CN113677362A - 用于增强细胞免疫疗法的方法 - Google Patents

用于增强细胞免疫疗法的方法 Download PDF

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Publication number
CN113677362A
CN113677362A CN202080026218.8A CN202080026218A CN113677362A CN 113677362 A CN113677362 A CN 113677362A CN 202080026218 A CN202080026218 A CN 202080026218A CN 113677362 A CN113677362 A CN 113677362A
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cells
car
cell
cancer
mpba
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CN202080026218.8A
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English (en)
Chinese (zh)
Inventor
A·M·Q·马尔康德斯
P·B·基尔科
宫崎宇广
C·J·图尔特勒
S·R·里德尔
C·K·周
S·P·弗拉赛雷
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Nektar Therapeutics
Fred Hutchinson Cancer Center
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Nektar Therapeutics
Fred Hutchinson Cancer Center
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Publication of CN113677362A publication Critical patent/CN113677362A/zh
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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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CN202080026218.8A 2019-04-05 2020-04-04 用于增强细胞免疫疗法的方法 Pending CN113677362A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962830212P 2019-04-05 2019-04-05
US62/830,212 2019-04-05
US201962861858P 2019-06-14 2019-06-14
US62/861,858 2019-06-14
US201962898473P 2019-09-10 2019-09-10
US62/898,473 2019-09-10
US201962944955P 2019-12-06 2019-12-06
US62/944,955 2019-12-06
PCT/US2020/026778 WO2020206395A1 (en) 2019-04-05 2020-04-04 Method for enhancing cellular immunotherapy

Publications (1)

Publication Number Publication Date
CN113677362A true CN113677362A (zh) 2021-11-19

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EP (1) EP3946426A4 (enExample)
JP (2) JP7672342B2 (enExample)
KR (1) KR20210149090A (enExample)
CN (1) CN113677362A (enExample)
AU (1) AU2020252569B2 (enExample)
CA (1) CA3134539A1 (enExample)
IL (1) IL286971A (enExample)
MX (1) MX2021012236A (enExample)
WO (1) WO2020206395A1 (enExample)

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EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
WO2024215987A1 (en) * 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
EP4694916A1 (en) * 2023-04-14 2026-02-18 SOTIO Biotech Inc. Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists
WO2025191133A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Il-21 muteins, fusion proteins comprising the same and uses thereof
WO2025191136A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
WO2025264864A1 (en) * 2024-06-18 2025-12-26 Fred Hutchinson Cancer Center Human anti-cd45 antibodies and uses thereof

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EP3568474A1 (en) 2017-01-10 2019-11-20 Intrexon Corporation Modulating expression of polypeptides via new gene switch expression systems
CN108728459B (zh) 2017-04-24 2023-08-04 上海恒润达生生物科技股份有限公司 靶向cd19的嵌合抗原受体并联合表达il-15的方法和用途
IL270634B2 (en) * 2017-05-15 2025-06-01 Nektar Therapeutics Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods
US12350312B2 (en) * 2017-09-06 2025-07-08 Fred Hutchinson Cancer Center Methods for improving adoptive cell therapy

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WO2020206395A1 (en) 2020-10-08
MX2021012236A (es) 2021-11-04
AU2020252569B2 (en) 2026-02-05
JP7672342B2 (ja) 2025-05-07
EP3946426A1 (en) 2022-02-09
IL286971A (en) 2021-12-01
JP2022526408A (ja) 2022-05-24
AU2020252569A1 (en) 2021-11-04
EP3946426A4 (en) 2023-01-04
US20230158164A1 (en) 2023-05-25
JP2025089477A (ja) 2025-06-12
KR20210149090A (ko) 2021-12-08
CA3134539A1 (en) 2020-10-08

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