CN113749998A - Composite acne-removing cream and preparation method thereof - Google Patents
Composite acne-removing cream and preparation method thereof Download PDFInfo
- Publication number
- CN113749998A CN113749998A CN202010508369.9A CN202010508369A CN113749998A CN 113749998 A CN113749998 A CN 113749998A CN 202010508369 A CN202010508369 A CN 202010508369A CN 113749998 A CN113749998 A CN 113749998A
- Authority
- CN
- China
- Prior art keywords
- parts
- acne
- composite
- extract
- cream according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006071 cream Substances 0.000 title claims abstract description 42
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 40
- 206010000496 acne Diseases 0.000 title claims abstract description 40
- 239000002131 composite material Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003974 emollient agent Substances 0.000 claims abstract description 14
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 12
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 12
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 12
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 12
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 12
- 239000002738 chelating agent Substances 0.000 claims abstract description 12
- 229940107681 dandelion root extract Drugs 0.000 claims abstract description 12
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 12
- 239000002184 metal Substances 0.000 claims abstract description 12
- 239000003755 preservative agent Substances 0.000 claims abstract description 12
- 230000002335 preservative effect Effects 0.000 claims abstract description 12
- 239000003381 stabilizer Substances 0.000 claims abstract description 12
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 10
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 10
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 10
- 229940036350 bisabolol Drugs 0.000 claims abstract description 10
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 10
- 229940082940 phellodendron amurense bark extract Drugs 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 241000736199 Paeonia Species 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 9
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000000265 homogenisation Methods 0.000 claims description 6
- 238000005086 pumping Methods 0.000 claims description 6
- 241000972673 Phellodendron amurense Species 0.000 claims description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 229930182478 glucoside Natural products 0.000 claims description 4
- 150000008131 glucosides Chemical class 0.000 claims description 4
- 229940075529 glyceryl stearate Drugs 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 4
- 229940100460 peg-100 stearate Drugs 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
- 229960003415 propylparaben Drugs 0.000 claims description 4
- 229940032094 squalane Drugs 0.000 claims description 4
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229940042585 tocopherol acetate Drugs 0.000 claims description 3
- 230000003255 anti-acne Effects 0.000 claims 7
- 230000000694 effects Effects 0.000 abstract description 6
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 14
- 238000000034 method Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 210000001732 sebaceous gland Anatomy 0.000 description 6
- 241000186427 Cutibacterium acnes Species 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 229940055019 propionibacterium acne Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 208000020154 Acnes Diseases 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 210000003780 hair follicle Anatomy 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000736 corneocyte Anatomy 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940051879 analgesics and antipyretics salicylic acid and derivative Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composite acne-removing cream which comprises the following components in parts by weight: water: 30-80 parts; dipotassium glycyrrhizinate: 0.01-0.5 part; emulsifier: 2.5-8 parts; and (3) an emollient: 5-20 parts of a solvent; phellodendron amurense bark extract: 0.01-5 parts; ethanol: 0.01-10 parts; the dandelion root extract: 0.01-5 parts; dipropylene glycol: 0.01-8 parts; propylene glycol: 0.01-8 parts; peony root bark extract: 0.01-5 parts; bisabolol: 0.01-0.5 part; mint leaf extract: 0.01-5 parts; metal chelating agent: 0.01-0.2 parts; antioxidant: 0.01-2 parts; preservative: 0.01-2 parts; a stabilizer: 0.1-5 parts. The invention also discloses a preparation method of the composite acne-removing cream. Through the mode, the composite acne removing cream disclosed by the invention has a good acne removing effect and is higher in health safety.
Description
Technical Field
The invention relates to the field of daily chemicals, and particularly relates to a composite acne-removing cream and a preparation method thereof.
Background
The acne cream products on the market are various, but salicylic acid and derivatives thereof are almost adopted to remove acnes from the angles of hair follicle penetration, drying and the like, and the effect of helping acnes to reduce red is achieved by removing cutin and acid value cleaning pores.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a composite acne-removing cream and a preparation method thereof, which can solve the technical problems in the prior art.
(II) technical scheme
In order to solve the above technical problems, the present invention provides the following technical solutions: the composite acne-removing cream comprises the following components in parts by weight:
water: 30-80 parts;
dipotassium glycyrrhizinate: 0.01-0.5 part;
emulsifier: 2.5-8 parts;
and (3) an emollient: 5-20 parts of a solvent;
phellodendron amurense bark extract: 0.01-5 parts;
ethanol: 0.01-10 parts;
the dandelion root extract: 0.01-5 parts;
dipropylene glycol: 0.01-8 parts;
propylene glycol: 0.01-8 parts;
peony root bark extract: 0.01-5 parts;
bisabolol: 0.01-0.5 part;
mint leaf extract: 0.01-5 parts;
metal chelating agent: 0.01-0.2 parts;
antioxidant: 0.01-2 parts;
preservative: 0.01-2 parts;
a stabilizer: 0.1-5 parts.
Preferably, the water is specifically deionized water or distilled water; the compound acne-removing cream also contains 0.01-0.1 part of an aromatizer, and the aromatizer is essence.
Preferably, the emulsifier is specifically: cetearyl alcohol + cetearyl glucoside, glyceryl stearate + PEG-100 stearate.
Preferably, the emollient is specifically: polydimethylsiloxane, caprylic/capric triglyceride, squalane.
Preferably, the metal chelating agent is EDTA-2 Na.
Preferably, the antioxidant is in particular tocopheryl acetate.
Preferably, the stabilizer is xanthan gum.
Preferably, the preservative is specifically: methyl hydroxybenzoate and propyl hydroxybenzoate.
In order to solve the above technical problem, the present invention provides another technical solution as follows: a preparation method of the composite acne-removing cream comprises the following steps:
step (1): dissolving 15 parts of the water with the dipotassium glycyrrhizinate for later use;
step (2): uniformly dispersing the stabilizer by the dipropylene glycol and the propylene glycol, adding the rest parts of water, adding the metal chelating agent, stirring for dissolving, and heating to 85 ℃;
and (3): mixing and heating the emollient, the emulsifier, the bisabolol, and the preservative to 85 ℃;
and (4): pumping the aqueous solution prepared in the step (2) into an emulsifying pot, pumping the mixed solution prepared in the step (3) into the emulsifying pot, carrying out vacuum homogenization at the rotating speed of 3000RPM for 5 minutes, and finally stirring and cooling to 45 ℃ to add the phellodendron bark extract, the dandelion root extract, the peony root bark extract, the mint leaf extract and the aqueous solution prepared in the step (1);
and (5): adding the antioxidant and the ethanol into a system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 3000RPM, then continuously stirring and cooling to 38 ℃, and discharging to finish the preparation of the composite acne cream.
Preferably, the step (5) is also added with the aromatizer.
(III) advantageous effects
Compared with the prior art, the invention provides the composite acne-removing cream and the preparation method thereof, and the composite acne-removing cream has the following beneficial effects:
(1) dipropylene glycol and ethanol are adopted to permeate, soften, clean and dredge pores blocked by the exuberant secretion of sebaceous glands, and simultaneously, the propionibacterium acnes and the like in hair follicles are sterilized; the amur corktree bark extract and the dandelion root extract are adopted to act on cell cohesion between corneocytes on the skin surface, effectively inhibit the propagation and growth of bacteria, and simultaneously do not change and influence microbial flora on the skin surface, so that the skin is kept in a healthy state; the effective antibacterial and repairing components of the product are subjected to transdermal penetration through the composite action of the dipropylene glycol and the ethanol, so that the transdermal performance of the product is greatly improved, and acne can be effectively eliminated.
(2) The peony root bark extract and the mint leaf extract are adopted to act on the surface of skin, relieve itching, repair damaged sebaceous glands and inhibit excessive secretion of the sebaceous glands, so that the growth of acnes is effectively controlled from the source, and the acne removing effect is good.
(3) In the process of effectively treating the pox skin, the moisture content of the skin is maintained by using an emollient to maintain the oil content of the surface layer of the skin and prevent the loss of moisture.
Drawings
Fig. 1 is a flow chart of steps of a preparation method of the composite acne-removing cream.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention relates to a composite acne-removing cream which comprises the following components in parts by weight:
water: 30-80 parts;
dipotassium glycyrrhizinate: 0.01-0.5 part;
emulsifier: 2.5-8 parts;
and (3) an emollient: 5-20 parts of a solvent;
phellodendron amurense bark extract: 0.01-5 parts;
ethanol: 0.01-10 parts;
the dandelion root extract: 0.01-5 parts;
dipropylene glycol: 0.01-8 parts;
propylene glycol: 0.01-8 parts;
peony root bark extract: 0.01-5 parts;
bisabolol: 0.01-0.5 part;
mint leaf extract: 0.01-5 parts;
metal chelating agent: 0.01-0.2 parts;
antioxidant: 0.01-2 parts;
preservative: 0.01-2 parts;
a stabilizer: 0.1-5 parts.
Wherein the water is specifically deionized water or distilled water. In addition, the compound acne removing cream can also contain 0.01-0.1 part of an aromatizer, and the aromatizer is essence.
The emulsifier may be specifically: cetearyl alcohol + cetearyl glucoside, glyceryl stearate + PEG-100 stearate. The emollient may specifically be: polydimethylsiloxane, caprylic/capric triglyceride, squalane. The metal chelating agent may specifically be EDTA-2 Na. The antioxidant is specifically tocopherol acetate. The stabilizer is xanthan gum. The preservative is specifically as follows: methyl hydroxybenzoate and propyl hydroxybenzoate.
Preferably, the composite acne cream disclosed by the invention comprises the following components in parts by weight in the embodiment 1:
water: 43.9 parts;
dipotassium glycyrrhizinate: 0.3 part;
emulsifier: 6 parts of (1);
and (3) an emollient: 11.5 parts;
phellodendron amurense bark extract: 3.5 parts;
ethanol: 8 parts of a mixture;
the dandelion root extract: 3.5 parts;
dipropylene glycol: 6 parts of (1);
propylene glycol: 7 parts;
peony root bark extract: 3.5 parts;
bisabolol: 0.3 part;
mint leaf extract: 3.5 parts;
metal chelating agent: 0.1 part;
antioxidant: 0.5 part;
preservative: 0.4 part;
a stabilizer: and 2 parts.
Preferably, the embodiment 2 of the composite acne-removing cream specifically comprises the following components in parts by weight:
water: 59.7 parts of a mixture;
dipotassium glycyrrhizinate: 0.3 part;
emulsifier: 5 parts of a mixture;
and (3) an emollient: 8.5 parts;
phellodendron amurense bark extract: 2.8 parts;
ethanol: 5 parts of a mixture;
the dandelion root extract: 2.8 parts;
dipropylene glycol: 5 parts of a mixture;
propylene glycol: 3.5 parts;
peony root bark extract: 2.8 parts;
bisabolol: 0.25 part;
mint leaf extract: 2.8 parts;
metal chelating agent: 0.05 part;
antioxidant: 0.25 part;
preservative: 0.2 part;
a stabilizer: 1 part;
an aromatizing agent: 0.05 part.
Preferably, the embodiment 3 of the composite acne-removing cream specifically comprises the following components in parts by weight:
water: 74.63 parts of a binder;
dipotassium glycyrrhizinate: 0.3 part;
cetearyl alcohol + cetearyl glucoside: 2 parts of (1);
glyceryl stearate + PEG-100 stearate: 2 parts of (1);
polydimethylsiloxane: 2.5 parts;
caprylic/capric triglyceride: 3 parts of a mixture;
squalane: 0.5 part;
phellodendron amurense bark extract: 1.5 parts;
ethanol: 2 parts of (1);
the dandelion root extract: 1.5 parts;
dipropylene glycol: 4 parts of a mixture;
propylene glycol: 2 parts of (1);
peony root bark extract: 1.5 parts;
bisabolol: 0.2 part;
mint leaf extract: 1.5 parts;
EDTA-2 Na: 0.05 part;
tocopherol acetate: 0.1 part;
methyl hydroxybenzoate: 0.1 part;
propyl hydroxybenzoate: 0.1 part;
xanthan gum: 0.5 part;
an aromatizing agent: 0.02 part.
The preparation method of the composite acne-removing cream comprises the following steps:
step (1): dissolving 15 parts of the water with the dipotassium glycyrrhizinate for later use;
step (2): uniformly dispersing the stabilizer by the dipropylene glycol and the propylene glycol, adding the rest parts of water, adding the metal chelating agent, stirring for dissolving, and heating to 85 ℃;
and (3): mixing and heating the emollient, the emulsifier, the bisabolol, and the preservative to 85 ℃;
and (4): pumping the aqueous solution prepared in the step (2) into an emulsifying pot, pumping the mixed solution prepared in the step (3) into the emulsifying pot, carrying out vacuum homogenization at the rotating speed of 3000RPM for 5 minutes, and finally stirring and cooling to 45 ℃ to add the phellodendron bark extract, the dandelion root extract, the peony root bark extract, the mint leaf extract and the aqueous solution prepared in the step (1);
and (5): adding the antioxidant and the ethanol into a system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 3000RPM, then continuously stirring and cooling to 38 ℃, and discharging to finish the preparation of the composite acne cream.
After the composite acne removing cream is detected to be qualified, bottling to obtain the finished product.
In addition, the above step (5) may further comprise adding the above-mentioned flavoring agent.
The safety and efficacy of the composite acne-removing cream disclosed by the invention are evaluated as follows:
the safety test method of the composite acne-removing cream comprises the following steps: selecting 30 test persons, carrying out a spot-sticking test, observing by naked eyes, and observing skin reaction after 24 hours:
the evaluation results of the patch tests show that in example 1, 29 persons showed negative reactions and 1 person showed suspicious reactions. In example 2, 30 persons showed a negative reaction, and 0 person showed a suspicious reaction. In example 3, 30 persons showed a negative reaction, and 0 person showed a suspicious reaction. According to the judgment standard of the skin patch experiment of human body in the 'cosmetic hygiene code' 2007 edition, the above examples 1-3 have no adverse reaction to human body.
The efficacy test of the composite acne-removing cream is to detect and evaluate the effect of the composite acne-removing cream on propionibacterium acnes through an inhibition test, namely, the propionibacterium acnes is put into a culture medium containing the composite acne-removing cream, and then the growth and the reproduction of the propionibacterium acnes are observed, and the results are as follows:
compared with the prior art, the invention provides the composite acne-removing cream and the preparation method thereof, and the composite acne-removing cream has the following beneficial effects:
(1) dipropylene glycol and ethanol are adopted to permeate, soften, clean and dredge pores blocked by the exuberant secretion of sebaceous glands, and simultaneously, the propionibacterium acnes and the like in hair follicles are sterilized; the amur corktree bark extract and the dandelion root extract are adopted to act on cell cohesion between corneocytes on the skin surface, effectively inhibit the propagation and growth of bacteria, and simultaneously do not change and influence microbial flora on the skin surface, so that the skin is kept in a healthy state; the effective antibacterial and repairing components of the product are subjected to transdermal penetration through the composite action of the dipropylene glycol and the ethanol, so that the transdermal performance of the product is greatly improved, and acne can be effectively eliminated.
(2) The peony root bark extract and the mint leaf extract are adopted to act on the surface of skin, relieve itching, repair damaged sebaceous glands and inhibit excessive secretion of the sebaceous glands, so that the growth of acnes is effectively controlled from the source, and the acne removing effect is good.
(3) In the process of effectively treating the pox skin, the moisture content of the skin is maintained by using an emollient to maintain the oil content of the surface layer of the skin and prevent the loss of moisture.
It is to be noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The composite acne-removing cream is characterized by comprising the following components in parts by weight:
water: 30-80 parts;
dipotassium glycyrrhizinate: 0.01-0.5 part;
emulsifier: 2.5-8 parts;
and (3) an emollient: 5-20 parts of a solvent;
phellodendron amurense bark extract: 0.01-5 parts;
ethanol: 0.01-10 parts;
the dandelion root extract: 0.01-5 parts;
dipropylene glycol: 0.01-8 parts;
propylene glycol: 0.01-8 parts;
peony root bark extract: 0.01-5 parts;
bisabolol: 0.01-0.5 part;
mint leaf extract: 0.01-5 parts;
metal chelating agent: 0.01-0.2 parts;
antioxidant: 0.01-2 parts;
preservative: 0.01-2 parts;
a stabilizer: 0.1-5 parts.
2. The composite anti-acne cream according to claim 1, characterized in that: the water is specifically deionized water or distilled water; the compound acne-removing cream also contains 0.01-0.1 part of an aromatizer, and the aromatizer is essence.
3. The composite anti-acne cream according to claim 1, characterized in that: the emulsifier is specifically as follows: cetearyl alcohol + cetearyl glucoside, glyceryl stearate + PEG-100 stearate.
4. The composite anti-acne cream according to claim 1, characterized in that: the emollient is specifically: polydimethylsiloxane, caprylic/capric triglyceride, squalane.
5. The composite anti-acne cream according to claim 1, characterized in that: the metal chelating agent is specifically EDTA-2 Na.
6. The composite anti-acne cream according to claim 1, characterized in that: the antioxidant is specifically tocopherol acetate.
7. The composite anti-acne cream according to claim 1, characterized in that: the stabilizer is xanthan gum.
8. The composite anti-acne cream according to claim 1, characterized in that: the preservative is specifically as follows: methyl hydroxybenzoate and propyl hydroxybenzoate.
9. The preparation method of the composite acne-removing cream according to claim 1, characterized by comprising the following steps:
step (1): dissolving 15 parts of the water with the dipotassium glycyrrhizinate for later use;
step (2): uniformly dispersing the stabilizer by the dipropylene glycol and the propylene glycol, adding the rest parts of water, adding the metal chelating agent, stirring for dissolving, and heating to 85 ℃;
and (3): mixing and heating the emollient, the emulsifier, the bisabolol, and the preservative to 85 ℃;
and (4): pumping the aqueous solution prepared in the step (2) into an emulsifying pot, pumping the mixed solution prepared in the step (3) into the emulsifying pot, carrying out vacuum homogenization at the rotating speed of 3000RPM for 5 minutes, and finally stirring and cooling to 45 ℃ to add the phellodendron bark extract, the dandelion root extract, the peony root bark extract, the mint leaf extract and the aqueous solution prepared in the step (1);
and (5): adding the antioxidant and the ethanol into a system, carrying out vacuum homogenization for 3 minutes at the rotating speed of 3000RPM, then continuously stirring and cooling to 38 ℃, and discharging to finish the preparation of the composite acne cream.
10. The preparation method of the composite acne cream according to claim 9, characterized in that: the step (5) is also added with the aromatizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010508369.9A CN113749998A (en) | 2020-06-06 | 2020-06-06 | Composite acne-removing cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010508369.9A CN113749998A (en) | 2020-06-06 | 2020-06-06 | Composite acne-removing cream and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113749998A true CN113749998A (en) | 2021-12-07 |
Family
ID=78785314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010508369.9A Pending CN113749998A (en) | 2020-06-06 | 2020-06-06 | Composite acne-removing cream and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113749998A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115844796A (en) * | 2022-12-27 | 2023-03-28 | 陕西慧康生物科技有限责任公司 | Water-in-oil composition with acne removal, skin rejuvenation and slow release effects and application |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873433A (en) * | 2015-05-28 | 2015-09-02 | 郑州市嘉蓓丽生物科技有限公司 | Moxa skin cream and preparing method thereof |
| CN105796462A (en) * | 2016-03-25 | 2016-07-27 | 无锡简玺生物科技有限公司 | Composition used for cleaning skin and preparation method thereof |
| CN109771345A (en) * | 2019-02-28 | 2019-05-21 | 北昊干细胞与再生医学研究院有限公司 | Oil-control cosmetic composite and its application |
| CN109865028A (en) * | 2019-04-11 | 2019-06-11 | 中国医学科学院北京协和医院 | A kind of Chinese medicinal ointment and preparation method thereof for the treatment of acne easy to carry, easy-to-use |
| CN110522761A (en) * | 2018-05-23 | 2019-12-03 | 浙江立恩生物科技有限公司 | It is a kind of to have effects that prevent and treat the biological polyoses of acne and its application |
-
2020
- 2020-06-06 CN CN202010508369.9A patent/CN113749998A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873433A (en) * | 2015-05-28 | 2015-09-02 | 郑州市嘉蓓丽生物科技有限公司 | Moxa skin cream and preparing method thereof |
| CN105796462A (en) * | 2016-03-25 | 2016-07-27 | 无锡简玺生物科技有限公司 | Composition used for cleaning skin and preparation method thereof |
| CN110522761A (en) * | 2018-05-23 | 2019-12-03 | 浙江立恩生物科技有限公司 | It is a kind of to have effects that prevent and treat the biological polyoses of acne and its application |
| CN109771345A (en) * | 2019-02-28 | 2019-05-21 | 北昊干细胞与再生医学研究院有限公司 | Oil-control cosmetic composite and its application |
| CN109865028A (en) * | 2019-04-11 | 2019-06-11 | 中国医学科学院北京协和医院 | A kind of Chinese medicinal ointment and preparation method thereof for the treatment of acne easy to carry, easy-to-use |
Non-Patent Citations (2)
| Title |
|---|
| 广州伊尔美生物科技有限公司: "《http://ftba.nmpa.gov.cn:81》", 6 December 2017, 国家食品药品监督管理局 * |
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115844796A (en) * | 2022-12-27 | 2023-03-28 | 陕西慧康生物科技有限责任公司 | Water-in-oil composition with acne removal, skin rejuvenation and slow release effects and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110731923B (en) | Enhanced moisturizing cosmetic compositions | |
| CN107550775B (en) | Natural plant anti-acne gel and preparation method thereof | |
| CN109431843B (en) | Moisturizing repair emulsion and preparation method thereof | |
| CN112245366A (en) | Permeation-promoting composition containing hyaluronic acid and application of permeation-promoting composition in cosmetics | |
| CN108524406A (en) | A kind of Golden flower facial mask and preparation method thereof | |
| CN113749998A (en) | Composite acne-removing cream and preparation method thereof | |
| CN108392446A (en) | Skin care compositions based on yellow tang extract and its application | |
| CN114848517A (en) | Moisturizing, oil-controlling, anti-inflammatory, bacteriostatic and acne-removing composition, acne-removing cosmetic containing composition and preparation method of acne-removing cosmetic | |
| CN106821935B (en) | Method for extracting antibacterial composition from limulus reagent waste to prepare cosmetics | |
| CN114028282B (en) | Oil-control skin-cleaning composition and preparation method and application thereof | |
| CN111956550A (en) | Skin-moistening cream with sun-blocking function and preparation method thereof | |
| CN110840787A (en) | Skin care active composition with acne removing and blemish repairing effects and application thereof | |
| CN1054284C (en) | Natural skin-care raw material-saussurea involucrata extract of alcohol | |
| KR20090107128A (en) | Camellia japonica flower composition which is extracted using cryogenic liquid nitrogen | |
| JP2002145754A (en) | Skin cosmetic | |
| JPH11171784A (en) | External preparation for skin | |
| CN109692137A (en) | A kind of moisturizing emulsion and preparation method thereof | |
| CN111481454A (en) | Preparation method of nourishing anti-cracking hand cream | |
| CN110934782A (en) | Moisturizing and hand-protecting cream containing deep seawater and preparation method thereof | |
| CN111067831A (en) | Repair milk and preparation method thereof | |
| CN112409198A (en) | Betaine salicylate and preparation method thereof | |
| CN109125242A (en) | A kind of external preparation and preparation method thereof for repairing acne print | |
| CN115645303B (en) | Water-in-oil composition with high water phase content and containing saccharides or acids, salts thereof or amino acids, and preparation method thereof | |
| CN108619062B (en) | Acne-removing composition and application thereof | |
| CN114159358B (en) | Repairing face cream capable of effectively removing free radicals and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211207 |