CN113825771A - 针对密蛋白18a2的抗体及其应用 - Google Patents

针对密蛋白18a2的抗体及其应用 Download PDF

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CN113825771A
CN113825771A CN202080036234.5A CN202080036234A CN113825771A CN 113825771 A CN113825771 A CN 113825771A CN 202080036234 A CN202080036234 A CN 202080036234A CN 113825771 A CN113825771 A CN 113825771A
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antibody
antigen
cancer
binding fragment
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CN113825771B (zh
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杨莹莹
李高
王亚宁
安振明
赵树雍
刘玉雪
刘世聪
张美娟
姜锦锦
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Qilu Pharmaceutical Co Ltd
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Abstract

提供抗CLDN18.2的抗体或其抗原结合片段、包含所述抗体或其抗原结合片段的衍生物以及药物组合物，以及所述抗体或其抗原结合片段在治疗癌症和检测诊断方面的相关应用。

Description

PCT国内申请，说明书已公开。

Claims (49)

  1. PCT国内申请，权利要求书已公开。
CN202080036234.5A 2019-05-16 2020-05-15 针对密蛋白18a2的抗体及其应用 Active CN113825771B (zh)

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Application Number Priority Date Filing Date Title
CN201910406762 2019-05-16
CN2019104067624 2019-05-16
PCT/CN2020/090427 WO2020228806A1 (zh) 2019-05-16 2020-05-15 针对密蛋白18a2的抗体及其应用

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CN113825771A true CN113825771A (zh) 2021-12-21
CN113825771B CN113825771B (zh) 2024-02-09

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US (1) US20220411492A1 (zh)
EP (1) EP3971208A4 (zh)
JP (1) JP7407841B2 (zh)
KR (1) KR20220024010A (zh)
CN (1) CN113825771B (zh)
AU (1) AU2020273695A1 (zh)
BR (1) BR112021023024A2 (zh)
CA (1) CA3138414A1 (zh)
WO (1) WO2020228806A1 (zh)

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Publication number Priority date Publication date Assignee Title
CN117120477A (zh) * 2020-11-10 2023-11-24 上海齐鲁制药研究中心有限公司 针对密蛋白18a2和cd3的双特异性抗体及其应用
WO2022100590A1 (zh) * 2020-11-10 2022-05-19 齐鲁制药有限公司 针对密蛋白18a2的adcc增强型人源化抗体及其应用
CN114634566B (zh) * 2020-12-16 2023-09-19 广州百暨基因科技有限公司 一种抗Claudin18_2的抗原结合片段、抗体及其应用
US20240092892A1 (en) * 2020-12-30 2024-03-21 Bio-Thera Solutions, Ltd. Anti-cldn18.2 antibody, and preparation method therefor and use thereof
CN114805571B (zh) * 2021-01-28 2023-08-25 广西鹭港生物医药科技有限公司 抗cldn18.2抗体及其应用
CN113416260B (zh) * 2021-04-14 2022-02-01 南京凯地医疗技术有限公司 靶向Claudin18.2的特异性嵌合抗原受体细胞及其制备方法和应用
AU2022275043A1 (en) * 2021-05-08 2023-02-16 Remegen Co., Ltd. Anti-Claudin 18.2 antibody and antibody-drug conjugate thereof
CA3233254A1 (en) * 2021-09-27 2023-03-30 Evopoint Biosciences Co., Ltd. Antibody, antibody-drug conjugate thereof and use thereof

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WO2015113576A1 (en) * 2014-01-29 2015-08-06 Biontech Ag Peptide mimotopes of claudin 18.2 and uses thereof
CN105073777A (zh) * 2013-02-20 2015-11-18 咖尼米德制药股份公司 用于治疗癌症的涉及抗密蛋白18.2抗体的组合疗法
CN105189554A (zh) * 2013-03-18 2015-12-23 咖尼米德制药股份公司 用于治疗癌症的涉及抗密蛋白18.2的抗体的疗法
CN107667118A (zh) * 2015-04-15 2018-02-06 加尼梅德药物有限公司 包含针对密封蛋白18.2之抗体的药物缀合物
CN108047331A (zh) * 2012-05-09 2018-05-18 加尼梅德药物公司 用于癌症诊断的针对密蛋白18.2的抗体

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