CN1126452C

CN1126452C - High stability chlorine-containing disinfectant and making method thereof

Info

Publication number: CN1126452C
Application number: CN 99115381
Authority: CN
Inventors: 王维加
Original assignee: Individual
Current assignee: Individual
Priority date: 1999-05-26
Filing date: 1999-05-26
Publication date: 2003-11-05
Anticipated expiration: 2019-05-26
Also published as: CN1275324A

Abstract

The present invention belongs to the technical field of disinfectants, which relates to a high-stability disnfectant containing chlorine and a preparation method thereof. The disinfectant comprises at least one of alkali metal hypochlorite or water solution containing hypochloric acid radicals, chlorite, anionic surfactants and complexing stabilizing agents, and a formed mixture exists in the water solution by a stable complexing coordination way. In the preparation method, the raw materials and water are added to a reaction kettle and heated to the temperature of 50 to 80 DEG C in a stirring state under the normal pressure, the materials react for 0.15 to 2 hours; then, the materials are cooled to the normal temperature to obtain a product having the pH value from 10 to 12, and the effective chlorine content is from 0.2 to 2.5%.

Description

Chlorine-containing disinfectant and its preparation method

The invention belongs to the technical field of disinfectants, and relates to a high-stability chlorine-containing disinfectant and a preparation method thereof.

Chlorine-containing disinfectants are efficient broad-spectrum disinfectants with the widest application range due to low price and easy availability, but effective chlorine of products is easy to degrade, and the sterilization effect is directly influenced, in order to solve the problem, many scientific and technological workers make continuous efforts, for example, the CN1034573A patent application discloses a stabilizer taking alkali metal hydroxide, alkali metal silicate and carbonate as sodium hypochlorite, the CN1080319A patent application discloses a stabilizer taking alkali metal alkylbenzene sulfonate and sodium tripolyphosphate as hypochlorite, and the CN1109097A patent application discloses a purpose of stabilizing the slow degradation of the effective chlorine in a hypochlorite aqueous solution through the synergistic effect of a plurality of surfactants. Although the methods have certain effect on improving the stability of the chlorine-containing disinfectant, the effect is still not obvious, for example, the best result (54 ℃/14 days) of a stability acceleration test is-71.62%, and the requirement is far from-10%, so that the method cannot adapt to the actual use requirement.

The invention aims to provide a high-efficiency broad-spectrum high-stability chlorine-containing disinfectant which has the advantages of very slow degradation of effective chlorine, good disinfection effect, weak metal corrosion effect, no stimulation and toxicity to human skin, low production cost, stable performance and convenient use, and a preparation method thereof.

The object of the present invention is achieved in the following manner. The high-stability chlorine-containing disinfectant comprises at least one of alkali metal hypochlorite or aqueous solution containing hypochlorite, chlorite, an anionic surfactant and a complexing stabilizer, wherein the formed mixture exists in the aqueous solution in a stable complexing coordination form. The aqueous solution containing hypochlorite can be sodium chlorate (NaClO) or bleaching powder (CaOCl)₂) Chlorinated trisodium phosphate ((NaPO)₄.11H2O)₄NaClO), Youjing (dichloroisocyanuric acid), etc. can dissociate OCl in water^-The substance of (1). The chlorite can be sodium chlorite (NaClO)₂) Potassium chlorite (KClO)₂) And chlorine dioxide (ClO)₂) And sodium percarbonate or percarbonate thereofStabilized chlorine dioxide absorbed by sodium borate. The complexing stabilizer is water-soluble phosphate (such as sodium tripolyphosphate Na)₅P₃O₁₀Sodium phosphate Na₃PO₄) Water-soluble silicate (e.g. sodium silicate Na)₂SiO₃.9H₂O) water-soluble carbonate (e.g. Na)₂CO₃). The anionic surfactant may be lauryl alcohol polyoxyethylene ether phosphate or other commonly used anionic surfactants. The high-stability chlorine-containing disinfectant can also contain alkali metal halide, and the alkali metal halide can be chlorine or iodine salt of sodium or potassium.

The high-stability chlorine-containing disinfectant comprises the following components in percentage by weight:

alkali metal hypochlorite or hypochlorite-containing aqueous solution contains effective chlorine 1-2.5%, chlorite 1-2.5%, alkali metal halide 0-0.02%, anionic surfactant 0.001-0.1%, complexing stabilizer 0.2-6.0%, and water

The preparation method of the high-stability chlorine-containing disinfectant comprises the steps of adding raw materials such as alkali metal hypochlorite or aqueous solution containing hypochlorite, chlorite, alkali metal halide, an anionic surfactant, a complexing stabilizer and the like and water into a reaction kettle, heating to 50-80 ℃ under the normal pressure stirring state to react the materials, timing for 0.15-2 hours, then cooling to room temperature (or cooling to 40 ℃, sampling to analyze effective chlorine, adjusting the concentration of the effective chlorine to the required concentration, and standing for 20-40 minutes), wherein the pH value of an obtained product is 10-12, and the content of the effective chlorine is 0.2-2.5%. In the above-mentioned production method, the reaction temperature of the materials is preferably 60 to 75 ℃ and more preferably 70 ℃ and the reaction time is preferably 0.15 to 1 hour and more preferably 20 minutes.

The following are non-limiting examples of the invention in order to further illustrate the invention.

1000Kg of product is prepared according to the following raw material adding amount

Remark on name of charging quantity (Kg)

Ingredient 1 ingredient 2

Sodium carbonate 1525 solid, technical grade

1014 solid, technical grade sodium tripolyphosphate

Sodium silicate 4570 liquid, sodium silicate 40%,

Na₂O/SiO₂＝1.03±0.03

Sodium hypochlorite 2626 liquid, available chlorine is more than or equal to 10%

Sodiumchlorite 1.21.2 solid, technical grade

Sodium chloride/sodium iodide 00.2 solid

Industrial grade 1.04.0 polyoxyethylene lauryl phosphate

Balance of water

The raw materials are put into a reaction kettle, heated to 70 ℃ under stirring, reacted for 30 minutes under normal pressure, and cooled to room temperature to obtain the product of the invention. The effective chlorine concentration of the obtained product is as follows: 0.257% and ingredient 2: 0.258% (weight percentage). When in actual use, the chlorine concentration is adjusted by water according to the required effective chlorine concentration.

In the embodiment, the sodium silicate can be liquid or solid, is compounded with sodium carbonate and sodium tripolyphosphate, has a synergistic stabilizing effect, is also a buffer regulator of a disinfectant, and avoids the defect that the sodium hydroxide is too strong in alkalinity and has great corrosion to skin and clothes when being used as a stabilizing synergist. Sodium chlorite produces chlorine dioxide by reacting with hypochlorite:

(wherein, Y is a ligand, and can be Si, C, P ion) alkali metal halide and OCl^-Ion pairing is formed, and the two synergistically enhance OCl^-The anion surfactant has the effects of slowing down metal corrosion, lubricating skin, removing dirt and the like. The respective functions achieve further synergistic effect after chemical complexation, and fig. 1 is an ultraviolet absorption spectrogram of the disinfectant, so that the raw materials exist in a product in a certain complexation coordination form to achieve the optimal effect of stabilizing the degradation of the chlorine preparation.

The following effects were achieved by testing two products made with ingredient 1 and ingredient 2 of this example:

1. accelerated stability test: after the sample is placed in a constant temperature cabinet at 54 ℃ for 14 days, the degradation rate of the measured effective chlorine content is less than or equal to 10 percent, and the requirement of shelf life can be completely met.

2. Metal corrosion test: the test result shows that the product of the invention has slight corrosion to aluminum, copper and basically no corrosion to stainless steel and carbon steel.

3. Bacterial propagule killing test: the disinfectant acts for 5 minutes under the concentration of 50mg/l, the killing rate to escherichia coli is 99.99 percent, the action time is 10 minutes, and the killing rate to staphylococcus aureus is 99.99 percent.

4. Bacillus subtilis var niger killing test: the disinfectant acts for 40 minutes under the concentration of 500mg/l, the killing rate of bacillus subtilis spores is 99.91 percent, and the disinfectant acts for 40 minutes under the concentration of 1000mg/l, and the killing rate reaches 100 percent.

5. The destructive effect test on the hepatitis B surface antigen: the disinfectant acts for 20 minutes at the concentration of 1000mg/l and acts for 5 minutes at the concentration of 2000mg/l, so that HBSAg antigen can be converted into negative.

6. Effect on killing of bacillus subtilis in the presence of organic matter: the disinfectant has slight influence on the bactericidal effect of bacillus subtilis spores in the presence of 25% and 50% of calf serum.

7. The field disinfection test results are as follows: the disinfectant is applied on site at the concentration of 1000mg/l, acts for 40 minutes, and has the sterilization rate of 100 percent on 50 pieces of used medical instruments, thereby meeting the sterilization requirement.

8. Acute radial and oral toxicity assay results: adopting Hohner method to breed Kunming white mouse LD₅₀Bw is more than 1000mg/kg, and the product of the invention is actually nontoxic according to the grading standard of acute toxicity in the disinfection technical Specification.

9. Disposable skin irritation test: according to the GB7919-87 standard, white guinea pigs are adopted, the integral average value of the skin irritation reaction is zero, and the skin irritation strength of the product is nonirritant.

The invention relates to a high-stability chlorine-containing disinfectant and a preparation method thereof, which changes the prior art into the common method of adopting strong alkalinity or sodium dodecyl benzene sulfonate or sodium tripolyphosphate and sodium silicate as stabilizers, uses the synergistic effect of hypochlorite and chlorine dioxide, and uses the ion pairing technology of chemical complexing coordination and alkali metal halide, solves the problems of poor stability of the prior chlorine-containing disinfectant product, overcomes the defects of high corrosivity to metal, large irritation to skin and the like, has the characteristics of no special requirements in the production process, easily available raw materials, low cost, stable quality, no three-waste pollution and the like, and has long-term shelf stability.

Description of the drawings: FIG. 1 is a graph of the UV absorption spectrum of a product of the present invention, wherein the graph is a spectral absorption curve, indicating the presence of a certain complex coordination form in the product.

Claims

1. A chlorine-containing disinfectant comprises chlorite, at least one of alkali metal hypochlorite or hypochlorite-containing aqueous solution, and is characterized by also comprising an anionic surfactant and a complexing stabilizer, wherein the formed mixture exists in the aqueous solution in a stable complexing coordination form, and the content ranges of the components are as follows (in percentage by weight):

effective chlorine content in alkali metal hypochlorite or hypochlorite-containing aqueous solution: 1-2.5% of chlorite, 1-2.5% of ionic surfactant, 0.001-0.1% of complexing stabilizer and the balance of water, wherein the complexing stabilizer is water-soluble phosphate, water-soluble silicate and water-soluble carbonate.

2. The chlorine-containing disinfectant as set forth in claim 1, wherein said hypochlorite-containing aqueous solution is selected from the group consisting of sodium hypochlorite (NaClO), bleaching powder (CaOCl)₂) Chlorinated trisodium phosphate ((NaPO)₄.11H₂O)₄NaClO), dichloroisocyanuric acid in water can dissociate to OCl^-The substance of (1).

3. The disinfectant containing chlorine as set forth in claim 1, wherein said chlorite is sodium chlorite (NaClO)₂) Potassium chlorite (KClO)₂) And chlorine dioxide (ClO)₂) And stabilized chlorine dioxide absorbed by sodium percarbonate or sodium perborate.

4. The chlorine-containing disinfectant as set forth in claim 1, wherein said anionic surfactant is lauryl alcohol polyoxyethylene ether phosphate or other commonly used anionic surfactants.

5. A chlorine-containing disinfectant as set forth in any one of claims 1 to 4, characterized in that it further comprises an alkali metal halide which may be a chlorine or iodine salt of sodium or potassium in an amount of 0-0.02%.

6. A process for preparing the disinfectant containing Cl includes such steps as adding alkali-metal hypochlorite or the aqueous solution containing hypochlorite, chlorite, alkali-metal halide, anionic surfactant and complexing stabilizer, and water to reactor, stirring while heating to 50-80 deg.C for 0.15-2 hr, cooling to ordinary temp, and regulating pH value to 10-12 and available Cl content to 0.2-2.5%.

7. The method for preparing chlorine-containing disinfectant as claimed in claim 6, wherein the reaction temperature of the materials is 60-75 ℃ and the reaction time is 0.15-1 hour.

8. The method according to claim 7, wherein the reaction temperature is 70 ℃ and the reaction time is 20 minutes.