CN113730337A - 一种鼻腔清洗液及其制备方法 - Google Patents
一种鼻腔清洗液及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种鼻腔清洗液及其制备方法，所述鼻腔清洗液包括按重量份数计的如下组分：海盐1～5份、薄荷提取物0.1～0.5份、金银花提取物0.5～2份、马齿苋提取物0.5～2份、芦荟提取物0.05～0.2份、黄岑提取物0.1～0.3份、透明质酸盐0.01～0.2份、山梨酸0.01～0.1份、蒸馏水70～100份。本发明所述的鼻腔清洗液配方安全，功效成分主要为中药提取物，具有杀菌消炎、通鼻醒脑、保湿防干燥的作用。
Description
技术领域
本发明属于医药领域，尤其是涉及一种鼻腔清洗液及其制备方法。
背景技术
鼻腔清洗液主要是用来对鼻腔进行清洁冲洗，可有效缓解感冒、鼻炎、天气干燥、灰尘、花粉等引起的鼻腔不舒适感。市面上的鼻腔清洗、护理类产品多种多样，以生理性海水清洗液、具有药理作用的清洗液为主，其中前者的功能较为单一，而后者多加入有抗生素，长期使用可能产生耐药性。
发明内容
有鉴于此，本发明旨在提出一种可有效缓解鼻腔不适感、通鼻醒脑、无毒副作用、安全性高的鼻腔清洗液，同时提供了其制备方法，以解决上述问题。
为达到上述目的，本发明的技术方案是这样实现的：
本发明一方面提供了一种鼻腔清洗液，包括按重量份数计的如下组分：海盐1～5份、薄荷提取物0.1～0.5份、金银花提取物0.5～2份、马齿苋提取物0.5～2份、芦荟提取物0.05～0.2份、黄岑提取物0.1～0.3份、透明质酸盐0.01～0.2份、山梨酸0.01～0.1份、蒸馏水70～100份。
进一步的，包括按重量份数计的如下组分：海盐3～4份、薄荷提取物0.3～0.4份、金银花提取物1～1.5份、马齿苋提取物1.5～2份、芦荟提取物0.1～0.15份、黄岑提取物0.1～0.3份、透明质酸盐0.1～0.2份、0.05～0.1份山梨酸、蒸馏水80～90份。
进一步的，所述薄荷提取物为薄荷脑。
进一步的，所述金银花提取物是将金银花清洗后，在冷水中浸泡后加热熬制浓缩后得到的浓缩液；所述马齿苋提取物和所述黄岑提取物采用与所述金银花提取物相同的方式得到。
进一步的，所述芦荟提取物是将芦荟清洗后，去皮切块后于热水中浸泡后，收集浸泡液，同时将浸泡后的芦荟块榨汁后收集汁液与浸泡水混合后，过滤去渣后，将滤液浓缩后得到的浓缩液。
进一步的，所述透明质酸盐为透明质酸钠。
薄荷脑系由薄荷的叶和茎中所提取，白色晶体，具有清凉止痒、通窍的作用。
金银花具有清热解毒的作用，金银花中含有绿原酸、木犀草素苷等药理活性成分，对溶血性链球菌、金黄葡萄球菌等多种致病菌及上呼吸道感染致病病毒等有较强的抑制力，另外还可增强免疫力、消炎、解热、止血(凝血)等作用。
马齿苋具有抗过敏、杀菌、凉血止血的功效。
芦荟具有比抗炎杀菌、保湿美容、镇痛镇静的作用。
黄岑具有清热燥湿、泻火解毒、止血的作用。
透明质酸盐具有良好的保湿，防干燥效果。
山梨酸为白色针状或粉末状晶体，对酵母、霉菌和许多真菌都具有抑制作用，是高效无毒防腐防霉剂。
本发明另一方面提供了一种鼻腔清洗液的制备方法，包括如下步骤：
S1、按照配比称取海盐、薄荷提取物、金银花提取物、马齿苋提取物、芦荟提取物、黄岑提取物、透明质酸钠、山梨酸及蒸馏水；
S2、将海盐、透明质酸钠、山梨酸及少部分蒸馏水预混合后，过滤，滤液得到预混液A；
S3、将薄荷提取物、金银花提取物、马齿苋提取物、芦荟提取物、黄岑提取物混及少部分蒸馏水混合后，过滤，滤液为预混液B；
S4、将预混液A、预混液B及剩余蒸馏水混合，在真空状态下搅拌均匀后灭菌，得到所述鼻腔清洗液。
进一步的，所述S1中，金银花提取物制备过程为：将金银花清洗后，在冷水中浸泡10～15h后，大火加热熬制沸腾后，转小火微沸腾下30～60min，浓缩后得到金银花提取物；马齿苋提取物和黄岑提取物采用与金银花提取物相同的方式得到。
进一步的，所述S1中，芦荟提取物制备过程为：将芦荟清洗后，去皮切成不大于2cm的小块后，于不低于70℃的热水中浸泡1～3h，收集浸泡液，同时将浸泡后的芦荟块榨汁后收集汁液与浸泡水混合后，过滤去渣，将滤液在60～90℃下浓缩后得到。
进一步的，所述S2和S3中，过滤为将预混液A、预混液B分别通过5～10微米的过滤器。
相对于现有技术，本发明所述的鼻腔清洗液及其制备方法具有以下优势：
(1)本发明所述的鼻腔清洗液配方安全，功效成分主要为中药提取物，具有杀菌消炎、通鼻醒脑、保湿防干燥的作用，可有效缓解鼻腔不适感；
(2)本发明所述的鼻腔清洗液的制备方法简单，制造成本低。
具体实施方式
除有定义外，以下实施例中所用的技术术语具有与本发明所属领域技术人员普遍理解的相同含义。以下实施例中所用的试验试剂，如无特殊说明，均为常规生化试剂；所述实验方法，如无特殊说明，均为常规方法。
下面结合实施例来详细说明本发明。
实施例1
按照如下重量份数称取各组分：
海盐3份、薄荷脑0.3份、金银花提取物1份、马齿苋提取物1、芦荟提取物0.1份、黄岑提取物0.2份、透明质酸盐0.1份、山梨酸0.05份、蒸馏水100份。
其中，金银花提取物、马齿苋提取物、黄岑提取物通过以下方法获得：
将金银花清洗后，在冷水中浸泡10h后，大火加热熬制沸腾后，转小火微沸腾下60min，浓缩后得到金银花提取物；马齿苋提取物和黄岑提取物采用与金银花提取物相同的方式得到。
芦荟提取物通过以下方法获得：
将芦荟清洗后，去皮切成2cm的小块后，于70℃的热水中浸泡3h，收集浸泡液，同时将浸泡后的芦荟块榨汁后收集汁液与浸泡水混合后，过滤去渣，将滤液在70℃下浓缩后得到。
将称取好的海盐、透明质酸钠、山梨酸及20份蒸馏水预混合后，通过10微米的过滤器过滤，滤液得到预混液A；
将薄荷提取物、金银花提取物、马齿苋提取物、芦荟提取物、黄岑提取物混及20份蒸馏水混合后，通过10微米的过滤器过滤，滤液为预混液B；
将预混液A、预混液B及剩余蒸馏水混合，在真空状态下搅拌均匀后，静置1h，灭菌，得到所述鼻腔清洗液。
实施例2
在实施例1的基础上，与实施例1不同的是按照如下重量份数称取各组分：
海盐5份、薄荷脑0.5份、金银花提取物0.5份、马齿苋提取物2、芦荟提取物0.2份、黄岑提取物0.3份、透明质酸盐0.2份、山梨酸0.1份、蒸馏水70份。
其它制备过程与实施例1相同。
实施例3
按照如下重量份数称取各组分：
海盐1份、薄荷脑0.1份、金银花提取物2份、马齿苋提取物0.5、芦荟提取物0.05份、黄岑提取物0.1份、透明质酸盐0.15份、山梨酸0.01份、蒸馏水90份。
其中，金银花提取物、马齿苋提取物、黄岑提取物通过以下方法获得：
将金银花清洗后，在冷水中浸泡15h后，大火加热熬制沸腾后，转小火微沸腾下40min，浓缩后得到金银花提取物；马齿苋提取物和黄岑提取物采用与金银花提取物相同的方式得到。
芦荟提取物通过以下方法获得：
将芦荟清洗后，去皮切成1cm的小块后，于90℃的热水中浸泡3h，收集浸泡液，同时将浸泡后的芦荟块榨汁后收集汁液与浸泡水混合后，过滤去渣，将滤液在90℃下浓缩后得到。
将称取好的海盐、透明质酸钠、山梨酸及20份蒸馏水预混合后，通过5微米的过滤器过滤，滤液得到预混液A；
将薄荷提取物、金银花提取物、马齿苋提取物、芦荟提取物、黄岑提取物混及20份蒸馏水混合后，通过5微米的过滤器过滤，滤液为预混液B；
将预混液A、预混液B及剩余蒸馏水混合，在真空状态下搅拌均匀后，静置1h，灭菌，得到所述鼻腔清洗液。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (10)
1.一种鼻腔清洗液，其特征在于，包括按重量份数计的如下组分：海盐1～5份、薄荷提取物0.1～0.5份、金银花提取物0.5～2份、马齿苋提取物0.5～2份、芦荟提取物0.05～0.2份、黄岑提取物0.1～0.3份、透明质酸盐0.01～0.2份、山梨酸0.01～0.1份、蒸馏水70～100份。
2.根据权利要求1所述的鼻腔清洗液，其特征在于：包括按重量份数计的如下组分：海盐3～4份、薄荷提取物0.3～0.4份、金银花提取物1～1.5份、马齿苋提取物1.5～2份、芦荟提取物0.1～0.15份、黄岑提取物0.1～0.3份、透明质酸盐0.1～0.2份、0.05～0.1份山梨酸、蒸馏水80～90份。
3.根据权利要求1所述的鼻腔清洗液，其特征在于：所述薄荷提取物为薄荷脑。
4.根据权利要求1所述的鼻腔清洗液，其特征在于：所述金银花提取物是将金银花清洗后，在冷水中浸泡后加热熬制浓缩后得到的浓缩液；所述马齿苋提取物和所述黄岑提取物采用与所述金银花提取物相同的方式得到。
5.根据权利要求1所述的鼻腔清洗液，其特征在于：所述芦荟提取物是将芦荟清洗后，去皮切块后于热水中浸泡后，收集浸泡液，同时将浸泡后的芦荟块榨汁后收集汁液与浸泡水混合后，过滤去渣后，将滤液浓缩后得到的浓缩液。
6.根据权利要求1所述的鼻腔清洗液，其特征在于：所述透明质酸盐为透明质酸钠。
7.权利要求1到6任一项所述的鼻腔清洗液的制备方法，其特征在于：包括如下步骤：
S1、按照配比称取海盐、薄荷提取物、金银花提取物、马齿苋提取物、芦荟提取物、黄岑提取物、透明质酸钠、山梨酸及蒸馏水；
S2、将海盐、透明质酸钠、山梨酸及少部分蒸馏水预混合后，过滤，滤液得到预混液A；
S3、将薄荷提取物、金银花提取物、马齿苋提取物、芦荟提取物、黄岑提取物混及少部分蒸馏水混合后，过滤，滤液为预混液B；
S4、将预混液A、预混液B及剩余蒸馏水混合，在真空状态下搅拌均匀后灭菌，得到所述鼻腔清洗液。
8.根据权利要求7所述的鼻腔清洗液的制备方法，其特征在于：所述S1中，金银花提取物制备过程为：将金银花清洗后，在冷水中浸泡10～15h后，大火加热熬制沸腾后，转小火微沸腾下30～60min，浓缩后得到金银花提取物；马齿苋提取物和黄岑提取物采用与金银花提取物相同的方式得到。
9.根据权利要求7所述的鼻腔清洗液的制备方法，其特征在于：所述S1中，芦荟提取物制备过程为：将芦荟清洗后，去皮切成不大于2cm的小块后，于不低于70℃的热水中浸泡1～3h，收集浸泡液，同时将浸泡后的芦荟块榨汁后收集汁液与浸泡水混合后，过滤去渣，将滤液在60～90℃下浓缩后得到。
10.根据权利要求7所述的鼻腔清洗液的制备方法，其特征在于：所述S2和S3中，过滤为将预混液A、预混液B分别通过5～10微米的过滤器。
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