CN1136846C - 用甲醛治疗动物传染病的注射剂 - Google Patents
用甲醛治疗动物传染病的注射剂 Download PDFInfo
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- CN1136846C CN1136846C CNB001134302A CN00113430A CN1136846C CN 1136846 C CN1136846 C CN 1136846C CN B001134302 A CNB001134302 A CN B001134302A CN 00113430 A CN00113430 A CN 00113430A CN 1136846 C CN1136846 C CN 1136846C
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 238000002347 injection Methods 0.000 title claims abstract description 22
- 239000007924 injection Substances 0.000 title claims abstract description 22
- 208000035473 Communicable disease Diseases 0.000 title claims abstract description 6
- 208000015181 infectious disease Diseases 0.000 title claims description 6
- 241001465754 Metazoa Species 0.000 title abstract description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims description 6
- 238000003304 gavage Methods 0.000 claims description 2
- 241000282898 Sus scrofa Species 0.000 abstract description 14
- 206010037660 Pyrexia Diseases 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 8
- 206010035148 Plague Diseases 0.000 abstract description 4
- 206010037742 Rabies Diseases 0.000 abstract description 4
- 206010043376 Tetanus Diseases 0.000 abstract description 4
- 241000607479 Yersinia pestis Species 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract description 2
- 241000282887 Suidae Species 0.000 abstract 2
- 206010011469 Crying Diseases 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 201000010099 disease Diseases 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- 238000011084 recovery Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 208000002979 Influenza in Birds Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000010255 intramuscular injection Methods 0.000 description 3
- 239000007927 intramuscular injection Substances 0.000 description 3
- 206010048282 zoonosis Diseases 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241001137251 Corvidae Species 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
- A61K31/115—Formaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本发明公开了用甲醛治疗动物传染病的注射剂，使用时甲醛浓度为0.01～4%的水溶液，可治疗猪瘟病、鸡瘟病、破伤风、口啼瘟、狂犬病等，疗效确切，且除初发患者以外中期病猪也有很好的疗效，一般注射一次即可痊愈，加服小苏打后无毒副作用，经此注射剂治疗以后的动物均发育正常，治疗后的母猪能正常生育。
Description
本发明涉及用甲醛治疗动物的传染病的注射剂。
动物传染病如猪瘟病、鸡瘟病、破伤风病、口蹄疫、狂犬病等均是死亡率极高的病毒性传染病，一般靠注射疫苗来预防，某些用于治疗的药物如猪瘟血清仅对初发病猪有效，但制作繁琐，成本高。甲醛是一种常用的消毒防腐外用药，至今未曾见用于治疗用药的报导。
本发明的目的是提供一种制作简便、成本低、疗效确切、无毒副作用的用甲醛制成治疗动物传染病的注射剂。
本发明的注射剂是使用时甲醛浓度为0.01～4％的水溶液。主要根据采用静脉注射、肌肉注射的二种不同方式采用不同的浓度，也根据动物不同的种类和体重的不同以及不同疾病和症状的不同采用不同的浓度。
当采用静脉注射时，由于直接进入血管，效力迅速，浓度可低一些，一般为0.01～0.2％。肌肉注射浓度要大一些，一般为0.1～4％，是根据不同动物、不同疾病采用不同的量。采用肌肉注射时，单用甲醛会产生局部肌肉疼痛，需配入0.1～2％的醇，为甘油、乙醇、苯甲醇、甲醇等作为镇痛剂。在注射甲醛水溶液的同时，为了消除甲醛进入动物体内与体内氧结合产生甲酸并积蓄造成毒副作用，还需同时灌服小苏打(片剂或粉剂)。由于小苏打可以中和甲醛与体内氧结合产生的甲酸，故不会产生毒副作用。其化学反应式如下：
经过多年临床实践，共治疗猪瘟1000余例、鸡瘟数百例、口啼疫病50多例、破伤风猪、牛、狂犬病猪、肺疫病等各种传染病。可以确认用甲醛制成的注射药可以治疗各种病毒及细菌感染所致动物传染病，不但疗效确切，且除初发患者以外中期病猪也有很好的疗效，除猪瘟病以外，其余疾病均只要注射一次即可痊愈，猪瘟病注射一次即可退烧。但有复发现象，需加注猪瘟疫苗，并过3～5天以后再注射甲醛溶液一次，经此注射剂治疗以后的动物均发育正常，治疗后的母猪能正常生育。
实施例1，甲醛注射治疗鸡瘟病。
| 例数 | 注射方式 | 甲醛浓度 | 用量 | 小苏打量 | 治疗简介 |
| 150例 | 肌肉 | 0.1～1％ | 5ml | 0.5g/片×4 | 1～2天后痊愈 |
实施例2，甲醛注射治疗猪瘟病。
| 例数 | 注射方式 | 甲醛浓度 | 用量 | 小苏打量 | 治疗简介 |
| 1000余例 | 肌肉 | 0.1～0.2％ | 150～250ml | 0.5g/片×40～200 | 注射一次可以退烧，但有复发，需注射猪瘟疫苗，过3～5天后再注射一次甲醛后痊愈。 |
| 300例 | 静脉 | 0.02～0.04％ | 30～150ml | 同上 |
实施例3，甲醛注射治疗其它动物传染病。
| 病类 | 例数 | 注射方式 | 甲醛浓度 | 用量 | 治疗简介 |
| 口啼疫猪 | 50 | 肌肉 | 0.7～4％×20ml | 20ml | 1～2天后痊愈 |
| 破伤风 | 6 | 肌肉 | 0.7～4％×20ml | 20ml | 1～2天后痊愈 |
| 狂犬病 | 3 | 肌肉 | 0.7～4％×20ml | 20ml | 1～2天后痊愈 |
| 肺疫病 | 2 | 肌肉 | 0.7～4％×20ml | 20ml | 1～2天后痊愈 |
Claims (2)
1、甲醛溶液在制备治疗非人动物传染病的药物中的应用，注射甲醛溶液的同时灌服小苏打。
2、根据权利要求1所述的甲醛溶液在制备治疗非人动物传染病的药物中的应用，其特征是甲醛溶液的浓度为0.01～4％。
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001134302A CN1136846C (zh) | 2000-05-15 | 2000-05-15 | 用甲醛治疗动物传染病的注射剂 |
| AT01401201T ATE401871T1 (de) | 2000-05-15 | 2001-05-11 | Methanal - injektion zur behandlung epidemischer tierkrankheiten |
| DE60134912T DE60134912D1 (de) | 2000-05-15 | 2001-05-11 | Methanal - Injektion zur Behandlung epidemischer Tierkrankheiten |
| EP01401201A EP1163903B1 (en) | 2000-05-15 | 2001-05-11 | Methanal injection treatment for animal epidemics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001134302A CN1136846C (zh) | 2000-05-15 | 2000-05-15 | 用甲醛治疗动物传染病的注射剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1276208A CN1276208A (zh) | 2000-12-13 |
| CN1136846C true CN1136846C (zh) | 2004-02-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001134302A Expired - Fee Related CN1136846C (zh) | 2000-05-15 | 2000-05-15 | 用甲醛治疗动物传染病的注射剂 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1163903B1 (zh) |
| CN (1) | CN1136846C (zh) |
| AT (1) | ATE401871T1 (zh) |
| DE (1) | DE60134912D1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006628A (zh) * | 2012-12-31 | 2013-04-03 | 刘宗山 | 甲醛在制备治疗动物和人类传染病的注射剂中的应用 |
| RU2535007C1 (ru) * | 2013-10-03 | 2014-12-10 | Федеральное государственное бюджетное научное учреждение "Саратовский научно-исследовательский ветеринарный институт" | Способ оздоровления хозяйств от некробактериоза крупного рогатого скота |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1938188A (en) * | 1987-06-05 | 1989-01-04 | Habib Al-Sioufi | Method and device for disinfecting biological fluids and container for same |
| US4833165A (en) * | 1987-10-07 | 1989-05-23 | Louderback Allan Lee | Method of inactivating HTLV-III virus in blood |
| RU2028804C1 (ru) * | 1992-03-08 | 1995-02-20 | Ласкавый Владислав Николаевич | Способ профилактики трансмиссивного гастроэнтерита свиней |
| WO1996028025A1 (en) * | 1995-03-10 | 1996-09-19 | Hemasure, Inc. | Inactivation of pathogens in blood and/or blood products using formaldehyde |
| RU2146134C1 (ru) * | 1999-06-29 | 2000-03-10 | Ласкавый Владислав Николаевич | Антивирусный препарат для инъекций |
-
2000
- 2000-05-15 CN CNB001134302A patent/CN1136846C/zh not_active Expired - Fee Related
-
2001
- 2001-05-11 EP EP01401201A patent/EP1163903B1/en not_active Expired - Lifetime
- 2001-05-11 AT AT01401201T patent/ATE401871T1/de not_active IP Right Cessation
- 2001-05-11 DE DE60134912T patent/DE60134912D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1276208A (zh) | 2000-12-13 |
| EP1163903A3 (en) | 2002-07-10 |
| ATE401871T1 (de) | 2008-08-15 |
| DE60134912D1 (de) | 2008-09-04 |
| EP1163903A2 (en) | 2001-12-19 |
| EP1163903B1 (en) | 2008-07-23 |
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