CN113729033B - Chlorine-containing disinfectant with high thermal stability and preparation method thereof - Google Patents
Chlorine-containing disinfectant with high thermal stability and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of disinfectant fluid, and discloses a chlorine-containing disinfectant with high thermal stability, which comprises the following raw materials in percentage by mass: 180-200g/l of sodium hypochlorite, 3-7g/l of stabilizer, 2-4g/l of chelating agent and 2-5g/l of surfactant; the stabilizer is one of potassium chlorate, sodium phosphate, sodium silicate and potassium bromide; the chelating agent is at least one of alkyl alcohol polyoxyethylene ether and prenol polyoxyethylene ether; the surfactant is one of sodium dodecyl benzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate sodium salt, lauryl alcohol sulfate sodium salt and dodecyl amphoteric betaine, and has low thermal decomposition efficiency and longer shelf life. The invention also provides a preparation method of the chlorine-containing disinfectant with high thermal stability, which has simple and effective process and low manufacturing cost.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to chlorine-containing disinfectant with high thermal stability and a preparation method thereof.
Background
The disinfectant includes ethanol disinfectant, glutaraldehyde disinfectant, chlorine-containing disinfectant of sodium hypochlorite, bleaching powder and bleaching powder extract, and the chlorine-containing disinfectant with chlorine as effective component is a product widely used for killing bacteria and virus, preventing diseases and inhibiting virus transmission.
The chlorine-containing disinfectant has the advantages of low price, good sterilization effect, high safety and the like, is popular, becomes a widely used popular consumer product, and promotes the development, production and development of disinfection products.
The chlorine-containing disinfection solution can effectively kill common bacteria such as escherichia coli, staphylococcus aureus, candida albicans and the like, is safe and reliable for human bodies and disinfection objects under a specified use concentration, but is easy to decompose and lose efficacy under the induction of sodium hypochlorite light, heat, acid and heavy metal serving as an effective component of the chlorine-containing disinfection solution, so that the chlorine-containing disinfection solution is poor in thermal stability and short in shelf life, and the production scheduling and storage difficulties of manufacturers are increased.
Disclosure of Invention
Based on the defects of the prior art, the invention provides the chlorine-containing disinfectant with high thermal stability, which has better thermal stability and longer quality guarantee period.
The invention also aims to provide a preparation method for producing the chlorine-containing disinfectant with high thermal stability, which has simple and effective process and low manufacturing cost.
In order to achieve the purpose, the invention adopts the following technical scheme:
a chlorine-containing disinfectant with high thermal stability comprises the following raw materials by mass concentration: 180-200g/l of sodium hypochlorite, 3-7g/l of stabilizing agent, 2-4g/l of chelating agent and 2-5g/l of surfactant;
the stabilizer is one of potassium chlorate, sodium phosphate, sodium silicate and potassium bromide;
the chelating agent is at least one of alkyl alcohol polyoxyethylene ether and isoamylene alcohol polyoxyethylene ether;
the surfactant is one of sodium dodecyl benzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate sodium salt, lauryl alcohol sulfate sodium salt and dodecyl amphoteric betaine.
Preferably, the sodium hypochlorite solution has an available chlorine content of 1.65g/l.
Preferably, the pH value of the chlorine-containing disinfection solution is 11.5-12.5.
Preferably, the raw materials comprise, by mass concentration: 190g/l of sodium hypochlorite, 3-5g/l of potassium bromide, 3-4g/l of alkyl alcohol polyoxyethylene ether and 2-3g/l of fatty alcohol polyoxyethylene ether sulfate sodium salt, wherein the pH value of the chlorine-containing disinfectant is 12-12.5; the effective chlorine content of the chlorine-containing disinfection solution during 1 year of storage is 1.4-1.65%.
Preferably, the raw materials comprise, by mass concentration: 190g/l of sodium hypochlorite, 5g/l of potassium bromide, 3g/l of alkyl alcohol polyoxyethylene ether and 3g/l of fatty alcohol polyoxyethylene ether sulfate sodium salt, wherein the pH value of the chlorine-containing disinfectant is 12; the available chlorine content of the chlorine-containing disinfection solution during 1 year of storage is 1.5-1.65%.
Furthermore, the invention also provides a preparation method of the chlorine-containing disinfection solution with high thermal stability, which is used for preparing the chlorine-containing disinfection solution with high thermal stability, and comprises the following steps:
s1) adding a pH value regulator into a sodium hypochlorite solution, and adjusting the pH value of the sodium hypochlorite solution to 11.5-12.5;
and S2) sequentially adding a stabilizer, a chelating agent and a surfactant into the sodium hypochlorite solution treated in the step S1), stirring, uniformly stirring, and cooling to room temperature to obtain the chlorine-containing disinfectant.
Preferably, in step S1), the temperature of the sodium hypochlorite solution is not higher than 30 ℃.
Preferably, in step S1), the pH regulator is a sodium hydroxide solution, the concentration of the sodium hydroxide solution is not higher than 15wt%, and the temperature of the sodium hydroxide solution is not higher than 25 ℃.
The technical scheme of the invention has the beneficial effects that: the chlorine-containing disinfectant with high thermal stability contains a stabilizer, a chelating agent and a surfactant, the stabilizer can effectively reduce the thermal decomposition efficiency of sodium hypochlorite in a solution, and molecules of the chelating agent and the surfactant and sodium hypochlorite molecules are subjected to complexation, so that the solubility of the sodium hypochlorite in water can be improved, the thermal stability of the sodium hypochlorite is improved, the thermal decomposition efficiency of the sodium hypochlorite is reduced, and the sodium hypochlorite has a longer quality guarantee period.
The effective chlorine content of the sodium hypochlorite solution is 1.65g/l, so that the sodium hypochlorite solution not only meets the sterilization requirement of the standard GB/T _36758-2018 chlorine-containing disinfectant sanitary requirement, but also has lower decomposition speed and better thermal stability compared with the sodium hypochlorite contained in the chlorine-containing disinfectant with higher concentration.
The preparation method of the chlorine-containing disinfectant with high thermal stability provided by the invention has the advantages of simple production process and low manufacturing cost.
Detailed Description
In the description herein, references to the description of the terms "embodiment," "example," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
The technical solution of the present invention will be further described with reference to the following embodiments.
A chlorine-containing disinfectant with high thermal stability comprises the following raw materials by mass concentration: 180-200g/l of sodium hypochlorite, 3-7g/l of stabilizer, 2-4g/l of chelating agent and 2-5g/l of surfactant;
the stabilizer is one of potassium chlorate, sodium phosphate, sodium silicate and potassium bromide;
the chelating agent is at least one of alkyl alcohol polyoxyethylene ether and prenol polyoxyethylene ether;
the surfactant is one of sodium dodecyl benzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate sodium salt, lauryl alcohol sulfate sodium salt and dodecyl amphoteric betaine.
The chlorine-containing disinfectant with high thermal stability contains the stabilizer, the chelating agent and the surfactant, the stabilizer can effectively reduce the thermal decomposition efficiency of sodium hypochlorite in a solution, and the chelating agent, molecules of the surfactant and sodium hypochlorite molecules are subjected to complexation, so that the solubility of the sodium hypochlorite in water can be improved, the thermal stability of the sodium hypochlorite is further improved, the thermal decomposition efficiency of the sodium hypochlorite is reduced, and the shelf life is longer.
Preferably, the sodium hypochlorite solution has an available chlorine content of 1.65g/l.
The sodium hypochlorite solution with the effective chlorine content of 1.65g/l is detected by a committee testing mechanism to meet the sterilization requirement of the standard GB/T _36758-2018 chlorine-containing disinfectant sanitation requirement, and compared with the sodium hypochlorite contained in the chlorine-containing disinfectant with higher concentration, the decomposition speed of the sodium hypochlorite is lower, and the thermal stability is better.
Preferably, the pH value of the chlorine-containing disinfection solution is 11.5-12.5.
The pH value is set to be between 11.5 and 12.5, so that the thermal decomposition of the sodium hypochlorite is relatively mild, and the thermal stability of the sodium hypochlorite contained in the chlorine-containing disinfection solution is favorably improved.
Preferably, the raw materials comprise the following components in percentage by mass: 190g/l of sodium hypochlorite, 3-5g/l of potassium bromide, 3-4g/l of alkyl alcohol polyoxyethylene ether and 2-3g/l of sodium fatty alcohol polyoxyethylene ether sulfate, wherein the pH value of the chlorine-containing disinfectant is 12-12.5; the effective chlorine content of the chlorine-containing disinfection solution during 1 year of storage is 1.4-1.65%.
The heat stability of the chlorine-containing disinfection solution has better performance, and the reduction rate of the available chlorine of the chlorine-containing disinfection solution in one year of storage is not more than 15%.
Preferably, the starting materials comprise: 190g/l of sodium hypochlorite, 5g/l of potassium bromide, 3g/l of alkyl alcohol polyoxyethylene ether and 3g/l of fatty alcohol polyoxyethylene ether sulfate sodium salt, wherein the pH value of the chlorine-containing disinfectant is 12; the available chlorine content of the chlorine-containing disinfection solution during 1 year of storage is 1.5-1.65%.
The heat stability of the chlorine-containing disinfectant has the best effect, and the reduction rate of the available chlorine of the chlorine-containing disinfectant in one year is less than 10%.
Furthermore, the invention also provides a preparation method of the chlorine-containing disinfection solution with high thermal stability, which is used for preparing the chlorine-containing disinfection solution with high thermal stability, and comprises the following steps:
s1) adding a pH value regulator into a sodium hypochlorite solution, and adjusting the pH value of the sodium hypochlorite solution to 11.5-12.5;
and S2) sequentially adding a stabilizer, a chelating agent and a surfactant into the sodium hypochlorite solution treated in the step S1), stirring, uniformly stirring, and cooling to room temperature to obtain the chlorine-containing disinfectant.
The production process is simple and the manufacturing cost is low.
Preferably, in step S1), the temperature of the sodium hypochlorite solution is not higher than 30 ℃.
If the temperature of the sodium hypochlorite solution is higher than 30 ℃, the sodium hypochlorite solution generates heat when being added, so that the temperature of the sodium hypochlorite solution is easily increased to exceed 40 ℃, the thermal decomposition of the sodium hypochlorite is increased, and the unsafe phenomenon that the sodium hydroxide solution splashes is easily generated.
Preferably, in step S1), the pH regulator is a sodium hydroxide solution, the concentration of the sodium hydroxide solution is not higher than 15wt%, and the temperature of the sodium hydroxide solution is not higher than 25 ℃.
The high-concentration sodium hydroxide solution is added to easily cause the disproportionation reaction of sodium hypochlorite, so that the sterilizing effect of the chlorine-containing disinfectant is reduced.
Examples 1 to 5 and comparative examples 1 to 4
1. The chlorine-containing disinfection solutions of the examples and the comparative examples were prepared by the following steps:
s1) adding a pH value regulator into a sodium hypochlorite solution, and adjusting the pH value of the sodium hypochlorite solution to 11.5-12.5;
s2) sequentially adding a stabilizer, a chelating agent and a surfactant into the sodium hypochlorite solution treated in the step S1), stirring, and cooling to room temperature after uniformly stirring to obtain the chlorine-containing disinfectant;
in the step S1), the temperature of the sodium hypochlorite solution is not higher than 30 ℃;
in the step S1), the pH value regulator is a sodium hydroxide solution, the concentration of the sodium hydroxide solution is not higher than 15wt%, and the temperature of the sodium hydroxide solution is not higher than 25 ℃.
2. The raw material components and ratios, and process parameters of each example and comparative example are detailed in table 1.
3. The chlorine-containing disinfectant prepared in each example and comparative example is stored for 1 year at the temperature of 30-37 ℃, and then the content of available chlorine is determined according to the requirement of appendix A of GB/T36758-2018 'hygienic requirement for chlorine-containing disinfectant', and the detection result is detailed in Table 1.
Table 1 raw material composition, process parameters and test results of each example and comparative example
The analysis of the test results according to the above examples and comparative examples is illustrated below:
1. the chlorine-containing disinfectant prepared in the embodiments 1 to 5 is stored for 1 year at the temperature of 30 to 37 ℃, and the measured reduction rate of the effective chlorine content is lower than 15 percent, which meets the regulation of the national standard GB/T36758-2018 hygienic requirement for chlorine-containing disinfectant; wherein the reduction rate of the available chlorine content of the examples 4 and 5 is less than 10%, for this reason, the invention continues to carry out the tracking experiment of the available chlorine content stored for 2 years in the temperature environment of 30-37 ℃, and the reduction rate of the available chlorine content of the corresponding examples 4 and 5 stored for 2 years is 14.5% and 11.5%, respectively, and is still less than 15%, which shows that the schemes of the examples 4 and 5 have better thermal stability; wherein the chlorine-containing disinfectant of the embodiment 5, which has a pH value of 12 and contains 190g/l of sodium hypochlorite, 5g/l of potassium bromide, 3g/l of alkyl alcohol polyoxyethylene ether and 3g/l of sodium fatty alcohol polyoxyethylene ether sulfate, has the best effect.
2. Comparative example 1 differs from example 5 in that: the chlorine-containing disinfectant of comparative example 1 is stored for 1 year at the temperature of 30-37 ℃, the measured reduction rate of the effective chlorine content is 17.6%, compared with example 5, the thermal stability is obviously reduced, and the disinfectant does not meet the regulation of national standard GB/T36758-2018' hygienic requirement for chlorine-containing disinfectant.
3. The difference of comparative example 2 compared to example 5 is that: the chlorine-containing disinfectant does not contain potassium bromide, the reduction rate of the effective chlorine content measured by storing the chlorine-containing disinfectant of the comparative example 2 for 1 year at the temperature of 30-37 ℃ is 20.6%, and compared with the thermal stability of the example 5, the reduction rate is more obvious, and the chlorine-containing disinfectant does not meet the regulation of the national standard GB/T36758-2018 'hygienic requirement for chlorine-containing disinfectants'.
4. The difference of comparative example 3 compared to example 5 is that: the chlorine-containing disinfectant does not contain potassium bromide and alkyl alcohol polyoxyethylene ether, the chlorine-containing disinfectant in the comparative example 3 is stored for 1 year in the temperature environment of 30-37 ℃, the measured reduction rate of the effective chlorine content is 36.4%, and compared with the example 5, the thermal stability is particularly obviously reduced, and the chlorine-containing disinfectant does not meet the regulation of the national standard GB/T36758-2018 'hygienic requirement for chlorine-containing disinfectants'.
5. Comparative example 4 differs from example 5 in that: the initial effective chlorine content of the chlorine-containing disinfectant of the comparative example 4 is 3.00g/l, the reduction rate of the measured effective chlorine content of the chlorine-containing disinfectant of the comparative example 4 is 28.3 percent when the chlorine-containing disinfectant is stored for 1 year in a temperature environment of 30-37 ℃, and the thermal stability is obviously reduced compared with that of the example 5, which shows that the higher the initial effective chlorine content of the chlorine-containing disinfectant is, the greater the reduction rate of the effective chlorine content after the chlorine-containing disinfectant is stored for 1 year is, and the chlorine-containing disinfectant does not meet the regulation of the national standard GB/T36758-2018 hygienic requirement for chlorine-containing disinfectants.
In conclusion, the chlorine-containing disinfectant with high thermal stability contains the stabilizer, the chelating agent and the surfactant, the stabilizer can effectively reduce the thermal decomposition efficiency of sodium hypochlorite in a solution, and the chelating agent, molecules of the surfactant and sodium hypochlorite molecules are subjected to complexation, so that the solubility of the sodium hypochlorite in water can be improved, the thermal stability of the sodium hypochlorite is further improved, the thermal decomposition efficiency of the sodium hypochlorite is reduced, and the shelf life is longer.
The effective chlorine content of the sodium hypochlorite solution is 1.65g/l, so that the sodium hypochlorite solution not only meets the sterilization requirement of the standard GB/T _36758-2018 chlorine-containing disinfectant sanitary requirement, but also has lower decomposition speed and better thermal stability compared with the sodium hypochlorite contained in the chlorine-containing disinfectant with higher concentration.
The preparation method of the chlorine-containing disinfectant with high thermal stability provided by the invention has the advantages of simple production process and low manufacturing cost.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
The technical principle of the present invention is described above in connection with specific embodiments. The description is only intended to explain the principles of the invention; and should not be construed as limiting the scope of the invention in any way. Based on the explanations herein; other embodiments of the invention will occur to those skilled in the art without the need for inventive faculty; all of which fall within the scope of the present invention.
Claims (6)
1. A chlorine-containing disinfectant with high thermal stability is characterized in that the raw materials comprise the following components in percentage by mass: 180-200g/l of sodium hypochlorite, 3-7g/l of stabilizer, 2-4g/l of chelating agent and 2-5g/l of surfactant;
the stabilizer is one of potassium chlorate, sodium phosphate, sodium silicate and potassium bromide;
the chelating agent is at least one of alkyl alcohol polyoxyethylene ether and prenol polyoxyethylene ether;
the surfactant is one of sodium dodecyl benzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate sodium salt, lauryl alcohol sulfate sodium salt and dodecyl amphoteric betaine;
the effective chlorine content of the sodium hypochlorite solution is 1.65g/l;
the pH value of the chlorine-containing disinfectant is 11.5-12.5;
the preparation of the chlorine-containing disinfectant comprises the following steps:
s1) adding a pH value regulator into a sodium hypochlorite solution with the temperature not higher than 30 ℃ to regulate the pH value of the sodium hypochlorite solution;
s2) sequentially adding a stabilizer, a chelating agent and a surfactant into the sodium hypochlorite solution treated in the step S1), stirring, and cooling to room temperature after uniformly stirring to obtain the chlorine-containing disinfectant;
in the step S1), the pH value regulator is a sodium hydroxide solution, the concentration of the sodium hydroxide solution is not higher than 15wt%, and the temperature of the sodium hydroxide solution is not higher than 25 ℃.
2. The chlorine-containing disinfection solution with high thermal stability as claimed in claim 1, wherein the raw materials comprise, by mass concentration: 190g/l of sodium hypochlorite, 3-5g/l of potassium bromide, 3-4g/l of alkyl alcohol polyoxyethylene ether and 2-3g/l of fatty alcohol polyoxyethylene ether sulfate sodium salt, wherein the pH value of the chlorine-containing disinfectant is 12-12.5; the available chlorine content of the chlorine-containing disinfection solution during 1 year of storage is 1.4-1.65%.
3. The chlorine-containing disinfection solution with high thermal stability as claimed in claim 1, wherein the raw materials comprise, by mass concentration: 190g/l of sodium hypochlorite, 5g/l of potassium bromide, 3g/l of alkyl alcohol polyoxyethylene ether and 3g/l of fatty alcohol polyoxyethylene ether sulfate sodium salt, wherein the pH value of the chlorine-containing disinfectant is 12; the available chlorine content of the chlorine-containing disinfection solution during 1 year of storage is 1.5-1.65%.
4. A method for preparing a chlorine-containing disinfection solution with high thermal stability, which is used for preparing the chlorine-containing disinfection solution with high thermal stability of any one of claims 1-3, and comprises the following steps:
s1) adding a pH value regulator into a sodium hypochlorite solution to adjust the pH value of the sodium hypochlorite solution;
and S2) sequentially adding a stabilizer, a chelating agent and a surfactant into the sodium hypochlorite solution treated in the step S1), stirring, uniformly stirring, and cooling to room temperature to obtain the chlorine-containing disinfectant.
5. The method as claimed in claim 4, wherein the temperature of the sodium hypochlorite solution in step S1) is not higher than 30 ℃.
6. The method as claimed in claim 4, wherein in step S1), the pH regulator is sodium hydroxide solution, the concentration of the sodium hydroxide solution is not higher than 15wt%, and the temperature of the sodium hydroxide solution is not higher than 25 ℃.
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| CN202111039284.1A CN113729033B (en) | 2021-09-06 | 2021-09-06 | Chlorine-containing disinfectant with high thermal stability and preparation method thereof |
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| CN202111039284.1A CN113729033B (en) | 2021-09-06 | 2021-09-06 | Chlorine-containing disinfectant with high thermal stability and preparation method thereof |
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