present invention.

Claims

1. A material mixing method for producing a facial filler is characterized by comprising the following steps:

s1, preparing a mixed base solution: injecting a proper amount of hyaluronic acid into the sodium hydroxide solution, uniformly stirring to prepare a hyaluronic acid solution, and standing for later use;

s2, adjusting substance preparation: soaking appropriate amount of nano hydroxyapatite in citric acid, treating, filtering and washing for later use;

s3, preparing a mixed solution: stirring the nano hydroxyapatite treated in the step S2, adding the nano hydroxyapatite into the hyaluronic acid solution in the step S1, adding a proper amount of water-soluble epoxy resin, stirring, heating, and standing for later use;

s4, fusion preparation: adding a proper amount of forming agent into the S3 standing solution, and mixing and stirring to obtain a secondary finished product;

2. The material mixing method for the production of facial fillers according to claim 1, wherein the hyaluronic acid is uronic acid, and the specific gravity of the sodium hydroxide solution and the hyaluronic acid solution is 1:9 according to the operation step in S1.

3. The method for mixing materials for facial filler production according to claim 1, wherein the filtering and washing treatment comprises washing the filtered nano hydroxyapatite with deionized water, soaking the washed nano hydroxyapatite in a silane coupling agent, and performing corona treatment on the nano hydroxyapatite soaked in the silane coupling agent according to the operation steps in S2.

4. The method for mixing materials for facial filler production as in claim 3, wherein the deionized water is used for rinsing 4-5 times, the silane coupling agent is soaked for 15-20min, and then the mixture is filtered and taken out for standby.

5. The mixing method of materials for facial filler production as set forth in claim 1, wherein the ratio of the nano hydroxyapatite and hyaluronic acid solution to the water-soluble epoxy resin is 2.

6. A process according to claim 5, wherein the heating is carried out in a water bath at 50-60 ℃ for 3-5h according to the procedure in S3.

7. The method for mixing materials for facial filler production according to claim 1, wherein the forming agent is glucitol according to the operation step in S4, and the specific gravity of the solution prepared in glucitol and S3 is 1:2.

8. The method for mixing materials for facial filler production according to claim 1, wherein the specific gravity of the sodium chloride solution and the adjuvant is 3:1 according to the operation step in S5.

9. The method for mixing materials for facial filler production according to claim 8, wherein the auxiliary agents are vitamins, collagen polypeptides, amino acids, curdlan, xanthan gum and sodium glycerophosphate, the vitamins are vitamin A, vitamin B6, vitamin B9 and vitamin C, the vitamins are one or more of aspartic acid, glutamic acid, glycine, serine and histidine, the specific gravity of which is 2.

10. The method for mixing materials for facial filler production, according to claim 9, wherein the standing temperature is 20-25 ℃ and the standing time is 4-5h according to the operation step in S5, and the dialysis is performed on the solution in S5 for 3-4d with deionized water.