CN113767096A - 一种6-取代氨基苯并呋喃化合物的制备方法 - Google Patents

一种6-取代氨基苯并呋喃化合物的制备方法 Download PDF

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Publication number
CN113767096A
CN113767096A CN202080033176.0A CN202080033176A CN113767096A CN 113767096 A CN113767096 A CN 113767096A CN 202080033176 A CN202080033176 A CN 202080033176A CN 113767096 A CN113767096 A CN 113767096A
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compound
formula
aryl
alkyl
cycloalkyl
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CN113767096B (zh
Inventor
张浩宇
徐超
陆伟栋
邵启云
冯君
贺峰
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C07C63/10—Halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/70—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本公开提供一种6‑取代氨基苯并呋喃化合物的制备方法。具体而言，本公开提供一种式Ⅲ所示化合物的制备方法，本公开提供的方法，可以显著提高反应的收率，为工业生产提供可能。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN202080033176.0A 2019-05-10 2020-05-08 一种6-取代氨基苯并呋喃化合物的制备方法 Active CN113767096B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910387881X 2019-05-10
CN201910387881 2019-05-10
PCT/CN2020/089113 WO2020228591A1 (zh) 2019-05-10 2020-05-08 一种6-取代氨基苯并呋喃化合物的制备方法

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CN113767096A true CN113767096A (zh) 2021-12-07
CN113767096B CN113767096B (zh) 2022-11-22

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TW (1) TW202108578A (zh)
WO (1) WO2020228591A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114456156A (zh) * 2020-11-09 2022-05-10 江苏恒瑞医药股份有限公司 一种6-取代氨基苯并呋喃化合物的纯化方法
PE20240881A1 (es) * 2021-08-30 2024-04-24 Jiangsu Hengrui Pharmaceuticals Co Ltd Uso de un inhibidor de la ezh2 en la preparacion de farmacos para el tratamiento del linfoma de linfocitos t
AU2022365986A1 (en) * 2021-10-15 2024-05-09 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Method for preparing benzofuran derivative
WO2023244918A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. Quinolone bcl6 bifunctional degraders
WO2023244917A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. 1,8-naphthyridin-2-one heterobifunctional bcl6 degraders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017084494A1 (zh) * 2015-11-19 2017-05-26 江苏恒瑞医药股份有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用
WO2018210302A1 (zh) * 2017-05-18 2018-11-22 江苏恒瑞医药股份有限公司 一种苯并呋喃类衍生物游离碱的晶型及制备方法
WO2019091450A1 (zh) * 2017-11-10 2019-05-16 江苏恒瑞医药股份有限公司 一种苯并呋喃衍生物的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017084494A1 (zh) * 2015-11-19 2017-05-26 江苏恒瑞医药股份有限公司 苯并呋喃类衍生物、其制备方法及其在医药上的应用
WO2018210302A1 (zh) * 2017-05-18 2018-11-22 江苏恒瑞医药股份有限公司 一种苯并呋喃类衍生物游离碱的晶型及制备方法
WO2019091450A1 (zh) * 2017-11-10 2019-05-16 江苏恒瑞医药股份有限公司 一种苯并呋喃衍生物的制备方法

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CN113767096B (zh) 2022-11-22
TW202108578A (zh) 2021-03-01
WO2020228591A1 (zh) 2020-11-19

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