CN113710257A - γδT细胞归巢和保留的方法，可选地使用自然杀伤细胞，以用于生成用于治疗的细胞组合物 - Google Patents

γδT细胞归巢和保留的方法，可选地使用自然杀伤细胞，以用于生成用于治疗的细胞组合物 Download PDF

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CN113710257A
CN113710257A CN202080030540.8A CN202080030540A CN113710257A CN 113710257 A CN113710257 A CN 113710257A CN 202080030540 A CN202080030540 A CN 202080030540A CN 113710257 A CN113710257 A CN 113710257A
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cells
cell
nicotinamide
population
cell population
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托尼·佩莱德
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Gamida Cell Ltd
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Gamida Cell Ltd
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/00—Cellular immunotherapy
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CN202080030540.8A 2019-02-24 2020-02-24 γδT细胞归巢和保留的方法，可选地使用自然杀伤细胞，以用于生成用于治疗的细胞组合物 Pending CN113710257A (zh)

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US201962809671P 2019-02-24 2019-02-24
US62/809,671 2019-02-24
PCT/IL2020/050206 WO2020170260A1 (en) 2019-02-24 2020-02-24 Method of homing and retention of gammadelta t cells for generating cell compositions for use in therapy

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US (1) US20220143086A1 (https=)
EP (1) EP3927353A4 (https=)
JP (2) JP7546582B2 (https=)
KR (1) KR20210133996A (https=)
CN (1) CN113710257A (https=)
AU (1) AU2020225597A1 (https=)
BR (1) BR112021016698A2 (https=)
CA (1) CA3130442A1 (https=)
IL (1) IL285806B2 (https=)
SG (1) SG11202109055UA (https=)
WO (1) WO2020170260A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3130442A1 (en) * 2019-02-24 2020-08-27 Gamida Cell Ltd. Method of homing and retention of gammadelta t cells for generating cell compositions for use in therapy
WO2023069322A1 (en) * 2021-10-20 2023-04-27 University Of Pittsburgh – Of The Commonwealth System Of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
KR20250172550A (ko) * 2023-01-17 2025-12-09 안선 바이오파르마, 아이엔씨. 감마 델타 t 세포의 생성 방법

Citations (6)

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US20100061963A1 (en) * 2005-11-29 2010-03-11 Tony Peled Methods of Improving Stem Cell Homing and Engraftment
CN102154205A (zh) * 2011-01-31 2011-08-17 郑骏年 高纯度、高细胞毒活性的γδT细胞的制备方法
CN107164322A (zh) * 2017-07-05 2017-09-15 泰山医学院附属医院 一种用于人γδT细胞扩增的培养基及其制备方法
CN107249605A (zh) * 2014-11-17 2017-10-13 阿迪塞特生物股份有限公司 工程化的γδT细胞
US20180200299A1 (en) * 2013-10-25 2018-07-19 Board Of Regents, The University Of Texas System Polyclonal gamma delta t cells for immunotherapy
CN108949685A (zh) * 2018-08-02 2018-12-07 吉林大学第医院 一种体外诱导扩增高杀伤活性γδT细胞的方法

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EP3184109B1 (en) * 2009-12-29 2020-11-18 Gamida-Cell Ltd. Methods for enhancing natural killer cell proliferation and activity
SG11201803419PA (en) * 2015-10-30 2018-05-30 The Regents Of The Universtiy Of California Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells
AU2017340644B2 (en) * 2016-10-05 2024-05-09 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to HLA homozygous immune cells
US10731128B2 (en) * 2016-11-22 2020-08-04 Alloplex Biotherapeutics, Inc. Compositions and methods for in vitro activation and expansion of serial killer T cell populations and passive immunization of a cancer patient with tumor cell killing cells
US12440578B2 (en) * 2017-02-22 2025-10-14 Io Biosciences, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
CA3130442A1 (en) * 2019-02-24 2020-08-27 Gamida Cell Ltd. Method of homing and retention of gammadelta t cells for generating cell compositions for use in therapy

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Publication number Priority date Publication date Assignee Title
US20100061963A1 (en) * 2005-11-29 2010-03-11 Tony Peled Methods of Improving Stem Cell Homing and Engraftment
CN102154205A (zh) * 2011-01-31 2011-08-17 郑骏年 高纯度、高细胞毒活性的γδT细胞的制备方法
US20180200299A1 (en) * 2013-10-25 2018-07-19 Board Of Regents, The University Of Texas System Polyclonal gamma delta t cells for immunotherapy
CN107249605A (zh) * 2014-11-17 2017-10-13 阿迪塞特生物股份有限公司 工程化的γδT细胞
CN107164322A (zh) * 2017-07-05 2017-09-15 泰山医学院附属医院 一种用于人γδT细胞扩增的培养基及其制备方法
CN108949685A (zh) * 2018-08-02 2018-12-07 吉林大学第医院 一种体外诱导扩增高杀伤活性γδT细胞的方法

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MITCHELL E. HORWITZ ET AL.: "Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment", CLINICAL MEDICINE, vol. 124, no. 7, pages 3121 - 3128, XP055557530, DOI: 10.1172/JCI74556 *

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JP2022521027A (ja) 2022-04-04
IL285806A (en) 2021-10-31
US20220143086A1 (en) 2022-05-12
EP3927353A4 (en) 2022-11-23
EP3927353A1 (en) 2021-12-29
IL285806B2 (en) 2025-05-01
AU2020225597A1 (en) 2021-10-07
BR112021016698A2 (pt) 2021-10-13
IL285806B1 (en) 2025-01-01
JP7546582B2 (ja) 2024-09-06
SG11202109055UA (en) 2021-09-29
JP2024088717A (ja) 2024-07-02
WO2020170260A1 (en) 2020-08-27
CA3130442A1 (en) 2020-08-27
KR20210133996A (ko) 2021-11-08

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