CN113813215B - Smearing type mask with blood coagulation and skin repairing functions and preparation method thereof - Google Patents
Smearing type mask with blood coagulation and skin repairing functions and preparation method thereof Download PDFInfo
- Publication number
- CN113813215B CN113813215B CN202111194587.0A CN202111194587A CN113813215B CN 113813215 B CN113813215 B CN 113813215B CN 202111194587 A CN202111194587 A CN 202111194587A CN 113813215 B CN113813215 B CN 113813215B
- Authority
- CN
- China
- Prior art keywords
- cuttlebone
- extracting
- extract
- parts
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000023555 blood coagulation Effects 0.000 title claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 61
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000008367 deionised water Substances 0.000 claims abstract description 20
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 20
- 230000008439 repair process Effects 0.000 claims abstract description 20
- 239000003906 humectant Substances 0.000 claims abstract description 11
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- 230000002335 preservative effect Effects 0.000 claims abstract description 11
- 239000002562 thickening agent Substances 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims abstract description 9
- 235000019082 Osmanthus Nutrition 0.000 claims abstract description 8
- 241000333181 Osmanthus Species 0.000 claims abstract description 8
- 230000001112 coagulating effect Effects 0.000 claims abstract description 4
- 230000001815 facial effect Effects 0.000 claims description 65
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 19
- 239000003208 petroleum Substances 0.000 claims description 19
- 238000001914 filtration Methods 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- 239000012259 ether extract Substances 0.000 claims description 15
- 239000006286 aqueous extract Substances 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 10
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 9
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 9
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 9
- 239000004302 potassium sorbate Substances 0.000 claims description 9
- 235000010241 potassium sorbate Nutrition 0.000 claims description 9
- 229940069338 potassium sorbate Drugs 0.000 claims description 9
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 9
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 238000002137 ultrasound extraction Methods 0.000 claims description 5
- 239000008868 Flower Essence Substances 0.000 claims description 4
- 229940049638 carbomer homopolymer type c Drugs 0.000 claims description 4
- 229940043234 carbomer-940 Drugs 0.000 claims description 4
- 230000008961 swelling Effects 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 11
- 206010000496 acne Diseases 0.000 abstract description 4
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 3
- 238000011084 recovery Methods 0.000 abstract description 3
- 230000001133 acceleration Effects 0.000 abstract description 2
- 230000004060 metabolic process Effects 0.000 abstract description 2
- 210000004400 mucous membrane Anatomy 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 37
- 238000012360 testing method Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 9
- 241000628997 Flos Species 0.000 description 8
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 206010040880 Skin irritation Diseases 0.000 description 7
- 231100000475 skin irritation Toxicity 0.000 description 7
- 230000036556 skin irritation Effects 0.000 description 7
- 230000000740 bleeding effect Effects 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 229920002125 Sokalan® Polymers 0.000 description 5
- 229960001631 carbomer Drugs 0.000 description 5
- 230000007794 irritation Effects 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 231100000321 erythema Toxicity 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000001953 sensory effect Effects 0.000 description 3
- 230000037380 skin damage Effects 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 239000004330 calcium propionate Substances 0.000 description 2
- 235000010331 calcium propionate Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 208000027744 congestion Diseases 0.000 description 2
- OPGYRRGJRBEUFK-UHFFFAOYSA-L disodium;diacetate Chemical compound [Na+].[Na+].CC([O-])=O.CC([O-])=O OPGYRRGJRBEUFK-UHFFFAOYSA-L 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 235000017454 sodium diacetate Nutrition 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000019710 soybean protein Nutrition 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000242564 Osmanthus fragrans Species 0.000 description 1
- 235000019083 Osmanthus fragrans Nutrition 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a smearing type mask with the functions of blood coagulation and skin repair, which comprises the following components in percentage by weight: 1% -10% of cuttlebone extract, 80% -90% of deionized water, 1% -10% of thickening agent, 15% -25% of humectant, 1% -10% of acid-base regulator, 1% -10% of preservative and 1% -10% of osmanthus essence. The invention combines the blood coagulation and mucous membrane repair functions of the cuttlebone extract and the cleaning, moisturizing and acne-removing functions of the mask, and has the effects of blood coagulation, damaged skin repair, metabolism promotion, capillary vessel expansion acceleration, cell vitality recovery and the like when the mask is applied. The mask capable of coagulating and repairing skin provided by the invention is simple in preparation method, remarkable in curative effect and wide in application prospect.
Description
Technical Field
The invention relates to an efficacy type smearing type facial mask, in particular to a smearing type facial mask with the functions of blood coagulation and skin repair; the invention also relates to a preparation method of the efficacy type smearing type facial mask.
Background
Bleeding and damage to the surface layer of human skin are common skin diseases, such as acne, skin damage and the like. For bleeding and skin damage caused by common skin problems, the adoption of functional skin care products for preventing and treating the bleeding and the skin damage is accepted by the public. The development of facial masks is more and more diverse. The facial mask is a product with enhanced efficacy in skin care products, the content of active ingredients is generally higher than that of the daily skin care products, and the active ingredients are more easily absorbed by the skin of the face due to the particularity of the formula and the using method.
At present, the types of facial masks mainly comprise three modes, namely a fiber facial mask, a tearing type facial mask and a smearing type facial mask. The fiber facial mask has poor affinity with skin, is only a carrier of essence, is thick and not conformable, has general air permeability, and can absorb moisture on the surface of the skin when being taken down in time after being dried; the tearing type mask has a certain effect on stubborn blackheads, but the skin is not good, large pores can be pulled, and the skin is injured; the essence components of the smearing type facial mask are not easy to evaporate, and the antipyretic and soothing effects of the smearing type facial mask have good effects on acute skin injuries (such as allergy, acne and scratch). Many clinical studies show that the traditional Chinese medicine has less irritation compared with western medicines, and effective medicinal ingredients in the traditional Chinese medicine mask can provide sufficient nutrient substances for skin through transdermal absorption, so that the traditional Chinese medicine mask is popular with patients due to the advantages of convenient operation, good curative effect, less adverse reaction, safety and durability.
Disclosure of Invention
The technical problem to be solved by the invention is to provide an application type facial mask with the functions of blood coagulation and skin repair, which can play the roles of blood coagulation, damaged skin repair, metabolism promotion, capillary vessel dilatation acceleration, cell vitality recovery and the like.
The invention also provides a preparation method of the mask capable of coagulating blood and repairing skin, which is simple to operate and has wide application prospect.
The technical problem to be solved by the present invention is achieved by the following technical means. The invention relates to a smearing type facial mask with the functions of blood coagulation and skin repair, which is characterized in that the main components of the facial mask are calculated according to the weight percentage and comprise the following components:
1% -10% of cuttlebone extract; the cuttlebone extract is one of a cuttlebone water extract, a cuttlebone alcohol extract and a cuttlebone petroleum ether extract;
80% -90% of deionized water;
1% -10% of a thickening agent;
15% -25% of a humectant;
1% -10% of an acid-base regulator;
1% -10% of a preservative;
1-10% of essence.
The preferable technical scheme of the smearing type mask with the function of blood coagulation and skin repair is as follows: the thickening agent is selected from one or more of xanthan gum, sodium alginate, hydroxyethyl cellulose and carbomer; the humectant is one or more selected from glycerol, propylene glycol, butanediol, sorbitol, sodium hyaluronate, collagen, and soybean protein; the pH regulator is selected from one or more of triethanolamine, DL-malic acid, citric acid and tartaric acid; the preservative is selected from one or more of potassium sorbate, calcium propionate, sodium diacetate and sodium lactate; the essence is one or more of flos Osmanthi Fragrantis essence, flos Rosae Rugosae essence, flos Jasmini sambac essence, and flos Magnoliae essence.
The preferable technical scheme of the smearing type mask with the function of blood coagulation and skin repair is as follows: the facial mask comprises the following main components in percentage by weight:
cuttlebone extract 8%;
85% of deionized water;
3% of a thickening agent;
20% of a humectant;
4% of an acid-base regulator;
4% of preservative;
2 percent of essence.
The preferable technical scheme of the smearing type mask with the function of blood coagulation and skin repair is as follows: the facial mask comprises the following main components in percentage by weight:
an aqueous extract of cuttlebone or an alcohol extract of cuttlebone or an extract of cuttlebone petroleum ether 8%;
85% of deionized water;
carbomer 940% by weight;
10% of glycerol;
6% of propylene glycol;
4% of sodium hyaluronate;
4% of triethanolamine;
4% of potassium sorbate;
2 percent of osmanthus flower essence.
The preferable technical scheme of the smearing type mask with the function of blood coagulation and skin repair is as follows: the facial mask comprises the following main components in percentage by weight:
8% of a mixture of the cuttlebone aqueous extract and the alcohol extract; the proportion of the cuttlebone aqueous extract to the alcohol extract mixture is 1;
85% of deionized water;
carbomer 940% by weight;
10% of glycerol;
6% of propylene glycol;
4% of sodium hyaluronate;
4% of triethanolamine;
4% of potassium sorbate;
2 percent of osmanthus flower essence.
The preferable technical scheme of the smearing type mask with the function of blood coagulation and skin repair is as follows: the preparation method of the cuttlebone aqueous extract comprises the following steps: cleaning Os Sepiae, and pulverizing; adding deionized water into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, soaking for 1 to 12 hours at room temperature, heating and refluxing for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, ultrasonically extracting the filter residue for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, combining the filtrates, centrifuging, taking the supernatant, and freeze-drying in a vacuum freeze-drying machine to obtain the solid cuttlebone aqueous extract.
The above-mentioned application type facial mask with the function of blood coagulation and skin repair further preferably adopts the technical scheme that: the preparation method of the cuttlebone alcohol extract comprises the following steps: cleaning Os Sepiae, and pulverizing; adding 50% -100% ethanol into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, soaking for 12 to 48 hours at room temperature, heating and refluxing for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, performing ultrasonic extraction on the filter residue for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, combining the filtrates, centrifuging, taking the supernatant, concentrating and drying to obtain the solid cuttlebone alcohol extract.
The preferable technical scheme of the smearing type mask with the function of blood coagulation and skin repair is as follows: the preparation method of the cuttlebone petroleum ether extract comprises the following steps: adding petroleum ether into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, and then, mixing the powder according to a ratio of 1 to 10, soaking the powder for 2 to 12 hours at room temperature, heating and refluxing for 1 to 3 hours, extracting and filtering, extracting filter residues for 1 to 3 times by the same method, performing ultrasonic extraction on the filter residues for 1 to 3 hours, extracting and filtering, extracting the filter residues for 1 to 3 times by the same method, combining filtrate, centrifuging, taking supernatant, concentrating and drying to obtain the solid cuttlebone petroleum ether extract.
The invention also discloses a preparation method of the smearing type mask capable of effectively coagulating blood and repairing damaged skin, which is characterized by comprising the following steps: weighing raw materials in proportion, firstly adding the cuttlebone extract into deionized water for dissolving, then adding the thickening agent for stirring and fully swelling, and then sequentially adding the humectant, the pH regulator, the preservative and the essence for mixing and stirring uniformly to prepare the facial mask.
Compared with the prior art, the invention has the following beneficial effects:
the active ingredients contained in the cuttlebone extract mask provided by the invention are raw materials, so that the mask has the functions of promoting mucous membrane repair and blood coagulation, is safe and reliable for external use, has no toxic or side effect, takes effect quickly, is simple in preparation method, easy to operate and low in cost, and has wide application prospects.
Detailed Description
Example 1: cuttlebone water extract mask
The mask is prepared from the following raw materials in parts by weight: 8 parts of cuttlebone water extract, 85 parts of deionized water, 940 parts of carbomer, 10 parts of glycerol, 6 parts of propylene glycol, 4 parts of sodium hyaluronate, 4 parts of triethanolamine, 4 parts of potassium sorbate and 2 parts of osmanthus essence.
Example 2: cuttlebone alcohol extract mask
The mask is prepared from the following raw materials in parts by weight: 8 parts of cuttlebone alcohol extract, 85 parts of deionized water, 940 parts of carbomer, 10 parts of glycerol, 6 parts of propylene glycol, 4 parts of sodium hyaluronate, 4 parts of triethanolamine, 4 parts of potassium sorbate and 2 parts of osmanthus essence.
Example 3: cuttlebone petroleum ether extract mask
The mask is prepared from the following raw materials in parts by weight: 8 parts of cuttlebone petroleum ether extract, 85 parts of deionized water, 940 parts of carbomer, 10 parts of glycerol, 6 parts of propylene glycol, 4 parts of sodium hyaluronate, 4 parts of triethanolamine, 4 parts of potassium sorbate and 2 parts of osmanthus essence.
The preparation methods of the embodiments 1, 2 and 3 are the same, and the raw materials are weighed according to the proportion, the cuttlebone extract is firstly added into deionized water to be dissolved, then the thickening agent is added to be stirred and fully swelled, and then the humectant, the acid-base regulator, the preservative and the essence are sequentially added to be mixed and stirred uniformly, so that the mask is prepared.
The following experiments were performed on the facial masks prepared by the preparation method provided by the present invention for the pharmaceutical materials in examples 1, 2 and 3.
Experiment 1 sensory index determination of cuttlebone extract facial mask
12 clean beakers were taken and divided into 4 groups (n = 3). Control group (no cuttlebone extract was given), example 1 cuttlebone water extract facial mask group, example 2 cuttlebone alcohol extract facial mask group, and example 3 cuttlebone petroleum ether extract facial mask group, respectively.
The determination is carried out by three aspects of appearance, smell and use feeling. The appearance of the facial mask is observed by a visual method, and the observation condition is performed in direct sunlight and room temperature. The prepared cuttlebone extract facial mask has no bad smell and accords with specific aroma. And observing whether the face mask using the cuttlebone extract has discomfort or not. Grading standard: the color and luster is good, the texture is uniform, no impurity exists, and no turbidity is 5 minutes; no bad smell and no fishy smell, and accords with the fragrance of the osmanthus fragrans for 5 minutes; after application, the medicine is mild and has no irritation, and the skin has no adverse reaction for 5 points.
TABLE 1 sensory index measurement results of facial mask
Note: p <0.05 compared to blank group.
The results in table 1 show that, compared with the control group, the appearance of the groups of examples 1, 2 and 3 was in accordance with the gel state, and the color was good without impurities and stains; no bad smell, and accords with the smell of specific essence; the use feeling is mild, no stimulation is caused, and no adverse reaction is caused. Therefore, the cuttlebone extract facial mask has good sensory indexes and meets the market facial mask standard.
Experiment 2 measurement of physical and chemical indexes of cuttlebone extract facial mask
40 clean small beakers were taken and divided into 4 groups (n = 10). Control group (no cuttlebone extract was given), example 1 cuttlebone water extract facial mask group, example 2 cuttlebone alcohol extract facial mask group, and example 3 cuttlebone petroleum ether extract facial mask group, respectively. The measurement is carried out by five aspects of pH value, viscosity, heat resistance, cold resistance and stability. The pH value of the cuttlebone extract functional facial mask is measured by a pH meter, and the quality indexes are as follows: pH value is 3.5-8.5, and the detection method comprises the following steps: measured as described in GB/T13531.1 (dilution method). The spreading of the mask is influenced by the viscosity, and the test method comprises the following steps: and detecting the viscosity of the mask by using a cosmetic viscometer. The heat resistance test method comprises the following steps: respectively placing the facial mask in an incubator at 40 ℃ (± 1 ℃), taking out the facial mask after 24 hours, observing a comparative facial mask sample, and observing whether the facial mask in the incubator has the phenomena of discoloration, thinning, layering, hardness change and the like, thereby judging the heat resistance of the facial mask. The cold resistance test method comprises the following steps: the facial mask is respectively placed in a refrigerator with the temperature of minus 5 ℃ to 15 ℃ (-1 ℃) and at room temperature, the facial mask is taken out after 24 hours, a comparative facial mask sample is observed, whether the facial mask placed in the refrigerator has the phenomena of color change, thinning, layering, hardness change and the like is observed, and therefore the cold resistance of the facial mask is judged. The stability test method comprises the following steps: centrifuging the prepared facial mask sample in a centrifuge (3000 r/min,15 min), taking out, and observing the separation and layering conditions of the facial mask sample. The scoring standard is as follows: the pH value is 3.5-8.5, the quality index is met, and the stimulation is not 5 points; the viscosity is between 33.5 and 34.5P, the film is easy to form, and the adhesiveness is good for 5 minutes; no color change, thinning, layering and hardening, no obvious difference between the temperature after being recovered to room temperature and the temperature before the experiment, and good heat resistance for 5 minutes; no color change, thinning, layering and hardening, no obvious difference between the room temperature and the room temperature before the experiment, and good cold resistance for 5 minutes; no layering and separation phenomena and good stability for 5 minutes.
Table 2 determination results of physical and chemical indicators of facial mask
Note: p <0.05 compared to blank group.
The results in Table 2 show that, compared with the control group, the pH values of the groups of examples 1, 2 and 3 meet the standard range of the mask, and the mask has the advantages of stable viscosity value, good adhesiveness, good heat resistance and cold resistance, no obvious change and good stability. Therefore, the cuttlebone functional facial mask has good physical and chemical indexes and meets the market standard.
Experiment 3 skin irritation and multiple skin irritation tests of cuttlebone efficacy mask
30 mice, each female and male, are divided into 3 groups (n = 10) randomly, and the groups are respectively a control group (not given with cuttlebone extract), a cuttlebone water extract facial mask group in example 1, a cuttlebone alcohol extract facial mask group in example 2 and a cuttlebone petroleum ether extract facial mask group in example 3.
Skin irritation test: depilating on both sides of spinal column (area of about 2 × 2 cm) with shaver, washing with distilled water, wiping, 6 hr later, applying Os Sepiae extract facial mask on the depilated skin, and fixing facial mask with gauze bandage. After 6 hours of smearing, the gauze is taken down, washed by warm water, and the skin conditions of 1, 24, 48 and 72 hours, such as no erythema, congestion, edema, hemorrhage, erosion, ulcer and the like, are carefully observed. Grading standard: one of 10 mice was counted as one score, and 10 scores were counted.
Multiple skin irritation tests: after 3 days, the test is carried out again according to the experimental method of the skin irritation test, the test is carried out for two weeks, and the skin of the animal to be tested is uniformly smeared with the facial mask for 1 to 3 times every day for careful observation.
Table 3 multiple skin irritation test results for the mask
The results in table 3 show that the control group was applied with the facial mask without the cuttlebone extract, and the skin reactions of the groups of examples 1, 2 and 3 after 1, 24, 48 and 72 hours after the application of the facial mask with the cuttlebone extract were observed, and no erythema, congestion, edema, hemorrhage, erosion, ulcer and the like were observed. According to the skin irritation intensity standard, the mask sample is free of irritation (0-0.4 min), and after multiple irritation experiments, the phenomena of erythema, erosion, bleeding and the like do not appear on the skin, so that the cuttlebone efficacy mask is proved to be mild, free of irritation and good in safety.
Experiment 4 functionality test of cuttlebone extract facial mask
15 mice, half male and female, were randomly divided into 3 groups (n = 5), and the two sides of the spine were removed by hair, divided into two parts, a control and B test, at 2cm intervals. Then, the same 'mouth' is drawn on the part A and the part B by the tool tip respectively at the part AB, the epidermis is injured without injuring the dermis, and the wound is exposed in the air for half an hour until the wound does not bleed again. The part A was coated with an excipient (no cuttlebone extract was given) as a control group, and the part B was coated with the cuttlebone water extract group of example 1, the cuttlebone alcohol extract group of example 2, and the cuttlebone petroleum ether extract group of example 3, respectively, and washed with warm water after 15 minutes, and then wiped dry with a cotton swab. The repair of the damaged skin was observed for 7 days, and the repair time was recorded and observed every 2 hours.
Table 4 functionality test results of cuttlebone extract facial mask
The results in table 4 show that, as shown in the control group and the groups in examples 1, 2 and 3, the time required for the damaged skin of the mouse to recover to no obvious scar is shortened compared with that of the control group after the cuttlebone aqueous extract mask, the cuttlebone alcohol extract mask and the cuttlebone petroleum ether extract mask are used, the efficacy mask prepared from the cuttlebone aqueous extract has the best effect, and adverse reactions such as erythema, hyperemia and the like are not found on the skin after the effective mask is used for 90.4 hours on average.
According to the recovery condition of a mouse, the cuttlebone aqueous extract functional facial mask has a good effect of repairing damaged skin, can quickly stop bleeding after damaged skin bleeds compared with a control group, and has good effects of stopping bleeding and repairing damaged skin.
Embodiment 4, an application type facial mask with the function of blood coagulation and skin repair, which comprises the following main components in percentage by weight:
8% of cuttlebone extract;
85% of deionized water;
3% of a thickening agent;
20% of a humectant;
4% of an acid-base regulator;
4% of preservative;
2 percent of essence.
The cuttlebone extract is one of a cuttlebone water extract, a cuttlebone alcohol extract and a cuttlebone petroleum ether extract; the thickening agent is selected from one of xanthan gum, sodium alginate, hydroxyethyl cellulose and carbomer; the humectant is selected from one of glycerol, propylene glycol, butanediol, sorbitol, sodium hyaluronate, collagen protein, and soybean protein; the pH regulator is selected from one of triethanolamine, DL-malic acid, citric acid and tartaric acid; the preservative is selected from one of potassium sorbate, calcium propionate, sodium diacetate and sodium lactate; the essence is selected from one of flos Osmanthi Fragrantis essence, flos Rosae Rugosae essence, flos Jasmini sambac essence, and flos Magnoliae essence.
The preparation method of the cuttlebone aqueous extract comprises the following steps: cleaning Os Sepiae, and pulverizing; mixing the prepared cuttlebone powder with deionized water according to a ratio of 1.
The preparation method of the cuttlebone alcohol extract comprises the following steps: cleaning Os Sepiae, and pulverizing; adding 75% ethanol into the prepared cuttlebone powder, mixing according to a ratio of 1 to 4, soaking at room temperature for 48 hours, heating and refluxing for 2 hours, extracting and filtering, extracting the filter residue by the same method for 2 times, performing ultrasonic extraction on the filter residue for 2 hours, extracting and filtering, extracting the filter residue by the same method for 2 times, combining the filtrate, centrifuging, taking the supernatant, concentrating and drying to obtain the solid cuttlebone alcohol extract.
The preparation method of the cuttlebone petroleum ether extract comprises the following steps: mixing the prepared cuttlebone powder with petroleum ether according to a ratio of 1.
Weighing raw materials in proportion, firstly adding the cuttlebone extract into deionized water for dissolving, then adding the thickening agent for stirring and fully swelling, and then sequentially adding the humectant, the pH regulator, the preservative and the essence for mixing and stirring uniformly to prepare the facial mask.
Example 5, the main components of the smearing type facial mask with the functions of blood coagulation and skin repair comprise the following components in percentage by weight:
8% of a mixture of the cuttlebone aqueous extract and the alcohol extract; the proportion of the mixture of the cuttlebone aqueous extract and the alcohol extract is 1;
85% of deionized water;
carbomer 940% by weight;
10% of glycerol;
6% of propylene glycol;
4% of sodium hyaluronate;
4% of triethanolamine;
4% of potassium sorbate;
2 percent of osmanthus flower essence.
The preparation method of the cuttlebone aqueous extract comprises the following steps: cleaning Os Sepiae, and pulverizing; mixing the prepared cuttlebone powder with deionized water according to a ratio of 1.
The preparation method of the cuttlebone alcohol extract comprises the following steps: cleaning Os Sepiae, and pulverizing; adding 50% ethanol into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, soaking for 12 hours at room temperature, heating and refluxing for 3 hours, extracting and filtering, extracting the filter residue for 3 times by the same method, ultrasonically extracting the filter residue for 3 hours, extracting and filtering, extracting the filter residue for 3 times by the same method, combining the filtrate, centrifuging, taking the supernatant, concentrating and drying to obtain the solid cuttlebone alcohol extract.
Weighing raw materials in proportion, firstly adding the cuttlebone extract into deionized water for dissolving, then adding the thickening agent for stirring and fully swelling, and then sequentially adding the humectant, the pH regulator, the preservative and the essence for mixing and stirring uniformly to prepare the facial mask.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all changes, modifications, substitutions and variations that can be made by the present specification are included in the scope of the present invention.
Claims (1)
1. The smearing type mask with the functions of blood coagulation and skin repair is characterized by comprising the following raw materials in parts by weight: 8 parts of cuttlebone water extract, cuttlebone alcohol extract or cuttlebone petroleum ether extract; 85 parts of deionized water; carbomer 940 parts; 10 parts of glycerol; 6 parts of propylene glycol; 4 parts of sodium hyaluronate; 4 parts of triethanolamine; 4 parts of potassium sorbate; 2 parts of osmanthus flower essence;
the preparation method of the cuttlebone aqueous extract comprises the following steps: cleaning Os Sepiae, and pulverizing; adding deionized water into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, soaking for 1 to 12 hours at room temperature, heating and refluxing for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, ultrasonically extracting the filter residue for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, combining the filter liquor, centrifuging, taking the supernatant, and freeze-drying in a vacuum freeze-drying machine to obtain a solid cuttlebone aqueous extract;
the preparation method of the cuttlebone alcohol extract comprises the following steps: cleaning Os Sepiae, and pulverizing; adding 50% -100% ethanol into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, soaking for 12 to 48 hours at room temperature, heating and refluxing for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, performing ultrasonic extraction on the filter residue for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, combining the filtrates, centrifuging, taking the supernatant, concentrating and drying to obtain a solid cuttlebone alcohol extract;
the preparation method of the cuttlebone petroleum ether extract comprises the following steps: adding petroleum ether into the prepared cuttlebone powder, mixing according to a ratio of 1 to 10, soaking for 2 to 12 hours at room temperature, heating and refluxing for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, performing ultrasonic extraction on the filter residue for 1 to 3 hours, extracting and filtering, extracting the filter residue for 1 to 3 times by the same method, combining the filtrate, centrifuging, taking the supernatant, concentrating and drying to obtain a solid cuttlebone petroleum ether extract;
the preparation method of the smearing type mask capable of effectively coagulating blood and repairing damaged skin comprises the following steps: weighing raw materials in proportion, firstly adding the cuttlebone extract into deionized water for dissolving, then adding the thickening agent for stirring and fully swelling, and then sequentially adding the humectant, the pH regulator, the preservative and the essence for mixing and stirring uniformly to prepare the facial mask.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111194587.0A CN113813215B (en) | 2021-10-13 | 2021-10-13 | Smearing type mask with blood coagulation and skin repairing functions and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111194587.0A CN113813215B (en) | 2021-10-13 | 2021-10-13 | Smearing type mask with blood coagulation and skin repairing functions and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113813215A CN113813215A (en) | 2021-12-21 |
| CN113813215B true CN113813215B (en) | 2022-10-11 |
Family
ID=78920377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111194587.0A Active CN113813215B (en) | 2021-10-13 | 2021-10-13 | Smearing type mask with blood coagulation and skin repairing functions and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113813215B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001097873A (en) * | 1999-09-30 | 2001-04-10 | Maruzen Pharmaceut Co Ltd | Active oxygen scavenger, platelet coagulation suppressing agent, skin cosmetic and bathing agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107320364A (en) * | 2017-06-09 | 2017-11-07 | 佛山汇沐化学科技有限公司 | A kind of facial mask with repair function |
| CN109091449A (en) * | 2018-10-31 | 2018-12-28 | 广东巴松那生物科技有限公司 | A kind of set face cream and the sleep mask of gel and preparation method thereof |
| CN111493200A (en) * | 2020-06-10 | 2020-08-07 | 江苏海洋大学 | Chewing gum with oral care function and preparation method and application thereof |
-
2021
- 2021-10-13 CN CN202111194587.0A patent/CN113813215B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001097873A (en) * | 1999-09-30 | 2001-04-10 | Maruzen Pharmaceut Co Ltd | Active oxygen scavenger, platelet coagulation suppressing agent, skin cosmetic and bathing agent |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113813215A (en) | 2021-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111658818B (en) | Medical repair dressing and application thereof | |
| CN109602686A (en) | A kind of aqueous gelled cosmetic compositions and preparation method thereof | |
| CN111632075B (en) | Exosome preparation for promoting skin wound healing and preparation method thereof | |
| CN109394737A (en) | Medical cold application and preparation method thereof | |
| CN104622740B (en) | Purposes of the Horse chest Nut P.E in cosmeceutical is prepared | |
| CN109350591B (en) | Dry facial mask for beautifying face and preparation method thereof | |
| CN112402347A (en) | Acne-removing repair composition containing fibronectin and preparation method thereof | |
| CN106038337B (en) | Anti-acne skin makeup liquid and its preparation method | |
| CN109157449B (en) | Anti-aging moisturizing essence and preparation process thereof | |
| KR102249700B1 (en) | Comsmetic composition comprising mint vinegar | |
| CN112274447B (en) | Dendrobium officinale polysaccharide-hyaluronic acid soluble microneedle and preparation method thereof | |
| CN110123953B (en) | Cold compress patch for promoting postoperative skin repair and preparation method thereof | |
| CN109453056A (en) | A kind of moisture saver mask liquid and preparation method thereof | |
| CN113813215B (en) | Smearing type mask with blood coagulation and skin repairing functions and preparation method thereof | |
| CN111870541A (en) | Herbal whitening compound composition, mask and preparation method thereof | |
| CN111803413A (en) | Noni SOD skin care product and preparation method thereof | |
| KR100887294B1 (en) | Cosmetic compositions containing hollyhock extracts | |
| CN106511213A (en) | Cosmetic containing plant extract liquid | |
| CN110859758A (en) | Whitening anti-aging repair type medical cold compress patch and preparation method thereof | |
| CN117297996A (en) | Hirudin freeze-dried mask and preparation method thereof | |
| CN111202821B (en) | Traditional Chinese medicine extract with allergy-relieving and anti-inflammatory effects as well as preparation method and application thereof | |
| CN108113916B (en) | Natural repair peptide mask liquid and preparation method thereof | |
| CN113081924A (en) | Antioxidant composition, preparation method and application | |
| KR100552307B1 (en) | The cosmetic materials of adding a composite extracted from chinese medicine mterias having effect of antiageing | |
| CN110025557A (en) | A kind of draft eye essence and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231031 Address after: 2081, building a, 88 Jianghai West Road, Liangxi District, Wuxi City, Jiangsu Province, 214000 Patentee after: Wuxi Xiangyuan Information Technology Co.,Ltd. Address before: No.59 Cangwu Road, hi tech Zone, Lianyungang City, Jiangsu Province 222000 Patentee before: Jiangsu Ocean University |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240605 Address after: No. 26, Longgang Road, the Nanling Mountain, Longgui Street, Baiyun District, Guangzhou, Guangdong 510550 Patentee after: GUANGZHOU OCEAN COSMETIC CO.,LTD. Country or region after: China Address before: 2081, building a, 88 Jianghai West Road, Liangxi District, Wuxi City, Jiangsu Province, 214000 Patentee before: Wuxi Xiangyuan Information Technology Co.,Ltd. Country or region before: China |
|
| TR01 | Transfer of patent right |