CN109125242A - A kind of external preparation and preparation method thereof for repairing acne print - Google Patents

A kind of external preparation and preparation method thereof for repairing acne print Download PDF

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Publication number
CN109125242A
CN109125242A CN201811267519.0A CN201811267519A CN109125242A CN 109125242 A CN109125242 A CN 109125242A CN 201811267519 A CN201811267519 A CN 201811267519A CN 109125242 A CN109125242 A CN 109125242A
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extract
fennel
coptis
preparation
flos chrysanthemi
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黄贤生
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Guangdong Kangzhichen Pharmaceutical Research And Development Co Ltd
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Guangdong Kangzhichen Pharmaceutical Research And Development Co Ltd
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85Polyesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70Biological properties of the composition as a whole
    • A61K2800/72Hypo-allergenic

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Abstract

The present invention discloses a kind of external preparation and preparation method thereof for repairing acne print, and ingredient is made of water 50-68%, glycerol 5-8%, propylene glycol 4-6%, allantoin 0.5-0.9%, Tween-80 1.2-1.6%, cetostearyl alcohol 2-4%, xanthan gum 2-4%, tea oil 0.1-0.4%, Rosa Damascana 0.2-0.5%, Flos Chrysanthemi 1-8%, pearl powder 0.01-0.2%, aloe extract 5-10%, mint extract 1-5%, coptis extract 1-5%, fennel 1-5%, shea butter 1-3%.And raw material is successively taken, stirring and dissolving discharges afterwards completely, can reach anti-acne print, improves scar and other effects.

Description

A kind of external preparation and preparation method thereof for repairing acne print
Technical field
The present invention relates to a kind of cosmetic fields, and in particular to a kind of external preparation and preparation method thereof for repairing acne print.
Background technique
Acne print is body reacts a kind of reparation that tissue damage generates, when the damage depth and corium or large area of skin The epidermis of skin blemish, the position cannot regenerate, will be by corium fabric cell, replaced the blood vessel of collagen and hyperplasia, in this way There have been acne prints.Acne print is because infection inflammation or external force extruding are formed, often because not having in whelk breaking-out Timely treatment appropriate is obtained, the inflammatory response of Skin Cell causes the destruction to skin histology, causes the generation of scar print; Generated consequence includes the generation of the destruction of skin, the defect of tissue and scar print, not only causes lacking for skin appearance It falls into, even more affects the normal organization of skin.Currently, market does not have effective method to repair acne print, therefore develop effective The external preparation for repairing acne print is technical problem in the urgent need to address.
Summary of the invention
Based on this, it is an object of the present invention to provide a kind of external preparations and preparation method thereof for repairing acne print, to solve above-mentioned back The problem of being proposed in scape technology.
A kind of external preparation for repairing acne print, ingredient are made of following weight ratio: water 50-68%, glycerol 5-8%, propylene glycol 4-6%, allantoin 0.5-0.9%, Tween-80 1.2-1.6%, cetostearyl alcohol 2-4%, xanthan gum 2-4%, tea oil 0.1- 0.4%, Rosa Damascana 0.2-0.5%, Flos Chrysanthemi 1-8%, pearl powder 0.01-0.2%, aloe extract 5-10%, mint extract 1- 5%, coptis extract 1-5%, fennel 1-5%, shea butter 1-3%.
Preferably, a kind of external preparation for repairing acne print, ingredient are made of following weight ratio: water 59.5%, glycerol 6%, third Glycol 4%, allantoin 0.5%, Tween-80 1.4%, cetostearyl alcohol 3%, xanthan gum 3%, tea oil 0.3%, Rosa Damascana 0.4%, Flos Chrysanthemi 3%, pearl powder 0.1%, aloe extract 7.5%, mint extract 3.5%, coptis extract 3.3%, fennel 1.5%, shea butter 3%.
A kind of external preparation and preparation method thereof for repairing acne print, preparation method is completed by following steps:
(1) Flos Chrysanthemi, fennel removal impurity and non-medicinal effects for taking formula ratio respectively, dry, crush Flos Chrysanthemi, fennel, mistake 20 meshes, obtain camomile pollen, fennel powder, for use;
(2) it prepares extract: taking the peppermint, aloe, the coptis of suitable deal to remove impurity and non-medicinal effects respectively, add water to cook It 2 times, decocts 1.5 hours every time, collecting decoction, filtration, decocting liquid is concentrated into 40-60 DEG C, and surveying relative density is the clear of 1.05-1.15 Cream, room temperature to be cooled to add ethyl alcohol to make alcohol content 65%, stir evenly, and refrigerate 24 hours, take supernatant, filter, filtrate recycling ethanol, It is concentrated into 45-60 DEG C, mint extract, aloe extract, coptis extract can be obtained;
(3) water of formula ratio is added in emulsion pot, after being heated to 70 DEG C, sequentially adds glycerol, propylene glycol, the allantois of formula ratio Element, polyoxyethylene sorbitan monoleate, cetostearyl alcohol, xanthan gum, camomile pollen, fennel powder, pearl powder, aloe extract, mint extract, Coptis extract, shea butter, tea oil, Rosa Damascana, keep the temperature 20 minutes, wherein every 10 minutes by 25 revs/min of mixing speed Emulsifying homogeneous is primary, totally 3 times, vacuumizes, then begins to cool cooling, discharges after taking semi-finished product inspection, inspection qualified;
(4) bottling becomes finished product after discharging.
In prescription of the invention, the effect of various raw materials are as follows:
Glycerol: referring generally to glycerine, and national standard is known as glycerol, colourless, odorless, sweet, and it is one that appearance, which is in clear and bright viscous liquid state, Kind of organic matter, the glycerol of the present embodiment meaning is the method using natural oil as raw material, also referred to as natural glycerin, with toughness, Anti-corrosive properties, hygroscopicity have moisten effect to skin, mucous membrane, and medicine retention can be made to extend the effect of drug local efficacy in affected part.
Propylene glycol: propylene glycol is the important source material of unsaturated polyester (UP), epoxy resin, polyurethane resin, the use of this respect Amount accounts for about 45% or so of propylene glycol aggregate consumption, and this unsaturated polyester (UP) is largely used to surface coating and reinforced plastics, propylene glycol Viscosity and good hygroscopicity, and it is nontoxic, thus be widely used as in food, medicine and cosmetics industry hygroscopic agent, antifreeze, Lubricant and solvent.
Allantoin: can be used for the processing of skin irritatin allergy, repair tender skin, scytitis, and empyrosis treatment mitigates and do not relax Accommodate skin wound repair, eliminate heat flush, coarse, the allergic phenomenas such as erythema, the natural process that can promote health and give To claim meaning impression, facilitates self perfection of skin, play the role of a kind of good skin conditioner.
Tween-80: for nonionic surface active agent, there are foreign odor, warm and slight bitter.It is polyoxyethylene sorbitol One of acid anhydride aliphatic ester series of products, this product are faint yellow to orange-yellow thick liquid;It is micro- to have special smell.Slightly bitter astringent taste has Warmth sensation.It is readily soluble in water, ethyl alcohol, methanol or ethyl acetate, the soluble,very slightly in mineral oil.Common surface in liquid preparation One kind of activating agent.For oil/water type emulsifier, it can be used as stabilizer, diffusant, antistatic agent, fiber lubricant etc..By sorb Sugar alcohol acid anhydride monoleate and ethylene oxide reaction are made.A kind of excellent O/W type emulsifier.
Cetostearyl alcohol: white crystalline solid, particle or wax stone shape, it is savory, have and inhibit greasy feeling, it is former to reduce wax class The effects of material stickiness, stable cosmetic gel.
Xanthan gum: xanthan gum is to send out liquor-saturated through Xanthomonas campestris by carbohydrate, the more pools of extracellular microorganism of generation.It is big due to it Molecule special construction and colloid property, and have multiple functions, can be used as emulsifier, stabilizer, gelling thickener, size, Film forming agent etc., is widely used in all fields of national economy.
Tea oil: tea oil is broad spectrum antimicrobial.It is extracted from the wood Myrtaceae Cajeputtree Leaf of port in a manner of distillation Pure natural plant essential oil, originate in Australia state.It is colourless to weak yellow liquid, there is characteristic perfume and antibacterial, anti-inflammatory, expelling parasite, mite killing The effect of.It is pollution-free, non-corrosive, permeability is strong.Treat acne, acne.Its unique fragrant strongly fragrant smell helps to refresh the mind.
Rosa Damascana: Rosa Damascana is rich in a variety of natural toxin-expellings, beauty treatment ingredient, dispelling stain, and beauty treatment skin keeps away skin Exempt from the infringement of outside contamination factor, the more white-skinned water profit of skin can be enabled, exempt the puzzlement of color spot.
Flos Chrysanthemi: the helpful sleep of Flos Chrysanthemi tea set, moisten skin the effect of, can help improve skin, promote bullet Property, edema is eliminated, tissue is strengthened.
Pearl powder: the Pharmacopoeia of the People's Republic of China and " dictionary of medicinal plant " indicate that pearl has calm the nerves arresting convulsion, improving eyesight Go screen, solution taking poison and growing muscle due and other effects, modern study also show pearl powder improve the immunity of the human body, delay senescence, freckle removing and whitening, benefit It fills calcareous etc. all with unique effect.
Aloe extract: it is a kind of liquid of colorless and transparent slightly stickiness to brown, there is many-sided beautifying skin function Can, there is strong absorption to ultraviolet light, hair is rotten and delays senescence.
Mint extract: the major functions: dispelling wind-heat, refresh oneself, promoting eruption.For anemopyretic cold, wind-warm syndrome from the beginning of, headache, hot eyes, Sore throat, aphtha, rubeola, morbilli, Breast bilges frowsty.Sword, essence skin, Sage Extract can be received.
Coptis extract: heat-clearing and damp-drying drug, purging fire for removing toxin.For damp and hot feeling of fullness, acid regurgitation, dysentery, yellow subcutaneous ulcer, high fever mind are vomitted Dusk, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, and carbuncle swells treat sore;Eczema, wet sore, purulent ear canal are controlled outside.
Fennel: promoting digestive juice secretion, increases gastrointestinal peristalsis, there is the effect of stomach invigorating, promoting the circulation of qi, helps to alleviate spasm, subtract Light pain.Anethene can promote bone marrow cell mature and be released into peripheral blood, there is apparent increasing leukocyte.
Shea butter: the extraction of shea butter is originated from " missible oil wood ", and " missible oil wood " is that a kind of have effects that magical maintenance Plant.Shea butter has effects that good deep layer is moistened, and can not only prevent season cracking, moreover it is possible to further restore and keep The natural elasticity of skin has effects that good deep layer is moistened.
Beneficial effects of the present invention: present component does not stimulate mildly, and skin will not generate dependence, natural herbs Formula can anti-sensitivity, can deep layer moisten moisturizing, equilibrium water oil skin, maintenance be damaged skin, increase skin shine and bullet Property.
Specific embodiment:
With reference to embodiment, claim of the invention is described in further detail.
Embodiment 1
It is provided by the invention it is a kind of repair acne print external preparation, be grouped as by following groups: water 59.5%, glycerol 6%, propylene glycol 4%, Allantoin 0.5%, Polyoxyethylene Sorbitan Monooleate 1.4%, cetostearyl alcohol 3%, xanthan gum 3%, tea oil 0.3%, Rosa Damascana 0.4%, Flos Chrysanthemi 3%, pearl powder 0.1%, aloe extract 7.5%, mint extract 3.5%, coptis extract 3.3%, fennel 1.5%, cream The wooden fruit oil 3%.
Embodiment 2
It is provided by the invention it is a kind of repair acne print external preparation, be grouped as by following groups: water 57.25%, glycerol 5%, propylene glycol 4%, Allantoin 0.5%, Polyoxyethylene Sorbitan Monooleate 1.3%, cetostearyl alcohol 2%, xanthan gum 2%, tea oil 0.4%, Rosa Damascana 0.4%, Flos Chrysanthemi 6%, pearl powder 0.15%, aloe extract 8%, mint extract 4%, coptis extract 4%, fennel 2%, shea butter 3%。
Embodiment 3
It is provided by the invention it is a kind of repair acne print external preparation, be grouped as by following groups: water 50.2%, glycerol 6%, propylene glycol 5%, Allantoin 0.5%, Polyoxyethylene Sorbitan Monooleate 1.4%, cetostearyl alcohol 3%, xanthan gum 3%, tea oil 0.4%, Rosa Damascana 0.4%, Flos Chrysanthemi 5%, pearl powder 0.1%, aloe extract 8%, mint extract 5%, coptis extract 5%, fennel 4%, shea butter 3%.
Embodiment 4
It is provided by the invention it is a kind of repair acne print external preparation, be grouped as by following groups: water 53.35%, glycerol 5%, propylene glycol 5%, Allantoin 0.4%, Polyoxyethylene Sorbitan Monooleate 1.3%, cetostearyl alcohol 3%, xanthan gum 3%, tea oil 0.4%, Rosa Damascana 0.4%, Flos Chrysanthemi 6%, pearl powder 0.15%, aloe extract 8%, mint extract 5%, coptis extract 4%, fennel 2%, shea butter 3%。
A kind of external preparation of above-mentioned any one group of reparation acne print the preparation method is as follows:
(1) Flos Chrysanthemi, fennel removal impurity and non-medicinal effects for taking formula ratio respectively, dry, crush Flos Chrysanthemi, fennel, mistake 20 meshes, obtain camomile pollen, fennel powder, for use;
(2) it prepares extract: taking the peppermint, aloe, the coptis of suitable deal to remove impurity and non-medicinal effects respectively, add water to cook It 2 times, decocts 1.5 hours every time, collecting decoction, filtration, decocting liquid is concentrated into 40-60 DEG C, and surveying relative density is the clear of 1.05-1.15 Cream, room temperature to be cooled to add ethyl alcohol to make alcohol content 65%, stir evenly, and refrigerate 24 hours, take supernatant, filter, filtrate recycling ethanol, It is concentrated into 45-60 DEG C, mint extract, aloe extract, coptis extract can be obtained;
(3) water of formula ratio is added in emulsion pot, after being heated to 70 DEG C, sequentially adds glycerol, propylene glycol, the allantois of formula ratio Element, polyoxyethylene sorbitan monoleate, cetostearyl alcohol, xanthan gum, camomile pollen, fennel powder, pearl powder, aloe extract, mint extract, Coptis extract, shea butter, tea oil, Rosa Damascana, keep the temperature 20 minutes, wherein every 10 minutes by 25 revs/min of mixing speed Emulsifying homogeneous is primary, totally 3 times, vacuumizes, then begins to cool cooling, discharges after taking semi-finished product inspection, inspection qualified;
(4) bottling becomes finished product after discharging.
Its application method of the invention are as follows: after cleaning skin, takes this product appropriate, be gently coated on affected part, 3-5 times on the one, etc. It can take effect to slowly osmotic absorption one month.
Points for attention of the present invention:
(1) it when skin has under the abnormal conditions such as wound, swollen, eczema, not use first please;
(2) place that be not stored in direct sunlight and high temperature is asked, so as not to it is rotten.
Typical case:
It is neat certain, female, 24 years old, the serious small pox of face, acne print, the colour of skin was low and deep, and after two courses for the treatment of of the invention, small pox inflammation disappears It moves back, acne print is gradually desalinated, and fat secretion is reduced, and obviously saturating white light is sliding for skin, no longer recurs after half a year.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (3)

1. a kind of external preparation for repairing acne print, which is characterized in that its ingredient is made of following weight ratio: water 50-68%, glycerol 5- 8%, propylene glycol 4-6%, allantoin 0.5-0.9%, Tween-80 1.2-1.6%, cetostearyl alcohol 2-4%, xanthan gum 2-4%, It is tea oil 0.1-0.4%, Rosa Damascana 0.2-0.5%, Flos Chrysanthemi 1-8%, pearl powder 0.01-0.2%, aloe extract 5-10%, thin Lotus extract 1-5%, coptis extract 1-5%, fennel 1-5%, shea butter 1-3%.
2. external preparation according to claim 1, which is characterized in that its ingredient is made of following weight ratio:
Water 59.5%, glycerol 6%, propylene glycol 4%, allantoin 0.5%, Tween-80 1.4%, cetostearyl alcohol 3%, xanthan gum 3%, tea oil 0.3%, Rosa Damascana 0.4%, Flos Chrysanthemi 3%, pearl powder 0.1%, aloe extract 7.5%, mint extract 3.5%, Coptis extract 3.3%, fennel 1.5%, shea butter 3%.
3. external preparation according to claim 2 and preparation method thereof, which is characterized in that the preparation method is by following step It is rapid to complete:
(1) Flos Chrysanthemi, fennel removal impurity and non-medicinal effects for taking formula ratio respectively, dry, crush Flos Chrysanthemi, fennel, mistake 20 meshes, obtain camomile pollen, fennel powder, for use;
(2) it prepares extract: taking the peppermint, aloe, the coptis of suitable deal to remove impurity and non-medicinal effects respectively, add water to cook It 2 times, decocts 1.5 hours every time, collecting decoction, filtration, decocting liquid is concentrated into 40-60 DEG C, and surveying relative density is the clear of 1.05-1.15 Cream, room temperature to be cooled to add ethyl alcohol to make alcohol content 65%, stir evenly, and refrigerate 24 hours, take supernatant, filter, filtrate recycling ethanol, It is concentrated into 45-60 DEG C, mint extract, aloe extract, coptis extract can be obtained;
(3) water of formula ratio is added in emulsion pot, after being heated to 70 DEG C, sequentially adds glycerol, propylene glycol, the allantois of formula ratio Element, polyoxyethylene sorbitan monoleate, cetostearyl alcohol, xanthan gum, camomile pollen, fennel powder, pearl powder, aloe extract, mint extract, Coptis extract, shea butter, tea oil, Rosa Damascana, keep the temperature 20 minutes, wherein every 10 minutes by 25 revs/min of mixing speed Emulsifying homogeneous is primary, totally 3 times, vacuumizes, then begins to cool cooling, discharges after taking semi-finished product inspection, inspection qualified;
(4) bottling becomes finished product after discharging.
CN201811267519.0A 2018-10-30 2018-10-30 A kind of external preparation and preparation method thereof for repairing acne print Withdrawn CN109125242A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112386554A (en) * 2019-08-19 2021-02-23 广东伊涵坊生物科技有限公司 Face cream for removing acne, acne mark and closed acne

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112386554A (en) * 2019-08-19 2021-02-23 广东伊涵坊生物科技有限公司 Face cream for removing acne, acne mark and closed acne

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Application publication date: 20190104