CN113750000A - Formula and preparation method of seal repairing skin care product - Google Patents

Formula and preparation method of seal repairing skin care product Download PDF

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Publication number
CN113750000A
CN113750000A CN202011462726.9A CN202011462726A CN113750000A CN 113750000 A CN113750000 A CN 113750000A CN 202011462726 A CN202011462726 A CN 202011462726A CN 113750000 A CN113750000 A CN 113750000A
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ceramide
stirring
water
skin
seal
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林殷瑜
梁小媚
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Guangzhou Yuanji Biological Technology Co ltd
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Guangzhou Yuanji Biological Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24Phosphorous; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

The invention discloses a seal repairing skin care product which is prepared from the following raw materials in percentage by weight: 78-87% of pure water, 2% of emulsifier, 10-25% of grease, 0.1-1% of allantoin, 5-10% of humectant, 0.5-5% of skin conditioner, 1.8% of thickener, 0.35% of preservative, 30.05-0.5% of ceramide, 0.5-2% of mung bean fermentation liquor, 0.5-10% of phytosterol ester, 0.05-0.5% of acetylated hyaluronic acid, 1% of VE, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium; the extraction process of the ceramide 3 comprises the following steps: fermentation and purification; the wrapping process comprises the following steps: the method comprises the steps of firstly, completely dissolving lecithin and cholesterol, pouring the lecithin and the cholesterol into a round-bottom flask, then adding water, EDTA sodium, disodium hydrogen phosphate and sodium dihydrogen phosphate, stirring until the lecithin and the cholesterol are completely dissolved, then starting a rotary evaporator, performing rotary evaporation until a dry film is formed, adding ceramide 3 and VE, mixing, finally adding a preservative, stirring until the mixture is uniform, and discharging. The invention has the effects of supplementing skin moisture, resisting allergy, calming skin, repairing and fading red on the face with skin inflammation, ulceration, allergy, dryness and sensitive red blood silk.

Description

Formula and preparation method of seal repairing skin care product
Technical Field
The invention relates to the technical field of skin care products, in particular to a formula of a sealing layer repairing skin care product, and especially relates to a formula of a sealing layer repairing skin care product and a preparation method thereof.
Background
With the development of science and technology and the pursuit of obvious visible beauty effects, photoelectric instruments or medical minimally invasive projects which can enable active ingredients to enter deep layers of skin more and more appear on the market. These products are quick to take effect, much more effective than the application products, but easily cause skin damage, and basically need to face the problems of dryness, sensitivity, facial damage and the like in the recovery period after the consumers use the products or the items. Therefore, under the present circumstances, there is a need to develop a product capable of relieving the pressure of minimally invasive damaged skin and accelerating skin self-repair, so as to reduce the burden of consumers in using instruments and minimally invasive procedures for beauty treatment.
The sebum membrane, as the outermost layer structure of the skin system, has two functions of moistening skin and natural barrier. The sebaceous membrane can secrete grease and keratinocyte required by the epidermal skin through sebaceous glands, and moisten the skin of a human body. The sebum membrane can also prevent skin moisture from evaporating, and make the skin moisture content at a stable value. The free fatty acid contained in the sebum membrane inhibits the growth of pathogenic microorganisms, and thus, it provides the skin with a self-cleansing function while acting as a skin barrier to prevent the entry of harmful substances from the outside into the skin layer. Therefore, when the sebum membrane is damaged, the skin loses the self-protection ability, and the skin is easy to have the phenomena of dryness, water shortage, red swelling, itching, allergy, red blood streak increase and the like under the unprepared state.
In the sebum membrane, 40% -50% of sebum is composed of ceramide, and the ceramide is phospholipid with ceramide as skeleton, so that the ceramide has the effects of directly repairing the sebum membrane so as to moisten the skin and repair skin barriers. Although the ceramide has an outstanding effect of repairing skin lipid membranes, the ceramide has the limitation of being difficult to dissolve when applied to skin care products. This limitation not only increases the difficulty of manufacture, but also affects the normal absorption of components by the skin and weakens the effect of ceramide.
Therefore, in order to break through the problem that the skin is difficult to absorb due to difficult dissolution, the invention prepares 3 dosage forms of solutions by changing the extraction method of ceramide and adding a liposome coating technology in the reproduction process, and only solves the problems of dryness, sensitivity and wound surface caused by temporary loss of the skin lipid membrane of the wound skin. It is desirable to alleviate the skin burden of more people after applying the new cosmetic approach with this solution.
Disclosure of Invention
On one hand, the technical problem to be solved by the invention is to provide a formula of a seal repairing skin care product, solve the technical problem of temporary loss of skin lipid membrane of wound skin by the skin care product in the prior art, and achieve the technical effects of improving the absorption efficiency of the repairing skin care product and repairing skin.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a formula of a seal skin care product is prepared from the following raw materials in percentage by weight:
78-87% of pure water, 2% of emulsifier, 10-25% of grease, 0.1-1% of allantoin, 5-10% of humectant, 0.5-5% of skin conditioner, 1.8% of thickener, 0.35% of preservative, 30.05-0.5% of ceramide, 0.5-2% of mung bean fermentation liquor, 0.5-10% of phytosterol ester, 0.05-0.5% of acetylated hyaluronic acid, 1% of VE, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium;
the ceramide 3 is obtained by an extraction process, and the extraction process comprises the following steps: firstly obtaining fermentation flora from rice, then husking sorghum, fumigating sorghum at high temperature, adding the fermentation flora for fermentation, wherein the fermentation temperature and the fermentation humidity are respectively 37 ℃ and 65%, breaking the wall, filtering and purifying to obtain ceramide 3;
the ceramide 3 is further processed by a coating process, and the coating process comprises the following steps: the method comprises the steps of firstly, completely dissolving lecithin and cholesterol, pouring the lecithin and the cholesterol into a round-bottom flask, then adding water, EDTA sodium, disodium hydrogen phosphate and sodium dihydrogen phosphate, stirring until the lecithin and the cholesterol are completely dissolved, then starting a rotary evaporator, performing rotary evaporation until a dry film is formed, adding ceramide 3 and VE, mixing, finally adding a preservative, stirring until the mixture is uniform, and discharging.
Preferably, the material is prepared from the following raw materials in percentage by weight:
78-87% of pure water, 0.05-0.5% of allantoin, 10% of humectant, 3-10% of skin conditioner, 0.2-0.4% of thickener, 0.35% of preservative, 30.1-1% of ceramide, 0.5-2% of mung bean fermentation liquor, VE 1%, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium.
More preferably, the composition is prepared from the following raw materials in percentage by weight:
78-87% of pure water, 0.1-1% of allantoin, 0.5-5% of skin conditioner, 0.35% of preservative, 30.05-0.5% of ceramide, 0.5-2% of mung bean fermentation liquor, 0.5-10% of phytosterol ester, 1% of VE, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium.
On the other hand, the invention aims to solve the problem of providing the seal repairing spray essence water, the seal repairing facial mask and the seal repairing facial cream respectively, which are prepared by the seal repairing skin care product formula.
The invention also aims to solve the problem of providing a preparation method of the spray essence water, which comprises the following steps:
(S01) heating and stirring: adding deionized water, glycerol and butanediol into a water kettle, heating to 90 ℃, stirring and keeping the temperature constant for 30 minutes;
(S02) cooling for the first time: cooling to 60 deg.C, adding radix Hamamelis mollis extractive solution, flos Matricariae Chamomillae water, allantoin and dolichol;
(S03) cooling again, stirring and discharging: cooling to 45 ℃, adding ceramide 3, mung bean fermentation liquor, acetylated sodium hyaluronate and preservative, uniformly stirring, and discharging into a clean container.
The invention also aims to solve the problem of providing a preparation method of the repair mask, which comprises the following steps:
(S01) heating and stirring: adding deionized water, glycerol, carbomer and betaine into a water kettle, heating to 90 ℃, stirring and keeping the temperature for 30 minutes;
(S02) cooling for the first time: cooling to 60 deg.C, adding flos Matricariae Chamomillae water, allantoin and dolol;
(S03) cooling again, stirring and discharging: cooling to 45 ℃, adding ceramide 3, mung bean fermentation liquor, acetylated sodium hyaluronate, preservative and triethanolamine, uniformly stirring, and discharging into a clean container.
The invention also aims to solve the problem of providing a preparation method of the seal repairing cream, which comprises the following steps:
(S1) heating the oil phase pan: putting palmitoyl hydrolyzed wheat protein potassium, cetostearyl alcohol, glyceryl stearate, PEG-100 stearate, phytosterol ester, hydrogenated palm oil, oleum Aesculi and cetyl alcohol into an oil phase pot, heating to 75 ℃, and keeping the temperature for 30 minutes;
(S2) heating the water phase pot: adding glycerol, betaine, allantoin and carbomer into a water phase pot, stirring with the water pot, stirring to dissolve completely, mixing well, heating to 85 deg.C, and holding for 30 min;
(S3) emulsifying pot feeding: opening the vacuum of an emulsifying pot to-0.05 MPa, pumping 1/3 aqueous phase materials into the emulsifying pot, pumping the aqueous phase materials, pumping the materials in the emulsifying pot while stirring at the rotating speed of 800r/min, pumping the remaining aqueous phase materials into the emulsifying pot after pumping the oil phase materials;
(S4) mixing: after the two phases are mixed, stirring continuously, heating to 85 ℃, keeping the average value at 5 minutes and rotating speed at 3000r/min under a vacuum state, keeping the temperature for 20 minutes, and cooling to 50 ℃;
(S5) discharging in vacuum: adding ceramide 3, semen Phaseoli Radiati fermentation liquid, jellyfish extract, acetylated sodium hyaluronate, triethanolamine and phenoxyethanol under vacuum, stirring, cooling to 40 deg.C, and discharging to clean container.
One or more technical solutions provided by the present application have at least the following technical effects or advantages:
according to the technical scheme, the adopted raw materials comprise ceramide 3, and the ceramide 3 is obtained through an extraction process, wherein the extraction process comprises the following steps: firstly obtaining fermentation flora from rice, then husking sorghum, fumigating sorghum at high temperature, adding the fermentation flora for fermentation, wherein the fermentation temperature and the fermentation humidity are respectively 37 ℃ and 65%, breaking the wall, filtering and purifying to obtain ceramide 3; in addition, the ceramide 3 is also processed by a coating process, and the coating process comprises the following steps: the method comprises the steps of firstly, completely dissolving lecithin and cholesterol, pouring the lecithin and the cholesterol into a round-bottom flask, then adding water, EDTA sodium, disodium hydrogen phosphate and sodium dihydrogen phosphate, stirring until the lecithin and the cholesterol are completely dissolved, then starting a rotary evaporator, performing rotary evaporation until a dry film is formed, adding ceramide 3 and VE, mixing, finally adding a preservative, stirring until the mixture is uniform, and discharging. Meanwhile, the problem that high-purity ceramide is not easy to dissolve in water and is not beneficial to skin absorption is solved through a packaging process, and the product plays a role of serving as a human body sebum membrane. The important raw material ceramide 3 in the formula is fermented and extracted by sorghum, and is easy to absorb by a human body. The technical problems of insufficient absorption effect of the skin care product and temporary loss of a skin lipid membrane of wound skin in the prior art are effectively solved, and the technical effects of improving the absorption efficiency of the skin care product and effectively repairing the skin are further realized.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
According to the technical scheme of the embodiment of the application, the problem of insufficient absorption effect of the skin care product in the prior art is solved by providing the formula of the seal skin care product, and the beneficial effect of improving the absorption efficiency of the skin care product is realized under the conditions that the skin care product is obtained by an amide 3 through a sorghum extraction process and is treated by a wrapping process.
The general idea of the embodiment of the invention for solving the technical problems is as follows:
the following raw materials are adopted:
78-87% of pure water, 2% of emulsifier, 10-25% of grease, 0.1-1% of allantoin, 5-10% of humectant, 0.5-5% of skin conditioner, 1.8% of thickener, 0.35% of preservative, 30.05-0.5% of ceramide, 0.5-2% of mung bean fermentation liquor, 0.5-10% of phytosterol ester, 0.05-0.5% of acetylated hyaluronic acid, 1% of VE, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium;
wherein, ceramide 3 is obtained by an extraction process, which comprises the following steps: firstly obtaining fermentation flora from rice, then husking sorghum, fumigating sorghum at high temperature, adding the fermentation flora for fermentation, wherein the fermentation temperature and the fermentation humidity are respectively 37 ℃ and 65%, breaking the wall, filtering and purifying to obtain ceramide 3; in addition, the ceramide 3 is also processed by a coating process, and the coating process comprises the following steps: the method comprises the steps of firstly, completely dissolving lecithin and cholesterol, pouring the lecithin and the cholesterol into a round-bottom flask, then adding water, EDTA sodium, disodium hydrogen phosphate and sodium dihydrogen phosphate, stirring until the lecithin and the cholesterol are completely dissolved, then starting a rotary evaporator, performing rotary evaporation until a dry film is formed, adding ceramide 3 and VE, mixing, finally adding a preservative, stirring until the mixture is uniform, and discharging. Meanwhile, the problem that high-purity ceramide is not easy to dissolve in water and is not beneficial to skin absorption is solved through a packaging process, and the product plays a role of serving as a human body sebum membrane. The important raw material ceramide 3 in the formula is fermented and extracted by sorghum, and is easy to absorb by a human body.
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments.
Example 1
Ceramide 3 is prepared from the following starting materials
62.21 percent of pure water, 350 percent of ceramide, 5 percent of lecithin, 0.14 percent of cholesterol, 1 percent of VE, 0.8 percent of disodium hydrogen phosphate, 0.3 percent of sodium dihydrogen phosphate, 0.35 percent of phenoxyethanol and 0.2 percent of EDTA sodium
The packaging process comprises the following steps: lecithin and cholesterol are completely dissolved and poured into a round-bottom flask, and then water, EDTA sodium, disodium hydrogen phosphate and sodium dihydrogen phosphate are added and stirred until the lecithin and the cholesterol are completely dissolved. Starting a rotary evaporator, enabling the water temperature to be 37 degrees, rotating at the speed of 30r/min, and starting rotary evaporation until a dry film is formed. Adding ceramide 3.VE average value for 20 minutes, rotating speed of 12500r/min, finally adding preservative, stirring uniformly, and discharging.
Wherein, the steps of fermentation and purification of extracting ceramide 3 from sorghum are as follows:
1) we found a flora A in rice
2) Husking the outermost layer of sorghum
3) Then fumigating at high temperature, adding strain A, fermenting at 37 deg.C and humidity of 65%
4) High-speed shearing wall breaking process
5) Filtering the filtrate
The following example used ceramide 3 to prepare ceramide 3 by the method of experiment 1.
Example 2
The preparation method of the spray essence water comprises the following steps:
raw materials:
ceramide 30.1%, semen Phaseoli Radiati fermentation liquid 0.5%, allantoin 0.2%, acetylated hyaluronic acid 0.1%, pure water 81.75%, butanediol 3.0%, glycerol 3.0%, betaine 2%, antiseptic (phenoxyethanol) 0.35%, skin conditioner (flos Rosae Davuricae extract) 4.0% and flos Matricariae Chamomillae water 5.02%
The preparation process comprises the following steps: adding deionized water, glycerol and butanediol into a water kettle, heating to 90 ℃, stirring and keeping the temperature for 30 minutes. Cooling to 60 deg.C, adding radix Hamamelis mollis extractive solution, flos Matricariae Chamomillae water, and allantoin, cooling to 45 deg.C, adding ceramide 3, semen Phaseoli Radiati fermentation broth, acetylated sodium hyaluronate, and antiseptic. Discharging the mixture into a clean container after uniformly stirring.
Example 3
The preparation method of the spray essence water comprises the following steps:
raw materials:
ceramide 30.3%, semen Phaseoli Radiati fermentation liquid 2%, allantoin 0.5%, acetylated hyaluronic acid 0.35%, pure water 81%, butanediol 3.0%, glycerol 3.0%, dolol 0.5%, antiseptic (phenoxyethanol) 0.35%, skin conditioner (flos Rosae Davuricae extract) 4.0% and flos Matricariae Chamomillae water 5.0%
The preparation process comprises the following steps: as described in example 2.
Example 4
The preparation method of the spray essence water comprises the following steps:
raw materials:
31 percent of ceramide, 2 percent of mung bean fermentation liquor, 0.5 percent of allantoin, 1 percent of acetylated hyaluronic acid, 79.65 percent of pure water, 3.0 percent of butanediol, 3.0 percent of glycerol, 0.5 percent of dolol, 0.35 percent of preservative (phenoxyethanol), 4.0 percent of skin conditioner (Jinlumei extract) and 5.0 percent of biological sugar gum
The preparation process comprises the following steps: as described in example 2.
Example 5
The preparation method of the repair mask comprises the following steps:
raw materials:
ceramide 30.2%, mung bean fermentation liquor 0.5%, acetylated sodium hyaluronate 0.3%, allantoin 0.15%, pure water 87.9%, humectant 3.0%, glycerin 4%, betaine 2%, allantoin 0.2%, preservative 0.35%, cellulose 0.2%, chamomile water 4% and dolac 0.5%
The preparation process comprises the following steps: adding deionized water, glycerol, cellulose and betaine into a water kettle, heating to 90 ℃, stirring and keeping the temperature for 30 minutes. Cooling to 60 deg.C, adding flos Matricariae Chamomillae water, allantoin, and dolol, cooling to 45 deg.C, adding ceramide 3, semen Phaseoli Radiati fermentation broth, acetylated sodium hyaluronate, and antiseptic, stirring, and discharging into a clean container.
Example 6
The preparation method of the repair mask comprises the following steps:
raw materials:
30.6 percent of ceramide, 0.5 percent of mung bean fermentation liquor, 0.15 percent of allantoin, 87.9 percent of pure water, 3.0 percent of humectant, 4 percent of glycerin, 2 percent of betaine, 0.2 percent of allantoin, 0.35 percent of preservative, 0.2 percent of carbomer, 4 percent of chamomile flower water, 0.5 percent of ducanol and 0.2 percent of triethanolamine.
The preparation process comprises the following steps: adding deionized water, glycerol, carbomer and betaine into a water kettle, heating to 90 deg.C, stirring, and holding at constant temperature for 30 min. Cooling to 60 deg.C, adding flos Matricariae Chamomillae water, allantoin, and dolol, cooling to 45 deg.C, adding ceramide 3, semen Phaseoli Radiati fermentation broth, acetylated sodium hyaluronate, antiseptic, and triethanolamine, stirring, and discharging into clean container.
Example 7
The preparation method of the repair mask comprises the following steps:
raw materials:
31 percent of ceramide, 0.5 percent of mung bean fermentation liquor, 0.15 percent of allantoin, 87.9 percent of pure water, 3.0 percent of humectant, 4 percent of glycerol, 2 percent of betaine, 0.2 percent of allantoin, 0.35 percent of preservative, 0.2 percent of phenoxyethanol, 4 percent of chamomile flower water, 0.5 percent of dolantin and 0.2 percent of triethanolamine
The preparation process comprises the following steps: adding deionized water, glycerol, carbomer and betaine into a water kettle, heating to 90 deg.C, stirring, and holding at constant temperature for 30 min. Cooling to 60 deg.C, adding flos Matricariae Chamomillae water, allantoin, and dolol, cooling to 45 deg.C, adding ceramide 3, semen Phaseoli Radiati fermentation broth, acetylated sodium hyaluronate, antiseptic, and triethanolamine, stirring, and discharging into clean container.
Example 8
The preparation method of the repair seal cream comprises the following steps:
raw materials:
pure water 69.85%, emulsifier (potassium palmitoyl hydrolyzed wheat protein/cetostearyl alcohol/glyceryl stearate): 2% PEG-100 stearate 1.5%, oil (propylene glycol dicaprylate/dicaprate): 3 percent of malus asiatica, 3 percent of shea butter, 2 percent of phytosterol ester, 3 percent of hydrogenated palm oil, 4 percent of seed fat of buckeye double (SHORA STENOPTERA), 4 percent of glycerin, 2 percent of betaine, 0.2 percent of allantoin, 0.2 percent of carbomer, 2.0 percent of cetyl alcohol, 0.35 percent of phenoxyethanol, 0.2 percent of triethanolamine, 31 percent of ceramide, 0.5 percent of mung bean fermentation liquor, 1 percent of jellyfish extract and 0.2 percent of acetylated sodium hyaluronate.
The preparation process comprises the following steps:
the palmitoylated hydrolysed wheat protein potassium/cetostearyl alcohol/glyceryl stearate, PEG-100 stearate,: adding propylene glycol dicaprylate/dicaprate, phytosterol ester, hydrogenated palm oil, and cetyl alcohol into oil phase pot, and heating to 75 deg.C. Keeping the temperature for 30 minutes, adding glycerol, betaine, allantoin and carbomer into a water phase pot, starting the water pot, stirring until the glycerol, the betaine, the allantoin and the carbomer are completely dissolved and uniformly mixed, heating to 85 ℃, and keeping the temperature for 30 minutes. And (3) starting the vacuum of the emulsifying pot to be-0.05 MPa, pumping 1/3 aqueous phase materials into the emulsifying pot, pumping the oil phase materials, stirring the emulsifying pot while changing the pumping speed to 800r/min, and pumping the remaining aqueous phase materials into the emulsifying pot after the oil phase materials are pumped. After the two phases are mixed, stirring is carried out continuously, the temperature is increased to 85 ℃, the average value is 5 minutes under a vacuum state, the rotating speed is 3000r/min, the temperature is kept for 20 minutes, and the temperature is reduced to 50 ℃. Adding ceramide 3, semen Phaseoli Radiati fermentation liquid, jellyfish extract, acetylated sodium hyaluronate, triethanolamine and phenoxyethanol under vacuum, stirring, cooling to 40 deg.C, and discharging to clean container.
Example 9
The preparation method of the repair seal cream comprises the following steps:
raw materials:
purified water 67.55%, emulsifier (potassium palmitoylated hydrolyzed wheat protein/cetostearyl alcohol/glyceryl stearate): 2%, PEG-100 stearate 1.5%, fats and oils (propylene glycol dicaprylate/dicaprate): 3%, coco-caprylate/caprate 3%, phytosterol ester 2%, pentaerythritol tetra (ethyl hexanoate) 3%, cetyl dimethicone 4%, glycerin 4%, betaine 2%, allantoin 0.2%, xanthan gum 0.2%, cetyl alcohol 2.0%, phenoxyethanol 0.35%, ceramide 32%, mung bean fermentation broth 0.5%, rhamnose 2%, zonulin 0.5%, and sodium hyaluronate 0.2%.
The preparation process comprises the following steps:
the palmitoylated hydrolysed wheat protein potassium/cetostearyl alcohol/glyceryl stearate, PEG-100 stearate,: propylene glycol dicaprylate/dicaprate, phytosterol ester, cetyl dimethicone, coco-caprylate/caprate, pentaerythritol tetra (ethyl hexanoate), cetyl alcohol were put into the oil phase pan and warmed to 75 ℃. Keeping the temperature for 30 minutes, adding glycerol, betaine, allantoin and xanthan gum into a water phase pot, starting a water pot, stirring until the glycerol, the betaine, the allantoin and the xanthan gum are completely dissolved and uniformly mixed, heating to 85 ℃, and keeping the temperature for 30 minutes. And (3) starting the vacuum of the emulsifying pot to be-0.05 MPa, pumping 1/3 aqueous phase materials into the emulsifying pot, pumping the oil phase materials, stirring the emulsifying pot while changing the pumping speed to 800r/min, and pumping the remaining aqueous phase materials into the emulsifying pot after the oil phase materials are pumped. After the two phases are mixed, stirring is carried out continuously, the temperature is increased to 85 ℃, the average value is 5 minutes under a vacuum state, the rotating speed is 3000r/min, the temperature is kept for 20 minutes, and the temperature is reduced to 50 ℃. Adding ceramide 3, semen Phaseoli Radiati fermentation broth, rhamnose, acetylated sodium hyaluronate, fibronectin and phenoxyethanol under vacuum, stirring, cooling to 40 deg.C, and discharging to clean container.
Example 10
The preparation method of the repair seal cream comprises the following steps:
raw materials:
purified water 59.45%, emulsifier (potassium palmitoylated hydrolyzed wheat protein/cetostearyl alcohol/glyceryl stearate): 2%, PEG-100 stearate 1.5%, grease: olive oil 3%, linseed oil 3%, phytosterol ester 5%, sweet almond oil 3%, cetyl polydimethylsiloxane 4%, glycerin 4%, rice fermentation liquor 5%, allantoin 0.2%, xanthan gum 0.2%, cetyl alcohol 2.0%, preservative (phenoxyethanol): 0.35%, tocopherol (vitamin E) 0.8%, ceramide 32%, mung bean fermentation liquor 0.5%, rhamnose 2%, trazonic 1.0% and acetylated sodium hyaluronate 1%
The preparation process comprises the following steps:
the palmitoylated hydrolysed wheat protein potassium/cetostearyl alcohol/glyceryl stearate, PEG-100 stearate,: propylene glycol dicaprylate/dicaprate, phytosterol ester, cetyl dimethicone, coco-caprylate/caprate, pentaerythritol tetra (ethyl hexanoate), cetyl alcohol were put into the oil phase pan and warmed to 75 ℃. Keeping the temperature for 30 minutes, adding glycerol, rice fermentation liquor, allantoin and xanthan gum into a water phase pot, starting the water pot to stir, stirring until the materials are completely dissolved and uniformly mixed, heating to 85 ℃, and keeping the temperature for 30 minutes. And (3) starting the vacuum of the emulsifying pot to be-0.05 MPa, pumping 1/3 aqueous phase materials into the emulsifying pot, pumping the oil phase materials, stirring the emulsifying pot while changing the pumping speed to 800r/min, and pumping the remaining aqueous phase materials into the emulsifying pot after the oil phase materials are pumped. After the two phases are mixed, stirring is carried out continuously, the temperature is increased to 85 ℃, the average value is 5 minutes under a vacuum state, the rotating speed is 3000r/min, the temperature is kept for 20 minutes, and the temperature is reduced to 50 ℃. Adding ceramide 3, semen Phaseoli Radiati fermentation broth, rhamnose, acetylated sodium hyaluronate, fibronectin and phenoxyethanol under vacuum, stirring, cooling to 40 deg.C, and discharging to clean container.
Test part:
3 sets of experiments were performed on the above 9 formulations and dosage forms to verify the effect.
1. Test specimen
(1) Seal repair spray 1 prepared in example 2 above
(2) Seal repair spray 2 prepared in example 3 above
(3) Seal repair spray 3 prepared in example 4 above
(4) Sealing repair mask 1 prepared in example 5 above
(5) Sealing repair mask 2 prepared in example 6 above
(6) Sealing repair mask 3 prepared in example 7 above
(7) Seal repairing cream 1 prepared in example 8 above
(8) Seal repair cream 2 prepared in example 9 above
(9) Seal repair cream 3 prepared in example 10 above
(10) Reference sample 9% physiological saline
(11) Vaseline as reference sample
2. Test object
90 persons with sensitive skin between 20 and 40 years old were selected and randomly divided into groups A, B and C. Each group has 30 people, and the people are respectively used as trial population of the three dosage form examples of spraying, facial mask and frost body.
3. Test method
a.A groups of testers applied test samples (1) (2) (3) and reference sample (10) to the upper and lower parts of the cheeks daily after cleansing the face in the morning and evening; the test samples (4) (5) (6) and the reference sample (10) were applied to the upper and lower cheek areas of the test subjects daily after cleansing the face in the morning and evening; group C testers applied test samples (7) (8) (9) and reference sample (10/11) to the upper and lower cheek areas daily after cleansing the face in the morning and evening
b. The test area was tested and the initial data at T0 (before use of the product) was recorded using a moisturmeter SC instrument, a VISIA generation 6 instrument, a skin microscopy analysis system (VisioScan VC 98). The subjects continued to use the samples for 28 consecutive days as required, and repeated the test procedure of T0 with a revisit test at T7, T14, and T28 days after use.
The test dimensions are as follows:
1) skin moisture measured by MoistureMeter SC instrument
2) Skin sensitivity measured by VISIA 6 th generation instrument
3) Skin wound degree measured by Visioscan VC98
1. Analysis of water content of horny layer: the skin water wettability is measured by an electrochemical principle indirect measurement method through a MoistureMeter SC detector, and the higher the numerical value is, the higher the skin water wettability is represented by data analysis of the moisture content of the tested stratum corneum.
2. Skin sensitivity analysis: a VISIA 6 th generation instrument is used for detecting and passing through three light sources of white light, ultraviolet light and polarized light, scanning the surface layer and the deep layer of the skin and observing whether the skin in a red area has related data of telangiectasia, wherein the larger the numerical value is, the thinner and more sensitive the skin is.
3. Skin wound degree analysis: the skin microscope analysis system (Visioscan VC98) collects images of local skin, and utilizes system software to analyze data of area proportion of skin damage degree (damage and inflammation), and the smaller the numerical value (SESM value), the smaller the skin damage proportion is, which indicates that the skin repair degree is higher.
4. Test results
TABLE 1 skin Change test results for group A test samples 1-3 and control 10
Figure RE-GDA0003008006740000091
Table 2: skin Change test results for group B test samples 4-6 and control 10
Figure RE-GDA0003008006740000101
Table 3: skin Change test results for group C test samples 7-9 and control 11
Figure RE-GDA0003008006740000111
After 30 days of test effect observation, the test effect of the group A is compared with that of the group A shown in the table 1; the test effect of the group B is shown in the table 2; the test effect comparison of group C is shown in Table 3. The data show that the preparation of the invention can effectively improve the skin from three latitude of water wettability, sensitivity and wound degree compared with a reference sample. The skin moisture degree is improved obviously, the best effect period is embodied between T0min and T7 days, and the average change rate of the three product forms is 44.75 percent respectively; 47.91 percent; 46.81% exhibited nearly one-fold moisturizing effect.
The seal repairing spray essence product has a superior effect on reducing sensitivity compared with other two forms, and the data show that the sensitivity value is in a descending trend after the product is used, the sensitivity is reduced to 38.95 percent, and the reduction range is larger than that of a mask formulation 24.68 percent and that of a cream formulation 37.51 percent. In the spray formulation, test sample 3 was the most effective, specifically represented by an increase in water retention of 188.01%, a sensitivity repair ratio of 47.18%, and 27.99% better than test samples 1&2 for wound repair.
The seal repairing mask product has a superior effect on wound repair compared with the other two forms, and the data show that the wound area is in a descending trend after the product is used, the wound area is reduced to 42.23 percent, and the reduction range is larger than that of 28.65 percent of spray formulation and 39.88 percent of cream formulation. In the mask formulation, test sample 3 was the most effective, specifically represented by an increase in moisture of 195.37%, a sensitivity repair ratio of 27.41%, and 47.14% better than test samples 1&2 for wound repair.
Compared with the other two forms, the sealing repair cream product has the strongest comprehensive capability, and the data shows that the wound area is in a descending trend after the product is used, the water wettability is improved by 222.82 percent, the sensitivity is reduced by 37.51 percent, the wound reduction rate is 39.88 percent, and the sealing repair cream product is close to a spray formulation with strong sensitive repair and a mask formulation with strong wound repair. In the cream form, test sample 3 was the most effective, specifically shown by an 238.69% increase in hydration with a sensitive repair ratio of 46.11% and 45.69% better than test samples 1&2 for wound repair.
From the test results in tables 1, 2 and 3, it can be known that when the specific weight percentage of the wrapped ceramide in the seal repairing product is gradually increased, the effects of moistening, repairing and sensitizing skin and repairing skin wounds are further obviously improved.
Most remarkably, when the proportion of the coating with 50% of ceramide content in the whole seal repairing system is 2%, the most comprehensive repairing effect of the fragile skin can be obtained.
And (3) displaying the repairing cases:
case one: the length of restoration is 2 weeks, daily use seal repair spraying essence collocation three times a week seal repair facial mask: the water wettability is improved by 196.6 percent; the sensitivity is reduced by 25.33%; the restoration degree is 22.1%, and the slight red spots on the face of the testee are completely eliminated.
Case two: the repair time is 3 weeks, and the seal repair spray is used daily: the water wettability is improved by 162.37%; sensitivity was reduced 38.29%; the restoration degree is 10.8%, and the slight red spots on the face of the testee are completely eliminated.
Case three: long 3 half months when restoreing, use the seal in earlier stage and repair cream No. 3, the later stage begins to match every week 4 times the seal and restores facial mask No. 3 and use the seal at any time and restore spraying essence No. 3: the water wettability is improved by 218.56 percent; the sensitivity is reduced by 32.14%; the degree of repair was 43.30%, and the red inflammation on the face of the test subjects was eliminated.
According to the technical scheme, the raw material ceramide can be fermented and extracted through sorghum in the preparation technology, and the ceramide is easy to absorb by a human body. Meanwhile, the problem that high-purity ceramide is not easy to dissolve in water and is not beneficial to skin absorption is solved through a special packaging technology, the product can play a role of temporarily serving as a human body sebum membrane, and subsequent troubles are reduced after more people use minimally invasive and medical and aesthetic projects. The skin care product is prepared by adding ceramide 3, rice fermentation broth, mung bean fermentation broth and allantoin into the formula, repairing skin lipid membrane, adding phytosterol ester seal layer to isolate external pollution, and moistening skin. The skin care product has effects of supplementing skin moisture, anti-allergy calming skin, repairing and removing red skin, and has three general functions aiming at skin inflammation, ulceration, allergic face, allergic dryness and sensitive red blood silk face.
The embodiments of the present invention have been described in detail, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.

Claims (9)

1. The formula of the seal repairing skin care product is characterized in that: the material is prepared from the following raw materials in percentage by weight:
78-87% of pure water, 2% of emulsifier, 10-25% of grease, 0.1-1% of allantoin, 5-10% of humectant, 0.5-5% of skin conditioner, 1.8% of thickener, 0.35% of preservative, 30.05-0.5% of ceramide, 0.5-2% of mung bean fermentation liquor, 0.5-10% of phytosterol ester, 0.05-0.5% of acetylated hyaluronic acid, 1% of VE, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium;
the ceramide 3 is obtained by an extraction process, and the extraction process comprises the following steps: firstly obtaining fermentation flora from rice, then husking sorghum, fumigating sorghum at high temperature, adding the fermentation flora for fermentation, wherein the fermentation temperature and the fermentation humidity are respectively 37 ℃ and 65%, breaking the wall, filtering and purifying to obtain ceramide 3;
the ceramide 3 is further processed by a coating process, and the coating process comprises the following steps: the method comprises the steps of firstly, completely dissolving lecithin and cholesterol, pouring the lecithin and the cholesterol into a round-bottom flask, then adding water, EDTA sodium, disodium hydrogen phosphate and sodium dihydrogen phosphate, stirring until the lecithin and the cholesterol are completely dissolved, then starting a rotary evaporator, performing rotary evaporation until a dry film is formed, adding ceramide 3 and VE, mixing, finally adding a preservative, stirring until the mixture is uniform, and discharging.
2. The seal repair skin care formulation of claim 1, wherein: the material is prepared from the following raw materials in percentage by weight:
78-87% of pure water, 0.05-0.5% of allantoin, 10% of humectant, 3-10% of skin conditioner, 0.2-0.4% of thickener, 0.35% of preservative, 30.1-1% of ceramide, 0.5-2% of mung bean fermentation liquor, VE 1%, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium.
3. The seal repair skin care formulation of claim 1, wherein: the material is prepared from the following raw materials in percentage by weight:
78-87% of pure water, 0.1-1% of allantoin, 0.5-5% of skin conditioner, 0.35% of preservative, 30.05-0.5% of ceramide, 0.5-2% of mung bean fermentation liquor, 0.5-10% of phytosterol ester, 1% of VE, 0.8% of disodium hydrogen phosphate, 0.3% of sodium dihydrogen phosphate and 0.2% of EDTA sodium.
4. The seal repairing and repairing cream is characterized in that: prepared from the seal skin care formulation of claim 1.
5. The utility model provides a seal repair facial mask which characterized in that: prepared from the seal skin care formulation of claim 2.
6. A seal repairing spray essence water: the method is characterized in that: prepared from the seal skin care formulation of claim 3.
7. A method of making the seal repair cream of claim 4, wherein: the method comprises the following steps:
(S1) heating the oil phase pan: putting palmitoyl hydrolyzed wheat protein potassium, cetostearyl alcohol, glyceryl stearate, PEG-100 stearate, phytosterol ester, hydrogenated palm oil, oleum Aesculi and cetyl alcohol into an oil phase pot, heating to 75 ℃, and keeping the temperature for 30 minutes;
(S2) heating the water phase pot: adding glycerol, betaine, allantoin and carbomer into a water phase pot, stirring with the water pot, stirring to dissolve completely, mixing well, heating to 85 deg.C, and holding for 30 min;
(S3) emulsifying pot feeding: opening the vacuum of an emulsifying pot to-0.05 MPa, pumping 1/3 aqueous phase materials into the emulsifying pot, pumping the aqueous phase materials, pumping the materials in the emulsifying pot while stirring at the rotating speed of 800r/min, pumping the remaining aqueous phase materials into the emulsifying pot after pumping the oil phase materials;
(S4) mixing: after the two phases are mixed, stirring continuously, heating to 85 ℃, keeping the average value at 5 minutes and rotating speed at 3000r/min under a vacuum state, keeping the temperature for 20 minutes, and cooling to 50 ℃;
(S5) discharging in vacuum: adding ceramide 3, semen Phaseoli Radiati fermentation liquid, jellyfish extract, acetylated sodium hyaluronate, triethanolamine and phenoxyethanol under vacuum, stirring, cooling to 40 deg.C, and discharging to clean container.
8. A method of preparing the seal repairing mask of claim 5, wherein: the method comprises the following steps:
(S01) heating and stirring: adding deionized water, glycerol, carbomer and betaine into a water kettle, heating to 90 ℃, stirring and keeping the temperature for 30 minutes;
(S02) cooling for the first time: cooling to 60 deg.C, adding flos Matricariae Chamomillae water, allantoin and dolol;
(S03) cooling again, stirring and discharging: cooling to 45 ℃, adding ceramide 3, mung bean fermentation liquor, acetylated sodium hyaluronate, preservative and triethanolamine, uniformly stirring, and discharging into a clean container.
9. A method for preparing the seal repairing spray essence of claim 6, which comprises the following steps: the method comprises the following steps:
(S01) heating and stirring: adding deionized water, glycerol and butanediol into a water kettle, heating to 90 ℃, stirring and keeping the temperature constant for 30 minutes;
(S02) cooling for the first time: cooling to 60 deg.C, adding radix Hamamelis mollis extractive solution, flos Matricariae Chamomillae water, allantoin and dolichol;
(S03) cooling again, stirring and discharging: cooling to 45 ℃, adding ceramide 3, mung bean fermentation liquor, acetylated sodium hyaluronate and preservative, uniformly stirring, and discharging into a clean container.
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CN103596579A (en) * 2011-05-12 2014-02-19 普罗碧欧尼株式会社 Rice-fermented food composition containing a rice-sweetened liquid, fermented by means of kimchi lactobacillus, as an effective ingredient, and having antibacterial and antiviral effects
CN109481338A (en) * 2019-01-04 2019-03-19 上海彤颜实业有限公司 Moisturizing maintenance composition and preparation method comprising ceramide and phytosterol

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CN103596579A (en) * 2011-05-12 2014-02-19 普罗碧欧尼株式会社 Rice-fermented food composition containing a rice-sweetened liquid, fermented by means of kimchi lactobacillus, as an effective ingredient, and having antibacterial and antiviral effects
CN109481338A (en) * 2019-01-04 2019-03-19 上海彤颜实业有限公司 Moisturizing maintenance composition and preparation method comprising ceramide and phytosterol

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CN116035944A (en) * 2022-12-29 2023-05-02 植然天成(北京)生物科技有限公司 Bionic fetal fat composition, cosmetic and preparation method thereof
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