CN111743835A - 一种粘膜修复抑菌液的组合物及应用 - Google Patents
一种粘膜修复抑菌液的组合物及应用 Download PDFInfo
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- CN111743835A CN111743835A CN202010647376.7A CN202010647376A CN111743835A CN 111743835 A CN111743835 A CN 111743835A CN 202010647376 A CN202010647376 A CN 202010647376A CN 111743835 A CN111743835 A CN 111743835A
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- extract
- mucosa
- menthol
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- repair
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Abstract
本发明提供了一种粘膜修复抑菌液，原料至少包含：薄荷醇、冰片、植物提取物；所述薄荷醇、冰片与植物提取物的重量比为5:5：(2‑10)；所述植物提取物至少包括黄芩提取物、金银花提取物、辛夷提取物、白芷提取物、苍耳子提取物的一种。本发明与现有技术相比的优点在于：可以根据需要应用于制备各种不同剂性的洗护用品，本发明采用多种富含扩张粘膜血管、润滑、清热、祛风、止痒、抗炎、抗菌等功能的原料，各原料相辅相成，可以清热解毒，止血、修复粘膜。此外，本发明制备的各种剂性洗护用品可以适用于鼻腔、口腔等各种细菌类、真菌类等感染，能迅速杀菌、促进粘膜的愈合，无任何毒副作用，使用方便，杀菌效果稳定，起效快。
Description
技术领域
本发明涉及抑菌洗护用品技术领域，具体是指一种粘膜修复抑菌液的组合物及应用。
背景技术
天然来源的植物提取物具有丰富的生物功能，如润滑粘膜、抑菌、除臭、止血、止痒、抗炎和口腔溃疡等疾病，合理有效的将具有以上功能的植物活性提取物复合使用，往往能达到意想不到的效果。因为植物活性分子之间具有强烈的协同增效作用，两种或者两种以上的提取物按照一定的比例混好后，可以充分的将各自活性分子的生物特性发挥到极致，达到单一使用一种提取物无法比拟的效果，称之为叠加效应。
发明内容
为了解决上述的技术问题，本发明提供了一种粘膜修复抑菌液，原料至少包含：薄荷醇、冰片、植物提取物；所述薄荷醇、冰片与植物提取物的重量比为5:5：(2-10)；所述植物提取物至少包括黄芩提取物、金银花提取物、辛夷提取物、白芷提取物、苍耳子提取物的一种。
作为一种优选的技术方案，本发明中所述维生素AD、薄荷醇、冰片的重量比为10:1:1。
作为一种优选的技术方案，本发明中所述薄荷醇、冰片与植物提取物的重量比为5：5：(5-9)。
作为一种优选的技术方案，本发明中所述黄芪提取物、苍耳子提取物、辛夷提取物重量比为1：(0.5-2)：(0.1-3)：(0.5-4)。
作为一种优选的技术方案，本发明中所述辛夷提取物、金银花提取物、白芷提取物的组合；所述辛夷提取物、金银花提取物、白芷提取物的组合的重量比为1：(0.5-2)：(0.5-1.5)。
本发明的第二个方面提供了一种所述的粘膜修复抑菌液的应用，应用于洗护用品、纺织物、无纺布、服装、床上用品、家居用品、医护用品中的一种。
作为一种优选的技术方案，本发明中所述洗护用品的剂性选自抑菌液剂(油剂)、抑菌乳液、抑菌喷雾、抑菌霜中的至少一种。
本发明的第三个方面提供了一种抑菌液剂，按重量百分比计，组分包含：5-20％所述的粘膜修复抑菌液组合物，维生素AD补足余量。
本发明的第四个方面提供了一种所述洗护用品的应用，其特征在于，应用于鼻腔、口腔中的一种。
与现有技术相比，本发明具有如下有益效果：
本发明提供了一种粘膜修复抑菌液的组合物，可以根据需要应用于制备各种不同剂性的洗护用品，本发明采用多种富含扩张粘膜血管、润滑、清热、祛风、止痒、抗炎、抗菌等功能的原料，各原料相辅相成，可以清热解毒，止血、修复粘膜。此外，本发明制备的各种剂性洗护用品可以适用于鼻腔、口腔等各种细菌类、真菌类等感染，能迅速杀菌、促进粘膜的愈合，无任何毒副作用，使用方便，杀菌效果稳定，起效快。
附图说明
图1为辛夷提取工艺流程图。
图2为金银花提取物工艺流程图。
具体实施方式
下面结合具体实施方式对本发明提供技术方案中的技术特征作进一步清楚、完整的描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
本技术领域技术人员可以理解，除非另外定义，这里使用的所有术语(包括技术术语和科学术语)具有与本发明所属领域中的普通技术人员的一般理解相同的意义。还应该理解的是，诸如通用字典中定义的那些术语应该被理解为具有与现有技术的上下文中的意义一致的意义，并且除非像这里一样定义，不会用理想化或过于正式的含义来解释。
本发明中的词语“优选的”、“优选地”、“更优选的”等是指，在某些情况下可提供某些有益效果的本发明实施方案。然而，在相同的情况下或其他情况下，其他实施方案也可能是优选的。此外，对一个或多个优选实施方案的表述并不暗示其他实施方案不可用，也并非旨在将其他实施方案排除在本发明的范围之外。
本发明提供了一种粘膜修复抑菌液的组合物，原料至少包含：薄荷醇、冰片、植物提取物；所述薄荷醇、冰片与植物提取物的重量比为5:5：(2-10)；所述植物提取物至少包括黄芩提取物、金银花提取物、辛夷提取物、白芷提取物、苍耳子提取物的一种。
在一些优选的实施方式中，所述薄荷醇、冰片与植物提取物的重量比为5：5：(5-9)；
在一些更优选的实施方式中，所述薄荷醇、冰片与植物提取物的重量比为5：5：7.5；
在一些实施方式中，所述原料还包含维生素AD；所述维生素AD、薄荷醇、冰片的重量比为：10:1:1
本发明提供了一种粘膜修复组合物，具有非常有益的深层快速杀菌的作用效果，发明人发现尤其是采用维生素AD、薄荷醇、冰片与特定的植物提取物之间的复配可以产生优异的协同增效的作用，提高抗菌组合物对于减少刺激增加修复粘膜效果，发明人认为可能是由于，维生素AD本身为人体所需的维生素，其中与薄荷醇、冰片复配后能够增强人体粘膜中的吸收修复的作用效果，在使用到人体粘膜后，能够更容易吸附至施用表面，延长其在施用部位的滞留的时间。
在一些实施方式中，所述植物提取物至少包括黄芩提取物、金银花提取物、辛夷提取物、白芷提取物、苍耳子提取物的一种。
在一些实施方式中，所述的粘膜修复抑菌液的组合物，其特征在于，所述植物提取物包括黄芪提取物、苍耳子提取物、辛夷提取物的组合；所述黄芪提取物、苍耳子提取物、辛夷提取物重量比为(0.5-2)：(0.1-3)：(0.5-4)。
在一些优选的实施方式中，所述黄芪提取物、苍耳子提取物、辛夷提取物重量比为1.1：0.7：1.5。
在一些实施方式中，所述植物提取物包括辛夷提取物、金银花提取物、白芷提取物的组合；所述辛夷提取物、金银花提取物、白芷提取物的组合的重量比为1：(0.5-2)：(0.5-1.5)。
在一些优选的实施方式中，所述辛夷提取物、金银花提取物、白芷提取物的组合的重量比为1：1.2：0.8。
本发明适用于鼻腔，干燥性鼻炎、萎靡性鼻炎、粘膜破损的防治和护理，促进粘膜的愈合。具有止血、止痒、抗菌消炎等功效；同时具有金黄色葡萄球菌、溶血性链球菌、绿脓杆菌、大肠杆菌、抗真菌、抗病毒等病原微生物效果。
薄荷醇
薄荷醇，有机化合物，无色针状结晶或粒状。为薄荷和薄荷精油中的主要成分，以游离和酯的状态存在。薄荷醇有8种异构体，它们的呈香性质各不相同，左旋薄荷醇具有薄荷香气并有清凉的作用，消旋薄荷醇也有清凉作用，其他的异构体无清凉作用。可用作牙膏、香水、饮料和糖果等的赋香剂。在医药上用作刺激药，作用于皮肤或粘膜，有清凉止痒作用；内服可用于头痛及鼻、咽、喉炎症等。
辛夷提取物
辛夷【Magnolia biondii Pamp.】又名紫玉兰、望春花，为木兰科木兰属植物。辛夷为常用中药，以干燥的花蕾供药用，具有温肺通窍、祛风散寒等功效。主治风寒感冒、鼻窦炎、牙痛、头痛等症。
在本发明中，所述的辛夷珠提取物可以购买得到，也可以通过自制得到；优选的，本发明中所述辛夷提取物通过本发明图1所示的制备方法制备得到。
在一些实施方式中，所述图1中辛夷提取物的详细制备方法，如下所示：
称取辛夷原料，进行粉碎过20-60目筛选，置于改装的手提式高压消毒器中，之后进行水蒸气蒸馏，得到挥发油，分装、入库即得。
在本发明中，所述的辛夷提取物的详细制备方法为本领域技术人员熟知的技术方法。
在本发明中，按照图1制备方法制备得到的辛夷提取物，产品品质要求按卫生部药品标准中国药典2010版检测结果符合规定。
本发明中，按照图1制备的所述辛夷提取液感官理化指标如表1所示。
表1辛夷提取液感官理化指标
本发明中，按照图1制备的所述辛夷提取液微生物含量指标如表2所示。
表2微生物含量指标
| 项目(project) | 标准(standard) |
| 细菌菌落总数(cfu/ml) | ≤200 |
| 真菌菌落总数(cfu/ml) | ≤100 |
| 大肠杆菌 | 不应检出 |
| 溶血性链球菌 | 不应检出 |
| 绿脓杆菌 | 不应检出 |
| 金黄色葡萄球菌 | 不应检出 |
在本发明中加入了一定的辛夷提取物，其中主要含有1,8-桉叶素、β-蒎烯、α-蒎烯和香桧烯等成分，其中1,8-桉叶素等活性成分能够显著提高抑菌液抑菌、止血、通鼻窍等作用。发明人进一步发现，加入适量的辛夷提取物与薄荷醇、冰片之间复配后不仅能够进一步的提高体系的抗菌作用，而且还具有非常好的止血效果也得到较好的增强。
金银花提取物
金银花为忍冬科植物忍冬的干燥花蕾或带初开的花。呈棒状，上粗下细，略弯曲，长2-3cm，上部直径3mm，下部直径1.5mm，表面黄白色或绿白色，密被短柔毛。主要有效成分为绿原酸(chlorogenicacid)和木樨草苷(Luteolin)。绿原酸广泛存在于植物中，以金银花、杜仲中的含量较高，具有广泛的药理作用。绿原酸在医药、日用化工、食品等领域都有广泛的应用。金银花提取物是一种提取物，提取自天然植物金银花，主要成份为绿原酸，颜色是棕色粉末，可做为药品、保健品、化妆品的原料。金银花提取物具有抗菌及增强免疫功能的作用，试验表明金银花对伤寒杆菌、副伤寒杆菌、大肠杆菌、变形杆菌、绿脓杆菌、百日咳杆菌、霍乱弧菌、葡萄球菌、链球菌、肺炎双球菌、脑膜炎球菌等均有抑制作用。金银花提取物还具有抑制耐药菌蛋白质合成，金银花提取物对金黄色葡萄球菌耐药植株的呼吸有显著刺激作用，多用于耐药菌株导致的内外科炎症，如治疗肺结核并发呼吸道感染、肺炎、急性细菌性痢疾、腹泻，也有用于降低咽喉部带菌率。
在本发明中，所述的金银花提取物可以购买得到，也可以通过自制得到；优选的，本发明中所述金银花提取物通过本发明图2所示的制备方法制备得到。
在一些实施方式中，所述图2中金银花提取物详细制备方法，如下所示：
称取金银花原料，进行粉碎过20-60目筛选，加入适量75％的乙醇进行沉淀，之后加入9倍的纯化水进行煮沸2.5小时，再加入等量的80％乙醇进行放置24小时，之后抽取上清液去除乙醇，分装、入库即得。
在本发明中，所述的金银花提取物的详细制备方法为本领域技术人员熟知的技术方法。
在本发明中，所述的金银花提取物的产品质要求按卫生部药品标准中国药典2010版检测结果符合规定。
在本发明中，所述金银花提取物的感官理化指标如表3所示。
表3所述金银花提取物的感官理化指标
| 项目(project) | 标准(standard) |
| 性状 | 淡黄色液体 |
| 气味 | 特殊香味 |
| 密度 | 1.002～1.031 |
| 折光 | 1.212～1.243 |
| 砷含量 | ≤3(mg/kg) |
| 重金属 | ＜10ppm |
| 含量 | 固含物＞10％ |
| 绿原酸 | 17％～28％ |
| PH值 | 4.0～8.0 |
在本发明中，所述金银花提取物的微生物含量指标如表4所示。
表4所述金银花提取物的微生物含量指标
| 项目(project) | 标准(standard) |
| 细菌菌落总数(cfu/ml) | ≤200 |
| 真菌菌落总数(cfu/ml) | ≤100 |
| 大肠杆菌 | 不应检出 |
| 溶血性链球菌 | 不应检出 |
| 绿脓杆菌 | 不应检出 |
| 金黄色葡萄球菌 | 不应检出 |
本发明的第二个方面提供了一种如所述的粘膜修复抑菌液的组合物应用，应用于洗护用品、医护用品中的一种。
Claims (9)
1.一种粘膜修复抑菌液的组合物，其特征在于，原料至少包含：薄荷醇、冰片、植物提取物；所述薄荷醇、冰片与植物提取物的重量比为5:5：(2-10)；所述植物提取物至少包括黄芩提取物、金银花提取物、辛夷提取物、白芷提取物、苍耳子提取物的一种。
2.如权利要求1所述的粘膜修复抑菌液的组合物，其特征在于，所述原料还包含维生素AD；所述维生素AD、薄荷醇、冰片的重量比为10:1:1。
3.如权利要求1所述的粘膜修复抑菌液的组合物，其特征在于，所述薄荷醇、冰片与植物提取物的重量比为5：5：(5-9)。
4.如权利要求1-3任一项所述的粘膜修复抑菌液的组合物，其特征在于，所述植物提取物包括黄芪提取物、苍耳子提取物、辛夷提取物的组合；所述黄芪提取物、苍耳子提取物、辛夷提取物重量比为1：(0.5-2)：(0.1-3)：(0.5-4)。
5.如权利要求1-4任一项所述的粘膜修复抑菌液组合物，其特征在于，所述植物提取物包括辛夷提取物、金银花提取物、白芷提取物的组合；所述辛夷提取物、金银花提取物、白芷提取物的组合的重量比为1：(0.5-2)：(0.5-1.5)。
6.一种如权利要求1-5任一项所述的粘膜修复抑菌液的应用，其特征在于，应用于洗护用品、纺织物、无纺布、服装、床上用品、家居用品、医护用品中的一种。
7.如权利要求6所述的粘膜修复抑菌液的应用，其特征在于，所述洗护用品的剂性选自抑菌液剂(油剂)、抑菌乳液、抑菌喷雾、抑菌霜中的至少一种。
8.一种如权利要求7所述的抑菌液剂，其特征在于，按重量百分比计，组分包含：5-20％如权利要求1-5任一项所述的粘膜修复抑菌液组合物，维生素AD补足余量。
9.一种如权利要求7所述洗护用品的应用，其特征在于，应用于鼻腔、口腔中的一种。
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