CN113791372B - Magnetic nanoparticle space positioning device and method - Google Patents
Magnetic nanoparticle space positioning device and method Download PDFInfo
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- CN113791372B CN113791372B CN202110941706.8A CN202110941706A CN113791372B CN 113791372 B CN113791372 B CN 113791372B CN 202110941706 A CN202110941706 A CN 202110941706A CN 113791372 B CN113791372 B CN 113791372B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1276—Measuring magnetic properties of articles or specimens of solids or fluids of magnetic particles, e.g. imaging of magnetic nanoparticles
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- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
Abstract
A magnetic nanoparticle space positioning device and a method relate to the technical field of biomedical engineering, and the device comprises: the device comprises an exciting coil, a detecting coil, an LC resonance circuit, an alternating current power supply circuit and a voltage detecting circuit. The method comprises the following steps: and constructing a first LC resonance circuit matched with the excitation coil, constructing a second LC resonance circuit matched with the detection coil, detecting a secondary magnetic field generated by exciting the magnetic nanoparticles by an alternating magnetic field by using the detection coil, amplifying, filtering and displaying the induced voltage in real time by using the voltage detection circuit, and determining the spatial distribution of the magnetic nanoparticles according to the amplitude of the detected voltage. The magnetic nanoparticle space positioning device and the magnetic nanoparticle space positioning method adopt a mode that an excitation coil and a detection coil are assembled into a scanning coil group, have simple structure and convenient operation, and can realize real-time detection and voltage display.
Description
Technical Field
The invention relates to a magnetic nanoparticle space positioning device and a magnetic nanoparticle space positioning method, and belongs to the technical field of biomedical engineering.
Background
Magnetic nanoparticles, which are nano-sized particles with superparamagnetism, have been widely studied and applied in the technical field of biomedical engineering in recent years, wherein accurate positioning and quantification of magnetic nanoparticles are key problems in the above applications.
The traditional magnetic nanoparticle positioning method needs to scan and image an object to be detected by using a closed magnetic field scanner. However, the closed magnetic field scanner is inconvenient to perform interventional operation, and has long scanning imaging time and poor real-time performance.
Therefore, there is a need for a magnetic nanoparticle spatial positioning device and method with a faster imaging speed, a simple structure and easy operation.
Disclosure of Invention
The invention aims to solve the problems that an imaging device in the prior art is inconvenient to close and carry out interventional operation, has poor real-time performance and the like, and provides a magnetic nanoparticle space positioning device and a magnetic nanoparticle space positioning method.
The technical scheme of the invention is as follows:
a magnetic nanoparticle spatial positioning device comprising: the exciting coil, the detecting coil, the LC resonance circuit, the alternating current power supply circuit and the voltage detecting circuit have the specific structure as follows:
the exciting coil is an annular uniform multi-turn coil and is used for transmitting a high-frequency alternating magnetic field to an annular region;
the detection coil is an annular uniform multi-turn coil and is used for detecting a secondary magnetic field generated by the magnetic nano particles under the excitation of a high-frequency alternating magnetic field;
the LC resonance circuit comprises a first LC resonance circuit and a second LC resonance circuit, the first LC resonance circuit is connected with the excitation coil, so that the excitation coil is in a resonance state and is used for generating a stronger alternating magnetic field with specific frequency, and the specific frequency is a first resonance frequency; the second LC resonance circuit is connected with the detection coil, so that the detection coil is in a resonance state and is used for enabling the detection coil to more easily detect a secondary magnetic field with a specific frequency generated by the magnetic nano particles, and the specific frequency is a second resonance frequency;
the alternating current power supply circuit is used for generating alternating voltage with a specific frequency required by exciting the coil;
the voltage detection circuit is used for amplifying and filtering the voltage signal on the detection coil and displaying the current detection voltage value.
Preferably, the second resonant frequency is three times the first resonant frequency, that is, the detection coil mainly detects a frequency-tripled component in a secondary magnetic field generated by exciting magnetic nanoparticles by an alternating magnetic field, so that aliasing with the exciting magnetic field is avoided.
Preferably, the ac power supply circuit includes a signal generating circuit and a power amplifying circuit.
Preferably, the voltage detection circuit includes a signal processing circuit and a voltage display circuit.
Preferably, the first resonant frequency is in the range of 10kHz to 100 kHz.
A magnetic nanoparticle spatial localization method comprising the steps of:
step S101: constructing a first LC resonant circuit matched with the exciting coil according to the frequency required by the exciting field, and transmitting an alternating magnetic field with a specific frequency along the axial direction of the exciting coil;
step S102: constructing a second LC resonance circuit matched with the detection coil, so that the detection frequency is three times of the frequency of the alternating magnetic field;
step S103: detecting a secondary magnetic field generated by exciting magnetic nano particles by an alternating magnetic field by using the detection coil, and forming induced voltage in the detection coil;
step S104: amplifying, filtering and displaying the induced voltage in real time by utilizing a voltage detection circuit;
step S105: simultaneously moving the exciting coil and the detecting coil to scan, excite and detect the detected object;
step S106: and determining the spatial distribution of the magnetic nano particles according to the amplitude of the detection voltage, wherein the larger the amplitude of the detection voltage is, the higher the concentration of the magnetic nano particles at the current position is.
Preferably, the exciting coil and the detecting coil are assembled into a scanning coil group, the scanning coil group is mechanically moved or manually moved to scan the tested object in real time, the scanning process is continuously excited and detected, and the detected voltage value is displayed on a display in real time.
Compared with the prior art, the magnetic nanoparticle space positioning device and the magnetic nanoparticle space positioning method have the advantages that:
1. the magnetic nanoparticle space positioning device and the magnetic nanoparticle space positioning method adopt a mode that an excitation coil and a detection coil are assembled into a scanning coil group, have simple structure and convenient operation, and can realize real-time detection and voltage display.
2. According to the magnetic nanoparticle space positioning device and method, in the process of scanning a detected object by using the scanning coil set, the induced voltage value can be changed, the voltage value at the position with high concentration of the magnetic nanoparticle solution can be larger, and the voltage value at the position without the magnetic nanoparticle is close to zero; the spatial position of the magnetic nano particles can be judged rapidly by utilizing the principle, and the concentration of the magnetic nano particles can be estimated quantitatively.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
FIG. 1 is a schematic diagram of a magnetic nanoparticle space positioning device according to the present invention;
FIG. 2 is a flow chart of a magnetic nanoparticle spatial positioning method of the present invention;
the attached table indicates:
1-excitation coil 2-detection coil
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
The term "and/or" is herein merely an association relationship describing an associated object, meaning that there may be three relationships, e.g., a and/or B, may represent: a exists alone, A and B exist together, and B exists alone. In addition, the term "at least one" herein means any one of a plurality or any combination of at least two of a plurality, for example, including at least one of A, B, C, and may mean including any one or more elements selected from the group consisting of A, B and C.
It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other.
The invention provides a magnetic nanoparticle space positioning device, the specific structure of which is shown in figure 1, comprising: the exciting coil 1, the detecting coil 2, an LC resonance circuit, an ac power supply circuit, and a voltage detecting circuit.
The exciting coil 1 is an annular uniform multi-turn coil and is used for transmitting a high-frequency alternating magnetic field to an in-loop area, the in-loop area not only comprises an area which is the same as the exciting coil 1 in horizontal plane, but also comprises a three-dimensional area in the axial direction of the exciting coil 1, and the high-frequency alternating magnetic field generated by the exciting coil 1 is a primary magnetic field.
The detection coil 2 is an annular uniform multi-turn coil and is used for detecting a secondary magnetic field generated by magnetic nano particles under the excitation of a high-frequency alternating magnetic field; the secondary magnetic field refers to a magnetic field generated after the magnetic nanoparticles are magnetized by an externally applied magnetic field, and is opposite to the primary magnetic field.
The LC resonance circuit comprises a first LC resonance circuit and a second LC resonance circuit, wherein the first LC resonance circuit is connected with the exciting coil 1, so that the exciting coil 1 is in a resonance state and is used for enabling the exciting coil 1 to generate a stronger alternating magnetic field with a specific frequency, and the specific frequency is a first resonance frequency; the second LC resonance circuit is connected with the detection coil 2, so that the detection coil 2 is in a resonance state, and the detection coil 2 is used for easily detecting a secondary magnetic field with a specific frequency generated by the magnetic nano particles, wherein the specific frequency is a second resonance frequency; distinguishing between the first resonant frequency and the second resonant frequency here means that the two resonant frequencies are different in magnitude; similarly, the first LC resonant circuit and the second LC resonant circuit are also different.
The alternating current power supply circuit comprises a signal generating circuit and a power amplifying circuit, and is used for generating alternating voltage with specific frequency required by the exciting coil 1; the specific frequency is typically in the range of 10kHz to 100 kHz.
The voltage detection circuit comprises a signal processing circuit and a voltage display circuit, and is used for amplifying and filtering a voltage signal on the detection coil 2 and displaying the current detection voltage value;
preferably, the second resonance frequency is three times of the first resonance frequency, namely the detection coil 2 mainly detects three times of frequency components in a secondary magnetic field generated by exciting magnetic nano particles by an alternating magnetic field, so that aliasing with the exciting magnetic field is avoided; the secondary magnetic field contains a plurality of frequency components, the frequency of the excitation magnetic field is the fundamental frequency of the secondary magnetic field, the largest component in the secondary magnetic field generated by the magnetic nano particles is a frequency tripling component except the fundamental frequency, and the frequency tripling refers to the fundamental frequency tripling.
The invention provides a magnetic nanoparticle space positioning method, the specific flow of which is shown in figure 2, comprising the following steps:
step S101: constructing a first LC resonant circuit matched with the exciting coil 1 according to the frequency required by the exciting field, and axially transmitting an alternating magnetic field with a specific frequency along the exciting coil 1;
step S102: constructing a second LC resonance circuit matched with the detection coil 2, so that the detection frequency is three times of the frequency of the alternating magnetic field;
step S103: detecting a secondary magnetic field generated by exciting magnetic nano particles by an alternating magnetic field by using a detection coil 2, and forming an induced voltage in the detection coil 2;
step S104: amplifying, filtering and displaying the induced voltage in real time by utilizing a voltage detection circuit;
step S105: simultaneously moving the exciting coil 1 and the detecting coil 2 to scan, excite and detect the detected object;
step S106: and determining the spatial distribution of the magnetic nano particles according to the amplitude of the detection voltage, wherein the larger the amplitude of the detection voltage is, the higher the concentration of the magnetic nano particles at the current position is.
The following describes in detail the implementation of the magnetic nanoparticle spatial positioning method provided by the present invention by a specific embodiment.
Example 1
Step S101: according to the required frequency of the exciting field, a first LC resonant circuit matched with the exciting coil 1 is constructed, and an alternating magnetic field with a specific frequency is emitted along the axial direction of the exciting coil 1.
After the frequency of the excitation magnetic field is determined, an LC resonant circuit matched with the excitation coil 1 is designed according to the impedance parameter of the excitation coil 1, so that the excitation coil 1 reaches a resonant state, and the working efficiency of the excitation coil 1 reaches the highest, namely the alternating magnetic field generated under the same excitation voltage is the strongest; the exciting coil 1 is supplied with power from an ac power source, and the exciting coil 1 generates an alternating magnetic field of a specific frequency in the axial direction, that is, a first resonance frequency of the exciting coil 1.
Step S102: a second LC resonance circuit matched with the detection coil 2 is constructed so that the detection frequency is three times the frequency of the alternating magnetic field.
The detection coil 2 also reaches a resonance state, so that the detection efficiency of the detection coil 2 on a magnetic field under the resonance frequency is highest; the detection coil 2 mainly detects a frequency tripling component in a secondary magnetic field generated by magnetic nanoparticles, wherein the frequency tripling refers to three times of the frequency of an excitation magnetic field; therefore, according to the impedance parameter of the detection coil 2, an LC resonant circuit matched with the detection coil 2 needs to be designed to make the detection coil 2 reach a resonant state, and the resonant frequency is three times of the frequency of the alternating magnetic field generated by the excitation coil 1.
Step S103: the detection coil 2 detects a secondary magnetic field generated by exciting magnetic nanoparticles with an alternating magnetic field, and an induced voltage is formed in the detection coil 2.
The magnetic nano particles are a superparamagnetic material, can generate stronger magnetization response under the excitation of an external magnetic field, and externally generate a secondary magnetic field; the secondary magnetic field is a primary magnetic field for distinguishing from the excitation magnetic field; when the secondary magnetic field magnetic induction line passes through the detection coil 2, an induced voltage is formed in the detection coil 2.
Step S104: and amplifying, filtering and displaying the induced voltage in real time by using a voltage detection circuit.
After the secondary magnetic field generates induced voltage in the detection coil 2, the induced voltage is transmitted to a voltage detection circuit through a lead, conventional amplification and filtering treatment are carried out on the induced voltage, and finally, the voltage value is displayed on a display screen in real time; the transmission and processing of the voltage is generally fast and easy to display in real time.
Step S105: and simultaneously, the exciting coil 1 and the detecting coil 2 are moved to scan, excite and detect the detected object.
The exciting coil 1 and the detecting coil 2 should be assembled into a scanning coil set, and the scanning coil set is moved mechanically or by hand to scan the object to be detected in real time, wherein the scanning process is a continuous exciting and detecting process, and the detected voltage value is displayed on the display in real time.
Step S106: and determining the spatial distribution of the magnetic nano particles according to the amplitude of the detection voltage, wherein the larger the amplitude of the detection voltage is, the higher the concentration of the magnetic nano particles at the current position is.
According to the Langiwan theory of magnetic nano particles, the concentration of the magnetic nano particle solution has a direct proportion relation with the detected induced voltage; in the process of scanning a measured object by using the scanning coil set, the induced voltage value can be changed, the voltage value at the position with high concentration of the magnetic nanoparticle solution can be larger, and the voltage value at the position without the magnetic nanoparticle is close to zero; the spatial position of the magnetic nano particles can be judged in real time by utilizing the principle, and the concentration of the magnetic nano particles can be quantitatively estimated.
The above-described embodiments are merely preferred embodiments of the present invention, and are not intended to limit the present invention in any way. Any person skilled in the art, using the disclosure above, may make many more possible variations and modifications of the technical solution of the present invention, or make many more modifications of the equivalent embodiments of the present invention without departing from the scope of the technical solution of the present invention. Therefore, all equivalent changes according to the inventive concept are covered by the protection scope of the invention without departing from the technical scheme of the invention.
Claims (3)
1. A magnetic nanoparticle spatial positioning method employing a magnetic nanoparticle spatial positioning device, the magnetic nanoparticle spatial positioning device comprising: excitation coil (1), detection coil (2), LC resonance circuit, alternating current power supply circuit and voltage detection circuit, its characterized in that:
the exciting coil (1) is an annular uniform multi-turn coil and is used for transmitting a high-frequency alternating magnetic field to an annular area;
the detection coil (2) is an annular uniform multi-turn coil and is used for detecting a secondary magnetic field generated by magnetic nano particles under the excitation of a high-frequency alternating magnetic field;
the LC resonance circuit comprises a first LC resonance circuit and a second LC resonance circuit, the first LC resonance circuit is connected with the excitation coil (1) to enable the excitation coil (1) to be in a resonance state, and the first LC resonance circuit is used for enabling the excitation coil (1) to generate a stronger alternating magnetic field with specific frequency, wherein the specific frequency is a first resonance frequency; the second LC resonance circuit is connected with the detection coil (2) to enable the detection coil (2) to be in a resonance state, and is used for enabling the detection coil (2) to detect a secondary magnetic field with a specific frequency generated by the magnetic nano particles more easily, wherein the specific frequency is a second resonance frequency; the second resonance frequency is three times of the first resonance frequency, namely the detection coil (2) mainly detects frequency tripled components in a secondary magnetic field generated by exciting magnetic nano particles by an alternating magnetic field, so that aliasing with the exciting magnetic field is avoided;
the alternating current power supply circuit is used for generating alternating voltage with specific frequency required by the exciting coil (1);
the voltage detection circuit is used for amplifying and filtering a voltage signal on the detection coil (2) and displaying a current detection voltage value;
the magnetic nanoparticle space positioning method comprises the following steps:
step S101: constructing a first LC resonant circuit matched with the exciting coil according to the frequency required by the exciting field, and transmitting an alternating magnetic field with a specific frequency along the axial direction of the exciting coil; the method comprises the following steps: after the frequency of the excitation magnetic field is determined, an LC resonant circuit matched with the excitation magnetic field is designed according to the impedance parameter of the excitation coil (1), so that the excitation coil (1) reaches a resonant state, and the working efficiency of the excitation coil (1) is maximized;
step S102: constructing a second LC resonance circuit matched with the detection coil (2) to enable the detection frequency to be three times of the frequency of the alternating magnetic field; the method comprises the following steps: according to the impedance parameter of the detection coil (2), an LC resonance circuit matched with the detection coil (2) is designed to enable the detection coil (2) to reach a resonance state;
step S103: detecting a secondary magnetic field generated by exciting magnetic nano particles by an alternating magnetic field by using the detection coil (2), and forming an induced voltage in the detection coil (2);
step S104: amplifying, filtering and displaying the induced voltage in real time by utilizing a voltage detection circuit;
step S105: simultaneously moving the exciting coil (1) and the detecting coil (2) to scan, excite and detect the detected object; the method comprises the following steps: assembling the exciting coil (1) and the detecting coil (2) into a scanning coil group, scanning a detected object in real time through mechanical movement or handheld movement of the scanning coil group, continuously exciting and detecting in the scanning process, and displaying the detected voltage value on a display in real time;
step S106: determining the spatial distribution of the magnetic nano particles according to the detection voltage amplitude, wherein the larger the detection voltage amplitude is, the higher the concentration of the magnetic nano particles at the current position is, the spatial position of the magnetic nano particles is judged in real time, and the concentration of the magnetic nano particles is quantitatively estimated;
the first resonant frequency is in the range of 10kHz to 100 kHz.
2. The method of claim 1, wherein the ac power circuit comprises a signal generation circuit and a power amplification circuit.
3. The method of spatial positioning of magnetic nanoparticles using a magnetic nanoparticle spatial positioning apparatus as recited in any one of claims 1 and 2, wherein the voltage detection circuit comprises a signal processing circuit and a voltage display circuit.
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