CN113874391B - 靶向baff-r/cd19的嵌合抗原受体修饰的t细胞及其用途 - Google Patents

靶向baff-r/cd19的嵌合抗原受体修饰的t细胞及其用途

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CN113874391B
CN113874391B CN202080028641.1A CN202080028641A CN113874391B CN 113874391 B CN113874391 B CN 113874391B CN 202080028641 A CN202080028641 A CN 202080028641A CN 113874391 B CN113874391 B CN 113874391B
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CN113874391A (zh
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H.秦
X.王
L.W.郭
S.J.福曼
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City of Hope
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CN202080028641.1A 2019-02-20 2020-02-20 靶向baff-r/cd19的嵌合抗原受体修饰的t细胞及其用途 Active CN113874391B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962808222P 2019-02-20 2019-02-20
US62/808,222 2019-02-20
PCT/US2020/019082 WO2020172440A1 (en) 2019-02-20 2020-02-20 Baff-r/cd19 targeted chimeric antigen receptor-modified t cells and use thereof

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CN113874391A CN113874391A (zh) 2021-12-31
CN113874391B true CN113874391B (zh) 2025-10-28

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US (1) US12545714B2 (https=)
EP (1) EP3927738A1 (https=)
JP (1) JP7593646B2 (https=)
KR (1) KR20210129125A (https=)
CN (1) CN113874391B (https=)
WO (1) WO2020172440A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020132291A1 (en) * 2018-12-19 2020-06-25 City Of Hope Baff-r bispecific t-cell engager antibody
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
WO2021163989A1 (en) * 2020-02-21 2021-08-26 Yinnuolai Biotech Ltd. Anti-baff receptor antibodies and uses thereof
EP4271817A2 (en) 2020-12-30 2023-11-08 Alaunos Therapeutics, Inc. Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
US20250319130A1 (en) * 2022-06-01 2025-10-16 Seattle Children’s Hospital d/b/a Seattle Children’s Research Institute Recombinant receptors binding b cell activation factor receptor and uses thereof

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WO2016149578A1 (en) * 2015-03-19 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dual specific anti-cd22-anti-cd19 chimeric antigen receptors
WO2018237022A1 (en) * 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
CN109311991A (zh) * 2016-06-06 2019-02-05 希望之城 Baff-r靶向嵌合抗原受体修饰的t细胞及其用途

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US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
DE102014105472B4 (de) 2014-04-16 2016-03-17 Sartorius Stedim Biotech Gmbh Misch- und Auftauvorrichtung
KR20160145802A (ko) 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
WO2017027291A1 (en) 2015-08-07 2017-02-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific car t-cells for solid tumor targeting
CN116041514A (zh) 2016-06-06 2023-05-02 希望之城 Baff-r抗体及其用途
CN108728459B (zh) 2017-04-24 2023-08-04 上海恒润达生生物科技股份有限公司 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途
AU2018269194B2 (en) 2017-05-15 2025-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors and their uses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016149578A1 (en) * 2015-03-19 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dual specific anti-cd22-anti-cd19 chimeric antigen receptors
CN109311991A (zh) * 2016-06-06 2019-02-05 希望之城 Baff-r靶向嵌合抗原受体修饰的t细胞及其用途
WO2018237022A1 (en) * 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF

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KR20210129125A (ko) 2021-10-27
US12545714B2 (en) 2026-02-10
EP3927738A1 (en) 2021-12-29
JP2022521240A (ja) 2022-04-06
CN113874391A (zh) 2021-12-31
US20220125840A1 (en) 2022-04-28
WO2020172440A1 (en) 2020-08-27
JP7593646B2 (ja) 2024-12-03

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