CN101485770A - Medicament composing prescription for treating leukoderma and technique for preparing the same - Google Patents
Medicament composing prescription for treating leukoderma and technique for preparing the same Download PDFInfo
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- CN101485770A CN101485770A CNA2009100211995A CN200910021199A CN101485770A CN 101485770 A CN101485770 A CN 101485770A CN A2009100211995 A CNA2009100211995 A CN A2009100211995A CN 200910021199 A CN200910021199 A CN 200910021199A CN 101485770 A CN101485770 A CN 101485770A
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Abstract
The invention provides a medicine composition for treating vitiligo and preparation technology thereof, and belongs to the field of preparation technology of traditional Chinese medicine. The medicine composition for treating vitiligo is extracted and prepared by taking natural traditional Chinese medicines as raw materials. The preparation technology is characterized in that: firstly, single medicines of peppers, namely weighing the peppers, using a gauze bag to loosely package the peppers, placing the gauze bag into a special soaking cylinder or a special soaking jar, adding 50 to 90 percent medical ethanol for submersion, adding a cover for sealing, soaking the peppers for 1 weak, and collecting percolate; and using ethanol to adjust the percolate to be 50 percent (as calculated by gram per 100 milliliters), performing subpackage on the percolate into spray bottles, sealing the spray bottles, and obtaining pepper tincture finished products; and secondly, a compound recipe of the peppers and Psoralea corylifolia, namely respectively taking 1.5 portions of the peppers and 1 portion of the Psoralea corylifolia according to weight ratio, uniformly mixing the peppers and the Psoralea corylifolia, loosely packaging the mixture into a gauze bag, placing the gauze bag into a special soaking cylinder or a special soaking jar, adding the 50 to 90 percent medical ethanol for submersion, adding a cover for sealing, soaking the mixture for 1 weak, and collecting percolate; and using the ethanol to adjust the percolate to be 50 percent, performing subpackage and sealing, and obtaining pepper compound tincture finished products. As proved by clinical research and animal experiments, the reagent has the function of treating slight and moderate vitiligo, has no obvious untoward reaction, and has low production cost due to rich sources of raw materials.
Description
Affiliated technical field
The invention belongs to the leukodermic medicine of treatment, is the leukodermic medicine of treatment that is prepared from through extraction by Pericarpium Zanthoxyli, Pericarpium Zanthoxyli and Fructus Psoraleae compatibility specifically.
Background technology
Vitiligo is a kind of limitation depigmentation of skin of late coming, is because the hypofunction of the interior tryrosinase system of the melanocyte of local skin pigment obstacle, skin and hair follicle makes epidermis obviously lack melanocyte, causes skin pigment to take off and loses and cause.Though vitiligo does not influence patient's health, the also symptom of no pain because it often occurs in exposure portion such as face, and influences attractive in appearancely, makes the patient often feel worried, can spread all over whole body when serious, brings to a certain degree influence for patient's physical and mental health.Leukodermic pathogeny does not still have clearly final conclusion so far, it is a kind of former depigmentation of skin relevant with autoimmune that more scholar tends to vitiligo, is that hypofunction, the forfeiture of tryrosinase system in the melanocyte owing to skin and hair follicle causes.Specifically be divided into following several theory.(1) theory of heredity: the various places report has 3%～40% patient to have positive family to make.Bhatta in 1992 etc. point out this sick polygenes character to the research of leukodermic hereditary property.Majumder in 1993 etc. have reported that leukodermic family gathers together pattern, and proposing that inherited genetic factors plays a part the generation of primary disease must.Nath in 1994 etc. carry out in fashion sick learning of vitiligo hereditary pattern and study, think to be the mutual epistatic action (be the interaction of different loci gene, make a hereditary character not appear in one's mind) of the genes that put in place such as multidigit point recessiveness that do not continue on many chromosomes because of another hereditary character coinciding in the above.(2) neural factor theory: the vitiligo skin lesion can produce when energy is nervous or enlarge, and the prompting neural factor works in morbidity.Experimentation confirms that noradrenalin, epinephrine, acetylcholine, melatonin etc. bleach at the external melanocyte of amphibian and Fish that can make.Someone infers that melanocyte produces the melanocyte ability and goes down, and is because its peripheral nerve chemical substance increases, the achievement that tyrosinase activity is lowered.Neurohistology studies have shown that white macula cutaneous nerve tip has the degeneration change, and histochemistry checks that white macula skin cholinesterase activity reduces.Also there is experiment confirm skin lesion place skin cholinergic activity to increase and the active deficiency of adrenergic.The leukodermic skin lesion of the clinical segmental pattern of seeing is segmental along nerve and scatters, and vitiligo patient is often occurred together vegetative nerve effect rate disorderly and white macula portion skin perspiration abnormal phenomena, all meets the neuro chemistry factor theory.The sympathetic nerve happiness increases, and may cause the release of media such as Melatonin to increase, and makes the synthetic minimizing of melanocyte.Early stage vitiligo skin lesion Merkel cell dissipates and also supports the effect of neural factor.(3) immunological theory: patients with vitiligo often produces other autoimmune diseases,, thyroiditis hyperfunction, diabetes, pernicious anemia, Addison disease, alopecia areata, dizzy nevus, ulcerative colitis, systemic lupus erythematosus (sle), scleroderma etc. as the thyroid effect, but there have the scholar to think by statistics to be all relevant with thyroid disease.Vitiligo patient exists cellular immunization and humoral immunization is unusual, and different experiments confirms D3 in the vitiligo skin lesion
+, CD4
+, CD8
+The T cell rises appreciably, and peripheral blood TH cell reduces, the TS cell enlargement.Can measure multiple autoantibody among the patients serum.Abroad have in report patient's blood over half and can measure more than one autoantibodys.As anti-thyroid antibody, anti-gastric parietal cell antibody and antinuclear antibody etc.But the most direct evidence is anti-melanocytic circulating antibody.Can measure the anti-melanocyte antibody of specificity among the patients serum, positive rate reaches 50%～93%, and its titre and the state of an illness are relevant.
Vitiligo claims " leucoderma " again in TCM Document, or " vitiligo ".The description of pair primary disease is promptly arranged in book copied on silk " 52 Bingfang ", and its is described be " in vain not the natural fibre line of meat "." element is asked. a wind opinion piece of writing " say: and " pathogenic wind hiding in the skin, must not be let out outward at interior must not leading to ", for a long time and blood stasis, skin loses that supporting bleaches forms this disease." all source of disease marquis's opinions " meaning: this also is by " ailment said due to cold or exposure is fought in skin, and the vim and vigour discord is given birth to also " for " leucoderma person, face and neck health skin and flesh complexion changed are white, and be different with color, the pain of also not itching, the leucoderma of meaning ".Clearly illustrated the etiology and pathogenesis of primary disease." the true select of surgery " also have " vitiligo ..., its color vitiligo, shape such as cloud sheet also do not have sufferings " record." medical science gold mirror. surgery heart method " point out: " this disease is from face and neck, and yellowish pink bleaches suddenly, shape class abnormal pigmentary deposit on the skin point, the pain of not itching.If because of following with the passing of time, even prolong and whole body.Fight mutually in skin by ailment said due to cold or exposure, cause make qi-blood disharmony " modern age doctor family when inheriting its theory, new development has been arranged again, three big views of primary disease morbidity have been proposed: the one, stagnation of liver-QI is caused a disease and is discussed; The 2nd, blood stasis causes a disease and discusses; The 3rd, the sick opinion of visceral dysfunction.
Chinese medicine it is generally acknowledged that leukodermic pathogeny is that ailment said due to cold or exposure is flourishing in the body, and that sends out gives birth in table.Leukodermic pathogenesis is to attack in the ailment said due to cold or exposure, causes the mechanism of qi operation not smooth, and the stagnation of QI is blood stasis then, and blood stasis is visceral dysfunction then; Its ailment said due to cold or exposure is flourishing in addition, easily gives birth to the cold-evil, and cold coagulation blood vessels, blood are not supported skin, and above pathogenesis causes the skin cervical carcinoma with cachexia, loses and support, and causes this disease eventually, and desire more must be set upright also.Show as the white macula that differing in size appears in skin, Se Bai such as porcelain, in sharp contrast with surrounding skin, extremely ugly.Sometimes the white macula transfixion breaks out again sometimes, increases rapidly, changes unpredictably.This be Chinese medicine what is called " wind benefaction and number become " also.
Vitiligo does not have the specific treatment method at present.For this stubborn disease, Chinese medicine has great advantage, accumulated rich experience, the furocoumarin that wherein with the Fructus Psoraleae is representative is a photosensitizer commonly used at present, it treats leukodermic mechanism of action: (1) absorbs 290nm～380nm ultraviolet, and this photosensitivity reaction has destroyed sulfhydryl compound in the skin, removes its inhibition to tyrosine kinase, activate tyrosine kinase, catalysis melanin generates; (2) stimulate chromaticness to form cell and discharge inflammatory mediator, act on the melanophore somatomedin, make remaining melanocyte propagation in epidermis or the hair follicle; (3) cell of Langerhan that reduces epidermis is eliminated in the expression of the relevant melanocyte antibody of vitiligo on the elimination melanocyte film, and blocking-up is to melanocytic cytotoxic reaction.Though vitiligo is a kind of dermatosis, no matter be western medicine, or Chinese medicine, think that all leukodermic pathogeny is in the body.Whether western medicine thinks, vitiligo is relevant with heredity, belongs to polygenic inheritance, and promptly by a plurality of Gene Handling, genetic mechanism is very complicated, fall ill and external environment stimulates substantial connection is arranged.In fact, leukodermic clinically morbidity just so.
Treat leukodermic medicine with Fructus Psoraleae, external main medication has: the methoxypsoralen sheet, and strengthen the pharmaceutical factory by French Kang Midi and produce, main component is Fructus Psoraleae extract 8-MOP, total effective rate is about 70.4%, and this agent has side effect such as gastrointestinal reaction and temporary transaminase raise; Domestic main employing Fructus Psoraleae list medicine preparation, or the tincture made of other Chinese medicines of Fructus Psoraleae compatibility uses, and formed by the ethanol configuration that the 30g Fructus Psoraleae adds 100ml75% as psoralea tincture; Compound kaliziranding is formulated by Fructus Psoraleae, Caulis Vernoniae andersonii, Radix Polygoni Multiflori, Radix Angelicae Sinensis etc.Also useful Chinese medicine adds oral 17-hydroxy-11-dehydrocorticosterone or external hormone therapy, and it is desirable that their curative effects are all owed, and toxic and side effects is more obvious.
Summary of the invention
It is definite to the purpose of this invention is to provide a kind of clinical efficacy, and toxic and side effects is little, the leukodermic medicine of treatment cheap and that have wide range of applications.
The implementation of the object of the invention is: treat leukodermic two first prescriptions, and the one, the Pericarpium Zanthoxyli single, put in special-purpose dip tank or the jar with bulk the installing of gauze bag the back of weighing, and adds the 50%-90% medical ethanol and flood, and seals, and flooded for 1 week, collects percolate; Adjust percolate to 50% (by/100 milliliters of grams) with ethanol, be sub-packed in the spray bottle, sealing promptly gets Pericarpium Zanthoxyli tincture finished product.The 2nd, Pericarpium Zanthoxyli and Fructus Psoraleae compound recipe, by weight getting 1 part of 1.5 parts in Pericarpium Zanthoxyli and Fructus Psoraleae respectively, with Pericarpium Zanthoxyli and Fructus Psoraleae mixing and the bulk gauze bag of packing into put special-purpose dip tank or jar in, adding the 50%-90% medical ethanol floods, seal, flooded for 1 week, collect percolate; Adjust percolate to 50% (by/100 milliliters of grams) with ethanol, be sub-packed in the spray bottle, sealing promptly gets Pericarpium Zanthoxyli compound spirit finished product.
Pericarpium Zanthoxyli is the dry mature skin of rutaceae green pepper Zanthoxylum schinifolium Sieb.et Zucc. or Pericarpium Zanthoxyli Zanthoxylum Bungeanum Maxim.Its acrid in the mouth, warm in nature, return spleen, stomach, kidney channel.Pericarpium Zanthoxyli is important edible spice, all contains quintessence oil in its fruit, the leaf, is one of traditional flavouring agent of China, and Pericarpium Zanthoxyli also belongs to the traditional Chinese medicine that higher-value is arranged of China, and its medication is with a long history, and the successive dynasties book on Chinese herbal medicine is all on the books.China's pharmacy works Shennong's Herbal the earliest carries, Pericarpium Zanthoxyli " acrid in the mouth, temperature cure mainly ailment said due to cold or exposure gas, and warming middle-JIAO removes arthralgia due to cold, and hard tooth makes eye bright, by the therapeutic method to keep the adverse QI flowing downwards ".The Compendium of Material Medica cloud: " green pepper, the thing of pure sun, its acrid in the mouth and fiber crops, its temperature is with warm.Go into lung and dispelling cold, control cough; Go into spleen and removing dampness, control anemofrigid-damp arthralgia, the edema dysentery; Go into right kidney and mend fire, control the sun frequency of micturition that declines, the weak all diseases of chronic dysentery of foot ".From these records as can be known, Pericarpium Zanthoxyli mainly has warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching.At present, be used for coldness and pain in the epigastrium in tcm clinical practice research and in using, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; The eczema pruritus is controlled in external.
Specific embodiments
The one, the Pericarpium Zanthoxyli single, put in special-purpose dip tank or the jar with bulk the installing of gauze bag the back of weighing, and adds the 50%-90% medical ethanol and flood, and seals, and flooded for 1 week, collects percolate; Adjust percolate to 50% (by/100 milliliters of grams) with ethanol, be sub-packed in the spray bottle, sealing promptly gets Pericarpium Zanthoxyli tincture finished product.The 2nd, Pericarpium Zanthoxyli and Fructus Psoraleae compound recipe, by weight getting 1 part of 1.5 parts in Pericarpium Zanthoxyli and Fructus Psoraleae respectively, with Pericarpium Zanthoxyli and Fructus Psoraleae mixing and the bulk gauze bag of packing into put special-purpose dip tank or jar in, adding the 50%-90% medical ethanol floods, seal, flooded for 1 week, collect percolate; Adjust percolate to 50% (by/100 milliliters of grams) with ethanol, be sub-packed in the spray bottle, sealing promptly gets Pericarpium Zanthoxyli compound spirit finished product.More than two kinds of tinctures can treat vitiligo well, and normal skin and damaged skin are had no stimulation, no sensitization, safe and reliable.And tincture directly is applied in the affected part, directly acts on target site, makes it more effectively carry out photosensitization, activates the activity of tryrosinase.
Attached: Related Experimental Study and clinical treatment vitiligo curative effect data
1 animal experiment study
1.1 local excitation test: behind the local one or many use of Cavia porcellus the present invention, observe the situation of skin to the preparation irritant reaction, the result shows, 1,12,24,48,72 hour to the stimulation score value of normal and damaged skin all＜0.5 behind a drug, proof this product has no stimulation to normal and damaged skin, do not have the statistics difference with blank solution, prove that this medicine has no stimulation to skin.To normal and repeatedly medication of damaged skin (7 days), the partial reaction of observation medication in 1,12,24,48 hour after the last medication, observe normal skin and damaged skin and stimulation all do not occur, each group stimulates scoring intensity score value all＜0.5, i.e. nonirritant.
1.2 skin anaphylactic test: divide four groups with albino guinea-pig, 10 every group, be respectively Pericarpium Zanthoxyli group of the present invention, Pericarpium Zanthoxyli+Fructus Psoraleae group, blank group, positive drug control group.Behind its this tincture of contact skin, observe the animal local skin.Blank group, Pericarpium Zanthoxyli group and Pericarpium Zanthoxyli+Fructus Psoraleae group contacts intact skin after 6 hours exciting, and observe at once and all do not have erythema and edema generation in 24,48,72 hours, and animal is acted normally, and no dysphoria is grabbed symptoms such as nose.Positive controls is then exciting the contact intact skin after 6 hours, observes at once all to occur erythema and edema generation in 24,48,72 hours, and dysphoria is arranged during animal, grabs symptoms such as nose.
The result shows that this reagent do not have sensitization, and is safe and reliable.
2 clinical trials
2.1 clinical data: 181 routine patients are my the outpatient service prescription on individual diagnosis person of school Affiliated Hospital, and are diagnosed as patients with vitiligo.Man's 112 examples, women 69 examples; 38 years old mean age (14～72 years old), average course of disease 3.5 years (1 month～21 years).Topical type 108 examples in 181 examples are distributed type 53 examples, segmental pattern 20 examples; The state of an illness is in example resting stages 133, carries out phases 48 example.All patients did not accept systematic treating in nearly 3 months, did not accept glucocorticoid, ultraviolet and the treatment of other medicine for external use in 2 weeks.181 routine patients are divided into matched group 56 examples by prescription on individual diagnosis order and white macula area size, Pericarpium Zanthoxyli tincture test group 64 example and Pericarpium Zanthoxyli compound spirit 61 examples.Three groups of patients have comparability aspect age, sex, the course of disease, the skin lesion area.
2.2 the administrated method and the course of treatment: being coated with tincture of the present invention outward behind the test group every day sooner or later clean skin, is a course of treatment around continuously, continuous use 2-3 course of treatment; Matched group uses 1% pimecrolimus emulsifiable paste (trade name: Ai Ningda), use to specifications morning every day.Judged that curative effects also write down untoward reaction in 3 months, occur then termination test at once of serious adverse reaction midway as treatment.
2.3 curative effect determinate standard: formulate according to document.
The criterion of vitiligo criterion of therapeutical effect is as follows.
Recovery from illness: white macula all disappears, and recovers the normal colour of skin.
Produce effects: white macula partly disappears or dwindles, and recovers area 〉=50% of the normal colour of skin.
Effectively: white macula partly dwindles, and recovers area＜50% of the normal colour of skin.
Invalid: regeneration of white macula non-pigment or expanded range.
Effective percentage is that cure rate adds obvious effective rate.
2.4 result: see Table 1.
Table 1 liang group patients with vitiligo treatment back curative effect relatively
*Illustrate: compare with the matched group effective percentage.
Observe through clinical contrast treatment at random, apparently higher than matched group, total effective rate has obvious statistical significance, proves that this reagent treatment vitiligo is evident in efficacy, does not find untoward reaction during the medication to leukodermic cure rate and obvious effective rate in this reagent.
Claims (5)
1, two kinds of leukodermic medicines of treatment, adopting natural Chinese medicine is that raw material extracts preparation and forms, and it is characterized in that this medicine forms compound recipe by single Pericarpium Zanthoxyli, Pericarpium Zanthoxyli and Fructus Psoraleae and dispose and form.
2, the leukodermic medicine of treatment according to claim 1 is characterized in that adopting the common process method to make tincture.
3, Chinese medicine according to claim 1 and preparation of compositions method thereof is characterized in that this method is: the Pericarpium Zanthoxyli single, and put in special-purpose dip tank or the jar with bulk the installing of gauze bag the back of weighing, adding the 50%-90% medical ethanol floods, seal, flooded for 1 week, collect percolate; Adjust percolate to 50% (by/100 milliliters of grams) with ethanol, be sub-packed in the spray bottle, sealing promptly gets the Pericarpium Zanthoxyli tincture.
4, the preparation method of Chinese medicine composition according to claim 1, it is characterized in that this method is: Pericarpium Zanthoxyli and Fructus Psoraleae compound recipe, by weight getting 1 part of 1.5 parts in Pericarpium Zanthoxyli and Fructus Psoraleae respectively, with Pericarpium Zanthoxyli and Fructus Psoraleae mixing and the bulk gauze bag of packing into put special-purpose dip tank or jar in, adding the 50%-90% medical ethanol floods, seal, flooded for 1 week, collect percolate; Adjust percolate to 50% (by/100 milliliters of grams) with ethanol, be sub-packed in the spray bottle, sealing promptly gets Pericarpium Zanthoxyli compound spirit finished product.
5, according to right 2,3,4 described methods, make tincture and be used for the treatment of vitiligo, its using method is a partial smearing, and 1-2 time on the one is a course of treatment all around.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100211995A CN101485770A (en) | 2009-02-19 | 2009-02-19 | Medicament composing prescription for treating leukoderma and technique for preparing the same |
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| CNA2009100211995A CN101485770A (en) | 2009-02-19 | 2009-02-19 | Medicament composing prescription for treating leukoderma and technique for preparing the same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123390B2 (en) | 2018-09-18 | 2021-09-21 | Kuwait University | Method for treating vitiligo |
| CN113663015A (en) * | 2021-09-13 | 2021-11-19 | 李小莎 | A topical Chinese medicinal composition for treating vitiligo |
-
2009
- 2009-02-19 CN CNA2009100211995A patent/CN101485770A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123390B2 (en) | 2018-09-18 | 2021-09-21 | Kuwait University | Method for treating vitiligo |
| CN113663015A (en) * | 2021-09-13 | 2021-11-19 | 李小莎 | A topical Chinese medicinal composition for treating vitiligo |
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Application publication date: 20090722 |