CN113663015A

CN113663015A - A topical Chinese medicinal composition for treating vitiligo

Info

Publication number: CN113663015A
Application number: CN202111065841.7A
Authority: CN
Inventors: 李小莎; 陈威; 李鑫
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-13
Filing date: 2021-09-13
Publication date: 2021-11-19

Abstract

The invention discloses a traditional Chinese medicine external composition for treating leucoderma, which is prepared from the following raw materials: fructus Psoraleae, flos Caryophylli, folium Artemisiae Argyi, rhizoma Acori Graminei, herba Speranskiae Tuberculatae, fructus Zanthoxyli, radix Angelicae Dahuricae, fructus Cnidii and radix Tripterygii Wilfordii. The Chinese medicinal composition for external use is smashed by a pulverizer, wrapped by paper to prepare medicated rolls, and then the affected parts are fumigated by the medicated rolls. In the formula of the invention, clove, moxa and pepper warm and dredge qi and blood, garden balsam stem and angelica dahurica warm and activate blood and dredge collaterals, psoralea fruit and common cnidium fruit warm and invigorate kidney and strengthen yang, tripterygium wilfordii is used for dispelling wind and removing toxicity, and all the medicines are compatible to make qi and blood warm and dredge channels and collaterals unobstructed. The leucoderma is the cold qi which is restricted on the skin, and the medicines are combined to warm and dredge, activate blood, warm kidney yang and assist yang qi to recover, so as to achieve the effects of dispelling wind and cold, warming channels and dredging collaterals.

Description

A topical Chinese medicinal composition for treating vitiligo

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine external composition for treating leucoderma.

Background

Vitiligo is a common acquired depigmentation skin disease, and is manifested by limitation or generalized. The melanocyte function of skin is lost or the number of cells is reduced, and the melanocyte function is usually found on the head, face, extremities, back, friction area, and the interface between skin and mucous membrane. The cause of this disease is still unclear. Recent studies have been thought to be related to the following factors: 1. the theory of genetics: vitiligo can appear in twins and families, which indicates that inheritance plays an important role in the pathogenesis of vitiligo. The research suggests that the vitiligo has incomplete penetrance and multiple pathogenic sites on the gene. 2. The theory of autoimmunity: vitiligo can be associated with autoimmune diseases, such as thyroid disease, diabetes, chronic adrenal hypofunction, pernicious anemia, rheumatic arthritis, malignant melanoma, etc. Antibodies specific to various organs, such as antithyroid antibodies, anti-parietal cell antibodies, anti-adrenal antibodies, anti-parathyroid antibodies, anti-smooth muscle antibodies, anti-melanocyte antibodies, etc., can also be detected in the serum. 3. Theory of psychology and neurochemistry: mental factors are closely related to the onset of vitiligo, and most patients suffer from mental trauma, overstrain, depressed mood or depression in the onset or skin damage development stage. Degeneration of nerve endings at the leukoplakia also supports the neurochemistry theory. 4. The theory of melanocyte self-destruction: antibodies and T lymphocytes can be produced in patients with vitiligo, suggesting that immune response may lead to melanocyte destruction. Toxic melanin precursors synthesized by the cells themselves and certain chemicals that cause skin discoloration may also selectively destroy melanocytes. 5. The theory of trace element deficiency: the decrease of copper or copper-blue protein level in blood and skin of vitiligo patients results in decrease of tyrosinase activity, thereby affecting melanin metabolism. 6. Other factors: vitiligo can also be induced by trauma, sunlight exposure and some light sensitive drugs. The existing treatment methods include the following methods:

1. hormone therapy

(1) The system treatment is mainly suitable for patients with generalized progressive vitiligo. The hormone is orally or intramuscularly injected to stabilize the leucoderma in the advancing stage as soon as possible.

(2) Topical treatment of topical glucocorticoids is effective in the treatment of localized vitiligo, but adverse effects caused by long-term topical glucocorticoids should be noted. The clinically commonly used medicines comprise halometasone ointment, mometasone furoate cream and the like. 2. Phototherapy and photochemotherapy: (1) phototherapy with narrow-wave ultraviolet (NB-UVB) has certain effect on treating limited or generalized vitiligo. (2) Photochemotherapy (PUVA) is a better treatment option for local externally-applied furocoumarins (8-MOP, psoralea tincture) and solarization of the limited vitiligo, and can be used for adults and children over 5 years old.

3. Transplantation therapy

It is suitable for patients with stable stage, small amount of skin damage, and no scar. Common methods include autologous epidermal transplantation, microdermabrasion, autologous cultured melanocyte transplantation, etc.

4. Immunosuppressant

The externally applied calcineurin inhibitor (tacrolimus, pimecrolimus) has certain effect on the parts which are not suitable for using hormone or in order to avoid adverse reaction caused by long-term application of hormone.

5. Vitamin D3 derivatives

The vitamin D3 derivative can be used in combination therapy with NB-UVB, PUVA, etc. Can also be used in combination with topical hormone and calcineurin inhibitor.

The above treatments are mainly to relieve symptoms, and the white spots cannot be completely cured. Therefore, there is a need for a product of external moxibustion for vitiligo which solves the above problems.

Disclosure of Invention

In order to solve the technical problems, the invention provides the traditional Chinese medicine external composition which is convenient to use and can thoroughly treat the vitiligo.

The technical scheme adopted by the invention is as follows: a traditional Chinese medicine external composition for treating leucoderma comprises the following raw materials: fructus Psoraleae, flos Caryophylli, folium Artemisiae Argyi, rhizoma Acori Graminei, herba Speranskiae Tuberculatae, fructus Zanthoxyli, radix Angelicae Dahuricae, fructus Cnidii and radix Tripterygii Wilfordii.

According to a further scheme, the traditional Chinese medicine external composition is prepared from the following raw materials in parts by weight: 12-17G of fructus psoraleae, 7-12G of clove, 8-12G of moxa, 8-12G of rhizoma acori graminei, 8-12G of garden balsam stem, 4-8G of pepper, 8-12G of radix angelicae, 8-12G of fructus cnidii and 5-7G of tripterygium wilfordii.

According to a further scheme, the traditional Chinese medicine external composition is prepared from the following raw materials in parts by weight: 15g of fructus psoraleae, 10g of clove, 10g of moxa, 10g of rhizoma acori graminei, 10g of garden balsam stem, 6g of pepper, 10g of radix angelicae, 10g of fructus cnidii and 6g of tripterygium wilfordii.

The Chinese medicinal composition is pulverized by pulverizer, wrapped with paper to make medicated roll, and then fumigated with medicated roll to local part.

The application method of the medicated roll comprises the following steps: one end of the medicated roll is ignited and is aligned with the white spot part, the distance from the medicated roll to the skin is 3-5 cm, and the medicated roll is suitable for feeling that the local part has warm feeling without burning pain, generally, the moxibustion is carried out for about 10 minutes every time until the local part of the skin becomes reddish or reddish. The operator can place the index finger and middle finger separately at two sides of the moxibustion position, and feel the local heating degree with the fingers, and adjust the height of the medicated roll to prevent scald.

The traditional Chinese medicine external composition comprises the following components:

psoralea fruit: pungent, bitter and warm in nature. Meridian tropism enters kidney and spleen meridians. The functions are mainly used for warming kidney and tonifying yang, absorbing qi and stopping diarrhea. Can be used for treating sexual impotence, spermatorrhea, frequent micturition, lumbago, gonalgia, asthma due to kidney deficiency, and diarrhea before dawn; it is used externally to treat vitiligo and alopecia areata. The main components of the medicine comprise coumarin, flavonoid and mono-mushroom phenol. Has obvious relaxation effect on tracheal contraction caused by histamine; has estrogen-like effect, and can enhance immunity and resist aging.

Clove: pungent and warm in nature and flavor. Meridian tropism includes spleen, stomach, lung and kidney meridians. The functions are mainly to warm the middle-jiao and descend the adverse flow of qi, tonify the kidney and strengthen yang. Can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency. Flos Caryophylli has effects of increasing gastric secretion, resisting gastric ulcer, relieving diarrhea, promoting bile flow, resisting inflammation, relieving pain, resisting anoxia, resisting blood coagulation, and inhibiting bacteria.

Moxa: the moxa is a natural processed product of the wormwood, and has the main effects of clearing and activating the channels and collaterals, warming the channels and stopping bleeding, dispelling cold and relieving pain, promoting tissue regeneration and preventing miscarriage, restoring yang and rescuing from collapse, and preserving health and protecting health. Contains volatile oil, sesquiterpene, flavonoid, etc. Has antibacterial, reticuloendothelial cell phagocytosis enhancing, antiasthmatic, anaphylactic shock resisting, antitussive, expectorant, gallbladder function promoting, and uterus exciting effects, and has effects on cardiovascular system, blood coagulation, blood platelet, and central nervous system.

Grassleaf sweelflag rhizome: pungent in nature, taste and flavor; bitter; mild in nature. Meridian tropism; liver; spleen meridian. The functions are mainly used for reducing phlegm and inducing resuscitation; eliminating dampness and promoting qi circulation; dispelling wind and benefiting paralysis; relieving swelling and pain. Coma due to major febrile disease; phlegm syncope; amnesia; tinnitus; deafness; abdominal distending pain; dysentery with vomiting; rheumatic arthralgia; traumatic injury; carbuncle, cellulitis and scabies. Mainly contains volatile oil, the main component of the volatile oil is octyl ether, and the like, and the volatile oil also contains amino acid, organic acid and saccharide. Rhizoma Acori Graminei can promote secretion of digestive juice, has relaxation effect on spasm of smooth muscle of stomach intestine, and volatile oil thereof has effects of relieving spasm of trachea and ileum of guinea pig caused by acetylcholine (Ach), histamine, and 5-tibiotamine (5-HT), and antiallergic effect; acorus gramineus also has analgesic and various bacteria inhibiting effects.

Garden balsam stem: pungent, bitter and warm in nature. Has little toxicity. Meridian tropism enters liver and kidney meridians. The functions are mainly used for dispelling wind and eliminating dampness, and detoxifying and relieving pain. For rheumatic joint pain; it is used externally to treat sore and ulcer with swelling and toxin. Contains speranskia herb extract and speranskia herb alcohol acetate.

Chinese prickly ash: pungent and warm in nature and flavor. Meridian tropism includes spleen, stomach and kidney meridians. The functions are mainly warming middle energizer and relieving pain, killing parasites and relieving itching. Can be used for treating abdominal psychroalgia, emesis, diarrhea, abdominal pain due to parasitic infestation, and ascariasis; it can be used for treating eczema and pruritus. The pricklyash peel contains 4-terpinenol, also contains pulegone and linalool. Has antiinflammatory, analgesic, anesthetic, antioxidant, antiaging, antifatigue, and anoxia resisting effects.

Radix angelicae: pungent and warm in nature and flavor. The meridian tropism is entered in stomach, large intestine and lung meridians. The functions are mainly used for dispelling wind and eliminating dampness, dredging orifices and relieving pain, and reducing swelling and expelling pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain. The radix Angelicae Dahuricae contains radix Angelicae sinensis essence, radix Angelicae sinensis brain, and radix Angelicae Dahuricae toxin. The angelicin can excite the brain-extending respiratory center, the vasomotor center and the vagus nerve, and can enhance respiration, increase blood pressure and slow pulse.

Fructus cnidii: pungent, bitter and warm in nature; has little toxicity. Meridian tropism enters kidney meridian. The functions are mainly used for warming kidney and strengthening yang, eliminating dampness, dispelling wind and killing parasites. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia. The product contains volatile oil, and mainly comprises pinine, isovalerian borneol ester, parsley phenol methyl ether, dihydroparsley alcohol, bergapten, osthole, isoanisic apigenin, etc. Has antiarrhythmic effect; inhibiting the heart; lowering blood pressure; a sex hormone-like effect; antifungal, insecticidal, trichomonal and spermicidal; dispel phlegm and relieve dyspnea; local anesthesia; anti-allergic reaction, anti-mutagenic effect; delaying aging; affecting the metabolism of plasma prostacyclin and inner cyclic nucleotides; inhibiting smooth muscle contraction; preventing and treating osteoporosis; has sedative and hypnotic effects.

Thunder god vine: bitter, pungent and cool in nature. It is toxic. The functions are mainly to dispel wind, detoxify and kill parasites. It can be used for treating rheumatic arthritis and skin pruritus by external application. Has antiinflammatory, immune system enhancing, cellular immunity inhibiting, humoral immunity inhibiting, and antitumor effects.

In the formula of the invention, clove, moxa and pepper warm and dredge qi and blood, garden balsam stem and angelica dahurica warm meridians and promote blood circulation and dredge collaterals, psoralea corylifolia and cnidium fruit warm kidney and invigorate yang, tripterygium wilfordii is used for dispelling wind and removing toxicity, and all the medicines are compatible to ensure that qi and blood warm and dredge channels and collaterals. The leucoderma is the cold qi which is restricted on the skin, and the medicines are combined to warm and dredge, activate blood, warm kidney yang and assist yang qi to recover, so as to achieve the effects of dispelling wind and cold, warming channels and dredging collaterals.

The invention has the beneficial effects that:

in the formula of the invention, the traditional Chinese medicine composition can achieve the effects of expelling wind and clearing away cold, and relaxing channels and collaterals.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, specific embodiments thereof are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention can be embodied in many different forms than those herein described and many modifications may be made by one skilled in the art without departing from the spirit and scope of the invention.

The present invention will be further described with reference to the following embodiments.

The invention relates to a traditional Chinese medicine external composition for treating leucoderma, which is prepared from the following raw materials: fructus Psoraleae, flos Caryophylli, folium Artemisiae Argyi, rhizoma Acori Graminei, herba Speranskiae Tuberculatae, fructus Zanthoxyli, radix Angelicae Dahuricae, fructus Cnidii, and radix Tripterygii Wilfordii. Wherein:

psoralea fruit: pungent, bitter and warm in nature. Meridian tropism enters kidney and spleen meridians. The functions are mainly used for warming kidney and tonifying yang, absorbing qi and stopping diarrhea. Can be used for treating sexual impotence, spermatorrhea, frequent micturition, lumbago, gonalgia, asthma due to kidney deficiency, and diarrhea before dawn; it is used externally to treat vitiligo and alopecia areata.

Clove: pungent and warm in nature and flavor. Meridian tropism includes spleen, stomach, lung and kidney meridians. The functions are mainly to warm the middle-jiao and descend the adverse flow of qi, tonify the kidney and strengthen yang. Can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.

Moxa: the moxa is a natural processed product of the wormwood, and has the main effects of clearing and activating the channels and collaterals, warming the channels and stopping bleeding, dispelling cold and relieving pain, promoting tissue regeneration and preventing miscarriage, restoring yang and rescuing from collapse, and preserving health and protecting health.

Grassleaf sweelflag rhizome: pungent in nature, taste and flavor; bitter; mild in nature. Meridian tropism; liver; spleen meridian. The functions are mainly used for reducing phlegm and inducing resuscitation; eliminating dampness and promoting qi circulation; dispelling wind and benefiting paralysis; relieving swelling and pain. Coma due to major febrile disease; phlegm syncope; amnesia; tinnitus; deafness; abdominal distending pain; dysentery with vomiting; rheumatic arthralgia; traumatic injury; carbuncle, cellulitis and scabies

Garden balsam stem: pungent, bitter and warm in nature. Has little toxicity. Meridian tropism enters liver and kidney meridians. The functions are mainly used for dispelling wind and eliminating dampness, and detoxifying and relieving pain. For rheumatic joint pain; it is used externally to treat sore and ulcer with swelling and toxin.

Chinese prickly ash: pungent and warm in nature and flavor. Meridian tropism includes spleen, stomach and kidney meridians. The functions are mainly warming middle energizer and relieving pain, killing parasites and relieving itching. Can be used for treating abdominal psychroalgia, emesis, diarrhea, abdominal pain due to parasitic infestation, and ascariasis; it can be used for treating eczema and pruritus.

Radix angelicae: pungent and warm in nature and flavor. The meridian tropism is entered in stomach, large intestine and lung meridians. The functions are mainly used for dispelling wind and eliminating dampness, dredging orifices and relieving pain, and reducing swelling and expelling pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.

Fructus cnidii: pungent, bitter and warm in nature; has little toxicity. Meridian tropism enters kidney meridian. The functions are mainly used for warming kidney and strengthening yang, eliminating dampness, dispelling wind and killing parasites. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia;

thunder god vine: bitter, pungent and cool in nature. It is toxic. The functions are mainly to dispel wind, detoxify and kill parasites. It can be used for treating rheumatic arthritis and skin pruritus by external application.

The following are clinical embodiments of the invention.

Example 1

12G of fructus psoraleae, 7G of clove, 8G of moxa, 8G of rhizoma acori graminei, 8G of garden balsam stem, 4G of pepper, 8G of radix angelicae, 8G of fructus cnidii and 5G of tripterygium wilfordii; the traditional Chinese medicine composition for external use is prepared.

Example 2

Respectively taking 15G of fructus psoraleae, 10G of clove, 10G of moxa, 10G of rhizoma acori graminei, 10G of garden balsam stem, 6G of pepper, 10G of radix angelicae, 10G of fructus cnidii and 6G of tripterygium wilfordii; the traditional Chinese medicine composition for external use is prepared.

Example 3

17G of fructus psoraleae, 12G of clove, 12G of moxa, 12G of rhizoma acori graminei, 12G of garden balsam stem, 8G of pepper, 12G of radix angelicae, 12G of fructus cnidii and 7G of tripterygium wilfordii; the traditional Chinese medicine composition for external use is prepared.

The invention provides 100 cases of clinical observation data of related patients, the 100 cases are divided into two groups according to the principle of random distribution, namely 60 cases of treatment groups and 40 cases of control groups, the patients in the two groups have no statistical significance in comparison in the aspects of disease conditions, personal basic conditions and the like, and the two groups have comparability.

Firstly, selecting a standard:

the vitiligo patients who meet the diagnosis standard have not been treated by applying systemic anti-vitiligo drug therapy, steroid hormones and other immunomodulators within 3 months; ② those who are ineffective after other treatments and have been discontinued for more than 1 month; ③ chronic diseases of liver and kidney without blood system.

II, diagnosis standard:

the leucoderma is diagnosed according to the leucoderma clinical diagnosis standard established by the pigment pathology group of the skin disease professional committee of the Chinese traditional and western medicine society. Firstly, removing the acquired pigment loss spots or pigment reduction spots; secondly, the skin damage boundary is clear and the shape is irregular; thirdly, deepening pigment at the edge of the skin damage; fourthly, the hair in the skin lesion can be whitened or the phenomenon of compound color around the hair follicle opening can be seen; white spots under wood lamp are porcelain white fluorescence. 3 of the 5 items can be confirmed to be leucoderma, and other leukoderma diseases need to be further excluded, wherein the condition (I) is a necessary condition.

Third, embodiment

The external traditional Chinese medicine composition is used by a treatment group to fumigate lesion parts externally according to requirements, and specifically comprises the following components: one end of the medicated roll is ignited and is aligned to the white spot part, 2-3 cm away from the skin, suspension moxibustion is carried out, the local part is preferably heated without burning pain, the moxibustion is preferably carried out until the skin turns deep red or is close to the normal skin color of a patient, the time is about 30min each time, 1 time/d, and if the focus is more and scattered, 2-3 white spot parts can be selected as the acupuncture point A (target skin lesion) for treatment. Wherein, the rotary moxibustion can be used for the patients with larger white spot area, namely the moxibustion is carried out by moving the medicated roll left and right or rotating repeatedly, so as to enlarge the moxibustion part. The treatment is carried out 1 time a day, 15 times a course of treatment, and the curative effect is observed after 3 continuous treatment courses.

Control drug group

The triamcinolone acetonide cream is locally applied externally, 2 times a day, 15 days are a course of treatment, and the curative effect is observed after continuous treatment for 3 courses of treatment.

Fourth, comparison results

Criteria for efficacy assessment

Skin lesions are judged according to the leucoderma clinical curative effect standard established by the pigment pathology group of the skin disease professional committee of the Chinese traditional and western medicine association. And (3) healing: white spots are completely removed, and normal skin color is recovered; the effect is shown: the white spot part is faded or reduced, and the area for recovering normal skin color accounts for more than or equal to 50 percent of the total area of skin damage; the method has the following advantages: the white spot part is faded or reduced, and the area for recovering normal skin color accounts for 10 to 50 percent of the total area of the skin damage; and (4) invalidation: the white spots are not changed or reduced, and the area for recovering normal skin color accounts for less than 10 percent of the total area of skin damage.

In the treatment group, the total number of cases is 38, 11 cases are cured, 18 cases are obviously effective, 7 cases are effective, and 2 cases are ineffective. The more obvious rate is 76.3 percent.

Control drug group: the total number of the cases is 30, wherein the cases are cured by 1 case, the effect is obvious by 3 cases, the effect is 18 cases, and the effect is not 8 cases. The more significant rate was 13.3%.

The clinical observation results show that the traditional Chinese medicine composition has good treatment effect on patients with the vitiligo in the stationary phase.

The traditional Chinese medicine composition is prepared into other dosage forms, the same or similar results are obtained in experiments, the listing is omitted, the description is prevented from being accumulated, and the application claims the traditional Chinese medicine composition (combination invention) rather than the dosage form or the preparation method, so that any dosage form prepared from the traditional Chinese medicine composition belongs to the protection scope of the application and medicines for treating the same diseases.

Claims

1. A traditional Chinese medicine external composition for treating leucoderma is characterized in that: the feed consists of the following raw materials: fructus Psoraleae, flos Caryophylli, folium Artemisiae Argyi, rhizoma Acori Graminei, herba Speranskiae Tuberculatae, fructus Zanthoxyli, radix Angelicae Dahuricae, fructus Cnidii and radix Tripterygii Wilfordii.

2. The topical Chinese medicinal composition for treating vitiligo according to claim 1, wherein: the feed is prepared from the following raw materials in parts by weight: 12-17G of fructus psoraleae, 7-12G of clove, 8-12G of moxa, 8-12G of rhizoma acori graminei, 8-12G of garden balsam stem, 4-8G of pepper, 8-12G of radix angelicae, 8-12G of fructus cnidii and 5-7G of tripterygium wilfordii.

3. The external traditional Chinese medicine composition for treating leucoderma according to claim 2, which is characterized in that: the feed is prepared from the following raw materials in parts by weight: 15g of fructus psoraleae, 10g of clove, 10g of moxa, 10g of rhizoma acori graminei, 10g of garden balsam stem, 6g of pepper, 10g of radix angelicae, 10g of fructus cnidii and 6g of tripterygium wilfordii.

4. The topical Chinese medicinal composition for treating vitiligo according to any one of claims 1 to 3, wherein: crushing the raw materials with a crusher, wrapping with paper to obtain medicated roll, and fumigating affected part with the medicated roll.

5. The topical Chinese medicinal composition for treating vitiligo according to claim 4, wherein: the local fumigation external medicine roll is as follows: one end of the medicated roll is ignited and is aligned with the white spot part, the distance from the medicated roll to the skin is 3-5 cm, and the medicated roll is suitable for feeling that the local part has warm feeling without burning pain, generally, the moxibustion is carried out for about 10 minutes every time until the local part of the skin becomes reddish or reddish.

6. The topical Chinese medicinal composition for treating vitiligo according to claim 5, wherein: when the operator smokes the affected part outside the medicated roll, the index finger and the middle finger are separately arranged at two sides of the moxibustion part, the fingers feel the local heating degree, and the height of the medicated roll is adjusted to prevent scald.