CN113855772B

CN113855772B - Traditional Chinese medicine composition and preparation for treating postpartum disease and preparation method and application thereof

Info

Publication number: CN113855772B
Application number: CN202111235382.2A
Authority: CN
Inventors: 高冰; 李晓娟; 姚喜; 王庆; 黄常友
Original assignee: Zigong Maternal and Child Health Hospital
Current assignee: Zigong Maternal and Child Health Hospital
Priority date: 2021-10-22
Filing date: 2021-10-22
Publication date: 2022-05-20
Anticipated expiration: 2041-10-22
Also published as: CN113855772A

Abstract

The invention provides a traditional Chinese medicine composition for treating postpartum diseases, which comprises, by weight, 20-40 parts of codonopsis pilosula, 20-40 parts of raw astragalus membranaceus, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of poria cocos, 10-30 parts of angelica sinensis, 10-30 parts of radix paeoniae alba, 10-30 parts of donkey-hide gelatin, 10-30 parts of morinda officinalis, 10-30 parts of cistanche, 10-30 parts of radix glehniae, 10-30 parts of cynanchum atratum bunge, 10-30 parts of cacumen biotae, 10-30 parts of hairyvein agrimonia herb and bud, 10-30 parts of leonurus, 10-30 parts of ligusticum wallichii, 10-30 parts of dandelion, 10-30 parts of notopterygium root, 10-30 parts of radix angelicae pubescentis, 10-30 parts of cassia twig, 10-30 parts of radix curcumae, 10-30 parts of radix rhapontici, 10-30 parts of rhizoma polygonati, 5-25 parts of rhizoma cyperi, 5-20 parts of fructus liquidambaris and 10-20 parts of radix glycyrrhizae preparata, it has good therapeutic effect on puerperal diseases; can promote puerperal involution of uterus and reduce puerperal hemorrhage; relieving postpartum body pain; regulating the mood of the puerpera; promoting puerperal galactopoiesis, preventing puerperal asthenia and anemia, and promoting puerperal rehabilitation.

Description

Traditional Chinese medicine composition and preparation for treating postpartum disease and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating postpartum diseases, a preparation method and application thereof.

Background

Puerpera develops diseases related to childbirth or puerperium in the puerperium, which is called postpartum disease. Common postpartum diseases include postpartum anemic fainting, postpartum abdominal pain, postpartum blood fatigue, postpartum convulsion, postpartum fever, postpartum general pain, postpartum depression, postpartum lochiorrhea, postpartum urinary obstruction, postpartum hypogalactia and the like. According to statistics, the proportion of patients with postpartum lochiorrhea is 40.2%, the proportion of patients with postpartum pain is 9.8%, and the proportion of patients with postpartum pain is 22.0%. The proportion of patients with other postpartum/non-postpartum diseases is 13.6%. Healthy people account for 8.3%. Epidemiological reports show that the incidence rate of postpartum hypogalactia accounts for 20-30% of that of puerpera, the incidence rate of postpartum depression accounts for 5-25% of that of puerpera, the incidence rate of postpartum diseases is high, the influence on the physical and mental health of women is wide, and the postpartum hypogalactia becomes an invisible social problem.

"Jingyue complete book, woman's rule" cloud: strengthening body resistance to eliminate pathogenic factors, tonifying deficiency and purging excess, and treating by tonifying qi and blood, soothing liver to relieve depression, activating blood and dispelling stasis. The western medicine treatment can not achieve the effects of removing qi and blood after delivery and treating excess deficiency syndrome, and women have the characteristics of excess deficiency and excess stasis after delivery, so various factors should be combined in treatment, individuality differences are found on the basis of commonness, and treatment is carried out according to syndrome differentiation. Syndrome differentiation is characterized by deficiency and excess intermingled with qi and blood deficiency and all pulse vacuity, qi stagnation and blood stasis, liver depression and qi stagnation, phlegm coagulation and damp obstruction. The treatment principle is one point, most of the lying-in women can be fed by breast milk, and part of western medicines have large toxic and side effects, such as the small dose of glucocorticoid can cause the growth retardation of infants, so that few lying-in women are willing to take western medicines for treatment.

Traditional Chinese medicine treatment such as acupuncture and massage, traditional Chinese medicine oral administration, rehabilitation and the like also has good curative effects on treating postpartum general pain, postpartum lochiorrhea, postpartum hypogalactia, postpartum depression, and cannot be deeply popularized due to the fear of acupuncture, inconvenience in carrying, incapability of continuously performing treatment after symptom improvement and the like of patients.

Disclosure of Invention

The first purpose of the invention is to provide a traditional Chinese medicine composition for treating postpartum diseases, which has better curative effect on the postpartum diseases, can promote the involution of postpartum uterus and reduce postpartum hemorrhage; relieving postpartum pain of the body; regulating the mood of the puerpera; promoting puerperal galactopoiesis, preventing puerperal asthenia and anemia, and promoting puerperal rehabilitation.

The second purpose of the invention is to provide the preparation and application of the traditional Chinese medicine preparation for treating postpartum disease, which can avoid the loss of medicine effect, ensure that the release rate of the effective ingredients of the medicine is high, and obviously improve the stability and dissolution rate of the medicine, thereby improving the treatment effect and cure rate of the medicine.

The embodiment of the invention is realized by the following technical scheme:

a traditional Chinese medicine composition for treating postpartum disease comprises the following components in parts by weight, comprises 20-40 parts of radix codonopsitis, 20-40 parts of raw astragalus root, 10-30 parts of largehead atractylodes rhizome, 10-30 parts of tuckahoe, 10-30 parts of angelica, 10-30 parts of white peony root, 10-30 parts of donkey-hide gelatin, 10-30 parts of morinda officinalis, 10-30 parts of desertliving cistanche, 10-30 parts of radix glehniae, 10-30 parts of cynanchum atratum, 10-30 parts of cacumen biotae, 10-30 parts of hairyvein agrimony, 10-30 parts of motherwort, 10-30 parts of szechuan lovage rhizome, 10-30 parts of dandelion, 10-30 parts of notopterygium root, 10-30 parts of radix angelicae pubescentis, 10-30 parts of cassia twig, 10-30 parts of radix curcumae, 10-30 parts of uniflower swisscentaury root, 10-30 parts of rhizoma polygonati, 5-25 parts of rhizoma cyperi, 5-20 parts of beautiful sweetgum fruit and 10-20 parts of honey-fried licorice root.

An application of a Chinese medicinal composition in the preparation of medicine for treating puerperal uterine involution, puerperal abdominal pain, puerperal general pain, lochiorrhea, puerperal hypogalactia, puerperal depression, puerperal constipation, puerperal fever due to internal injury, and puerperal alopecia is provided.

A preparation prepared from a traditional Chinese medicine composition for treating postpartum disease comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.

Further, the preparation is in the form of any one of granules, capsules, paste, tablets, decoction, powder or pills.

A preparation method of a capsule for treating postpartum disease comprises the following steps: (1) taking radix codonopsitis, raw radix astragali, rhizoma atractylodis macrocephalae, poria cocos, angelica sinensis and radix paeoniae alba according to formula dosage, cleaning, airing, respectively crushing, and uniformly mixing to obtain mixed powder A;

(2) soaking the rest components in water for 10-30 min; boiling, decocting, filtering, and concentrating to obtain extract with relative density of 1.25-1.35;

(3) then placing the extract obtained in the step (2) into a vacuum drier for fluidized drying, and carrying out combined transportation and crushing to obtain mixed powder B;

(4) and (3) uniformly mixing the mixed powder A obtained in the step (1) and the mixed powder B obtained in the step (3), and filling the mixture into capsules to obtain finished products.

The technical scheme of the embodiment of the invention at least has the following advantages and beneficial effects:

1. the traditional Chinese medicine composition has better curative effect on postpartum diseases by using the treatment principle of strengthening body resistance to eliminate pathogenic factors and tonifying deficiency and excess and the treatment method of soothing liver and relieving depression, activating blood and removing stasis and tonifying qi and blood; can promote puerperal involution of uterus and reduce puerperal hemorrhage; relieving postpartum pain of the body; regulating the mood of the puerpera; promoting puerperal galactopoiesis, preventing puerperal asthenia and anemia, and promoting puerperal rehabilitation.

2. The traditional Chinese medicine composition disclosed by the invention fully considers the commonality of postpartum recuperation and the special personality of postpartum disease prevention and treatment, adopts a comprehensive care method, is capable of protecting health and treating diseases and preventing diseases, is mild in medicine property, small in side effect, good in taste and convenient to store and take, is beneficial to patients to insist on taking and is easy to popularize.

3. The preparation method of the invention can give full play to the efficacy of each drug, avoid the loss of the efficacy, ensure that the release rate of the active ingredients of the drugs is high, and can obviously improve the stability and the dissolution rate of the drugs, thereby improving the treatment effect and the cure rate of the drugs.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The following provides a specific description of a traditional Chinese medicine composition for treating postpartum diseases, a preparation method thereof, a using method thereof and application thereof.

Further, the traditional Chinese medicine composition comprises, by weight, 20-35 parts of codonopsis pilosula, 20-35 parts of raw astragalus membranaceus, 10-25 parts of bighead atractylodes rhizome, 10-25 parts of poria cocos, 10-25 parts of angelica sinensis, 10-25 parts of radix paeoniae alba, 10-25 parts of donkey-hide gelatin, 10-25 parts of morinda officinalis, 10-25 parts of cistanche, 10-25 parts of radix glehniae, 10-25 parts of cynanchum atratum bunge, 10-25 parts of cacumen biotae, 10-25 parts of hairyvein agrimonia herb and bud, 10-25 parts of leonurus, 10-25 parts of ligusticum wallichii, 10-25 parts of dandelion, 10-25 parts of notopterygium root, 10-25 parts of radix angelicae pubescentis, 10-25 parts of cassia twig, 10-25 parts of radix curcumae, 10-25 parts of uniflower swisscentaury root, 10-25 parts of rhizoma polygonati, 5-20 parts of rhizoma cyperi, 5-15 parts of fructus liquidambaris and 15-20 parts of honey-fried licorice root.

Further, the traditional Chinese medicine composition comprises, by weight, 30 parts of codonopsis pilosula, 30 parts of raw astragalus membranaceus, 20 parts of bighead atractylodes rhizome, 20 parts of poria cocos, 20 parts of angelica sinensis, 20 parts of radix paeoniae alba, 20 parts of donkey-hide gelatin, 20 parts of morinda officinalis, 20 parts of cistanche, 20 parts of radix glehniae, 20 parts of cynanchum atratum, 20 parts of cacumen biotae, 20 parts of hairyvein agrimony, 20 parts of leonurus, 20 parts of ligusticum wallichii, 20 parts of dandelion, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of cassia twig, 20 parts of radix curcumae, 20 parts of radix rhapontici, 20 parts of rhizoma polygonati, 15 parts of rhizoma cyperi, 10 parts of fructus liquidambaris and 10 parts of radix glycyrrhizae preparata.

Further, the traditional Chinese medicine composition comprises, by weight, 25 parts of codonopsis pilosula, 20 parts of raw astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 15 parts of angelica sinensis, 15 parts of white peony root, 20 parts of donkey-hide gelatin, 15 parts of morinda officinalis, 15 parts of cistanche, 15 parts of radix glehniae, 20 parts of cynanchum atratum, 10 parts of cacumen biotae, 10 parts of hairyvein agrimony, 15 parts of leonurus, 15 parts of ligusticum wallichii, 10 parts of dandelion, 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 10 parts of cassia twig, 10 parts of radix curcumae, 15 parts of radix rhapontici, 15 parts of rhizoma polygonati, 10 parts of rhizoma cyperi, 10 parts of fructus liquidambaris and 15 parts of honey-fried licorice root.

Codonopsis pilosula, radix Codonopsis is neutral in nature, sweet in flavor and slightly sour. It enters spleen and lung meridians. Tonify middle-jiao and Qi, invigorate spleen and benefit lung. Can be used for treating spleen and lung deficiency, short breath, palpitation, anorexia, loose stool, asthma, cough, internal heat, and diabetes. Suitable for people with weak constitution, deficiency of qi and blood, sallow complexion and weak constitution after illness and delivery.

Raw astragalus root: sweet in flavor and slightly warm in nature, entering lung, spleen, liver and kidney meridians. Has effects of invigorating qi, consolidating superficial resistance, promoting sore, promoting granulation, and inducing diuresis, and can be used for treating deficiency of qi and blood, spontaneous perspiration, chronic diarrhea, proctoptosis, metroptosis, nephritis edema, albuminuria, diabetes, and chronic ulcer.

White atractylodes rhizome: bitter, sweet and warm, entering spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Tu Bai Zhu strengthens spleen, harmonizes stomach and prevents abortion. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and threatened abortion.

Tuckahoe, poria cocos: sweet, bland and mild. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

Chinese angelica: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Has the effects of enriching blood, promoting blood circulation, regulating menstruation, relieving pain, moistening intestines and relaxing bowels. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. The wine angelica sinensis can activate blood and promote menstruation.

White peony root: bitter, sour and slightly cold. It enters liver and spleen meridians. Pacify liver and alleviate pain, nourish blood and regulate menstruation, astringe yin and check sweating. Can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.

E, donkey-hide gelatin: sweet and neutral. It enters lung, liver and kidney meridians. Tonify blood, nourish yin, moisten dryness and stop bleeding. Can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, muscle weakness, vexation, insomnia, deficient wind stirring, cough due to dryness of lung, overstrain cough, hemoptysis, hematemesis, hematuria, hematochezia, metrorrhagia, and gestational fetal leakage.

Morinda officinalis: sweet and pungent in flavor and slightly warm in nature. It enters kidney and liver meridians. Has the effects of tonifying kidney yang, strengthening tendons and bones, and dispelling wind-damp. Can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, menoxenia, cold pain of lower abdomen, rheumatic arthralgia, and flaccidity of tendons and bones.

Cistanche deserticola: sweet, salty and warm. It enters kidney and large intestine meridians. Tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation. Can be used for treating sexual impotence, infertility, soreness of waist and knees, weakness of tendons and bones, constipation due to intestinal dryness.

Radix glehniae: sweet, slightly bitter and slightly cold. It enters lung and stomach meridians. To nourish yin, clear lung-heat, nourish stomach and promote fluid production. It can be used for treating cough due to lung heat, cough due to overstrain, phlegm and blood, and thirst due to body fluid consumption due to febrile disease.

Radix cynanchi atrati: bitter, salty and cold. It enters stomach, liver and kidney meridians. Clear heat and cool blood, induce diuresis to treat stranguria, remove toxicity and cure sore. Can be used for treating fever due to pathogenic heat, yin deficiency, bone steaming, fatigue, puerperal fever due to blood deficiency, heat stranguria, blood stranguria, carbuncle, cellulitis, and toxic swelling.

Cacumen biotae: bitter, astringent and cold. It enters lung, liver and spleen meridians. Cool blood to stop bleeding, grow hair and blacken hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, alopecia due to blood heat, and premature gray hair.

Agrimony: bitter, astringent and mild. It enters heart and liver meridians. Astringe to stop bleeding, check malaria, stop dysentery and remove toxicity. Can be used for treating hemoptysis, hematemesis, metrorrhagia, malaria, dysentery with bloody stool, carbuncle, sore, pruritus vulvae, and leukorrhagia.

Motherwort herb, bitter and pungent in flavor, slightly cold in nature, enters liver, pericardium and bladder meridians. It can be used for treating menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema, oliguria, and pyocutaneous disease. Can be used for promoting the discharge of residual tissues and blood stasis in uterine cavity after delivery and promoting the involution of uterus.

Chuan Xiong is pungent in flavor and warm in nature; it enters liver, gallbladder and heart meridians; powder for raising fragrance; has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; can be used for treating menoxenia, dysmenorrhea, amenorrhea, dystocia, lochiorrhea, puerperal lochiorrhea, abdominal pain, lump, chest and hypochondrium pain, traumatic injury, swelling and pain, headache, dizziness, dim eyesight, arthralgia due to wind-cold-dampness, numbness of limbs, superficial infection, and pyocutaneous disease.

Dandelion: bitter, sweet and cold. It enters liver and stomach meridians. Clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Can be used for treating furuncle, pyogenic infection, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with damp-heat pathogen.

Notopterygium root: pungent and bitter with warm nature. Enter bladder and kidney meridians. Has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain. Wind-cold type common cold, wind-cold-dampness arthralgia, neck rigidity, spasm of muscles, soreness and pain of joints, edema due to wind-damp, carbuncle, deep-rooted carbuncle and sore.

Radix angelicae pubescentis: pungent and bitter with slightly warm nature. It enters kidney and bladder meridians. Has the effects of dispelling wind and removing dampness, and relieving pain and pain of arthralgia. Can be used for treating arthralgia due to wind-cold-dampness, lumbago, gonalgia, headache due to wind-cold-yin deficiency, and headache due to wind-cold-dampness.

Gui Zhi, pungent, sweet and warm in nature and flavor, enters bladder, heart and lung meridians. Has effects in inducing sweat, expelling pathogenic factors from muscles, warming channels, promoting blood circulation, supporting yang, regulating qi, expelling cold, and relieving pain. Can be used for treating wind-cold exterior syndrome, arthralgia due to cold-dampness, and cold limbs; amenorrhea and dysmenorrhea; with symptoms of lumps, obstruction of qi in the chest, palpitation, phlegm-fluid retention, difficult urination. Can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.

Yu jin is pungent and bitter in flavor and enters heart, lung and liver meridians. Has effects in promoting qi circulation, relieving depression, protecting liver, promoting bile flow, dispelling blood stasis, stopping bleeding, cooling blood, and clearing away heart-fire. It can be used for treating chest pain, abdominal pain, hypochondriac pain, mania, coma due to febrile disease, hematemesis, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, and jaundice.

Rhapontic uniflower root, bitter and salty in nature and taste, cold in nature, enters stomach and large intestine meridians. Has the effects of clearing away heat and toxic materials, relieving swelling, expelling pus, dredging channels, promoting lactation, and dredging tendons and vessels. It has good therapeutic effect on female puerperal little floating juice or galactostasis, and can also be used for treating breast distending pain and mastitis.

Rhizoma polygonati: sweet and neutral. It enters spleen, lung and kidney meridians. Tonify qi and yin, invigorate spleen, moisten lung and tonify kidney. Can be used for treating weakness of spleen and stomach, asthenia, xerostomia, anorexia, lung deficiency, cough, essence and blood deficiency, and internal heat diabetes.

Cyperus rotundus, pungent in flavor, slightly bitter and neutral in nature, enters liver and triple energizer meridians. Has effects in regulating qi, resolving stagnation, regulating menstruation, and relieving pain. It can be used for treating incoordination between liver and stomach, qi stagnation, abdominal distention, menoxenia, and dysmenorrhea. Can be used for treating pain due to stagnation of liver-qi, especially gynecological diseases and menoxenia.

The road is through: bitter and neutral. It enters liver and kidney meridians. Dispel wind, activate collaterals, induce diuresis and dredge meridians. Can be used for treating arthralgia, numbness, spasm, edema, distention and amenorrhea.

Honey-fried licorice root: sweet and neutral. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Under the guidance of the theory of traditional Chinese medicine, the invention is inspired by the classic clinical treatment thought of traditional Chinese medicine, and is obtained through a large number of preparation process tests and years of practice, and the traditional Chinese medicine considers that the pathogenesis of postpartum diseases has the following four characteristics: firstly, excessive blood loss, blood and body fluid loss, floating of deficient yang or deficient fire; secondly, the stagnation of blood stasis can lead to the impairment of qi movement, unsmooth blood circulation or disorder of qi movement; thirdly, deficiency of qi and blood or stagnation of qi due to depression of the liver, stagnation of phlegm and blood in the middle energizer, resulting in postpartum deficiency; and fourthly, excessive blood loss after childbirth, heart blood deficiency, or invasion of cold evil, unsmooth blood circulation, blood stasis disturbing the mind, or emotional damage, and stagnation of liver qi. Therefore, various factors should be combined in treatment, and different individuality should be found on the basis of commonness, so as to treat based on syndrome differentiation. Syndrome differentiation is characterized by deficiency and excess intermingled with qi and blood deficiency and all pulse vacuity, qi stagnation and blood stasis, liver depression and qi stagnation, phlegm coagulation and damp obstruction. The treatment principle should be strengthening body resistance to eliminate pathogenic factors, tonifying deficiency and purging excess, and the treatment method is mainly characterized by tonifying qi and blood, soothing liver and relieving depression, activating blood and dissolving stasis. The treatment principle of strengthening body resistance to eliminate pathogenic factors, tonifying deficiency and reducing excess and the treatment method of soothing liver and relieving depression, activating blood and removing stasis and tonifying qi and blood fully take the commonality of postpartum conditioning and the special personality of preventing and treating postpartum diseases into consideration, the method of comprehensive care is adopted, the idea of 'treating disease before childbirth' is easily emphasized, the overall prevention is mainly carried out, and the treatment is not carried out until the puerpera has symptoms such as severe depression, body pain, hypogalactia and the like.

Therefore, the codonopsis pilosula and the raw astragalus root which are used together for tonifying qi are mainly used as monarch drugs in the traditional Chinese medicine composition. Poria and Atractylodis rhizoma for invigorating spleen; the angelica, the donkey-hide gelatin and the white paeony root are ministerial drugs which can enrich the blood and assist the monarch drugs in tonifying qi and nourishing the blood. Rhizoma Ligustici Chuanxiong and herba Leonuri are used for promoting qi and blood circulation; herba et Gemma Agrimoniae has astringent and hemostatic effects; morinda officinalis warms kidney yang to remove cold in uterus; cistanche deserticola has the effects of tonifying kidney yang, benefiting essence and blood and relaxing bowel; notopterygium root and pubescent angelica root, rhizoma et radix Notopterygii and radix Angelicae Pubescentis, being pungent and warm, prevent the invasion of pathogenic wind-cold; rhizoma Cyperi and radix Curcumae have effects of dispersing stagnated liver qi, relieving qi stagnation, and regulating qi flow; the beautiful sweetgum fruit and the uniflower swisscentaury root dredge the channels and collaterals to promote lactation; bei Sha Shen and Bai Wei nourish yin to remove yin deficiency and internal heat; rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, invigorating kidney, cooling blood, stopping bleeding, promoting hair growth, and blackening hair; the dandelion has the effects of clearing heat and removing toxicity, eliminating carbuncle and dissipating stagnation, and is beneficial to preventing and treating breast diseases. Prepared licorice root, radix Glycyrrhizae Praeparata, as a guiding drug, has the effects of invigorating the spleen and replenishing the middle-jiao, and harmonizing the effects of the other drugs in the recipe. The medicines are combined to play the roles of tonifying qi and blood, activating blood circulation to dissipate blood stasis, soothing liver and relieving depression, consolidating the constitution and preventing pathogenic factors. Is suitable for treating conventional puerperal uterine involution, puerperal abdominal pain, puerperal general pain, lochiorrhea, puerperal hypogalactia, puerperal depression, puerperal constipation, puerperal internal injury fever, puerperal alopecia, etc. It can be used for both health promotion and treatment of diseases, and also for prevention of diseases.

A preparation method of a traditional Chinese medicine preparation for treating postpartum disease comprises the following steps:

(1) taking radix codonopsitis, raw radix astragali, rhizoma atractylodis macrocephalae, poria cocos, angelica sinensis and radix paeoniae alba according to formula dosage, cleaning, airing, respectively crushing, and uniformly mixing to obtain mixed powder A;

Further, when decocting in the step (2), boiling with strong fire for 10-20 minutes, decocting with slow fire for 20 minutes, filtering, and naturally cooling to 55-60 deg.C to obtain Chinese medicinal decoction.

Further, when the fluidized drying is performed in the step (3), the gradient drying is performed: firstly heating at 110-130 ℃ for 30-50 minutes, then heating at 60-100 ℃ for 20-40 minutes, and finally heating at 15-30 ℃ for 10-30 minutes.

Example 1: capsule for treating postpartum disease and preparation method thereof

The formula comprises the following components: 20g of codonopsis pilosula, 20g of raw astragalus membranaceus, 10g of bighead atractylodes rhizome, 10g of poria cocos, 10g of angelica sinensis, 30g of white paeony root, 30g of donkey-hide gelatin, 10g of morinda officinalis, 10g of cistanche, 10g of radix glehniae, 10g of cynanchum atratum bunge, 10g of cacumen biotae, 30g of hairyvein agrimonia herb and bud, 30g of leonurus, 30g of ligusticum wallichii, 10g of dandelion, 10g of notopterygium root, 10g of radix angelicae pubescentis, 10g of cassia twig, 10g of radix curcumae, 10g of uniflower swisscentaury root, 10g of rhizoma polygonati, 5g of rhizoma cyperi, 20g of fructus liquidambaris and 10g of honey-fried licorice root.

The preparation method comprises the following steps: the method comprises the following specific steps:

(1) cleaning and airing codonopsis pilosula, raw astragalus, bighead atractylodes rhizome, poria cocos, angelica sinensis and white paeony root according to the formula amount, respectively crushing the codonopsis pilosula, the raw astragalus, the bighead atractylodes rhizome, the poria cocos, the angelica sinensis and the white paeony root, and uniformly mixing the crushed materials to obtain mixed powder A;

(2) soaking the rest components in water for 20 min; boiling with strong fire for 15 min, decocting with slow fire for 20 min, filtering, naturally cooling to 55 deg.C, filtering, and concentrating to obtain Chinese medicinal extract with relative density of 1.3;

(3) then placing the extract obtained in the step (2) into a vacuum drier for fluidized drying, firstly heating at 120 ℃ for 40 minutes, then heating at 80 ℃ for 30 minutes, and finally heating at 20 ℃ for 20 minutes; and crushing by combined transportation to obtain mixed powder B;

Example 2: capsule for treating postpartum disease and preparation method thereof

The formula comprises the following components: 40g of codonopsis pilosula, 40g of raw astragalus membranaceus, 30g of bighead atractylodes rhizome, 30g of poria cocos, 30g of angelica sinensis, 10g of white paeony root, 10g of donkey-hide gelatin, 30g of morinda officinalis, 30g of cistanche, 30g of radix glehniae, 30g of cynanchum atratum bunge, 30g of cacumen biotae, 10g of hairyvein agrimonia herb and bud, 10g of leonurus, 10g of ligusticum wallichii, 30g of dandelion, 30g of notopterygium root, 30g of radix angelicae pubescentis, 30g of cassia twig, 30g of radix curcumae, 30g of uniflower swisscentaury root, 30g of rhizoma polygonati, 25g of rhizoma cyperi, 5g of fructus liquidambaris and 20g of honey-fried licorice root.

The preparation process was identical to example 1.

Example 3: capsule for treating postpartum disease and preparation method thereof

The formula comprises the following components: the method comprises the following steps: 30g of codonopsis pilosula, 30g of raw astragalus membranaceus, 20g of bighead atractylodes rhizome, 20g of poria cocos, 20g of angelica sinensis, 20g of white paeony root, 20g of donkey-hide gelatin, 20g of morinda officinalis, 20g of cistanche deserticola, 20g of radix glehniae, 20g of cynanchum atratum bunge, 20g of cacumen biotae, 20g of hairyvein agrimonia herb and bud, 20g of leonurus, 20g of ligusticum wallichii, 20g of dandelion, 20g of notopterygium root, 20g of radix angelicae pubescentis, 20g of cassia twig, 20g of radix curcumae, 20g of uniflower swisscentaury root, 20g of rhizoma polygonati, 15g of rhizoma cyperi, 10g of fructus liquidambaris and 10g of honey-fried licorice root.

The preparation process was identical to example 1.

Example 4: capsule for treating postpartum disease and preparation method thereof

The formula comprises the following components: the method comprises the following steps: 25g of codonopsis pilosula, 20g of raw astragalus membranaceus, 15g of bighead atractylodes rhizome, 15g of poria cocos, 15g of angelica sinensis, 15g of white paeony root, 20g of donkey-hide gelatin, 15g of morinda officinalis, 15g of cistanche deserticola, 15g of radix glehniae, 20g of cynanchum atratum bunge, 10g of cacumen biotae, 10g of hairyvein agrimonia herb and bud, 15g of leonurus, 15g of ligusticum wallichii, 10g of dandelion, 10g of notopterygium root, 10g of radix angelicae pubescentis, 10g of cassia twig, 10g of radix curcumae, 15g of uniflower swisscentaury root, 15g of rhizoma polygonati, 10g of rhizoma cyperi, 10g of fructus liquidambaris and 15g of honey-fried licorice root.

The preparation process was identical to example 1.

Example 5: capsule for treating postpartum disease and preparation method thereof

The formula comprises the following components: the method comprises the following steps: 22g of codonopsis pilosula, 23g of raw astragalus membranaceus, 18g of bighead atractylodes rhizome, 19g of poria cocos, 19g of angelica sinensis, 18g of white paeony root, 18g of donkey-hide gelatin, 17g of morinda officinalis, 16g of cistanche, 18g of radix glehniae, 22g of cynanchum atratum bunge, 16g of cacumen biotae, 16g of hairyvein agrimonia herb and bud, 18g of leonurus, 18g of ligusticum wallichii, 18g of dandelion, 18g of notopterygium root, 18g of radix angelicae pubescentis, 16g of cassia twig, 18g of radix curcumae, 18g of uniflower swisscentaury root, 18g of rhizoma polygonati, 16g of rhizoma cyperi, 13g of fructus liquidambaris and 18g of honey-fried licorice root.

The preparation process was identical to example 1.

Example 6: capsule for treating postpartum disease and preparation method thereof

The formula comprises the following components: the method comprises the following steps: 28g of codonopsis pilosula, 22g of raw astragalus membranaceus, 14g of bighead atractylodes rhizome, 16g of poria cocos, 16g of angelica sinensis, 12g of white paeony root, 14g of donkey-hide gelatin, 26g of morinda officinalis, 26g of cistanche, 28g of radix glehniae, 12g of cynanchum atratum bunge, 18g of cacumen biotae, 18g of hairyvein agrimonia herb and bud, 22g of leonurus, 16g of ligusticum wallichii, 24g of dandelion, 22g of notopterygium root, 22g of radix angelicae pubescentis, 26g of cassia twig, 22g of radix curcumae, 22g of uniflower swisscentaury root, 16g of rhizoma polygonati, 18g of rhizoma cyperi, 16g of fructus liquidambaris and 18g of honey-fried licorice root.

The preparation process was identical to example 1.

Examples of the experiments

(1) Subject: 333 patients were selected for inclusion in the study, which were delivered to the hospital (from the home health care facility, women, tribute city) for obstetrical delivery at 02-2021 and 10 months in 2020 and which met the following criteria and were divided into 2 groups according to the random numerical method:

control group: 166 cases, 20-35 years old, mean age (27.99 + -5.844) years old, 37-42 weeks gestational period after childbirth, and body weight 61.08 + -6.049 kg;

treatment groups: 167 cases, 20-35 years old, mean age (27.61 + -4.782) years old, 37-42 weeks gestational period after childbirth, weight 60.07 + -6.042 kg;

the comparison of the above data in 2 groups shows that the difference is not statistically significant (P >0.05), which indicates that the basic data of two groups of study objects are not obviously different and the two groups of samples are comparable.

(2) Inclusion criteria were: 1) the age is more than or equal to 20 years and less than or equal to 35 years; 2)37W is less than or equal to 42W of gestational week; 3) the estimated weight of the fetus is less than or equal to 2500 g and less than or equal to 5000 g; 4) single-birth pregnant women who are born in the same day or are undergoing caesarean section; 5) the drug indications in the study are met; 6) signing the informed consent.

Exclusion criteria: 1) those who do not meet the criteria for diagnosis of postpartum disease; 2) patients with serious diseases such as heart, liver, kidney and hematopoietic system; 3) complicated with serious infectious diseases such as active pulmonary tuberculosis and AIDS; 4) unwilling to collaborate; 5) the labor bleeding is more than or equal to 1500 mL; 6) pathological pregnancy, such as severe pelvic infection, hypertensive syndrome during pregnancy, gestational diabetes, intrahepatic cholestasis during pregnancy, inland placenta hominis, placenta implantation, DIC, severe blood coagulation disorder and other diseases which may seriously affect the blood coagulation function of the puerpera; 7) various psychogenic diseases diagnosed in the past; 8) those diagnosed with rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis, sjogren's syndrome, etc.; 9) those who are allergic or intolerant to traditional Chinese medicines; 10) those with communication impairment or poor compliance; 11) after hysterectomy.

(3) The application and observation method comprises the following steps:

control group: adopts a conventional treatment method, and comprises the following steps: newly formed granules; it is taken with hot water, 2 bags per time, 3 times per day.

Treatment groups: the capsule prepared in the embodiment 3 of the invention is taken orally with 2 doses, 1 bag per time and 3 times per day before meals.

(4) Standard of care

Clinical studies are respectively carried out on the control group and the treatment group from multiple angles such as traditional Chinese medicine syndrome integration, postpartum (1d, 3d) blood lochiorrhea amount, blood lochiorrhea duration, postpartum (3d, 42d) uterus (length, width and height) sum, uterine cavity hematocele, EPDS score, progesterone, estradiol, prolactin level and the like.

(5) Statistical treatment

The data obtained in the research are analyzed by adopting statistical software SPSS 22.0, the metering data conforming to normal distribution are expressed by means of average +/-standard deviation, the inter-group comparison adopts independent sample t test, and the intra-group comparison adopts paired sample t test; the counting data are expressed in percentage, and the comparison among groups is expressed in chi²The test shows that the test level alpha is 0.05, and P <0.05 shows that the difference is statistically significant.

(6) The experimental results are as follows:

(6.1) comparison of white blood cells, C-reactive protein and traditional Chinese medicine syndrome score

The comparison results of the white blood cells, the C-reactive protein and the traditional Chinese medicine syndrome score on the 1 st day after delivery are shown in the table 1.

TABLE 1 comparison of white blood cells, C-reactive protein, and Chinese medicine syndrome scores

As can be seen from Table 1: the leucocyte, C-reactive protein and traditional Chinese medicine syndrome score of two groups of postpartum 3 days have no obvious difference (P >0.05) through independent sample T test comparison, the leucocyte and C-reactive protein of two groups of postpartum 42 days have no obvious difference (P >0.05) through independent sample T test comparison, but the traditional Chinese medicine syndrome score of postpartum 42 days has extremely obvious difference (P < 0.001); and (4) conclusion: the leucocyte, the C reactive protein and the traditional Chinese medicine syndrome score of the treatment group and the control group on the 3 rd day are all obviously lower than the 1 st day, and the leucocyte, the C reactive protein and the traditional Chinese medicine syndrome score of the 42 th day are all obviously lower than the 3 rd day; therefore, the capsule provided by the invention has obvious long-term effect after 42 days of delivery.

(6.2) comparing the amount of postpartum lochia, the length of lochia and the three diameters of uterus (length, width and height), the results are shown in Table 2.

TABLE 2 postpartum lochia, length of lochia and ratio of uterus (length, width, height) to diameter

From the data in table 2 it can be seen that: the comparison of the lochia blood volume of the 1 st day after delivery has no obvious difference (P >0.05), the comparison of the lochia blood volume of the 3 rd day in the two groups has obvious difference, the treated group is obviously more than the control group (P <0.05), the comparison of the length of lochia time of the two groups has statistical significance, the treated group is shorter than the control group (P <0.05), the uterus diameter of the two groups on the 3 rd day after delivery and the independent sample T test indicate that the treated group is smaller than the control group, and the difference has statistical significance (P < 0.01). The uterus diameter and comparison of the two groups 42 days after delivery were not statistically significant (P > 0.05). And (4) conclusion: the capsule provided by the invention has obvious effects of promoting the discharge of postpartum lochia, shortening lochia duration and promoting the involution of uterus as soon as possible, and has obvious clinical value.

(6.3) comparing the postpartum pain of the body by using the integration of the traditional Chinese medicine syndromes, and the result is shown in a table 3.

TABLE 3 comparison of the integral of the traditional Chinese medicine syndromes of postpartum pain of the body

As can be seen from Table 3: the traditional Chinese medicine integration comparison of the 1 st day after delivery between the two groups adopts independent sample T test, the result has no statistical significance (p is more than 0.05), and the two groups are prompted to have no difference in body pain and illness state and have comparability. The traditional Chinese medicine syndrome integral comparison of two groups of postpartum days 3 adopts independent sample T test, which indicates that the obvious statistical significance (P is less than 0.01) is achieved, and the effect of the treatment group is better than that of the control group. The results of the T test on independent samples used for comparing the traditional Chinese medicine syndrome integrals of two groups of postpartum patients for 42 days have obvious statistical significance, (P is less than 0.01), and the treatment group with the long-term treatment effect is superior to the control group. And (4) conclusion: the traditional Chinese medicine syndrome integration of the treatment group and the control group on the 3 rd day is lower than that of the 1 st day, and the traditional Chinese medicine syndrome integration of the 42 th day is obviously lower than that of the 3 rd day, so that the postpartum body pain can be effectively relieved and treated, but the traditional Chinese medicine syndrome integration of the treatment group on the 42 th day is far lower than that of the control group, which shows that the capsule disclosed by the invention not only has the effect of relieving the recent postpartum body pain, but also has a more obvious long-term effect, is more obvious in relieving pain of the postpartum body pain, and has obvious clinical value.

(6.4) comparing the postpartum depression conditions, wherein the traditional Chinese medicine syndrome integral comparison and the Edinburgh depression scale are adopted between the two groups, and the comparison result is shown in a table 4.

TABLE 4 comparison of postpartum depression

As can be seen from the results in Table 4, the comparison of the traditional Chinese medicine score on day 1 after delivery and the score of the Edinburgh depression scale between the two groups were tested by independent sample T, and the results were not statistically significant (p >0.05), indicating that there was no difference in depression between the two groups and that the two groups were comparable. The comparison of the traditional Chinese medicine syndrome integrals at 42 th day after delivery of the two groups adopts independent sample T test, which indicates that the obvious statistical significance is achieved (P is less than 0.01), and the effect of the treatment group is better than that of the control group. The comparison of the Edinburgh depression scales of two groups after 42 days of delivery with the T test result of an independent sample has obvious statistical significance, (P is less than 0.01), and the treatment group for treating depression with long-term effect is also superior to the control group. And (4) conclusion: the traditional Chinese medicine syndrome score and the Edinburgh depression scale score of the treatment group and the control group on the 42 th day are lower than those on the 1 st day, which shows that the capsule of the invention has the effect of relieving depression. The traditional Chinese medicine syndrome score and the Edinburgh depression scale score of the treatment group are far lower than those of the control group 42 days after delivery, so that the following results are obtained: the capsule has quicker and more obvious effect on relieving depression and has obvious clinical value.

(6.5) comparing postpartum hypogalactia conditions, wherein the traditional Chinese medicine syndrome integral comparison and prolactin level comparison are adopted between the two groups, and the results are shown in a table 5.

TABLE 5 comparison of postpartum depression

As shown in the results in Table 5, the comparison of the traditional Chinese medicine integral and prolactin in the 1 st day after delivery between the two groups by adopting the independent sample T test has no statistical significance (p is more than 0.05), which indicates that the conditions of hypogalactia between the two groups are not different and the two groups have comparability. The comparison of the traditional Chinese medicine syndrome integrals at 42 th day after delivery of the two groups adopts independent sample T test, which indicates that the obvious statistical significance is achieved (P is less than 0.01), and the effect of the treatment group is better than that of the control group. Compared with the results of independent sample T test, the prolactin in two groups after 42 days of delivery have obvious statistical significance (P is less than 0.01), which indicates that the treatment group for treating the long-term hypogalactia effect is also superior to the control group. And (4) conclusion: the traditional Chinese medicine syndrome integration of the treatment group and the control group on the 42 th day is lower than that of the 1 st day, and the prolactin is higher than that of the 1 st day, which shows that the capsule has the effects of reducing the traditional Chinese medicine hypogalactia syndrome and improving the prolactin. The comparison shows that the capsule of the invention has more obvious effects on improving the traditional Chinese medicine symptoms with less milk and improving prolactin, has obvious clinical value and is worthy of clinical popularization.

Typical case data:

1. mingzhi, woman, hospitalization number: 3352 the patient produces a live baby by cesarean section after 40+5 weeks of abortion, has little lochia and lower abdomen pain on 2 nd day of postpartum, has good sleep, and is convenient for regulation. A dark red tongue with yellow and greasy coating and a wiry and thready pulse. Traditional Chinese medicine diagnosis: postpartum blood stasis, 2 doses are given according to the preparation and the using method thereof provided by the embodiment, 1 bag per time, 3 times per day, and the preparation is taken before meals. After continuous treatment for 4 days, the lochia of the patient is obviously reduced, the abdomen is not painful, the sleep is good, and the stool is normal.

2. Girl, hospitalization number: 3353A, pregnant woman is waiting for birth of LOA in uterus due to pregnancy of G1P036+5 weeks, fetal distress, pregnancy complicated with subclinical hypothyroidism, pregnancy complicated with mycotic vaginitis, pregnancy complicated with condyloma acuminatum of vulva, marginal umbilical cord placenta entrance, less milk in day 2 after delivery, lower abdomen pain, slight lochia, anorexia, anus exhausting, constipation, dark red tongue, yellow tongue fur, and wiry pulse. Traditional Chinese medicine diagnosis: postpartum blood stasis, 2 doses are given according to the preparation and the using method thereof provided by the embodiment, 1 bag per time, 3 times per day, and the preparation is taken before meals. The treatment is continued for 4 days, the patient has full breast, good breast milk amount, good uterine contraction, no pain in abdomen, and little lochiorrhea. Sleep well, stool is normal.

3. Plum allergy, female, hospitalization number: 3352A patient can stop menstruation for 38+1 week, with abdominal pain 4+ hour, and can produce a live baby, and on day 2 of childbirth, the baby has less milk, slight pain in lower abdomen, slight lochiorrhea, anorexia, undigested stool, dark red tongue, white and thick tongue coating, and soft and rapid pulse. Dialectical traditional Chinese medicine: postpartum stagnation, spleen deficiency and dampness stagnation. The preparation and the using method thereof provided by the embodiment are taken 2 times, 1 bag per time and 3 times per day before meals. After continuous treatment for 3 days, the lochia of the patient is obviously reduced, the abdomen is not painful, the sleep is good, and the stool is normal. The spirit and the appetite are good.

4. Ran something lotus, woman, hospital number: 3282A living baby is born in good order because of the 'amenorrhea 39+5 weeks, abdominal pain 1-day', puerperal has less milk, clear and mild spirit, lower abdomen pain, waist soreness and swelling pain, poor appetite, poor sleep, dull-red tongue, white fur, and wiry pulse on the 2 nd day of postpartum. Dialectical traditional Chinese medicine: postpartum stasis. According to the preparation and the using method thereof provided by the embodiment, the traditional Chinese medicine postpartum ointment formula 2 for promoting blood circulation, removing blood stasis and relieving pain is taken orally, one bag is taken every time, 3 times a day, and the traditional Chinese medicine postpartum ointment formula is taken before meals. After continuous treatment for 4 days, the lumbago of the patient disappears, the breast is sufficient, the abdomen is not painful, and the sleep is good.

5. Macbanqi, female, hospital admission: 3280 the infant is born by caesarean section and has less milk, little language, clear mind and apathy in puerperal 2 days after birth due to the 'amenorrhea 39+1 week, abdominal pain 10+ hour'. Slight pain in the lower abdomen, little lochiorrhea, poor appetite, poor sleep, dull red tongue with white coating, and wiry pulse. Dialectical traditional Chinese medicine: postpartum depression syndrome. According to the preparation and the using method thereof provided by the embodiment, 2 doses are given, and the preparation is orally taken one bag at a time for 3 times per day; the continuous treatment for 4 days has stable mood, full breast, good milk amount, good uterine contraction, no pain in abdomen, and little lochia. Sleep well, stool and urine are normal.

6. Plum, woman, hospitalization number: 3287 the patient can stop menstruation for 39+2 weeks and then flow water into vagina for 1 hr to produce a live baby, and the patient has little lochia at 2 days after delivery, and has good sleep quality and convenient regulation. A dark red tongue with thin and yellow coating and a wiry pulse. Traditional Chinese medicine diagnosis: postpartum blood stasis. The preparation and the using method thereof provided by the embodiment are taken 2 times, 1 bag per time and 3 times per day before meals. The continuous treatment for 3 days has the advantages of double breast distension, sufficient breast amount, obvious reduction of lochia, no pain in the abdomen, good sleep and normal defecation of patients.

Claims

1. A traditional Chinese medicine composition for treating postpartum diseases is characterized in that, according to parts by weight, is prepared from 20-40 parts of radix codonopsitis, 20-40 parts of raw astragalus root, 10-30 parts of atractylodes macrocephala, 10-30 parts of poria cocos, 10-30 parts of angelica, 10-30 parts of white peony root, 10-30 parts of donkey-hide gelatin, 10-30 parts of morinda officinalis, 10-30 parts of cistanche deserticola, 10-30 parts of radix glehniae, 10-30 parts of cynanchum atratum bunge, 10-30 parts of cacumen biotae, 10-30 parts of agrimony, 10-30 parts of motherwort, 10-30 parts of ligusticum wallichii, 10-30 parts of dandelion, 10-30 parts of notopterygium root, 10-30 parts of radix angelicae pubescentis, 10-30 parts of cassia twig, 10-30 parts of radix curcumae, 10-30 parts of uniflower swisscentaury root, 10-30 parts of rhizoma polygonati, 5-25 parts of rhizoma cyperi, 5-20 parts of fructus liquidambaris and 10-20 parts of honey-fried licorice root.

2. The traditional Chinese medicine composition for treating postpartum disease as claimed in claim 1, which is prepared from, by weight, 20-35 parts of codonopsis pilosula, 20-35 parts of raw astragalus membranaceus, 10-25 parts of bighead atractylodes rhizome, 10-25 parts of poria cocos, 10-25 parts of angelica sinensis, 10-25 parts of radix paeoniae alba, 10-25 parts of donkey-hide gelatin, 10-25 parts of morinda officinalis, 10-25 parts of cistanche, 10-25 parts of radix glehniae, 10-25 parts of cynanchum atratum bunge, 10-25 parts of cacumen biotae, 10-25 parts of agrimony, 10-25 parts of leonurus, 10-25 parts of ligusticum wallichii, 10-25 parts of dandelion, 10-25 parts of notopterygium root, 10-25 parts of radix angelicae pubescentis, 10-25 parts of cassia twig, 10-25 parts of radix curcumae, 10-25 parts of uniflower swisscentaury root, 10-25 parts of rhizoma polygonati, 5-20 parts of rhizoma cyperi, 5-15 parts of fructus liquidambaris, 15-20 parts of honey-fried licorice root.

3. The traditional Chinese medicine composition for treating postpartum disease according to claim 1, which is characterized by comprising, by weight, 30 parts of codonopsis pilosula, 30 parts of raw astragalus membranaceus, 20 parts of bighead atractylodes rhizome, 20 parts of poria cocos, 20 parts of angelica sinensis, 20 parts of radix paeoniae alba, 20 parts of donkey-hide gelatin, 20 parts of morinda officinalis, 20 parts of cistanche, 20 parts of radix glehniae, 20 parts of cynanchum atratum bunge, 20 parts of cacumen biotae, 20 parts of agrimonia pilosa, 20 parts of motherwort, 20 parts of ligusticum wallichii, 20 parts of dandelion, 20 parts of notopterygium root, 20 parts of radix angelicae pubescentis, 20 parts of cassia twig, 20 parts of radix curcumae, 20 parts of uniflower swisscentaury root, 20 parts of rhizoma polygonati, 15 parts of rhizoma cyperi, 10 parts of fructus liquidambaris and 10 parts of honey-fried licorice root.

4. The traditional Chinese medicine composition for treating postpartum disease according to claim 1, which is characterized by comprising, by weight, 25 parts of codonopsis pilosula, 20 parts of raw astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 15 parts of angelica sinensis, 15 parts of radix paeoniae alba, 20 parts of donkey-hide gelatin, 15 parts of morinda officinalis, 15 parts of cistanche, 15 parts of radix glehniae, 20 parts of cynanchum atratum bunge, 10 parts of cacumen biotae, 10 parts of agrimonia pilosa, 15 parts of motherwort, 15 parts of ligusticum wallichii, 10 parts of dandelion, 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 10 parts of cassia twig, 10 parts of radix curcumae, 15 parts of uniflower swisscentaury root, 15 parts of rhizoma polygonati, 10 parts of rhizoma cyperi, 10 parts of fructus liquidambaris and 15 parts of honey-fried licorice root.

5. Use of the Chinese medicinal composition of any one of claims 1-4 in the preparation of a medicament for treating postpartum uterine involution, postpartum abdominal pain, postpartum general pain, lochiorrhea, postpartum hypogalactia, postpartum depression, and postpartum constipation.

6. A traditional Chinese medicine preparation for treating postpartum diseases is characterized by comprising the traditional Chinese medicine composition of any one of claims 1-4, and the preparation is in a form of any one of granules, capsules, paste, tablets, decoction, powder or pills.

7. The traditional Chinese medicine preparation for treating postpartum disease as claimed in claim 6, wherein the preparation is in the form of capsule.

8. The preparation method of the traditional Chinese medicine preparation for treating postpartum disease according to claim 7, which is characterized by comprising the following steps:

(2) soaking the rest components in water for 10-30 min; decocting, filtering, and concentrating to obtain extract with relative density of 1.25-1.35;

9. The method for preparing a Chinese medicinal preparation for treating postpartum disease as claimed in claim 8, wherein the decoction in step (2) is carried out by boiling with strong fire for 10-20 minutes, decocting with slow fire for 20 minutes, filtering, and naturally cooling to 55-60 ℃.

10. The method for preparing a Chinese medicinal preparation for treating postpartum disease as claimed in claim 8, wherein the fluidized drying in step (3) is performed by gradient drying: firstly heating at 110-130 ℃ for 30-50 minutes, then heating at 60-100 ℃ for 20-40 minutes, and finally heating at 15-30 ℃ for 10-30 minutes.