CN113861191B - 抑制cdk4/6活性化合物的晶型及其应用 - Google Patents

抑制cdk4/6活性化合物的晶型及其应用 Download PDF

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CN113861191B
CN113861191B CN202111208432.8A CN202111208432A CN113861191B CN 113861191 B CN113861191 B CN 113861191B CN 202111208432 A CN202111208432 A CN 202111208432A CN 113861191 B CN113861191 B CN 113861191B
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CN113861191A (zh
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王义乾
张春辉
王家炳
丁列明
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Betta Pharmaceuticals Co Ltd
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Betta Pharmaceuticals Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/245Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255Tartaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202111208432.8A 2018-06-21 2019-06-21 抑制cdk4/6活性化合物的晶型及其应用 Active CN113861191B (zh)

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CN202111208432.8A CN113861191B (zh) 2018-06-21 2019-06-21 抑制cdk4/6活性化合物的晶型及其应用

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CNPCT/CN2018/092194 2018-06-21
CN2018092194 2018-06-21
CN202111208432.8A CN113861191B (zh) 2018-06-21 2019-06-21 抑制cdk4/6活性化合物的晶型及其应用
CN201980037275.3A CN112424202B (zh) 2018-06-21 2019-06-21 抑制cdk4/6活性化合物的晶型及其应用
PCT/CN2019/092239 WO2019242719A1 (zh) 2018-06-21 2019-06-21 抑制cdk4/6活性化合物的晶型及其应用

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EP (1) EP3812386A4 (es)
JP (1) JP7430656B2 (es)
KR (1) KR20210024004A (es)
CN (2) CN112424202B (es)
AU (1) AU2019290722B2 (es)
BR (1) BR112020026052A2 (es)
CA (1) CA3104365A1 (es)
EA (1) EA202190036A1 (es)
IL (1) IL279579B2 (es)
MX (1) MX2020013847A (es)
PH (1) PH12020552236A1 (es)
SG (1) SG11202012858QA (es)
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CN117222411A (zh) * 2021-03-24 2023-12-12 贝达药业股份有限公司 药物组合、包含其的试剂盒及其用途
WO2023131179A1 (zh) * 2022-01-05 2023-07-13 贝达药业股份有限公司 苯并咪唑衍生物或其盐在治疗白血病中的用途
CN115872923B (zh) * 2022-12-29 2023-04-28 成都泰和伟业生物科技有限公司 一种化合物及其制备方法

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CN106608879A (zh) * 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
WO2017102796A1 (en) * 2015-12-16 2017-06-22 F. Hoffmann-La Roche Ag HETEROARYL AMIDE SULTAM DERIVATIVES AS RORc MODULATORS
WO2017206924A1 (zh) * 2016-06-01 2017-12-07 贝达药业股份有限公司 抑制蛋白激酶活性化合物的晶型及其应用
CN107690431A (zh) * 2015-07-08 2018-02-13 豪夫迈·罗氏有限公司 作为RORc调节剂的芳基磺内酰胺衍生物
CN107849012A (zh) * 2015-04-28 2018-03-27 重庆复创医药研究有限公司 一类激酶抑制剂

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CN104592251B (zh) * 2015-01-23 2019-10-01 上海复星医药产业发展有限公司 4-(稠杂环取代氨基)-1h-吡唑-3-甲酰胺类化合物及其用途
DK3559000T3 (da) * 2016-12-22 2022-06-07 Betta Pharmaceuticals Co Ltd Benzimidazol-derivater, fremgangsmåder til fremstilling og anvendelser deraf
WO2019035008A1 (en) * 2017-08-15 2019-02-21 Beijing Xuanyi Pharmasciences Co., Ltd. INHIBITORS OF CDK4 / 6 AND THEIR USE

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CN107849012A (zh) * 2015-04-28 2018-03-27 重庆复创医药研究有限公司 一类激酶抑制剂
CN107690431A (zh) * 2015-07-08 2018-02-13 豪夫迈·罗氏有限公司 作为RORc调节剂的芳基磺内酰胺衍生物
CN106608879A (zh) * 2015-10-27 2017-05-03 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
WO2017102796A1 (en) * 2015-12-16 2017-06-22 F. Hoffmann-La Roche Ag HETEROARYL AMIDE SULTAM DERIVATIVES AS RORc MODULATORS
WO2017206924A1 (zh) * 2016-06-01 2017-12-07 贝达药业股份有限公司 抑制蛋白激酶活性化合物的晶型及其应用

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Claus U. Jessen等.Synthesis of N-protected 14C-Labelled (2E)-5-amino-5-methylhex-2-enoic acid analogues.《Journal of Labelled Compounds and Radiopharmaceuticals》.2001,第44卷(第4期),第266页. *
Convenient in situ synthesis of nonracemic N-protected β-amino aldehydes from β-amino acids. Applications in Wittig reactions and heterocycle synthesis;Simon B.Davied等;《Tetrahedron Letters》;19990205;第40卷;第1230-1231页 *
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CA3104365A1 (en) 2019-12-26
JP7430656B2 (ja) 2024-02-13
JP2021529175A (ja) 2021-10-28
EA202190036A1 (ru) 2021-03-24
AU2019290722A1 (en) 2021-01-28
US20210261546A1 (en) 2021-08-26
PH12020552236A1 (en) 2021-06-28
EP3812386A4 (en) 2022-03-30
TW202016114A (zh) 2020-05-01
IL279579B (en) 2022-10-01
AU2019290722B2 (en) 2023-12-21
CN112424202A (zh) 2021-02-26
CN112424202B (zh) 2021-09-17
WO2019242719A1 (zh) 2019-12-26
SG11202012858QA (en) 2021-02-25
IL279579A (en) 2021-03-01
TWI786303B (zh) 2022-12-11
EP3812386A1 (en) 2021-04-28
BR112020026052A2 (pt) 2021-03-23
CN113861191A (zh) 2021-12-31
US12043622B2 (en) 2024-07-23
IL279579B2 (en) 2023-02-01
KR20210024004A (ko) 2021-03-04

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