CN113827534A - Yandangshan calamus root extracting solution and application thereof in cosmetics - Google Patents
Yandangshan calamus root extracting solution and application thereof in cosmetics Download PDFInfo
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- 235000011996 Calamus deerratus Nutrition 0.000 title claims abstract description 92
- 239000002537 cosmetic Substances 0.000 title claims abstract description 24
- 240000008167 Calamus deerratus Species 0.000 title 1
- 244000205574 Acorus calamus Species 0.000 claims abstract description 112
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 40
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 230000001815 facial effect Effects 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000001014 amino acid Nutrition 0.000 claims abstract description 25
- 150000001413 amino acids Chemical class 0.000 claims abstract description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 20
- RKFAZBXYICVSKP-UHFFFAOYSA-N beta- asarone Natural products COC1=CC(OC)=C(C=CC)C=C1OC RKFAZBXYICVSKP-UHFFFAOYSA-N 0.000 claims abstract description 17
- RKFAZBXYICVSKP-WAYWQWQTSA-N beta-asarone Chemical compound COC1=CC(OC)=C(\C=C/C)C=C1OC RKFAZBXYICVSKP-WAYWQWQTSA-N 0.000 claims abstract description 17
- NNWHUJCUHAELCL-UHFFFAOYSA-N cis-Methyl isoeugenol Natural products COC1=CC=C(C=CC)C=C1OC NNWHUJCUHAELCL-UHFFFAOYSA-N 0.000 claims abstract description 17
- NNWHUJCUHAELCL-PLNGDYQASA-N cis-isomethyleugenol Chemical compound COC1=CC=C(\C=C/C)C=C1OC NNWHUJCUHAELCL-PLNGDYQASA-N 0.000 claims abstract description 17
- 150000002576 ketones Chemical class 0.000 claims abstract description 17
- 229940116837 methyleugenol Drugs 0.000 claims abstract description 17
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000012907 honey Nutrition 0.000 claims abstract description 15
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 7
- 239000004220 glutamic acid Substances 0.000 claims abstract description 7
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 101150101199 CHSB gene Proteins 0.000 claims abstract description 4
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
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- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 52
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 244000024893 Amaranthus tricolor Species 0.000 claims description 4
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- 238000002360 preparation method Methods 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 claims description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 24
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 15
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 13
- 206010000496 acne Diseases 0.000 abstract description 13
- 230000000770 proinflammatory effect Effects 0.000 abstract description 11
- 230000002401 inhibitory effect Effects 0.000 abstract description 9
- 206010061218 Inflammation Diseases 0.000 abstract description 6
- 230000004054 inflammatory process Effects 0.000 abstract description 6
- 241000186427 Cutibacterium acnes Species 0.000 abstract description 5
- 229940055019 propionibacterium acne Drugs 0.000 abstract description 5
- 241000228245 Aspergillus niger Species 0.000 abstract description 4
- 230000001154 acute effect Effects 0.000 abstract description 4
- 230000003255 anti-acne Effects 0.000 abstract description 4
- 230000001684 chronic effect Effects 0.000 abstract description 4
- JDRSMPFHFNXQRB-IBEHDNSVSA-N decyl glucoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JDRSMPFHFNXQRB-IBEHDNSVSA-N 0.000 abstract description 3
- 241000235342 Saccharomycetes Species 0.000 abstract description 2
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
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- NIDRYBLTWYFCFV-UHFFFAOYSA-N (-)-calanolide b Chemical compound C1=CC(C)(C)OC2=C1C(OC(C)C(C)C1O)=C1C1=C2C(CCC)=CC(=O)O1 NIDRYBLTWYFCFV-UHFFFAOYSA-N 0.000 description 1
- AGUISGUERLMHFF-PKIAMQTDSA-N (1s,4r,5s,8r)-1,8-dimethyl-4-propan-2-ylspiro[4.5]decane-3,9-dione Chemical compound CC(C)[C@H]1C(=O)C[C@H](C)[C@]11CC(=O)[C@H](C)CC1 AGUISGUERLMHFF-PKIAMQTDSA-N 0.000 description 1
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 description 1
- LAEJTNRXQGCKMM-UHFFFAOYSA-N Acorone Natural products CC(C)C1CC(=O)C(C)C12CCC(C)C(=O)C2 LAEJTNRXQGCKMM-UHFFFAOYSA-N 0.000 description 1
- 241000134916 Amanita Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
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- 230000015572 biosynthetic process Effects 0.000 description 1
- 229930184135 calanolide Natural products 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
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- 238000005485 electric heating Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- AGUISGUERLMHFF-UHFFFAOYSA-N epiacorone Natural products CC(C)C1C(=O)CC(C)C11CC(=O)C(C)CC1 AGUISGUERLMHFF-UHFFFAOYSA-N 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
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- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an extractive solution of Yandangshan calamus root and its application in cosmetics, the components of the extractive solution include alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus watery glycol and calamus ketone, the cosmetics are amino acidsThe amino acid facial cleansing honey consists of the following raw materials: phase A: 20-23% of water, 0.03-0.1% of EDTA disodium, 3-5% of glycerol, 0.3-0.8% of glyceryl polyether-26 and 0.1-0.3% of xanthan gum; phase B: cocoyl glutamic acid TEA salt-20-30%, CK 30-4-6%, RunmindTM10-18% of COP, 1-3% of polyglycerol-10, 7-9% of CHSB, 1-3% of PLANTACARE2000 UP; the invention has obvious anti-inflammatory activity and acne-removing effect, can inhibit the production of proinflammatory factors, has anti-inflammatory effect on acute, chronic and some immune inflammation models, has strong bacteriostatic effect on saccharomycetes and propionibacterium acnes, has obvious inhibitory effect on microsporomycetes, aspergillus niger and white rhodobacter chrous, and is suitable for being applied to facial cleansing products.
Description
Technical Field
The invention relates to the technical field of daily necessities, in particular to an Yandangshan calamus root extracting solution and application thereof in cosmetics.
Background
The formation of acnes is mainly related to factors such as heredity, endocrine, facial cleanness and sanitation and the like, which easily cause sebum metabolic disturbance, and skin grease secretion is excessively vigorous, so that a large number of microorganisms are bred and gathered, and further inflammation is caused, and acne and acnes are caused;
along with the development of the society and the improvement of the quality of life of people, the requirements of people on the use feeling and the efficacy of the facial cleanser are gradually improved, at present, various types of facial cleansers such as soap-based facial cleanser, amino acid facial cleanser, foam facial cleanser, facial cleansing gel and the like exist in the market, the facial cleanser has various efficacies of moisturizing, deoiling, moistening, acne resistance and the like, and the amino acid facial cleanser is milder and safer than the soap-based facial cleanser;
however, the traditional amino acid facial cleanser has the phenomenon of poor anti-inflammatory activity and anti-acne effect, cannot inhibit the production of proinflammatory factors, and does not have anti-inflammatory effect on acute, chronic and some immune inflammation models; meanwhile, the composition cannot effectively inhibit yeast, propionibacterium acnes, bacilli, microsporomycetes, aspergillus niger and white pearly fungi, and is not suitable for being applied to facial cleansing products.
Disclosure of Invention
The invention aims to provide an Amanita tricolor root extracting solution and application thereof in cosmetics, which solve the problems that the traditional amino acid facial cleanser has poor anti-inflammatory activity and anti-acne effect, can not inhibit the generation of proinflammatory factors, and has no anti-inflammatory effect on acute, chronic and some immune inflammation models; meanwhile, the composition cannot effectively inhibit yeast, propionibacterium acnes, bacilli, microsporomycetes, aspergillus niger and white pearly fungi, and is not suitable for being applied to facial cleansing products.
The purpose of the invention can be realized by the following technical scheme:
an extractive solution of Amaranthus tricolor root comprises alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, Acorus calamus dilol and Acorus calamus ketone;
the application of Yandangshan calamus root extracting solution in cosmetics is amino acid facial cleansing honey which is composed of the following raw materials:
phase A: 20-23% of water, 0.03-0.1% of EDTA disodium, 3-5% of glycerol, 0.3-0.8% of glyceryl polyether-26 and 0.1-0.3% of xanthan gum;
phase B: cocoyl glutamic acid TEA salt-20-30%, CK 30-4-6%, RunmindTM10-18% of COP, 1-3% of polyglycerol-10, 7-9% of CHSB and 1-3% of PLANTACARE2000 UP;
and C phase: cetiol HE-0.1-0.3%, RunqatTM SMC18——0.4～0.6％；
Phase D: 1-3% of carbopol aqua SF-1 and 5-7% of water;
phase E: 0.5 to 0.7 percent of sodium hydroxide aqueous solution;
and (3) phase F: 0.3-0.6% of p-hydroxyacetophenone, 0.3-0.6% of hexanediol and 2-4% of butanediol;
phase G: 7-9% of calamus root extracting solution;
preferably, the sum of the mass fractions of the components of the A phase, the B phase, the C phase, the D phase, the E phase, the F phase and the G phase is 100%.
Preferably, the cocoyl glutamic acid TEA has a salt active content of 30%.
Preferably, the mass fraction of the sodium hydroxide aqueous solution is 10%.
Preferably, the specific preparation steps of the cosmetic are as follows:
the method comprises the following steps: mixing the F phase, heating to 55-60 ℃ for dissolving, and cooling for later use;
step two: adding water into a main pot, pre-dispersing the powder in the phase A by using glycerol, pouring the pre-dispersed powder into the water, heating to 80-85 ℃, stirring until the pre-dispersed powder is completely dissolved and transparent, performing weak homogenization and uniform dispersion for multiple times, sequentially adding other components, and stirring until the pre-dispersed powder is completely dissolved;
step three: sequentially adding the components of the phase B, stirring until the components are completely dissolved, preserving heat for 15-20 minutes after the components are dissolved, defoaming, and beginning to cool;
step four: sequentially adding the C-phase components when the temperature is reduced to 55-60 ℃, and uniformly stirring;
step five: pre-dispersing the phase D, adding the pre-dispersed phase D into a main pot, stirring the pre-dispersed phase D and the main pot until the pre-dispersed phase D and the main pot are completely and uniformly stirred, and adding the pre-dispersed phase D into the phase E for neutralization for 10 to 15 minutes;
step six: when the temperature is reduced to 40-45 ℃, adding the prepared F phase and G phase, and uniformly stirring;
step seven: cooling to room temperature, detecting and discharging to obtain the cosmetic amino acid facial cleansing honey.
The invention has the beneficial effects that:
the calamus root extracting solution provided by the invention is derived from an aromatic medicinal plant with a long medicinal history, mainly contains alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus glycol, calamus ketone and the like, has obvious anti-inflammatory activity and acne-removing effect, can inhibit the generation of proinflammatory factors, and has anti-inflammatory effect on acute, chronic and some immune inflammation models; has strong bacteriostatic effect on saccharomycetes and propionibacterium acnes; meanwhile, the facial cleanser has obvious inhibition effect on microsporomycetes, aspergillus niger and white pearly fungi, and is suitable for being applied to facial cleansing products.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
An extractive solution of Amaranthus tricolor root comprises alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, Acorus calamus dilol and Acorus calamus ketone;
the application of Yandangshan calamus root extracting solution in cosmetics is amino acid facial cleansing honey which is composed of the following raw materials:
phase A: 20-23% of water, 0.03-0.1% of EDTA disodium, 3-5% of glycerol, 0.3-0.8% of glyceryl polyether-26 and 0.1-0.3% of xanthan gum;
phase B: cocoyl glutamic acid TEA salt-20-30%, CK 30-4-6%, RunmindTM10-18% of COP, 1-3% of polyglycerol-10, 7-9% of CHSB and 1-3% of PLANTACARE2000 UP;
and C phase: cetiol HE-0.1-0.3%, RunqatTM SMC18——0.4～0.6％；
Phase D: 1-3% of carbopol aqua SF-1 and 5-7% of water;
phase E: 0.5 to 0.7 percent of sodium hydroxide aqueous solution;
and (3) phase F: 0.3-0.6% of p-hydroxyacetophenone, 0.3-0.6% of hexanediol and 2-4% of butanediol;
phase G: 7-9% of calamus root extracting solution.
The sum of the mass fractions of the components of the phase A, the phase B, the phase C, the phase D, the phase E, the phase F and the phase G is 100 percent.
The cocoyl glutamic acid TEA salt active content was 30%.
The mass fraction of the sodium hydroxide aqueous solution was 10%.
The preparation method of the cosmetic comprises the following steps:
the method comprises the following steps: mixing the F phase, heating to 55-60 ℃ for dissolving, and cooling for later use;
step two: adding water into a main pot, pre-dispersing the powder in the phase A by using glycerol, pouring the pre-dispersed powder into the water, heating to 80-85 ℃, stirring until the pre-dispersed powder is completely dissolved and transparent, performing weak homogenization and uniform dispersion for multiple times, sequentially adding other components, and stirring until the pre-dispersed powder is completely dissolved;
step three: sequentially adding the components of the phase B, stirring until the components are completely dissolved, preserving heat for 15-20 minutes after the components are dissolved, defoaming, and beginning to cool;
step four: sequentially adding the C-phase components when the temperature is reduced to 55-60 ℃, and uniformly stirring;
step five: pre-dispersing the phase D, adding the pre-dispersed phase D into a main pot, stirring the pre-dispersed phase D and the main pot until the pre-dispersed phase D and the main pot are completely and uniformly stirred, and adding the pre-dispersed phase D into the phase E for neutralization for 10 to 15 minutes;
step six: when the temperature is reduced to 40-45 ℃, adding the prepared F phase and G phase, and uniformly stirring;
step seven: cooling to room temperature, detecting and discharging to obtain the cosmetic amino acid facial cleansing honey.
The formula of the amino acid face-cleansing honey cosmetic is shown in table 1:
TABLE 1 formulation ratio of amino acid face-cleaning honey cosmetics
Example two
The physical and chemical indexes, efficacy and safety of the Yandangshan calamus root extract and the cosmetic containing the same (application example one) are tested as follows:
first, physicochemical index test
Sensory testing: visually observing the properties of the product to see whether the product is abnormal or not;
and (3) heat resistance test: putting the sample into an electric heating constant temperature incubator at the temperature of (40 +/-1) DEG C for 24 hours, and observing whether phenomena such as thinning, discoloration, layering, hardness change and the like exist after the temperature is recovered to judge the heat resistance of the sample;
cold resistance: putting the sample into a refrigerator at (-5-10) + -1 ℃ for 24 hours, and observing whether phenomena such as thinning, color change, layering, hardness change and the like exist after the room temperature is recovered to judge the cold resistance of the sample;
and (3) centrifugal test: and (3) placing the sample in a centrifuge, testing for 30min at the rotating speed of 2000-4000 r/min, and observing the separation and delamination conditions of the sample.
The results are shown in Table 2, and the Yandangshan Acorus calamus root extract and the cosmetic containing the same (application example one) are stable.
TABLE 2 Yandangshan Acorus calamus root extract and application example 1 physicochemical index test results
| Item | Yandangshan calamus root extract | Application embodiment 1 |
| Sensory index | No abnormality | No abnormality |
| Thermal stability | Stabilization | Stabilization |
| Stability to freezing | Stabilization | Stabilization |
| Centrifugal stability | Stabilization | Stabilization |
Second, efficacy test
1. Anti-inflammatory Activity assay
(1) Anti-inflammatory activity test of calamus root extract
In order to verify the anti-inflammatory activity of the calamus root extracting solution, the expression inhibition activity of proinflammatory cytokines (TNF-alpha and IL-6) is adopted, and the specific experimental steps are as follows:
RAW264.7 cells were inoculated in a 24-well plate at 1.8 × 105 cells/mL for 18 hours in DMEM medium supplemented with 10% fetal bovine serum, the medium was removed, 50 μ L of a sample prepared at 10-fold concentration (1mg/mL) and 450 μ L of a medium containing 1 μ g/mL LPS were treated, after 24 hours and 24 hours of culture, the medium was centrifuged (12000rpm for 3 minutes), the proinflammatory cytokine production content of the obtained supernatant was measured, all samples were subjected to cryopreservation (-20 ℃) until quantification, and the proinflammatory cytokine was quantified by mouse enzyme-linked immunosorbent assay (ELISA) kit, and the r2 value of the standard curve of the standard was 0.99 or more.
Comparative example 1: the difference from the calamus root extract is that comparative example 1 contains alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, calamus glycol, does not contain acolone (equal amount of acolone is replaced by water), and other components are the same as the calamus root extract.
Comparative example 2: the difference from the calamus root extract is that comparative example 2 contains alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, and calanolide, does not contain calanolic glycol (water is used to replace equivalent amount of calanolic glycol), and other components are the same as the calamus root extract.
Preparing 1%, 3% and 5% calamus root extract and the aqueous solutions of comparative example 1 and comparative example 2 according to the mass ratio, respectively, and testing the anti-inflammatory activity of the samples with different concentrations according to the above steps, wherein the results are as follows:
1) TNF-alpha expression inhibitory Activity
The inhibitory activity of pro-inflammatory cytokines (pro-inflammatory cytokines) TNF- α produced during the inflammatory reaction was measured, and the results are shown in table 3, whereby it was confirmed that the anti-inflammatory activity of the extract solution of Acorus calamus root was higher as the concentration was increased (1%, 3%, 5%); compared with the anti-inflammatory activity of the comparative examples 1 and 2, the calamus root extracting solution with the same concentration has obvious anti-inflammatory activity, which shows that the calamus root extracting solution compounded by alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus glycol and calamus ketone has the anti-inflammatory effect.
TABLE 3 measurement results of antiinflammatory Activity of Acorus calamus root extract and comparative example 1
2) IL-6 expression inhibitory Activity
The result of measuring the IL-6 expression inhibition activity is shown in Table 4, the calamus root extract has obvious influence on the expression of one IL-6 in pro-inflammatory cytokines (pro-inflammatory cytokines).
TABLE 4 determination results of antiinflammatory Activity of Acorus calamus root extract and comparative example 2
(2) Application formula anti-inflammatory activity test of calamus root extracting solution
The amino acid facial cleansing honey of the application example I is used as an experimental group, and a blank group, a comparison group 1 and a comparison group 2 are added.
The blank group is an amino acid face-cleaning honey formula without adding calamus root extract.
Comparative group 1: the difference from the experimental group is that the added rhizoma Acori Calami extractive solution is different, the added rhizoma Acori Calami extractive solution of comparative group 1 does not contain Acorus calamus ketone (water is used to replace the same amount of Acorus calamus ketone), and other components are the same as those in the application example.
Comparative group 2: the difference from the experimental group is that the added calamus root extract is different, the comparative group 1 added calamus root extract does not contain calamus dilute glycol (water is used to replace the same amount of calamus dilute glycol), and other components are the same as the application examples.
The formulation process of the blank group, comparative group 1 and comparative group 2 was the same as that of the experimental group, the anti-inflammatory activity test was conducted according to the above procedure, and the results of the TNF-. alpha.expression inhibitory activity and IL-6 expression inhibitory activity are shown in Table 5.
TABLE 5 anti-inflammatory activity test results of application formula of rhizoma Acori Calami extract
According to the anti-inflammatory activity test results of the application formula of the calamus root extracting solution in the table 5, the amino acid facial cleanser prepared by adding the calamus root extracting solution has much higher anti-inflammatory activity than the amino acid facial cleanser without adding the calamus root extracting solution, and the calamus root extracting solution compounded by alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus glycol and calamus ketone has the anti-inflammatory effect.
2. Bacteriostasis test
(1) Bacteriostatic test of calamus root extract
In order to verify the bacteriostatic effect of the calamus root extracting solution, according to GB15979-2002 (hygienic Standard for Disposable sanitary articles) appendix C4 'test method for bacteriostatic performance of dissolution type anti (bacteriostatic) bacteria product', the method comprises the following steps:
a. test samples: rhizoma Acori Calami extractive solution.
b. Preparation of bacterial suspension: and (3) washing a 24-hour culture of the propionibacterium acnes by using 0.03mol/L phosphate buffer solution to prepare 104-106 CFU/mL bacterial suspension.
c. Respectively taking 1g of test sample, adding 0.1mL of the bacterial suspension, uniformly coating and mixing, starting timing, adding 9mL0.03mol/L of phosphate buffer solution after 20min, fully and uniformly mixing, properly diluting, taking 3 dilutions, respectively taking 1mL of the dilutions, placing in two parallel dishes, adding corresponding culture medium, culturing for 24h under the anaerobic condition of (36 +/-1) DEG C, counting colonies, repeating the above tests for 3 times, taking an average value, and setting a blank control group.
The calculation formula of the bacteriostatic rate is as follows: and X is (A-B)/A X100%, wherein X is the bacteriostasis rate, A is the average recovered colony of the control sample, and B is the average recovered colony of the test sample.
The evaluation criteria for efficacy were: (1) the bacteriostatic rate is more than or equal to 90 percent; (2) the bacteriostasis rate is 50-90% effective; (3) the bacteriostasis rate is less than 50 percent, which is ineffective.
The blank group was distilled water.
Comparative example 1: the difference from the calamus root extract is that comparative example 1 contains alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, calamus glycol, does not contain acolone (equal amount of acolone is replaced by water), and other components are the same as the calamus root extract.
Comparative example 2: the difference from the calamus root extract is that comparative example 1 contains alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, and acorone, does not contain calamus glycol (the same amount of calamus glycol is replaced by water), and other components are the same as the calamus root extract.
1 percent, 3 percent and 5 percent of calamus root extract, and the aqueous solutions of the comparative example 1(1 percent) and the comparative example 2(1 percent) are respectively prepared according to the mass ratio, and the bacteriostatic effect of samples with different concentrations is tested according to the bacteriostatic test steps, and the results are shown in table 6.
TABLE 6 bacteriostatic test results of Acorus calamus root extractive solution and comparative example
The results in table 6 show that the calamus root extract has better bacteriostatic effect with the increase of the concentration (1%, 3%, 5%); compared with the bacteriostatic effects of the comparative examples 1 and 2, the calamus root extracting solution with the same concentration has a remarkable bacteriostatic effect, and the effect of effectively inhibiting bacteria is shown by the calamus root extracting solution compounded by alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus glycol and calamus ketone.
(2) Application formula bacteriostasis test of calamus root extracting solution
The amino acid facial cleansing honey of example 1 was used as an experimental group, and a blank group, a comparative group 1 and a comparative group 2 were added.
The blank group is an amino acid face-cleaning honey formula without adding calamus root extract.
Comparative group 1: the difference from the experimental group is that the added extract of Acorus calamus root is different, the extract of Acorus calamus root added in the comparative group 1 does not contain Acorus calamus ketone (the same amount of Acorus calamus ketone is replaced by water), and other components are the same as those in the application example 1.
Comparative group 2: the difference from the experimental group is that the added Acorus calamus root extract solution is different, the added Acorus calamus root extract solution of the comparative group 1 does not contain Acorus calamus dilol (water is used to replace the same amount of Acorus calamus dilol), and other components are the same as the application example 1.
The formulation process of the blank group, the comparison group 1 and the comparison group 2 is the same as that of the experimental group, the bacteriostasis test is carried out according to the bacteriostasis test steps, and the results are shown in table 7.
TABLE 7 bacteriostatic test results of application formula of rhizoma Acori Calami root extractive solution
According to the bacteriostatic test results of the application formula of the calamus root extracting solution shown in table 7, the amino acid facial cleanser prepared by adding the calamus root extracting solution has a better bacteriostatic effect than the amino acid facial cleanser without adding the calamus root extracting solution, and the calamus root extracting solution compounded by alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus glycol and calamus ketone has the bacteriostatic effect.
3. Acne removal test
(1) Oil secretion inhibition test of calamus root extract
Test samples: calamus root extract, blank, comparative example 1, comparative example 2.
The blank group was distilled water.
Comparative example 1: the difference from the calamus root extract is that comparative example 1 contains alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, calamus glycol, does not contain acolone (equal amount of acolone is replaced by water), and other components are the same as the calamus root extract.
Comparative example 2: the difference from the calamus root extract is that comparative example 1 contains alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol and caladone, does not contain calamus glycol (the same amount of calamus glycol is replaced by water), and other components are the same as the calamus root extract.
The aqueous solutions of 1%, 3% and 5% calamus root extract and comparative examples 1 and 2 were prepared according to the mass ratio, and the acne removing effect was tested according to the following test methods.
The test method comprises the following steps: selecting 60 oily or mixed skin subjects (age 20-35 years), randomly dividing into 6 groups (10 in each group), and respectively smearing different test samples (rhizoma Acori Calami extractive solution, blank group, comparative example 1, and comparative example 2) on each group. The test samples were administered to the subjects once a day, morning and evening, for 28 consecutive days. Before and 28 days after the use, the oil content of the skin surface of the forehead part is respectively detected by an oil measuring instrument for 3 times, the average value is taken, the reduction of the oil content of the skin surface is calculated, and the test evaluation result is shown in table 8.
TABLE 8 test results of the inhibition of lipid secretion by the extract of Acorus calamus root
From the results in table 8, it can be seen that as the concentration of the calamus root extract increases (1%, 3%, 5%), the reduction of skin oil secretion increases and the acne removing effect is better; compared with the acne removing effects of the comparative examples 1 and 2, the rhizoma acori graminei extracting solution with the same concentration has an obvious acne removing effect, and the effect of removing acnes is shown by the rhizoma acori graminei extracting solution compounded by alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, calamus glycol and calamus ketone.
(2) Application formula of calamus root extracting solution for inhibiting oil secretion test
Taking the amino acid facial cleansing honey of example 1 as an experimental group, and adding a blank group, a comparison group 1 and a comparison group 2;
the blank group is an amino acid face-cleaning honey formula without adding calamus root extract.
Comparative group 1: the difference from the experimental group is that the added extract of Acorus calamus root is different, the extract of Acorus calamus root added in the comparative group 1 does not contain Acorus calamus ketone (the same amount of Acorus calamus ketone is replaced by water), and other components are the same as those in the application example 1.
Comparative group 2: the difference from the experimental group is that the added Acorus calamus root extract solution is different, the added Acorus calamus root extract solution of the comparative group 1 does not contain Acorus calamus dilol (water is used to replace the same amount of Acorus calamus dilol), and other components are the same as the application example 1.
The formula process of the blank group, the comparison group 1 and the comparison group 2 is the same as that of the experimental group, the acne removing test is carried out according to the test method, and the result is shown in a table 9.
Table 9 application formula of calamus root extract for inhibiting oil secretion test result
According to the acne removing test result of the application formula of the calamus root extracting solution in the table 9, the amino acid facial cleanser prepared by adding the calamus root extracting solution has a better acne removing effect than the amino acid facial cleanser without adding the calamus root extracting solution, and the calamus root extracting solution compounded by alpha-, beta-asarone, cis-methyl iso-eugenol, methyl eugenol, calamus glycol and calamus ketone has the acne removing effect.
The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.
Claims (6)
1. The Yandangshan calamus root extracting solution is characterized in that: the extract comprises alpha-, beta-asarone, cis-methyl isoeugenol, methyl eugenol, calamus glycol and calamus ketone.
2. The use of the extractive solution of Amaranthus tricolor root according to claim 1 in cosmetics, wherein the extractive solution is prepared by the following steps: the cosmetic is amino acid facial cleansing honey which is prepared from the following raw materials:
phase A: 20-23% of water, 0.03-0.1% of EDTA disodium, 3-5% of glycerol, 0.3-0.8% of glyceryl polyether-26 and 0.1-0.3% of xanthan gum;
phase B: cocoyl glutamic acid TEA salt-20-30%, CK 30-4-6%, RunmindTM10-18% of COP, 1-3% of polyglycerol-10, 7-9% of CHSB, PLANTACARE2000UP——1～3％；
And C phase: cetiol HE-0.1-0.3%, RunqatTM SMC18——0.4～0.6％；
Phase D: 1-3% of carbopol aqua SF-1 and 5-7% of water;
phase E: 0.5 to 0.7 percent of sodium hydroxide aqueous solution;
and (3) phase F: 0.3-0.6% of p-hydroxyacetophenone, 0.3-0.6% of hexanediol and 2-4% of butanediol;
phase G: 7-9% of calamus root extracting solution.
3. The application of the Yandangshan calamus root extracting solution in the cosmetics according to the claim 2 is characterized in that: the sum of the mass fractions of the components of the phase A, the phase B, the phase C, the phase D, the phase E, the phase F and the phase G is 100 percent.
4. The application of the Yandangshan calamus root extracting solution in the cosmetics according to the claim 2 is characterized in that: the cocoyl glutamic acid TEA salt active content was 30%.
5. The application of the Yandangshan calamus root extracting solution in the cosmetics according to the claim 2 is characterized in that: the mass fraction of the sodium hydroxide aqueous solution is 10%.
6. The use of the extract of Amaranthus tricolor root as claimed in any one of claims 2-5 in cosmetics, wherein: the preparation method of the cosmetic comprises the following steps:
the method comprises the following steps: mixing the F phase, heating to 55-60 ℃ for dissolving, and cooling for later use;
step two: adding water into a main pot, pre-dispersing the powder in the phase A by using glycerol, pouring the pre-dispersed powder into the water, heating to 80-85 ℃, stirring until the pre-dispersed powder is completely dissolved and transparent, performing weak homogenization and uniform dispersion for multiple times, sequentially adding other components, and stirring until the pre-dispersed powder is completely dissolved;
step three: sequentially adding the components of the phase B, stirring until the components are completely dissolved, preserving heat for 15-20 minutes after the components are dissolved, defoaming, and beginning to cool;
step four: sequentially adding the C-phase components when the temperature is reduced to 55-60 ℃, and uniformly stirring;
step five: pre-dispersing the phase D, adding the pre-dispersed phase D into a main pot, stirring the pre-dispersed phase D and the main pot until the pre-dispersed phase D and the main pot are completely and uniformly stirred, and adding the pre-dispersed phase D into the phase E for neutralization for 10 to 15 minutes;
step six: when the temperature is reduced to 40-45 ℃, adding the prepared F phase and G phase, and uniformly stirring;
step seven: cooling to room temperature, detecting and discharging to obtain the cosmetic amino acid facial cleansing honey.
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