CN113791372A - Magnetic nanoparticle space positioning device and method - Google Patents
Magnetic nanoparticle space positioning device and method Download PDFInfo
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- CN113791372A CN113791372A CN202110941706.8A CN202110941706A CN113791372A CN 113791372 A CN113791372 A CN 113791372A CN 202110941706 A CN202110941706 A CN 202110941706A CN 113791372 A CN113791372 A CN 113791372A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
- G01R33/1276—Measuring magnetic properties of articles or specimens of solids or fluids of magnetic particles, e.g. imaging of magnetic nanoparticles
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
Abstract
A magnetic nanoparticle space positioning device and a method relate to the technical field of biomedical engineering, and the device comprises: excitation coil, detection coil, LC resonance circuit, alternating current power supply circuit and voltage detection circuit. The method comprises the following steps: the method comprises the steps of constructing a first LC resonance circuit matched with an exciting coil and a second LC resonance circuit matched with a detection coil, detecting a secondary magnetic field generated by excitation of magnetic nanoparticles by an alternating magnetic field by using the detection coil, amplifying, filtering and displaying induction voltage in real time by using a voltage detection circuit, and determining the spatial distribution of the magnetic nanoparticles according to the amplitude of the detection voltage. The magnetic nanoparticle space positioning device and method provided by the invention adopt a mode that the excitation coil and the detection coil are assembled into the scanning coil group, have a simple structure, are convenient to operate, and can realize real-time detection and voltage display.
Description
Technical Field
The invention relates to a magnetic nanoparticle space positioning device and a magnetic nanoparticle space positioning method, and belongs to the technical field of biomedical engineering.
Background
Magnetic nanoparticles, a nanoscale particle with superparamagnetism, have been widely studied and applied in recent years in the technical field of biomedical engineering, wherein accurate positioning and quantification of magnetic nanoparticles are key issues in the above applications.
The traditional magnetic nano particle positioning method needs to utilize a closed magnetic field scanner to scan and image an object to be detected. However, the enclosed magnetic field scanner is not convenient for interventional operation, and has long scanning imaging time and poor real-time performance.
Therefore, there is a need for a magnetic nanoparticle spatial positioning apparatus and method with faster imaging speed, simple structure and easy operation.
Disclosure of Invention
The invention aims to solve the problems that an imaging device in the prior art is closed, is inconvenient to perform interventional operation, is poor in real-time performance and the like, and provides a magnetic nanoparticle space positioning device and a magnetic nanoparticle space positioning method.
The technical scheme of the invention is as follows:
a magnetic nanoparticle spatial localization apparatus, comprising: excitation coil, detection coil, LC resonance circuit, alternating current power supply circuit and voltage detection circuit, the concrete structure is:
the excitation coil is an annular uniform multi-turn coil and is used for transmitting a high-frequency alternating magnetic field to an inner area of the ring;
the detection coil is an annular uniform multi-turn coil and is used for detecting a secondary magnetic field generated by the magnetic nanoparticles under the excitation of a high-frequency alternating magnetic field;
the LC resonance circuit comprises a first LC resonance circuit and a second LC resonance circuit, the first LC resonance circuit is connected with the exciting coil, so that the exciting coil is in a resonance state, and the first LC resonance circuit is used for enabling the exciting coil to generate a stronger alternating magnetic field with a specific frequency, and the specific frequency is a first resonance frequency; the second LC resonance circuit is connected with the detection coil, so that the detection coil is in a resonance state and is used for enabling the detection coil to more easily detect a secondary magnetic field with a specific frequency generated by the magnetic nanoparticles, wherein the specific frequency is a second resonance frequency;
the alternating current power supply circuit is used for generating alternating voltage with a specific frequency required by the exciting coil;
the voltage detection circuit is used for amplifying and filtering the voltage signal on the detection coil and displaying the current detection voltage value.
Preferably, the second resonance frequency is three times of the first resonance frequency, that is, the detection coil mainly detects a frequency-tripling component in a secondary magnetic field generated by excitation of the magnetic nanoparticles by the alternating magnetic field, thereby avoiding aliasing with the excitation magnetic field.
Preferably, the alternating current power supply circuit includes a signal generating circuit and a power amplifying circuit.
Preferably, the voltage detection circuit includes a signal processing circuit and a voltage display circuit.
Preferably, the first resonance frequency is in the range of 10kHz to 100 kHz.
A magnetic nanoparticle space positioning method comprises the following steps:
step S101: constructing a first LC resonance circuit matched with the exciting coil according to the frequency required by the exciting magnetic field, and transmitting an alternating magnetic field with a specific frequency along the axial direction of the exciting coil;
step S102: constructing a second LC resonance circuit matched with the detection coil so that the detection frequency is three times of the frequency of the alternating magnetic field;
step S103: detecting a secondary magnetic field generated by excitation of the magnetic nanoparticles by the alternating magnetic field by using the detection coil, and forming an induction voltage in the detection coil;
step S104: amplifying, filtering and displaying the induced voltage in real time by using a voltage detection circuit;
step S105: simultaneously moving the exciting coil and the detecting coil to scan, excite and detect the object to be detected;
step S106: and determining the spatial distribution of the magnetic nanoparticles according to the detection voltage amplitude, wherein the higher the detection voltage amplitude is, the higher the concentration of the magnetic nanoparticles at the current position is.
Preferably, the exciting coil and the detecting coil are assembled into a scanning coil group, the scanning coil group is moved in real time through mechanical movement or hand holding, the object to be detected is scanned, the scanning process is continuously excited and detected, and the detected voltage value is displayed on a display in real time.
Compared with the prior art, the magnetic nanoparticle space positioning device and the method have the advantages that:
1. the magnetic nanoparticle space positioning device and method provided by the invention adopt a mode that the excitation coil and the detection coil are assembled into the scanning coil group, have a simple structure, are convenient to operate, and can realize real-time detection and voltage display.
2. According to the magnetic nanoparticle space positioning device and method, in the process of scanning a measured object by using the scanning coil group, the induced voltage value can be changed, the position voltage value with high concentration of a magnetic nanoparticle solution can be larger, and the position voltage value without magnetic nanoparticles is close to zero; the spatial position of the magnetic nanoparticles can be quickly judged by utilizing the principle, and meanwhile, the concentration of the magnetic nanoparticles can be quantitatively estimated.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.
FIG. 1 is a schematic structural diagram of a magnetic nanoparticle spatial orientation device of the present invention;
FIG. 2 is a flow chart of a magnetic nanoparticle spatial localization method of the present invention;
description of the attached table designations:
1-excitation coil 2-detection coil
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the related invention are shown in the drawings.
The term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the term "at least one" herein means any one of a plurality or any combination of at least two of a plurality, for example, including at least one of A, B, C, and may mean including any one or more elements selected from the group consisting of A, B and C.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
The invention provides a magnetic nanoparticle space positioning device, the specific structure of which is shown in figure 1, and the device comprises: an excitation coil 1, a detection coil 2, an LC resonance circuit, an ac power supply circuit, and a voltage detection circuit.
The excitation coil 1 is an annular uniform multi-turn coil and is used for emitting a high-frequency alternating magnetic field to an intra-annular area, the intra-annular area not only comprises an area on the same horizontal plane as the excitation coil 1, but also comprises a three-dimensional area in the axial direction of the excitation coil 1, and the high-frequency alternating magnetic field generated by the excitation coil 1 is a primary magnetic field.
The detection coil 2 is an annular uniform multi-turn coil and is used for detecting a secondary magnetic field generated by the magnetic nanoparticles under the excitation of a high-frequency alternating magnetic field; the secondary magnetic field refers to a magnetic field generated after the magnetic nano particles are magnetized by an external magnetic field and is opposite to the primary magnetic field.
The LC resonance circuit comprises a first LC resonance circuit and a second LC resonance circuit, the first LC resonance circuit is connected with the exciting coil 1, so that the exciting coil 1 is in a resonance state and is used for enabling the exciting coil 1 to generate a stronger alternating magnetic field with a specific frequency, and the specific frequency is a first resonance frequency; the second LC resonance circuit is connected to the detection coil 2 to make the detection coil 2 in a resonance state, and is used for making the detection coil 2 more easily detect a secondary magnetic field of a specific frequency generated by the magnetic nanoparticles, wherein the specific frequency is a second resonance frequency; distinguishing the first resonance frequency from the second resonance frequency here means that the two resonance frequencies are different in magnitude; similarly, the first LC resonance circuit and the second LC resonance circuit are also different.
The alternating current power supply circuit comprises a signal generating circuit and a power amplifying circuit, and is used for generating alternating voltage with specific frequency required by the exciting coil 1; the specific frequency is generally in the range of 10kHz to 100 kHz.
The voltage detection circuit comprises a signal processing circuit and a voltage display circuit and is used for amplifying and filtering the voltage signal on the detection coil 2 and displaying the current detection voltage value;
preferably, the second resonance frequency is three times of the first resonance frequency, that is, the detection coil 2 mainly detects the triple frequency component in the secondary magnetic field generated by the excitation of the magnetic nanoparticles by the alternating magnetic field, thereby avoiding aliasing with the excitation magnetic field; the secondary magnetic field contains a plurality of frequency components, the frequency of the excitation magnetic field is the fundamental frequency of the secondary magnetic field, except for the fundamental frequency, the largest component in the secondary magnetic field generated by the magnetic nanoparticles is a triple frequency component, and the triple frequency refers to triple fundamental frequency.
The invention provides a magnetic nanoparticle space positioning method, the specific flow of which is shown in figure 2, and the method comprises the following steps:
step S101: according to the frequency required by the excitation magnetic field, a first LC resonance circuit matched with the excitation coil 1 is constructed, and an alternating magnetic field with a specific frequency is emitted along the axial direction of the excitation coil 1;
step S102: a second LC resonance circuit matched with the detection coil 2 is constructed so that the detection frequency is three times the frequency of the alternating magnetic field;
step S103: detecting a secondary magnetic field generated by excitation of the magnetic nanoparticles by the alternating magnetic field by using the detection coil 2, and forming an induced voltage in the detection coil 2;
step S104: amplifying, filtering and displaying the induced voltage in real time by using a voltage detection circuit;
step S105: simultaneously moving the exciting coil 1 and the detecting coil 2 to scan, excite and detect the object to be detected;
step S106: and determining the spatial distribution of the magnetic nanoparticles according to the detection voltage amplitude, wherein the higher the detection voltage amplitude is, the higher the concentration of the magnetic nanoparticles at the current position is.
The following is a detailed description of the specific implementation of the above-mentioned magnetic nanoparticle spatial localization method provided by the present invention with a specific embodiment.
Example 1
Step S101: according to the frequency required by the exciting magnetic field, a first LC resonance circuit matched with the exciting coil 1 is constructed, and an alternating magnetic field with a specific frequency is emitted along the axial direction of the exciting coil 1.
After the frequency of the excitation magnetic field is determined, an LC resonance circuit matched with the frequency is designed according to the impedance parameter of the excitation coil 1, so that the excitation coil 1 reaches a resonance state, the working efficiency of the excitation coil 1 reaches the highest, and the alternating magnetic field generated under the same excitation voltage is strongest; the exciting coil 1 is powered by an alternating current power supply, so that the exciting coil 1 generates an alternating magnetic field with a specific frequency along the axial direction, namely the first resonant frequency of the exciting coil 1.
Step S102: the second LC resonance circuit matched with the detection coil 2 is constructed so that the detection frequency is three times the frequency of the alternating magnetic field.
The detection coil 2 in the invention also needs to reach a resonance state, so that the detection efficiency of the detection coil 2 to the magnetic field under the resonance frequency is highest; the detection coil 2 mainly detects the triple frequency component in the secondary magnetic field generated by the magnetic nano particles, wherein the triple frequency is three times of the frequency of the excitation magnetic field; therefore, it is necessary to design an LC resonance circuit matching the detection coil 2 according to the impedance parameter of the detection coil 2 so that the detection coil 2 reaches a resonance state, the resonance frequency being three times the frequency of the alternating magnetic field generated by the excitation coil 1.
Step S103: the detection coil 2 detects a secondary magnetic field generated by excitation of the magnetic nanoparticles by the alternating magnetic field, and an induced voltage is formed in the detection coil 2.
The magnetic nano particles are a superparamagnetic material, can generate stronger magnetization response under the excitation of an external magnetic field, and generate a secondary magnetic field outwards; for the secondary magnetic field and the excitation magnetic field, the excitation magnetic field is a primary magnetic field; when the secondary magnetic field lines pass through the detection coil 2, an induced voltage is formed in the detection coil 2.
Step S104: and the voltage detection circuit is used for amplifying, filtering and displaying the induced voltage in real time.
After the secondary magnetic field generates induced voltage in the detection coil 2, the induced voltage is transmitted to a voltage detection circuit through a lead, the induced voltage is subjected to conventional amplification and filtering processing, and finally, a voltage value is displayed on a display screen in real time; the transmission and processing of the voltage is usually fast and easy to display in real time.
Step S105: and simultaneously moving the exciting coil 1 and the detecting coil 2 to scan, excite and detect the object to be detected.
The exciting coil 1 and the detecting coil 2 should be assembled into a scanning coil set, the scanning process is a continuous exciting and detecting process by mechanically moving or manually moving the scanning coil set to scan the measured object in real time, and the detected voltage value is displayed on the display in real time.
Step S106: and determining the spatial distribution of the magnetic nanoparticles according to the detection voltage amplitude, wherein the higher the detection voltage amplitude is, the higher the concentration of the magnetic nanoparticles at the current position is.
According to the Langmuim theory of magnetic nanoparticles, the concentration of the magnetic nanoparticle solution and the detected induced voltage have a direct proportional relationship; in the process of scanning the measured object by using the scanning coil group, the induced voltage value changes, the position voltage value with high concentration of the magnetic nano particle solution is larger, and the position voltage value without the magnetic nano particles is close to zero; by utilizing the principle, the spatial position of the magnetic nanoparticles can be judged in real time, and meanwhile, the concentration of the magnetic nanoparticles can be quantitatively estimated.
The above-described embodiments are merely preferred embodiments of the present invention, which is not intended to limit the present invention in any way. Those skilled in the art can make many changes, modifications, and equivalents to the embodiments of the invention without departing from the scope of the invention as set forth in the claims below. Therefore, equivalent variations made according to the idea of the present invention should be covered within the protection scope of the present invention without departing from the contents of the technical solution of the present invention.
Claims (7)
1. A magnetic nanoparticle spatial localization apparatus, comprising: excitation coil (1), detection coil (2), LC resonance circuit, alternating current power supply circuit and voltage detection circuit, its characterized in that:
the excitation coil (1) is an annular uniform multi-turn coil and is used for transmitting a high-frequency alternating magnetic field to an inner ring area;
the detection coil (2) is an annular uniform multi-turn coil and is used for detecting a secondary magnetic field generated by the magnetic nanoparticles under the excitation of a high-frequency alternating magnetic field;
the LC resonance circuit comprises a first LC resonance circuit and a second LC resonance circuit, the first LC resonance circuit is connected with the exciting coil (1), so that the exciting coil (1) is in a resonance state, and the first LC resonance circuit is used for enabling the exciting coil (1) to generate a stronger alternating magnetic field with a specific frequency, and the specific frequency is a first resonance frequency; the second LC resonance circuit is connected with the detection coil (2), so that the detection coil (2) is in a resonance state, and the second LC resonance circuit is used for enabling the detection coil (2) to detect a secondary magnetic field with a specific frequency generated by the magnetic nano particles more easily, wherein the specific frequency is a second resonance frequency;
the alternating current power supply circuit is used for generating alternating voltage with a specific frequency required by the exciting coil (1);
the voltage detection circuit is used for amplifying and filtering the voltage signal on the detection coil (2) and displaying the current detection voltage value.
2. The magnetic nanoparticle spatial localization device according to claim 1, wherein the second resonance frequency is three times the first resonance frequency, i.e. the detection coil (2) mainly detects the third harmonic component in the secondary magnetic field generated by excitation of magnetic nanoparticles by the alternating magnetic field, avoiding aliasing with the excitation magnetic field.
3. The magnetic nanoparticle spatial localization apparatus of any one of claims 1, 2, wherein the ac power supply circuit comprises a signal generation circuit and a power amplification circuit.
4. The magnetic nanoparticle spatial localization device of any one of claims 1 or 2, wherein the voltage detection circuit comprises a signal processing circuit and a voltage display circuit.
5. A magnetic nanoparticle spatial localization arrangement according to any one of claims 1 or 2, wherein the first resonant frequency is in the range 10kHz to 100 kHz.
6. A magnetic nanoparticle space orientation method using the magnetic nanoparticle space orientation device according to any one of claims 1 to 5, comprising the steps of:
step S101: according to the frequency required by the excitation magnetic field, a first LC resonance circuit matched with the excitation coil (1) is constructed, and an alternating magnetic field with a specific frequency is emitted along the axial direction of the excitation coil (1);
step S102: constructing a second LC resonance circuit matched with the detection coil (2) so that the detection frequency is three times of the frequency of the alternating magnetic field;
step S103: detecting a secondary magnetic field generated by exciting the magnetic nanoparticles by the alternating magnetic field by using the detection coil (2), and forming an induced voltage in the detection coil (2);
step S104: amplifying, filtering and displaying the induced voltage in real time by using a voltage detection circuit;
step S105: simultaneously moving the exciting coil (1) and the detecting coil (2) to scan, excite and detect the object to be detected;
step S106: and determining the spatial distribution of the magnetic nanoparticles according to the detection voltage amplitude, wherein the higher the detection voltage amplitude is, the higher the concentration of the magnetic nanoparticles at the current position is.
7. The magnetic nanoparticle spatial localization method according to claim 6, wherein the step S105 specifically comprises: and the excitation coil (1) and the detection coil (2) are assembled into a scanning coil group, the scanning coil group is mechanically moved or is moved by hands to scan the measured object in real time, the scanning process is continuously excited and detected, and the detected voltage value is displayed on a display in real time.
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