CN108272649B - IgY-containing clear mouthwash and preparation method thereof - Google Patents
IgY-containing clear mouthwash and preparation method thereof Download PDFInfo
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- CN108272649B CN108272649B CN201810283928.3A CN201810283928A CN108272649B CN 108272649 B CN108272649 B CN 108272649B CN 201810283928 A CN201810283928 A CN 201810283928A CN 108272649 B CN108272649 B CN 108272649B
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 33
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 27
- 229920001661 Chitosan Polymers 0.000 claims abstract description 25
- 239000000243 solution Substances 0.000 claims abstract description 19
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- 235000010447 xylitol Nutrition 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
- KLLLJCACIRKBDT-UHFFFAOYSA-N 2-phenyl-1H-indole Chemical compound N1C2=CC=CC=C2C=C1C1=CC=CC=C1 KLLLJCACIRKBDT-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003381 stabilizer Substances 0.000 claims abstract description 13
- 239000004386 Erythritol Substances 0.000 claims abstract description 7
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019414 erythritol Nutrition 0.000 claims abstract description 7
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 7
- 229940009714 erythritol Drugs 0.000 claims abstract description 7
- 239000000796 flavoring agent Substances 0.000 claims abstract description 7
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 7
- 239000005714 Chitosan hydrochloride Substances 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 42
- 238000002156 mixing Methods 0.000 claims description 21
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical group CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 15
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 15
- 229940041616 menthol Drugs 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 13
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 4
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 2
- 235000019477 peppermint oil Nutrition 0.000 claims description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 8
- 239000000594 mannitol Substances 0.000 abstract description 6
- 229960001855 mannitol Drugs 0.000 abstract description 6
- 210000000214 mouth Anatomy 0.000 abstract description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract description 4
- 229930195725 Mannitol Natural products 0.000 abstract description 4
- 235000010355 mannitol Nutrition 0.000 abstract description 4
- 238000009776 industrial production Methods 0.000 abstract description 3
- 239000008367 deionised water Substances 0.000 description 19
- 229910021641 deionized water Inorganic materials 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000605986 Fusobacterium nucleatum Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a clear mouthwash containing IgY and a preparation method thereof, wherein the clear mouthwash containing IgY comprises the following components in percentage by mass: IgY0.1-0.5%; 0.1-0.5% of 20% chlorhexidine; 0.01-0.15% of a stabilizer I; 0.2-4% of a stabilizer II; tween-800.002-0.01%; 0.01-0.05% of a flavoring agent; the balance of water; wherein the stabilizer I is one or more of chitosan, chitosan hydrochloride or chitosan acetate; the stabilizer II is one or more of xylitol, erythritol or mannitol. The content of IgY and chlorhexidine in the clear mouthwash provided by the invention is stable, the solution is clear, the smell is fragrant, and the clear mouthwash is easily accepted by people; the mouthwash can inhibit pathogenic bacteria in oral cavity, and has the advantages of simple preparation process, low production cost, easy industrial production and good market prospect.
Description
Technical Field
The invention relates to the technical field of daily chemical industry and medicine production, in particular to a clear mouthwash containing IgY and a preparation method thereof.
Background
Along with the improvement of living standard of people, the continuous pursuit of beauty also pays more and more attention to oral hygiene. Biofilms formed by pathogenic bacteria such as staphylococcus and streptococcus mutans in the oral cavity are adsorbed on the oral cavity and tooth surfaces, and harm to human oral health.
Chlorhexidine is the most powerful disinfectant of guanidine, has a weak killing effect on gram-positive bacteria, gram-negative bacteria and fungi, has a weak killing effect on mycobacterium tuberculosis and certain fungi with strong resistance, has only an inhibiting effect on bacterial spores, has no bad smell, has small irritation and is easily accepted by users. IgY can treat diseases caused by bacteria, viruses and the like, such as diseases caused by porphyromonas gingivalis and fusobacterium nucleatum composite strains, and can be directly adhered to the cell wall of pathogenic bacteria, so that the integrity of the pathogenic bacteria cells is changed, and the growth of the pathogenic bacteria is directly inhibited; and the IgY can well kill helicobacter pylori, staphylococcus aureus, escherichia coli and candida albicans.
As a means for sterilization, disinfection, anti-inflammation and irregular tooth prevention, in the field of liquid oral combination, the complex bactericide prepared by compounding the egg yolk antibody (IgY) and the chlorhexidine can better kill the oral pathogenic bacteria. Therefore, it is very significant to develop a compound bactericide containing IgY and chlorhexidine.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the IgY-containing clear mouthwash, which has stable content of IgY and chlorhexidine, clear solution and fragrant smell and is easily accepted by people; the mouthwash can inhibit pathogenic bacteria in oral cavity, and has the advantages of simple preparation process, low production cost, easy industrial production and good market prospect.
Another object of the present invention is to provide a process for the preparation of the above-mentioned IgY-containing clear collutory.
In order to achieve the purpose, the invention adopts the following technical scheme:
the IgY-containing clear mouthwash consists of the following components in percentage by mass:
IgY 0.1～0.5%；
0.1-0.5% of 20% chlorhexidine;
0.01-0.15% of a stabilizer I;
0.2-4% of a stabilizer II;
tween-800.002-0.01%;
0.01-0.05% of a flavoring agent;
the balance of water;
wherein the stabilizer I is one or more of chitosan, chitosan hydrochloride or chitosan acetate; the stabilizer II is one or more of xylitol, erythritol or mannitol.
The inventor of the invention finds that although the mixed solution of the IgY and the chlorhexidine has good effects of disinfection, sterilization, anti-inflammation and the like, the IgY solution is unstable at normal temperature, and the titer of the IgY solution tends to be reduced about half a year, so that the curative effect of the IgY solution is influenced. And the IgY and the chlorhexidine have compatibility reaction when being prepared into the mouthwash, and white flocculent precipitate is separated out. In order to solve the problems of stability and curative effect, the inventor finds that when a proper amount of chitosan or chitosan salt is added into a mixed solution of the IgY and the chlorhexidine, the compatibility reaction of the IgY and the chlorhexidine can be well blocked, the mouthwash is kept in a clear state all the time, and meanwhile, the stability of the IgY and the chlorhexidine in an aqueous solution is facilitated. On the basis, the addition of a proper amount of sugar alcohol is more beneficial to the stability of the IgY in the aqueous solution, thereby improving the overall stability and curative effect of the product.
Preferably, the IgY-containing clear mouthwash consists of the following components in percentage by mass:
IgY 0.15～0.5%；
0.15-0.5% of 20% chlorhexidine;
0.01-0.1% of a stabilizer I;
0.5-3% of a stabilizer II;
tween-800.002-0.005%;
0.01-0.05% of a flavoring agent;
the balance being water.
Preferably, the flavoring agent is menthol and/or peppermint oil.
Preferably, the stabilizer I is chitosan, the stabilizer II is xylitol, and the flavoring agent is menthol.
The preparation method of the IgY-containing clear mouthwash comprises the following steps:
s1: adding tween-80 and correctant into part of warm water under stirring, stirring to dissolve, cooling, adding stabilizer II, and stirring to dissolve;
s2: adding IgY into the rest water, stirring until the IgY is dissolved, and filtering;
s3: and (3) uniformly mixing the solutions obtained in the S1 and the S2, adding the stabilizer I, uniformly stirring and mixing, adding the chlorhexidine, uniformly stirring and mixing, and filtering to obtain the IgY-containing clear mouthwash.
Preferably, the stabilizer I is added in the form of a solution, and the mass concentration of the solution of the stabilizer I is 0.5-1.5%.
Preferably, in S1, the warm water has a temperature of 40-50 ℃.
Preferably, in S1, the amount of the warm water is 20% of the total mass of the water.
Compared with the prior art, the invention has the following beneficial effects:
the content of IgY and chlorhexidine in the clear mouthwash provided by the invention is stable, the solution is clear, the smell is fragrant, and the clear mouthwash is easily accepted by people; the mouthwash can inhibit pathogenic bacteria in oral cavity, and has the advantages of simple preparation process, low production cost, easy industrial production and good market prospect.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.
Unless otherwise indicated, reagents and materials used in the present invention are commercially available.
Example 1
A clear collutory containing IgY comprises the following components:
5g of IgY, 1.4g of 20% chlorhexidine, 0.7g of chitosan hydrochloride, 4g of erythritol, 800.05 g of tween-9 g, 0.1g of menthol and 988.75g of deionized water.
The preparation method comprises the following steps:
(1) under the stirring state, adding tween 80 and menthol into 198g of deionized water at the temperature of 40-50 ℃, stirring until the deionized water is dissolved, cooling, adding erythritol, and stirring until the erythritol is dissolved;
(2) adding the IgY into the rest deionized water, stirring until the IgY is dissolved, and filtering;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2), adding chitosan hydrochloride, uniformly stirring and mixing, adding chlorhexidine, uniformly stirring and mixing, filtering, and subpackaging to obtain the compound preparation.
Example 2
A clear collutory containing IgY comprises the following components:
IgY 3g, 20% chlorhexidine 1.2g, chitosan 0.9g, chitosan acetate 0.6g, xylitol 17g, mannitol 18g, Tween-800.02 g, menthol 0.5g, and deionized water 958.78 g.
The preparation method comprises the following steps:
(1) under the stirring state, adding tween 80 and menthol into deionized water with the total amount of 192g and the temperature of 40-50 ℃, stirring until the deionized water is dissolved, cooling, adding xylitol-mannitol, and stirring until the xylitol-mannitol is dissolved;
(2) adding the IgY into the rest deionized water, stirring until the IgY is dissolved, and filtering;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2), adding chitosan-acetic acid chitosan, uniformly stirring and mixing, adding chlorhexidine, uniformly stirring and mixing, filtering, and subpackaging to obtain the compound preparation.
Example 3
A clear collutory containing IgY comprises the following components:
IgY 1.3g, 20% chlorhexidine 5g, chitosan 0.1g, xylitol 22g, Tween 800.05 g, menthol 0.3g, and deionized water 971.25 g.
The preparation method comprises the following steps:
(1) adding tween 80 and menthol into 194g of deionized water at the temperature of 40-50 ℃ under the stirring state, stirring until the tween 80 and the menthol are dissolved, cooling, adding xylitol, and stirring until the xylitol is dissolved;
(2) adding the IgY into the rest deionized water, stirring until the IgY is dissolved, and filtering;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2), adding chitosan, uniformly stirring and mixing, adding chlorhexidine, uniformly stirring and mixing, and subpackaging to obtain the compound chlorhexidine.
Example 4
A clear collutory containing IgY comprises the following components:
IgY 2.5g, 20% chlorhexidine 3.5g, chitosan 1.5g, xylitol 35g, Tween 800.03 g, menthol 0.5g, deionized water 956.97 g.
The preparation method comprises the following steps:
(1) under the stirring state, adding tween 80 and menthol into deionized water with the total amount of 192g and the temperature of 40-50 ℃, stirring until the deionized water is dissolved, cooling, adding xylitol, and stirring until the xylitol is dissolved;
(2) adding the IgY into the rest deionized water, stirring until the IgY is dissolved, and filtering;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2), adding chitosan, uniformly stirring and mixing, adding chlorhexidine, uniformly stirring and mixing, filtering, and subpackaging to obtain the compound preparation.
Example 5
A clear collutory containing IgY comprises the following components:
IgY 1.3g, 20% chlorhexidine 5g, chitosan 0.7g, xylitol 40g, Tween 800.07 g, menthol 0.3g, and deionized water 952.63 g.
The preparation method comprises the following steps:
(1) under the stirring state, adding tween 80 and menthol into 198g of deionized water with the temperature of 40-50 ℃, stirring until the deionized water is dissolved, cooling, adding xylitol, and stirring until the xylitol is dissolved;
(2) adding the IgY into the rest deionized water, stirring until the IgY is dissolved, and filtering;
(3) and (3) uniformly mixing the solutions obtained in the step (1) and the step (2), adding chitosan, uniformly stirring and mixing, adding chlorhexidine, uniformly stirring and mixing, filtering, and subpackaging to obtain the compound preparation.
Comparative example 1
The comparative example provides a mouthwash having the same components and amounts as example 1, except that the mouthwash does not contain the stabilizer i (chitosan or a salt thereof); the preparation process is as in example 1.
Comparative example 2
In the mouth wash provided by the comparative example, the addition amount of chitosan is 0.08g, and other components and contents are the same as those in the example 1; the preparation process is as in example 1.
Comparative example 3
The mouth wash provided by the comparative example has the same components and contents as those of example 1 except that the mouth wash does not contain the stabilizing agent II (sugar alcohols); the preparation process is as in example 1.
Comparative example 4
In the mouth wash provided by the comparative example, the addition amount of xylitol is 1.8g, and other components and contents are the same as those in the example 1; the preparation process is as in example 1.
The mouth rinse samples provided in the above examples and comparative examples were sampled, inspected for appearance, and compared, and the results are shown in table 1.
Table 1 quality comparative test results of examples and comparative examples
As can be seen from the results of the mass comparison experiments between the examples and the comparative examples in Table 1, the addition of chitosan and its salts, xylitol, erythritol and mannitol enables the IgY-containing mouth rinse to remain clear and the solution remains clear over time. The chitosan and the salt thereof are not added in the comparative example 1, the chitosan and the salt thereof are added in the comparative example 2, the addition amount of the chitosan and the salt thereof is small, the sugar alcohol is not added in the comparative example 3, the addition amount of the sugar alcohol is small in the comparative example 4, the gargle prepared in the comparative examples 3 and 4 is clear in appearance, but the stabilizing agent II is not added, and the stability of IgY is poor, so that the bactericidal performance of the gargle is influenced; the gargle prepared in comparative examples 1-2 is poor in appearance and shape, turns turbid after being placed at room temperature, and is remarkably poor in sterilization effect after a sample is stored for 12 months.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. The IgY-containing clear mouthwash is characterized by consisting of the following components in percentage by mass:
wherein the stabilizer I is one or more of chitosan, chitosan hydrochloride or chitosan acetate; the stabilizer II is xylitol and/or erythritol.
2. The IgY-containing clear mouthwash according to claim 1, characterized in that the IgY-containing clear mouthwash consists of the following components in percentage by mass:
3. the IgY-containing clear mouthwash according to claim 1, wherein the flavoring agent is menthol and/or peppermint oil.
4. The IgY-containing clear mouthwash according to claim 1, wherein the stabilizer I is chitosan, the stabilizer II is xylitol and the flavoring agent is menthol.
5. A process for preparing a clear IgY-containing collutory according to any one of claims 1 to 4, characterized in that it comprises the following steps:
s1: adding tween-80 and correctant into part of warm water under stirring, stirring to dissolve, cooling, adding stabilizer II, and stirring to dissolve;
s2: adding IgY into the rest water, stirring until the IgY is dissolved, and filtering;
s3: and (3) uniformly mixing the solutions obtained in the S1 and the S2, adding the stabilizer I, uniformly stirring and mixing, adding the chlorhexidine, uniformly stirring and mixing, and filtering to obtain the IgY-containing clear mouthwash.
6. The preparation method according to claim 5, wherein the stabilizer I is added in the form of a solution, and the mass concentration of the stabilizer I solution is 0.5-1.5%.
7. The method according to claim 5, wherein the warm water is at a temperature of 40 to 50 ℃ in S1.
8. The method according to claim 5, wherein the amount of the warm water in S1 is 20% by mass of the total water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810283928.3A CN108272649B (en) | 2018-04-02 | 2018-04-02 | IgY-containing clear mouthwash and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810283928.3A CN108272649B (en) | 2018-04-02 | 2018-04-02 | IgY-containing clear mouthwash and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108272649A CN108272649A (en) | 2018-07-13 |
| CN108272649B true CN108272649B (en) | 2021-01-29 |
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| CN201810283928.3A Active CN108272649B (en) | 2018-04-02 | 2018-04-02 | IgY-containing clear mouthwash and preparation method thereof |
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| CN110801406A (en) * | 2019-11-27 | 2020-02-18 | 成都格瑞珂诗生物科技有限公司 | Multi-effect facial mask repairing liquid and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0900560A1 (en) * | 1997-09-09 | 1999-03-10 | Hironori Oka | Tooth coating composite and its preparation |
| CN101564534A (en) * | 2008-11-12 | 2009-10-28 | 大连理工大学 | Specific yolk antibody preparation for controlling halitosis pathogens and application thereof |
| CN102860932A (en) * | 2012-10-18 | 2013-01-09 | 上海美加净日化有限公司 | Gingivitis and gingivitis ozostomia preventing mouthwash prepared by anti-porphyromonas gingivalis and IgY antibody with fusobacterium nucleatum specificity |
| CN102973939A (en) * | 2012-10-18 | 2013-03-20 | 上海美加净日化有限公司 | IgY antibody preparation having mixed specificity for resistance to streptococcus mutans and streptococcus sobrinus, and preparation method and IgY total toothpaste |
| CN104644478A (en) * | 2013-11-19 | 2015-05-27 | 山东瑞泰奇洗涤消毒科技有限公司 | Sterilizing type gargle with nursing repair effect |
| CN105106023A (en) * | 2015-09-10 | 2015-12-02 | 依莱恩(上海)实业有限公司 | Micro-needle eye mask raw material, micro-needle eye mask made of same and making method of micro-needle eye mask |
| CN105218666A (en) * | 2015-11-12 | 2016-01-06 | 广东京豪医药科技开发有限公司 | A kind of method adopting cationic polysaccharide to prepare yelk antibody with high bioactivity |
| CN106214510A (en) * | 2016-08-31 | 2016-12-14 | 广东工业大学 | A kind of anti-antozostomatic yolk antibody collutory and preparation method thereof |
| CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016191389A2 (en) * | 2015-05-27 | 2016-12-01 | Merial, Inc. | Compositions containing antimicrobial igy antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (ohc) microorganisms |
-
2018
- 2018-04-02 CN CN201810283928.3A patent/CN108272649B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0900560A1 (en) * | 1997-09-09 | 1999-03-10 | Hironori Oka | Tooth coating composite and its preparation |
| CN101564534A (en) * | 2008-11-12 | 2009-10-28 | 大连理工大学 | Specific yolk antibody preparation for controlling halitosis pathogens and application thereof |
| CN102860932A (en) * | 2012-10-18 | 2013-01-09 | 上海美加净日化有限公司 | Gingivitis and gingivitis ozostomia preventing mouthwash prepared by anti-porphyromonas gingivalis and IgY antibody with fusobacterium nucleatum specificity |
| CN102973939A (en) * | 2012-10-18 | 2013-03-20 | 上海美加净日化有限公司 | IgY antibody preparation having mixed specificity for resistance to streptococcus mutans and streptococcus sobrinus, and preparation method and IgY total toothpaste |
| CN104644478A (en) * | 2013-11-19 | 2015-05-27 | 山东瑞泰奇洗涤消毒科技有限公司 | Sterilizing type gargle with nursing repair effect |
| CN105106023A (en) * | 2015-09-10 | 2015-12-02 | 依莱恩(上海)实业有限公司 | Micro-needle eye mask raw material, micro-needle eye mask made of same and making method of micro-needle eye mask |
| CN105218666A (en) * | 2015-11-12 | 2016-01-06 | 广东京豪医药科技开发有限公司 | A kind of method adopting cationic polysaccharide to prepare yelk antibody with high bioactivity |
| CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
| CN106214510A (en) * | 2016-08-31 | 2016-12-14 | 广东工业大学 | A kind of anti-antozostomatic yolk antibody collutory and preparation method thereof |
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