CN108652996A - A kind of oral care health promoting liquid containing lysozyme - Google Patents
A kind of oral care health promoting liquid containing lysozyme Download PDFInfo
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- CN108652996A CN108652996A CN201810645294.1A CN201810645294A CN108652996A CN 108652996 A CN108652996 A CN 108652996A CN 201810645294 A CN201810645294 A CN 201810645294A CN 108652996 A CN108652996 A CN 108652996A
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- lysozyme
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of oral care health promoting liquid containing lysozyme, includes each component of following mass percent：Moisturizer 1~20%, sodium chloride 0.01~1%, emulsifier 0.1~2%, chelating agent 0.01~1%, lysozyme 0.01~2%, zinc compound 0.01~0.1%, essence 0.01~1%, sweetener 0.01~0.5%, deionized water surplus.The present invention compounds zinc compound and lysozyme, on the one hand the serum zinc concentration of oral cavity partial can be improved, zinc ion is by inhibiting the interaction between bacterium glucose metabolism and bacteria cell wall, intraoral bacteria planting is reduced, and lysozyme bactericidal and bacteriostatic effect can be reinforced in the presence of zinc ion；On the other hand, the two combined use can cover and reduce very well the metallic taste and bitterness sense that zinc salt is brought.In addition, being compounded by adding sodium chloride, moisturizer and other components, the bitterness sense of lysozyme can not only be improved, moreover it is possible to which the bactericidal activity for effectively improving lysozyme achievees the purpose that high-efficient and lasting is antibacterial.
Description
Technical field
The present invention relates to lysozyme applied technical fields, and in particular, to a kind of oral care health care containing lysozyme
Liquid.
Background technology
Oral problem mainly caused by bacterium, is arranged using effective gargle, toothpaste and oral disease therapeutic etc.
The quantity of pathogenic bacteria in oral cavity can be substantially reduced by applying, and improvement even is eliminated mouth disease.The oral cares such as mouthwash, toothpaste are produced
Why product can realize that these functions are mainly the active constituent or antipathogenic composition in product, these antipathogenic compositions are mostly medium-height grass
Medicine and chemical classes bacteriostatic agent, chemical classes bacteriostatic agent such as triclosan, Cetylpyridinium Chloride, chlorohexidene, antibiotic etc., commonly using containing this
The oral care product of a little ingredients be easy to cause oral bacteria ecological disturbance, or makes bacterial resistance occurred, cannot reach prevention
The effect of mouth disease causes other multiple oral diseases instead.
Lysozyme (Lysozyme) is a kind of non-specific material composition in saliva, can be suppressed growth of microorganism, with
Antibiotic or the comparison of other antibacterial substances, it is not in drug resistance that lysozyme, which is used for a long time,.Lysozyme, which is one kind, can be broken carefully
The obligate hydrolase of β-Isosorbide-5-Nitrae glycosidic bond in bacterium whole cell peptidoglycan between N-acetyl-glucosamine and -acetylmuramic acid, belongs to
Muramidase.Lysozyme can selectively solubilized target microorganism wall and make its inactivation, mammalian cell-free wall, because
This, lysozyme is not damaged to oral cavity tissue, but plays a protective role, and is added in oral care implement and inhibits oral cavity normal
See that pathogenic microorganisms has preferable promotion and application foreground.But since lysozyme sheet is as proteinaceous components, conventional mouth
Essential surfactant, foaming agent, binder, sweetener, chemical preservative etc. can different journeys in chamber nursing materials
Degree causes bacteriolyze enzyme denaturation, to cause its active reduction or loss.Therefore, how effective protection lysozyme activity, increase
Strong lysozyme bactericidal effect is that it is applied to one of the difficult point of oral care product.Meanwhile the bitterness sense that lysozyme is brought is also
It is applied to one of the limiting factor of oral care product.
In addition, the recurrent aphthous ulcer in oral mucosal disease has recurrent and self limiting, it is considered that pathogenic factor and people
Body immunity function is extremely related.In addition many researchs also indicate that zinc-deficiency is one of most important pathogenic factors of recurrent aphthous ulcer, because
This adds zinc salt in oral care product and is conducive to treat recurrent aphthous ulcer, still, zinc salt have metallic taste strongly,
Bitter taste and astringent sense, if the zinc salt containing high dose, sense of discomfort are especially strong in oral care product.
Invention content
The purpose of the invention is to overcome the above-mentioned deficiency of the prior art, a kind of oral care containing lysozyme is provided
Zinc compound and lysozyme are used in combination by health promoting liquid, the present invention, on the one hand can improve the serum zinc concentration of oral cavity partial, zinc
Ion reduces intraoral bacteria planting by the interaction between inhibition bacterium glucose metabolism and bacteria cell wall,
And lysozyme bactericidal and bacteriostatic effect can be reinforced in the presence of zinc ion；On the other hand, the two combined use can be covered very well
The metallic taste and bitterness sense brought with reduction zinc salt.It is additionally compounded by adding sodium chloride, moisturizer and other components, not only
The bitterness sense of lysozyme can be improved, moreover it is possible to which the bactericidal activity for effectively improving lysozyme achievees the purpose that high-efficient and lasting is antibacterial.
To achieve the goals above, the present invention is achieved by following scheme：
A kind of oral care health promoting liquid containing lysozyme, includes each component of following mass percent：Moisturizer 1~
20%, sodium chloride 0.01~1%, emulsifier 0.1~2%, chelating agent 0.01~1%, lysozyme 0.01~2%, containing zinc impregnation conjunction
Object 0.01~0.1%, essence 0.01~1%, sweetener 0.01~0.5%, deionized water surplus.
Biological lysozyme participates in the immune response of body as one of body nospecific immunity factor, to keep machine
Body physiological equilibrium.Lysozyme can also improve and enhance phagocytosis and the digestive function of macrophage, activated leukocyte phagocytic function, from
And enhance the immunity of body.Lysozyme also has the function of activating blood platelet, can improve tissue local blood circulation, enhance
Local defense function.The present invention compounds zinc compound and lysozyme, on the one hand can improve the serum zinc concentration of oral cavity partial,
It is fixed to reduce intraoral bacterium by inhibiting the interaction between bacterium glucose metabolism and bacteria cell wall for zinc ion
It plants, moreover, lysozyme bactericidal and bacteriostatic effect can be reinforced in the presence of zinc ion；On the other hand, the two combined use can be fine
Cover and reduce the metallic taste and bitterness sense that zinc salt is brought.
In addition, by adding sodium chloride, the bitterness sense of lysozyme can be improved, obtain the pleasing mouth-feel of comfortable；It is logical
Addition moisturizer is crossed, lysozyme mouthwash mouthfeel can be improved, the bactericidal activity of lysozyme is effectively improved, it is antibacterial to reach high-efficient and lasting
Purpose.
Preferably, the zinc compound is zinc citrate, zinc chloride, zinc acetate, zinc gluconate, zinc lactate, wine
Stone acid zinc, zinc malate any one or more of.
Preferably, the mass percent of the lysozyme is 0.05~2%.
Preferably, the moisturizer is sorbierite, propylene glycol, glycerine any one or more of.
Preferably, the mass percent of the moisturizer is 5~20%.
Preferably, the emulsifier is any one of poloxamer188, Crodaret or two kinds.
Preferably, the chelating agent is EDETATE SODIUM.EDETATE SODIUM (disodium ethylene diamine tetraacetate) is a kind of good
Stabilizer, complexing of metal ion agent.Common metal ion such as Co2+、Cu2+、Fe2+、Zn2+Etc. making lysozyme deposits be denaturalized, cause
Activity declines or loses activity.The EDETATE SODIUM of appropriate concentration not only can be with metal ion common in complex system such as Co2+、
Cu2+、Fe2+、Zn2+Deng preventing these metal ions by bacteriolyze enzyme denaturation, while having facilitation to the activity of lysozyme.One side
Face EDETATE SODIUM can be such that cell growth slows down, disappear conducive to lysozyme with the important meals ions binding of certain needed for cell growth
Solve cell wall；Another aspect EDETATE SODIUM can directly destroy cell wall, be allowed to be easier to be attacked by lysozyme.
Preferably, the dosage form of the oral care health promoting liquid is aqua or spray.
Above-mentioned oral care health care liquid energy effectively, enduringly inhibits the bacterium in oral cavity, and the bacterium includes but not limited to
Streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, Escherichia coli.
Specific embodiment as one preferred, each component of the following mass percent of oral care health promoting liquid：
Sorbierite 0~10%, glycerine 0~15%, propylene glycol 0~5%, sodium chloride 0~1%, Crodaret 0~2%,
Poloxamer188 0~1%, EDETATE SODIUM 0.2~1%, lysozyme 0.05~2%, zinc chloride 0~0.1%, zinc gluconate 0~
0.7%, essence 0.5~1%, saccharin sodium 0.03~0.5%, deionized water surplus.
Compared with prior art, the invention has the advantages that：
The present invention compounds zinc compound and lysozyme, on the one hand can improve the serum zinc concentration of oral cavity partial, zinc from
Son reduces intraoral bacteria planting by the interaction between inhibition bacterium glucose metabolism and bacteria cell wall, and
And lysozyme bactericidal and bacteriostatic effect can be reinforced in the presence of zinc ion；On the other hand, the two combined use can cover very well and
Reduce the metallic taste and bitterness sense that zinc salt is brought.In addition, compounded by adding sodium chloride, moisturizer and other components, it can not only
Improve the bitterness sense of lysozyme, moreover it is possible to which the bactericidal activity for effectively improving lysozyme achievees the purpose that high-efficient and lasting is antibacterial.
Specific implementation mode
The present invention is made with reference to specific embodiment and further being elaborated, the embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.Test method used in following embodiments is normal unless otherwise specified
Rule method；Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Influence of 1 zinc citrate of embodiment to lysozyme fungistatic effect
1, the composition containing different proportion zinc citrate and lysozyme is configured, specific formula is formulated 1~7 in being shown in Table 1.
2, with reference to the evaluation method of QB 2738-2012 daily chemical products antibacterial bacteriostatic effects, formula 1~7 in table 1 is measured
Composition to Streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, Escherichia coli inhibiting effect.
3, experimental result
According to 1~7 proportioning of formula, the composition containing lysozyme is made, obtains composition and tests its bacteriostasis rate at once
(%).
The fungistatic effect of the formula of table 1 1~7
In addition, also measured were the bacteriostasis rate (%) when adding lysozyme, zinc citrate respectively, as shown in table 2.
Table 2 adds fungistatic effect when lysozyme, zinc citrate respectively
| Ingredient | It is formulated A | It is formulated B | It is formulated C | It is formulated D | It is formulated E | It is formulated F | It is formulated G | It is formulated H |
| Zinc citrate | / | / | / | / | / | 0.01 | 0.05 | 0.1 |
| Lysozyme | 0.1 | 0.5 | 1.0 | 1.5 | 2.0 | / | / | / |
| Deionized water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
| It is total | 100% | 100% | 100% | 100% | 100% | 100% | 100% | 100% |
| Bacteriostasis rate (Streptococcus mutans) | 20.46 | 32.35 | 50.27 | 68.70 | 83.05 | 31.64 | 50.25 | 65.22 |
| Bacteriostasis rate (porphyromonas gingivalis) | 20.44 | 32.31 | 50.24 | 68.74 | 83.07 | 31.67 | 50.24 | 65.27 |
| Bacteriostasis rate (staphylococcus aureus) | 20.49 | 32.34 | 50.23 | 68.75 | 83.00 | 31.63 | 50.29 | 65.23 |
| Bacteriostasis rate (Escherichia coli) | 20.40 | 32.36 | 50.22 | 68.72 | 83.08 | 31.61 | 50.22 | 65.24 |
As shown in Table 2, the bacteriostasis of individual zinc citrate and lysozyme is not very strong, the dosage of the two
When higher respectively, bacteriostasis rate just significantly improves.
Compare Tables 1 and 2 as a result, understanding：After lysozyme and zinc citrate compound, the bacteriostasis rate of mixture significantly increases
By force, there is conspicuousness.This illustrates that lysozyme and zinc citrate while use produce synergistic effect, and the two compounding can more preferably inhibit
Bacterial growth or quickly kill bacterium.Zinc ion is combined with bacteria cell wall, softens cell wall, to lysozyme hydrolysis cell wall
Peptide glycan have catalytic action, accelerate its hydrolysis rate simultaneously lysozyme hydrolysis peptide glycan reaction rate improve, cell wall
Permeability is quickly opened, and zinc ion enters in cell, destroys bacterium internal structure, and the two coordinative role accelerates bacterial death.
4 but in the presence of zinc ion, bacteriolyze enzyme denaturation may be made, with the extension of resting period, bacteriostasis rate persistently drops
It is low.The bacteriostasis rate of the composition of contrived experiment test formulations 1 and formula 2 storage different time, the results are shown in Table 3.
After 3 lysozyme of table and zinc citrate mixing, fungistatic effect when different time is stored
A kind of oral care health promoting liquid containing lysozyme of embodiment 2
1, a kind of oral care health promoting liquid containing lysozyme, application examples 1~4 during specific formula is shown in Table 4.
2, with reference to the evaluation method of QB 2738-2012 daily chemical products antibacterial bacteriostatic effects, the oral cavity shield of each application examples is measured
Manage health promoting liquid to Streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, Escherichia coli inhibiting effect.It will apply
After 45 DEG C of 1~4 oral care health promoting liquid high temperature of example is placed 3 months, antibacterial test is carried out.And synchronism detection control 1,2 and of control
(in addition to not sodium chloride-containing, the type and content of remaining component are identical as application examples 1 for control 1 for the fungistatic effect of control 3；Control 2 removes
Outside without moisturizer, the type and content of remaining component are identical as application examples 1；Control 3 is outside sodium chloride-containing and moisturizer, remaining
The type and content of component are identical as application examples 1).Measurement result is as shown in table 4.
3, experimental result
The formula and its fungistatic effect of table 4 application examples 1~4 and 1~3 oral care health promoting liquid of control
It can be seen that according to the testing result of table 4 and the compositions of additives of different ratio be added to oral care health care
In liquid, the bacteriostasis rate of bacteriostasis rate comparison control 1, control 2 and the control 3 of 1~4 oral care health promoting liquid of application examples, which has, significantly to be carried
Height, and there is significant difference.The present invention combines zinc citrate and lysozyme according to specific proportioning, improves molten
The fungistatic effect of bacterium enzyme, external source supplement defend ingredient in oral cavity, can inhibit the generation of bacterium and the formation of calculus dentalis, reduce tooth bacterium
Spot reduces bleeding gums.In addition, by compounding zinc citrate and lysozyme with other auxiliary materials, significant collaboration is reached and has made
With even if oral care health promoting liquid will not influence the antibacterial effect of zinc citrate and lysozyme by placement in (3 months) for a long time
Fruit can play efficient, persistently antibacterial effect.
4, use mouthfeel and the scoring of each application examples also measured were, scoring, for full marks, the results are shown in Table 5 with 10 points.
Use mouthfeel and the scoring of 5 application examples 1~4 of table and 1~3 oral care health promoting liquid of control
It can be seen that according to the testing result of table 5 by adding sodium chloride, the bitterness sense of lysozyme can be improved, obtained
The pleasing mouth-feel of comfortable；By adding moisturizer, lysozyme mouthwash mouthfeel can be improved, effectively improve the sterilization of lysozyme
Activity achievees the purpose that high-efficient and lasting is antibacterial.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than is protected to the present invention
The limitation of shield range can also be made on the basis of above description and thinking for those of ordinary skill in the art
Other various forms of variations or variation, there is no necessity and possibility to exhaust all the enbodiments.It is all the present invention
All any modification, equivalent and improvement etc., should be included in the protection of the claims in the present invention made by within spirit and principle
Within the scope of.
Claims (8)
1. a kind of oral care health promoting liquid containing lysozyme, which is characterized in that include each component of following mass percent：It protects
Humectant 1~20%, sodium chloride 0.01~1%, emulsifier 0.1~2%, chelating agent 0.01~1%, lysozyme 0.01~2% contain
Zinc compound 0.01~0.1%, essence 0.01~1%, sweetener 0.01~0.5%, deionized water surplus.
2. oral care health promoting liquid according to claim 1, which is characterized in that the zinc compound be zinc citrate,
Zinc chloride, zinc acetate, zinc gluconate, zinc lactate, zinc tartrate, zinc malate any one or more of.
3. oral care health promoting liquid according to claim 1, which is characterized in that the mass percent of the lysozyme is
0.05~2%.
4. oral care health promoting liquid according to claim 1, which is characterized in that the moisturizer be sorbierite, propylene glycol,
Glycerine any one or more of.
5. oral care health promoting liquid according to claim 1, which is characterized in that the mass percent of the moisturizer is 5
~20%.
6. oral care health promoting liquid according to claim 1, which is characterized in that the emulsifier is poloxamer188, gathers
Any one of ethylene oxide rilanit special or two kinds.
7. oral care health promoting liquid according to claim 1, which is characterized in that the chelating agent is EDETATE SODIUM.
8. according to any one of claim 1 to the 7 oral care health promoting liquid, which is characterized in that the oral care health promoting liquid
Dosage form be aqua or spray.
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| CN201810645294.1A CN108652996A (en) | 2018-06-21 | 2018-06-21 | A kind of oral care health promoting liquid containing lysozyme |
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| CN201810645294.1A CN108652996A (en) | 2018-06-21 | 2018-06-21 | A kind of oral care health promoting liquid containing lysozyme |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110237241A (en) * | 2019-07-05 | 2019-09-17 | 广州康云生物科技有限公司 | A kind of compositions of additives containing lysozyme and plant extracts |
| CN110251664A (en) * | 2019-07-05 | 2019-09-20 | 广州康云生物科技有限公司 | A kind of oral nursing liquid containing lysozyme and plant extracts |
| CN110917339A (en) * | 2019-12-27 | 2020-03-27 | 遵义医学院附属医院 | Lysostaphin gel and application thereof in MRSA infected wound surface |
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| CN110251664A (en) * | 2019-07-05 | 2019-09-20 | 广州康云生物科技有限公司 | A kind of oral nursing liquid containing lysozyme and plant extracts |
| CN110917339A (en) * | 2019-12-27 | 2020-03-27 | 遵义医学院附属医院 | Lysostaphin gel and application thereof in MRSA infected wound surface |
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Application publication date: 20181016 |