CN114344230A - Composition for inhibiting bacteria, removing mites and removing acnes, and preparation method and application thereof - Google Patents
Composition for inhibiting bacteria, removing mites and removing acnes, and preparation method and application thereof Download PDFInfo
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- CN114344230A CN114344230A CN202111618676.3A CN202111618676A CN114344230A CN 114344230 A CN114344230 A CN 114344230A CN 202111618676 A CN202111618676 A CN 202111618676A CN 114344230 A CN114344230 A CN 114344230A
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Abstract
The application relates to a composition for inhibiting bacteria, removing mites and removing acnes, a preparation method and application thereof, and belongs to the field of daily cosmetics. The composition for inhibiting bacteria, removing mites and removing acnes is prepared from the following raw materials: 6-8 parts of betaine hydrochloride, 12-15 parts of leucine methyl ester hydrochloride, 9-12 parts of methionine ethyl ester hydrochloride, 8-10 parts of thickening agent, 15-18 parts of glycerol, 4-6 parts of pH regulator, 18-20 parts of benzoyl peroxide, 27-30 parts of herbal extract and 38-45 parts of water. The application of the composition is that the bacteriostatic acarid-removing acne-removing composition is added into daily cosmetics in an addition content of 10-20 wt%. The bacteriostatic, mite-removing and acne-removing composition can be added and applied as daily cosmetics of various different types, the prepared daily cosmetics have skin care effects of bacteriostasis, mite removal, acne removal, inflammation diminishing and the like, and the composition has mild effect, is beneficial to repairing of skin barriers, and enables the skin to be recovered to be healthy.
Description
Technical Field
The invention relates to the field of daily cosmetics, in particular to a composition with antibacterial and acne-removing effects, a preparation method and application thereof.
Background
Along with the development of the society, people pay more and more attention to the pursuit of beauty, the efficacy appeal of skin care products is more and more, besides the basic moisturizing efficacy, the skin care products also have various different efficacies of whitening, removing freckles, resisting aging and the like, and the daily cosmetics with the acne removing efficacy occupy a larger share in the market.
The problems of pore blockage, bacterium breeding and the like caused by the fact that sebum is exuberant are usually caused due to the fact that the skin is caused by the fact that sebum is exuberant in secretion, so that the products aiming at the acne removing effect on the market pay more attention to how to control oil better, but the problems that skin inflammation is difficult to relieve due to the fact that water loss is usually ignored are solved, and the problems that the existing products are large in irritation, dry and skinned skin after the products are used, poor in acne removing effect and the like are required to be further improved.
Disclosure of Invention
In order to improve the acne removing effect, the application provides a composition for inhibiting bacteria, removing mites and removing acnes, a preparation method and application thereof.
The application provides a composition for inhibiting bacteria, removing mites and removing acnes, a preparation method and application thereof, and the following technical scheme is adopted:
in a first aspect, the application provides a composition for inhibiting bacteria, removing mites and removing acnes, which adopts the following technical scheme:
the composition for inhibiting bacteria, removing mites and removing acnes is prepared from the following raw materials in parts by weight: 6-8 parts of betaine hydrochloride, 12-15 parts of leucine methyl ester hydrochloride, 9-12 parts of methionine ethyl ester hydrochloride, 8-10 parts of thickening agent, 15-18 parts of glycerol, 4-6 parts of pH regulator, 18-20 parts of benzoyl peroxide, 27-30 parts of herbal extract and 38-45 parts of water.
In addition, through compounding the betaine hydrochloride and the benzoyl peroxide, the benzoyl peroxide permeates into the horny layer to inhibit the growth of pathogenic bacteria such as propionibacterium acnes and the like causing whelks, and meanwhile, the betaine hydrochloride can maintain the ion balance of water, reduce the water loss caused by osmotic pressure shock due to the damage of the close arrangement of the membrane lipid of the horny layer, ensure the onset process to be milder, reduce the secretion of sebum, improve the skin environment and further reduce the breeding of skin mites or other microorganisms and the formation of comedones and acnes.
Preferably, the herbal extract is prepared from the following raw materials: 2.5-3.0 parts of clove, 1.5-2.0 parts of mulberry, 1.0-1.3 parts of tree peony bark, 1.0-1.3 parts of angelica dahurica, 0.8-1.0 part of belvedere fruit, 0.8-1.0 part of cochinchnese asparagus root, 0.8-1.0 part of polygala root, 0.8-1.0 part of dwarf lilyturf tuber, 0.8-1.0 part of angelica, 0.5-0.7 part of dittany bark, 0.5-0.7 part of ginseng and 0.5-0.7 part of liquorice.
The herbal extract is prepared by compounding the herbal plants, and antibacterial ingredients such as terpenoids, flavonoids, saponins and the like in various plants are combined, so that the metabolism of microorganisms bred on the skin is disturbed, the growth of the microorganisms is hindered, and the acne growing condition of the skin caused by the breeding of the microorganisms is reduced.
Preferably, the pH regulator comprises the following components in parts by weight: 2-3 parts of glycolic acid and 2-3 parts of hyaluronic acid.
By adopting the components as the pH regulator, the alkaloid of the herbal extract exists in a salt form, so that the irritation to the skin is reduced, and in addition, the coordination of the glycolic acid and the hyaluronic acid can help to change the arrangement tissue of stratum corneum lipid, so that the transdermal permeability is better, and the herbal extract can better permeate the skin to play a role in inhibiting bacteria, removing mites and removing acnes.
Preferably, the herbal extract is prepared from the following raw materials in parts by weight: 2.5 to 3.0 parts of common cnidium fruit, 2.5 to 3.0 parts of medlar, 1.5 to 2.0 parts of fragrant solomonseal rhizome, 1.0 to 1.3 parts of pine pollen and 0.5 to 0.7 part of oriental waterplantain rhizome.
By adding the herbal plants for compounding, the effect of synergistically promoting permeation among antibacterial active ingredients in the herbal extract can be further improved, so that the acne removing effect is quicker and more obvious.
Preferably, the thickener comprises one or more of myristyl alcohol, stearyl alcohol and hydroxypropyl cellulose.
By adopting the components as the thickening agent, the dispersion compatibility of the raw materials is better, the durability of skin adhesion can be increased, the herbal extract and the benzoyl peroxide continuously act on the epidermis, and the antibacterial and anti-inflammatory effects are favorably improved.
In a second aspect, the application provides a preparation method of a composition for inhibiting bacteria, removing mites and removing acnes, which adopts the following technical scheme:
a preparation method of a composition for inhibiting bacteria, removing mites and removing acnes comprises the following steps:
the method comprises the following steps: weighing the herbal extract raw materials according to the proportion, mixing and crushing the raw materials, and then mixing the crushed raw materials according to the proportion of 1: mixing the solid-liquid ratio of 10 with 75-80wt% ethanol solution, reflux-extracting at 70 + -2 deg.C for 2h, filtering to obtain filtrate, evaporating the filtrate under reduced pressure, concentrating to remove ethanol, and concentrating to density of 1.35 + -0.05 g/mL to obtain herbal extract;
step two: dissolving the thickening agent and the pH regulator in water according to a ratio, adding the herbal extract, and hermetically stirring at the temperature of 35 +/-1 ℃ for 12-14 hours to obtain the herbal bacteriostatic agent;
step three: mixing betaine hydrochloride, leucine methyl ester hydrochloride, methionine ethyl ester hydrochloride, glycerol and herbal bacteriostatic agent according to proportion, and standing at 40 + -1 deg.C for 3-4 h.
The preparation method comprises the steps of extracting all herbal raw materials by using ethanol to obtain herbal extracts, and stirring and mixing the thickening agent, the pH regulator and the herbal extracts at 35 +/-1 ℃ to protect active ingredients in the herbal extracts to a certain degree, so that the herbal extracts are not easy to oxidize and deteriorate and can be better stored, the irritation of the herbal extracts to the skin can be reduced, and the acne-removing and skin-protecting effects are better.
In a third aspect, the application provides an application of the composition for inhibiting bacteria, removing mites and removing acnes, and adopts the following technical scheme: the composition is added into a daily cosmetic, and the addition content of the composition in the daily cosmetic is 10-20 wt%.
By taking the bacteriostatic, acarid-removing and acne-removing composition as a component of the daily cosmetics at a proper addition content, the daily cosmetics have mild effect and better acne-removing and inflammation-diminishing effects.
Preferably, the daily cosmetic is skin lotion, skin cream, skin gel, face cleanser or soap.
The bacteriostatic acarid-removing acne-removing composition can be prepared into daily cosmetics of different preparation types, has good compatibility and wide application range, and is favorable for acting on the skin in multiple aspects to play a role in bacteriostasis, diminishing inflammation, removing acnes and removing acarids.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the composition prepared by compounding betaine hydrochloride, leucine methyl ester hydrochloride, methionine ethyl ester hydrochloride, benzoyl peroxide, herbal extracts and other raw materials has excellent permeability in skin cuticle, has skin care effects of reducing skin grease secretion, inhibiting microbial growth, removing mites, removing acnes, diminishing inflammation and the like, can maintain the water balance of cuticle membrane while promoting the renewal and metabolism of aged cuticle, and has the advantages of milder acne-removing effect taking process, difficult skin drying and peeling and better skin care effect;
2. the herbal extract is prepared by compounding various herbaceous plants such as clove, mulberry, tree peony bark, angelica dahurica, belvedere fruit, cochinchnese asparagus root, thinleaf milkwort root-bark, dwarf lilyturf tuber, Chinese angelica, dittany bark, ginseng, liquorice and the like, and various rich active ingredients are mutually cooperated, so that the herbal extract has good effects on inhibiting the growth of skin microorganisms, diminishing inflammation and calming the skin and maintaining the water-oil balance of the skin;
3. the composition for inhibiting bacteria, removing acnes and removing mites is prepared into daily cosmetics according to the adding content of 10-20wt%, so that various functional components in the composition can mildly and effectively act on the skin, the composition has an excellent skin-care effect, and the composition for inhibiting bacteria, removing acnes and removing mites is suitable for preparing various types of daily cosmetics and has a good application value.
Detailed Description
The present application will be described in further detail with reference to examples.
Examples
Example 1
The preparation method of the bacteriostatic acarid-removing acne-removing composition comprises the following steps:
the method comprises the following steps: weighing the herbal extract raw materials according to the proportion in table 1, uniformly mixing, crushing to an average particle size of 2mm, and then mixing the crushed raw materials according to the proportion of 1: mixing the solid-liquid ratio of 10 with 75 wt% ethanol solution, reflux-extracting at 70 + -2 deg.C for 2h, filtering to obtain filtrate, evaporating the filtrate under reduced pressure, concentrating to remove ethanol, and concentrating to density of 1.34g/mL to obtain herbal extract;
step two: dissolving a thickening agent and a pH regulator in water according to the proportion shown in the table 2, adding the herbal extract, hermetically stirring at the temperature of 35 +/-1 ℃, and stirring at the rotating speed of 180r/min for 12 hours to obtain the herbal bacteriostatic agent;
step three: according to the proportion, the betaine hydrochloride, the leucine methyl ester hydrochloride, the methionine ethyl ester hydrochloride, the glycerol, the benzoyl peroxide and the herbal bacteriostatic agent are hermetically stirred, the mixture is stirred at the rotating speed of 60r/min for 1h until the mixture is uniformly dispersed, and the mixture is vacuumized to remove air bubbles introduced by stirring, so that the bacteriostatic mite-removing and acne-removing composition is obtained.
Example 2
The preparation method of the bacteriostatic acarid-removing acne-removing composition comprises the following steps:
the method comprises the following steps: weighing the herbal extract raw materials according to the proportion in table 1, uniformly mixing, crushing to an average particle size of 2mm, and then mixing the crushed raw materials according to the proportion of 1: mixing the solid-liquid ratio of 10 with 80wt% ethanol solution, reflux-extracting at 70 + -2 deg.C for 3 hr, filtering to obtain filtrate, evaporating the filtrate under reduced pressure, concentrating to remove ethanol, and concentrating to density of 1.39g/mL to obtain herbal extract;
step two: dissolving a thickening agent and a pH regulator in water according to the proportion shown in the table 2, adding the herbal extract, hermetically stirring at the temperature of 35 +/-1 ℃, and stirring at the rotating speed of 180r/min for 14 hours to obtain the herbal bacteriostatic agent;
step three: according to the proportion, the betaine hydrochloride, the leucine methyl ester hydrochloride, the methionine ethyl ester hydrochloride, the glycerol, the benzoyl peroxide and the herbal bacteriostatic agent are hermetically stirred, the mixture is stirred at the rotating speed of 60r/min for 1h until the mixture is uniformly dispersed, and the mixture is vacuumized to remove air bubbles introduced by stirring, so that the bacteriostatic mite-removing and acne-removing composition is obtained.
Example 3
The preparation method of the bacteriostatic acarid-removing acne-removing composition comprises the following steps:
the method comprises the following steps: weighing the herbal extract raw materials according to the proportion in table 1, uniformly mixing, crushing to an average particle size of 2mm, and then mixing the crushed raw materials according to the proportion of 1: mixing the solid-liquid ratio of 10 with 75 wt% ethanol solution, reflux-extracting at 70 + -2 deg.C for 3 hr, filtering to obtain filtrate, evaporating the filtrate under reduced pressure, concentrating to remove ethanol, and concentrating to density of 1.31g/mL to obtain herbal extract;
step two: dissolving a thickening agent and a pH regulator in water according to the proportion shown in the table 2, adding the herbal extract, hermetically stirring at the temperature of 35 +/-1 ℃, and stirring at the rotating speed of 180r/min for 14 hours to obtain the herbal bacteriostatic agent;
step three: according to the proportion, the betaine hydrochloride, the leucine methyl ester hydrochloride, the methionine ethyl ester hydrochloride, the glycerol, the benzoyl peroxide and the herbal bacteriostatic agent are hermetically stirred, the mixture is stirred at the rotating speed of 60r/min for 1h until the mixture is uniformly dispersed, and the mixture is vacuumized to remove air bubbles introduced by stirring, so that the bacteriostatic mite-removing and acne-removing composition is obtained.
Examples 4 to 7
The difference from example 1 is that the raw materials and the mixture ratio of the raw materials in examples 4-7 are different, the mixture ratio of the herbal extract raw materials in examples 1-7 is detailed in table 1, and the mixture ratio of the bacteriostatic acaricidal acne-removing composition in examples 1-7 is detailed in table 2.
TABLE 1 herbal extract raw materials and their ratios
The above herbal materials are commercially available dry products, and after purchase, the floating dust is cleaned with water and dried to prepare the herbal extract.
TABLE 2 raw materials of the composition for inhibiting bacteria, removing mites and removing acne and their mixture ratio (unit: kg)
The raw materials are all commercial products, wherein the betaine hydrochloride is betaine hydrochloride of Shandong Rui hong biological technology limited company, the leucine methyl ester hydrochloride is D-leucine methyl ester hydrochloride of Hubei Yun Mg technology limited company, and the methionine ethyl ester hydrochloride is D-methionine ethyl ester hydrochloride of Suzhou Qihong biological technology limited company.
Comparative example
Comparative example 1 is different from example 1 in that the composition of comparative example 1 is prepared without adding herbal extract, and 5.2kg of stearyl alcohol and 24.8kg of water are added in step two.
Comparative example 2 is different from example 1 in that the betaine hydrochloride is replaced by equal mass of glycerol in step three of comparative example 2.
Comparative example 3 is different from example 1 in that the addition preparation is carried out in step three of comparative example 3 by replacing leucine methyl ester hydrochloride with glycerol of equal mass.
Comparative example 4 is different from example 1 in that glycerol of the same mass is added instead of methionine ethyl ester hydrochloride in step three of comparative example 4.
Application example
Application examples 1 to 7
A skin care gel for inhibiting bacteria, removing mites and removing acnes is prepared by putting the antibacterial acne removal compositions prepared in examples 1-7 and other raw materials into a stirring kettle according to a formula table in a table 3, stirring, keeping the temperature at 15 +/-1 ℃ during stirring, vacuumizing to remove bubbles after stirring uniformly, and discharging.
TABLE 3 formula table of bacteriostatic, acarid-removing and acne-removing skin care gel
Application examples 8 to 14
A face cleaning cream for inhibiting bacteria, removing mites and removing acnes is prepared by putting the antibacterial acne removing compositions prepared in examples 1-7 and other raw materials into an emulsifying pot according to a formula shown in Table 4, emulsifying and dispersing at a temperature of 35 +/-1 ℃ in the emulsifying process, vacuumizing to remove bubbles after uniform dispersion, and discharging.
TABLE 4 formula table of bacteriostatic, mite-killing and acne-removing facial cleanser
Performance test
1. Skin parameter detection
1.1 Experimental Equipment: multifunctional skin tester MPA580, facial image acquisition and analysis system VISIA.
1.2 subjects: the skin problems of acne, acne and the like exist on the face for more than 1 year after 18-28 years of age, and people with unstable hormones in the body such as gestation period or lactation period and people with inflammatory dermatosis, people with high physique sensitivity and the like are excluded.
1.3 detection sample: the products prepared in the examples 1 to 14 are applied, the comparison samples 1 to 4 are set for tests, the formulas of the comparison samples 1 to 4 are different from the formula of the application example 8 in that the composition prepared in the proportion of 1 to 4 in pair is replaced by the composition for inhibiting bacteria, removing mites and removing acnes, and the rest raw materials and the adding amount are uniform.
1.4 test methods: the products obtained in application examples 1 to 14, control samples 1 to 4, and commercial samples (commercially available facial cleansers of a certain brand) were distributed to subjects for use, and 5 subjects were used for each of the application examples, the control samples, and the commercial products. The testee stops using the skin care product with the acne removing function before receiving the test, the skin care product is replaced by a common moisturizing skin care product, and the facial condition is detected after one week. Before detection, the face is cleaned, and after sitting still for 30min in a constant temperature and humidity environment (the temperature is 24 +/-1 ℃ and the relative humidity is 50 +/-10%), the face skin detection is carried out. After the first test, the subjects were instructed to use the products in the morning and at night (before sleep and after wake-up) every day, except for changing the products, the skin care products were used as usual, were used for 30 days, and were subjected to the facial skin test again on day 14 and day 30.
1.5 detection items:
1.5.1 facial porphyrin value: the method comprises the steps of collecting facial images through a facial Image collecting and analyzing system VISIA, analyzing facial porphyrin values through Image processing software Image Pro Plus, wherein the porphyrin values represent the metabolic activity degree of microorganisms, and the microorganisms are more active when the porphyrin values are higher.
1.5.2 moisture content: the detection device is a multifunctional skin tester MPA580, the device probe is CM825, the detection principle is that the size of the dielectric constant is in positive correlation with the water content of the surface of the skin, the content of water can be reflected through the capacitance change of the probe, and the unit of the detection value is C.U to represent the water content of the surface of the skin.
1.5.3 oil content: the detection device is a multifunctional skin tester MPA580, the device probe is SM815, the detection principle is that the probe contains a delustering adhesive tape, the adhesive tape becomes semitransparent after absorbing grease, the transparency is higher when the grease is more, the light transmission quantity of the probe can reflect the content of the grease, and the unit of the detection value is mu g/cm2To represent the oil content of the skin surface.
1.6 data results: the average of 5 subjects for each sample was recorded and is shown in tables 5-1, 5-2, and 5-3.
TABLE 5-1 facial porphyrin values
TABLE 5-2 skin moisture content test results
TABLE 5-3 skin oil content test results
2. Data analysis
According to the above detection data, the skin care gel products containing the anti-bacteria and mite-removing acne-removing composition of application examples 1-7 and the facial cleanser containing the anti-bacteria and mite-removing acne-removing composition of application examples 8-14 have good effects of inhibiting the growth of microorganisms on the skin, and have more excellent effects of increasing the water content of the skin and reducing the oil content of the skin compared with the commercial products. The product added with the bacteriostatic acarid-removing acne-removing composition has the effect of conditioning the water-oil balance of the skin, inhibits the growth of microorganisms, and reduces skin problems such as acne and the like caused by the breeding of oil and microorganisms.
Compared with the detection data of the control samples 1-4 and the application example 8, the compound herbal extract, the betaine hydrochloride, the leucine methyl ester hydrochloride and the methionine ethyl ester hydrochloride have a coordinated effect, so that the daily chemical product containing the antibacterial mite-killing acne-removing composition has good acne-removing and inflammation-diminishing effects, is milder and non-irritant, is beneficial to repairing damaged skin barriers, and gradually restores the skin to a flawless and healthy state.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. The composition for inhibiting bacteria, removing mites and removing acnes is characterized by comprising the following raw materials in parts by weight: 6-8 parts of betaine hydrochloride, 12-15 parts of leucine methyl ester hydrochloride, 9-12 parts of methionine ethyl ester hydrochloride, 8-10 parts of thickening agent, 15-18 parts of glycerol, 4-6 parts of pH regulator, 18-20 parts of benzoyl peroxide, 27-30 parts of herbal extract and 38-45 parts of water.
2. The composition for inhibiting bacteria, removing mites and removing acnes as claimed in claim 1, wherein the herbal extract is prepared from the following raw materials in parts by weight: 2.5-3.0 parts of clove, 1.5-2.0 parts of mulberry, 1.0-1.3 parts of tree peony bark, 1.0-1.3 parts of angelica dahurica, 0.8-1.0 part of belvedere fruit, 0.8-1.0 part of cochinchnese asparagus root, 0.8-1.0 part of polygala root, 0.8-1.0 part of dwarf lilyturf tuber, 0.8-1.0 part of angelica, 0.5-0.7 part of dittany bark, 0.5-0.7 part of ginseng and 0.5-0.7 part of liquorice.
3. The composition for inhibiting bacteria, removing mites and removing acnes as claimed in claim 2, wherein the pH regulator comprises the following components in parts by weight: 2-3 parts of glycolic acid and 2-3 parts of hyaluronic acid.
4. The composition for inhibiting bacteria, removing mites and removing acnes as claimed in claim 2, wherein the herbal extract is prepared from the following raw materials in parts by weight: 2.5 to 3.0 parts of common cnidium fruit, 2.5 to 3.0 parts of medlar, 1.5 to 2.0 parts of fragrant solomonseal rhizome, 1.0 to 1.3 parts of pine pollen and 0.5 to 0.7 part of oriental waterplantain rhizome.
5. The composition for inhibiting bacteria, removing mites and removing acnes as claimed in claim 1, wherein said thickening agent comprises one or more of myristyl alcohol, stearyl alcohol and hydroxypropyl cellulose.
6. A method for preparing the bacteriostatic acaricidal acne-removing composition as defined in any one of claims 1 to 5, which comprises the following steps:
the method comprises the following steps: weighing the herbal extract raw materials according to the proportion, mixing and crushing the raw materials, and then mixing the crushed raw materials according to the proportion of 1: mixing the solid-liquid ratio of 10 with 75-80wt% ethanol solution, reflux-extracting at 70 + -2 deg.C for 3 hr, filtering to obtain filtrate, evaporating the filtrate under reduced pressure, concentrating to remove ethanol, and concentrating to density of 1.35 + -0.05 g/mL to obtain herbal extract;
step two: dissolving the thickening agent and the pH regulator in water according to a ratio, adding the herbal extract, and hermetically stirring at the temperature of 35 +/-1 ℃ for 12-14 hours to obtain the herbal bacteriostatic agent;
step three: uniformly mixing betaine hydrochloride, leucine methyl ester hydrochloride, methionine ethyl ester hydrochloride, glycerol, benzoyl peroxide and herbal bacteriostatic agent according to a ratio to obtain the antibacterial agent.
7. Use of the bacteriostatic, acaricidal and acne-removing composition as defined in any one of claims 1 to 5, wherein the composition is added to a daily cosmetic, and the addition content of the composition in the daily cosmetic is 10-20 wt%.
8. The application of the composition for inhibiting bacteria, removing mites and removing acnes as claimed in claim 7, wherein the daily cosmetics are skin lotion, skin cream, skin gel, facial cleanser or perfumed soap.
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| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
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| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
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