CN1137406A - Yunan Baiyao (White Drug-Powder) tablet and preparation method thereof - Google Patents
Yunan Baiyao (White Drug-Powder) tablet and preparation method thereof Download PDFInfo
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- CN1137406A CN1137406A CN 96103380 CN96103380A CN1137406A CN 1137406 A CN1137406 A CN 1137406A CN 96103380 CN96103380 CN 96103380 CN 96103380 A CN96103380 A CN 96103380A CN 1137406 A CN1137406 A CN 1137406A
- Authority
- CN
- China
- Prior art keywords
- yunnan
- tablet
- yunnan baiyao
- magnesium stearate
- extract powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 44
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920002472 Starch Polymers 0.000 claims abstract description 17
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims abstract description 17
- 239000008107 starch Substances 0.000 claims abstract description 17
- 235000019698 starch Nutrition 0.000 claims abstract description 17
- 239000008187 granular material Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000007779 soft material Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 7
- 239000000080 wetting agent Substances 0.000 claims abstract description 4
- 239000009306 yunnan baiyao Substances 0.000 claims description 53
- 239000000284 extract Substances 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 18
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 16
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 16
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 16
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 16
- -1 Hydroxypropyl Chemical group 0.000 claims description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 10
- 239000008101 lactose Substances 0.000 claims description 10
- 238000005507 spraying Methods 0.000 claims description 10
- 229940032147 starch Drugs 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 238000009495 sugar coating Methods 0.000 claims description 6
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims 2
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- 230000002950 deficient Effects 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010054787 Haemorrhoidal haemorrhage Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061577 Ulcer haemorrhage Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 235000020965 cold beverage Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a Yunnan White tablet and its preparation method. The Yunnan white Drug-Powder is used as raw material, in which the starch, low-substituted hydroxypropyl cellulose and avicel are added, uniformly mixed, then a proper quantity of ethyl alcohol or distilled water is added as wetting agent. The above-mentioned materials are uniformly stirred and made into a soft material, then the soft material is granulated and dried. The dried granular material is uniformly mixed with magnesium stearate, and tabletted to form the invented product. It is a new dosage form, and easy to take in.
Description
The present invention relates to a kind of novel form of the Chinese famous medicine-YUNNAN BAIYAO of a kind of tradition, is raw material with the YUNNAN BAIYAO exactly specifically, with its Chinese patent medicine that is prepared into the tablet form, the invention still further relates to the preparation method of this medicine.
YUNNAN BAIYAO is a kind of evident in efficacy, traditional famous medicine of having won fame both at home and abroad, formulated in 1904, clinical verification through a nearly century, confirmed that it has the effect of removing stasis to stop bleeding, promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling, be used for the treatment of traumatic injury, swelling and pain due to blood stasis, haematemesis, hemoptysis, have blood in stool, disease such as hemorrhoidal bleeding, metrostaxis, ulcer haemorrhage, determined curative effect.But, because YUNNAN BAIYAO is a kind of traditional powder, 4 gram medicated powder are housed in every bottle, in the life-time service process, exist following defective:
When 1, the patient used, each consumption was difficult to grasp.Because every bottle of BAIYAO has 4 grams, and each consumption is 0.25～0.5 gram, can't accurately grasp each taking dose when the patient uses, so that has influenced the curative effect of medicine.
2, the bitter taste that medicated powder had makes particularly young patient of patient or long-term user be difficult to swallow, and refusal is taken.
3, because medicated powder is very thin, small number of patients causes to choke when being eager to swallow to be coughed, and causes acute pharyngolaryngitis.
The object of the present invention is to provide a kind of whole therapeutic efficiencies of YUNNAN BAIYAO that both comprised, can overcome YUNNAN BAIYAO novel form-YUNNAN BAIYAO of above-mentioned defective and preparation method thereof again.
Solution of the present invention is modern advanced preparation process and an equipment of utilization, traditional YUNNAN BAIYAO powder is made can overcome above-mentioned defective and don't influence the YUNNAN BAIYAO that it uses curative effect.
Tablet of the present invention is made 10000 (weight ratios) by following component:
YUNNAN BAIYAOFEN 2.5-5Kg starch 0.07-0.1Kg
Microcrystalline Cellulose 0.08-0.2Kg y magnesium stearate 0.02-0.08Kg
Low-substituted hydroxypropyl cellulose 0.1-0.6Kg
The formula optimization scope of tablet of the present invention is:
YUNNAN BAIYAOFEN 2.5-5Kg starch 0.075-0.095Kg
Microcrystalline Cellulose 0.085-0.195Kg magnesium stearate 0.025-0.075Kg
Low-substituted hydroxypropyl cellulose 0.15-0.55Kg
The optimum weight proportioning of tablet of the present invention:
YUNNAN BAIYAOFEN 2.5Kg starch 0.09Kg
Microcrystalline Cellulose 0.195Kg magnesium stearate 0.075Kg
Low-substituted hydroxypropyl cellulose 0.5Kg
The method that above-mentioned each component is made tablet of the present invention has following three kinds:
Method for making one: full crude drug powder sheet
With YUNNAN BAIYAOFEN, starch, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose mix homogeneously, adding adequate amount of ethanol or distilled water is wetting agent, stir and make soft material, with 14-20 purpose screen cloth with soft material make granule dry to the granule water content be 3-10%, bake out temperature is controlled at 40-100 ℃, then magnesium stearate is added mix homogeneously in the granule that drying crosses, tabletting promptly gets tablet of the present invention.
Two: half extractum sheets of method for making
1, with 1/2nd amount of YUNNAN BAIYAOFEN in the component, be that 80-95%, 50-70%, three kinds of Different concentrations of alcohol solution of 30-40% extract with containing the alcohol amount respectively, discard medicinal residues, extracting solution makes the YUNNAN BAIYAO extract powder after concentrating under reduced pressure, drying.
2, with YUNNAN BAIYAO extract powder and second half YUNNAN BAIYAOFEN and starch, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose mix homogeneously, promptly get tablet of the present invention by method for making 1 described method tabletting, sugar coating or film-coat.
Method for making three: full extractum sheet
1, the whole YUNNAN BAIYAOFEN in the component is made the YUNNAN BAIYAO extract powder with the extracting method of YUNNAN BAIYAO extract powder in the method for making two.
2, with YUNNAN BAIYAO extract powder and YUNNAN BAIYAOFEN and starch, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose mix homogeneously, as stated above it tabletting, sugar coating or film-coat are promptly got tablet of the present invention.
Tablet of the present invention is also made 10000 with the raw material and the method for following weight ratio:
YUNNAN BAIYAOFEN extractum 1-3Kg spraying lactose 0.25-0.75Kg
Magnesium stearate 0.03-0.12Kg hydroxypropyl emthylcellulose 0.25-0.75Kg
The preferable range of the proportioning of tablet of the present invention is:
YUNNAN BAIYAO extract powder 0.8-2.8Kg spraying lactose 0.2-0.7Kg
Magnesium stearate 0.024-0.08Kg hydroxypropyl emthylcellulose 0.2-0.7Kg
The best proportioning of tablet of the present invention is:
YUNNAN BAIYAO extract powder 1.25Kg spraying lactose 0.45Kg
Magnesium stearate 0.05Kg hydroxypropyl emthylcellulose 0.45Kg
The preparation method of tablet of the present invention is: with YUNNAN BAIYAO extract powder, spraying lactose, hydroxypropyl emthylcellulose mix homogeneously, add an amount of distilled water or ethanol, stir and make soft material, with the 12-20 eye mesh screen soft material is made granule, under 40-100 ℃ of temperature, dry to the granule water content be 3-10%, add magnesium stearate as lubricant, tabletting promptly gets the bright tablet of this law behind the mix homogeneously.
YUNNAN BAIYAO of the present invention is compared with existing YUNNAN BAIYAO has following characteristics:
1, original effect of YUNNAN BAIYAO (powder) and therapeutic domain have been kept.
2, dosage is accurate, has overcome the difficulty that is difficult for grasping dosage when the patient takes.
3, make tablet after, covered the bitter taste of powder, taking convenience.
Causing when 4, having avoided swallowing chokes coughs, and the infringement throat is taken safety.
5, make tablet after, the effective ingredient content of Unit Weight improves, impurity content significantly reduces, medicine effective time can prolong, and reduces medicining times.
Embodiment 1 full crude drug powder sheet
YUNNAN BAIYAO of the present invention is to make with the raw material and the method for following weight ratio:
YUNNAN BAIYAOFEN 2.5Kg low-substituted hydroxypropyl cellulose 0.5Kg
Starch 0.09Kg microcrystalline Cellulose 0.195Kg
Magnesium stearate 0.075Kg
With YUNNAN BAIYAOFEN, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose mix homogeneously, add adequate amount of ethanol or distilled water as wetting agent, stir and make soft material, with 20 purpose screen clothes soft material is made granule, with granule dry to water content be 4～6%, bake out temperature is controlled at≤and 70 ℃, in the granule that drying is crossed, add the magnesium stearate mix homogeneously, tabletting promptly gets tablet of the present invention.
Embodiment 2 half extractum sheets
YUNNAN BAIYAO of the present invention is to make with the raw material and the following method of identical weight ratio among the embodiment 1:
1, with the amount of YUNNAN BAIYAOFEN in the component 1/2nd, be that 80-95%, 50-70%, three kinds of Different concentrations of alcohol solution of 30-40% extract with containing alcohol respectively, discard medicinal residues, extracting solution promptly gets the YUNNAN BAIYAO extract powder after concentrating under reduced pressure, drying.
2,, promptly get tablet of the present invention after pressing method among the embodiment 1 and condition tabletting, sugar coating or film-coat with YUNNAN BAIYAO extract powder and second half YUNNAN BAIYAOFEN and low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose mix homogeneously.
Embodiment 3 full extractum sheets
YUNNAN BAIYAO of the present invention is to make with the raw material and the following method of identical weight ratio among the embodiment 1:
1, with whole YUNNAN BAIYAOFEN in the component, makes the YUNNAN BAIYAO extract powder with the method for preparing the YUNNAN BAIYAO extract powder among the embodiment 2.
2,, promptly get tablet of the present invention after pressing method among the embodiment 1 and condition tabletting, sugar coating or film-coat with YUNNAN BAIYAO extract powder and YUNNAN BAIYAOFEN, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose mix homogeneously.
Embodiment 4 slow release YUNNAN BAIYAO
YUNNAN BAIYAO of the present invention is to make with the raw material and the method for following weight ratio:
YUNNAN BAIYAO extract powder 1.25Kg spraying lactose 0.45Kg
Hydroxypropyl emthylcellulose 0.45Kg magnesium stearate 0.05Kg
The preparation method of tablet of the present invention is: YUNNAN BAIYAOFEN is made the YUNNAN BAIYAO extract powder with the method for preparing YUNNAN BAIYAO extractum among the embodiment 2, then the YUNNAN BAIYAO extract powder is pressed above-mentioned weight ratio and spraying lactose, hydroxypropyl emthylcellulose mix homogeneously, add an amount of distilled water or ethanol, stir and make soft material, with 20 eye mesh screens soft material is made granule, under 60～70 ℃ temperature, dry to the granule water content be 3～5%, add magnesium stearate as lubricant, tabletting behind the mix homogeneously promptly gets tablet of the present invention.
The instructions of taking of tablet of the present invention: oral, four times on the one, each 1-2 sheet is used warm water delivery service, and the child is cut down according to the circumstance.
Slow releasing tablet: oral, a twice-daily, each 1-2 sheet is used warm water delivery service.
Application notice: be not taken by pregnant women, take medicine to avoid in one day and eat Semen Viciae fabae, Fish and sour cold drinks and snachs thing.
Claims (8)
1, a kind of YUNNAN BAIYAO is characterized in that it is the tablet made from the raw material and the method for following weight ratio:
YUNNAN BAIYAOFEN 2.5-5Kg starch 0.07-0.1 Kg
Low-substituted hydroxypropyl cellulose 0.1-0.6Kg
Microcrystalline Cellulose 0.08-0.2Kg magnesium stearate 0.02-0.08Kg
With YUNNAN BAIYAOFEN, starch, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose mix homogeneously, add adequate amount of ethanol or distilled water as wetting agent, stir and make soft material, with 14-20 purpose screen cloth soft material is made granule, dry to the granule water content at 3-10%, bake out temperature is controlled at 40-100 ℃, magnesium stearate is added mix homogeneously in the granule that above-mentioned drying crosses again, and is pressed into 10000 and gets final product.
2, a kind of YUNNAN BAIYAO according to claim 1 is characterized in that the preferable range of the weight proportion of each raw material is:
YUNNAN BAIYAOFEN 2.5-5Kg starch 0.075-0.095Kg
Microcrystalline Cellulose 0.085-0.195Kg magnesium stearate 0.025-0.075Kg
Low-substituted hydroxypropyl cellulose 0.15-0.55Kg
3, a kind of YUNNAN BAIYAO according to claim 1 is characterized in that the optimum weight proportioning of raw material is:
YUNNAN BAIYAOFEN 2.5Kg starch 0.09Kg microcrystalline Cellulose 0.195Kg
Magnesium stearate 0.075Kg low-substituted hydroxypropyl cellulose 0.5Kg
4, a kind of YUNNAN BAIYAO is characterized in that this tablet is the tablet that adopts described each raw material weight ratio of claim 1 and the preparation of following method:
1. the amount with YUNNAN BAIYAOFEN in the component 1/2nd is that 80-95%, 50-70%, three kinds of Different concentrations of alcohol solution of 30-40% extract with containing the alcohol amount respectively, discards medicinal residues, and extracting solution promptly gets the YUNNAN BAIYAO extract powder after concentrating under reduced pressure, drying.
2. with YUNNAN BAIYAO extract powder and second half YUNNAN BAIYAOFEN and starch, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose mix homogeneously, by described method of claim 1 and condition, through granulation, drying, in dried particles, add magnesium stearate, get final product after being pressed into 10000, sugar coating or film-coat.
5, a kind of YUNNAN BAIYAO is characterized in that this tablet is the tablet that adopts described each raw material weight ratio of claim 1 and the preparation of following method:
1. YUNNAN BAIYAOFEN in the component is extracted with the extracting method in the claim 4, made the YUNNAN BAIYAO extract powder.
2. with YUNNAN BAIYAO extract powder and YUNNAN BAIYAOFEN and starch, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose mix homogeneously, by described method of claim 1 and condition tabletting, sugar coating or film-coat promptly get tablet of the present invention.
6, a kind of YUNNAN BAIYAO with slow releasing function is characterized in that this tablet is the tablet made from the raw material and the method for following weight ratio:
1. tablet of the present invention is made 10000 tablets of tablets by the weight ratio of following each component:
YUNNAN BAIYAO extract powder 1-3Kg spraying lactose 0.25-0.75Kg
Hydroxypropyl emthylcellulose 0.26-0.75Kg magnesium stearate 0.03-0.12Kg
Above-mentioned YUNNAN BAIYAO extract powder is that the preparation method by the YUNNAN BAIYAO extract powder in the claim 4 makes.
2. with YUNNAN BAIYAO extract powder, spraying lactose, hydroxypropyl emthylcellulose mix homogeneously, add an amount of ethanol or distilled water, stir and make soft material, with the 12-20 eye mesh screen soft material is made granule, under 40-100 ℃ temperature, dry to the granule water content be 3-10%, add magnesium stearate then as lubricant, tabletting promptly gets tablet of the present invention behind the mix homogeneously.
7, a kind of YUNNAN BAIYAO according to claim 6 is characterized in that the preferable range of each components by weight is:
YUNNAN BAIYAO extract powder 0.8-0.28Kg spraying lactose 0.2-0.7Kg
Hydroxypropyl emthylcellulose 0.2-0.7Kg magnesium stearate 0.024-0.08Kg
8, a kind of YUNNAN BAIYAO according to claim 6 is characterized in that the optimum weight ratio of each component is:
YUNNAN BAIYAO extract powder 1.25Kg spraying lactose 0.45Kg
Hydroxypropyl emthylcellulose 0.45Kg magnesium stearate 0.05Kg
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96103380A CN1053581C (en) | 1996-04-08 | 1996-04-08 | Yunnan Baiyao tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96103380A CN1053581C (en) | 1996-04-08 | 1996-04-08 | Yunnan Baiyao tablet and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1137406A true CN1137406A (en) | 1996-12-11 |
| CN1053581C CN1053581C (en) | 2000-06-21 |
Family
ID=5118036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96103380A Expired - Fee Related CN1053581C (en) | 1996-04-08 | 1996-04-08 | Yunnan Baiyao tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1053581C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100453070C (en) * | 2003-12-13 | 2009-01-21 | 昆明紫健生物技术有限公司 | Aseptic dry powder spray agent and production method in use for stopping the blood and diminishing inflammation in wound |
-
1996
- 1996-04-08 CN CN96103380A patent/CN1053581C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100453070C (en) * | 2003-12-13 | 2009-01-21 | 昆明紫健生物技术有限公司 | Aseptic dry powder spray agent and production method in use for stopping the blood and diminishing inflammation in wound |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1053581C (en) | 2000-06-21 |
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Granted publication date: 20000621 Termination date: 20110408 |