CN108404044A - A kind of compound plant stacte essential oil of Huoxue Jieyu - Google Patents
A kind of compound plant stacte essential oil of Huoxue Jieyu Download PDFInfo
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Abstract
It is an object of the present invention to provide a kind of compound plant stacte essential oil of Huoxue Jieyu, it is made of the material medicine of following components by weight percent meter：10 50 parts of 10 30 parts of rhizoma cyperi, 10 35 parts of Radix Curcumae, 5 25 parts of green peel, 5 20 parts of turmeric, 5 20 parts of costus root, 5 30 parts of Exocarpium Citri Rubrum, 5 30 parts of safflower, 5 40 parts of Radix Angelicae Sinensis, 10 30 parts of caulis perllae, 5 20 parts of rhizoma atractylodis, 10 30 parts of chamomile and Rhizoma Chuanxiong, abundant raw material of the present invention, preparation method is simple, extracting method is simple, recovery rate is high, Extracting temperature is low, destructible active ingredient is not allowed, good effect, it is the innovation in medicament for treatment of depression, it is worth with very strong Clinical practice, there is significant economic and social benefit.
Description
Technical field
The present invention relates to medicine, the compound plant stacte essential oil of especially a kind of Huoxue Jieyu.
Background technology
With the development of society, the increasing of the pressure such as people's the accelerating rhythm of life, and study, work, life, depression
The incidence of disease constantly rises, which is referred to as " STOP Emotion Cold ", it is prevailing in world community, society just as common cold
It can each stratum and various people.According to WHO report, it is contemplated that arrive the year two thousand twenty, depression will be as leading to human death and disable
Second major class disease.As traditional medicine is by public receiving and support, Chinese traditional treatment is increasingly paid attention to by the masses.Depression exists
Traditional Chinese medicine category melancholia scope, Chinese medicine think that gas is the master of the whole body, flow round without stopping that body of feeling at ease is strong, and stasis is then disease.Vital essence pent-up,
Blood vessels are obstructed be disease root；Ancient Chinese medicine doctor thinks that the main sick position of depression is liver, is related to the five internal organs, is hindered with feelings will, mechanism of qi
Stasis is depression because using qi activity disturbance, the five internal organs disorder of qi and blood as the interpretation of the cause, onset and process of an illness.Before investigation finds the common tcm syndrome of depression
8 are syndrome of stagnation of liver qi and spleen deficiency, Liver depression and Qi stagnation, syndrome of deficiency of both heart and spleen, insufficiency of the kidney yang card, syndrome of yin deficiency of liver and kidney, heart and gallbladder syndrome of qi deficiency, the stagnation of the circulation of vital energy
The tired card of blood, syndrome of disharmony between heart and kidney.
Currently, though the treatment about depression is there are many drug and technological means, mainly psychotherapy, physiotherapy
And drug therapy, drug treatment are the primary treatment measures of the above depressive episode of moderate, the clinically antidepression of a line
Medicine includes mainly selective serotonin reuptake inhibitor, serotonin and norepinephrine reuptake inhibitors, goes first
Adrenaline and specific serotonin energy antidepressants etc., however, these drugs exist more high relapse rate, Time of Administration it is long,
Effect is unsatisfactory, side effect is larger, is also easy to produce drug resistance etc..Therefore, the improvement in medicament for treatment of depression and innovation gesture
It must go.
Invention content
For the above situation, to overcome the defect of the prior art, it is an object of the present invention to provide a kind of answering for Huoxue Jieyu
Square plant stacte essential oil can effectively solve the problem of that the medication for the treatment of depression provides curative effect, prevents side effect.
The technical solution that the present invention solves is that a kind of compound plant stacte essential oil of Huoxue Jieyu, is by following weight group
The material medicine of meter is divided to be made：10-30 parts of rhizoma cyperi, 10-35 parts of Radix Curcumae, 5-25 parts of green peel, 5-20 parts of turmeric, costus root 5-20
Part, 5-30 parts of Exocarpium Citri Rubrum, 5-30 parts of safflower, 5-40 parts of Radix Angelicae Sinensis, caulis perllae be 10-30 parts sub-, 5-20 parts of rhizoma atractylodis, 10-30 parts of chamomile and
10-50 parts of Rhizoma Chuanxiong, wherein material medicine is obtained into essential oil of traditional Chinese medicine using subcritical fluid extraction method, adds preservative, preservative
Weight ratio with essential oil of traditional Chinese medicine is 1-10:1000, the subcritical fluid extraction method is, by above-mentioned pulverizing medicinal materials, to cross No. 2-6
Medicine sieves, and obtains traditional Chinese medicine powder, is fitted into extraction kettle, vacuumizes, and at pressure 0.5-1.0MPa, solvent butane is added in extraction kettle,
The w/v of extraction 2-5 times, each Chinese medicine powder solvent and butane is 1：2-5, w/v refer to solid in terms of g, liquid
Body is in terms of ml, and 30-60 DEG C of each extraction temperature, extraction time 40-120min, butane is recovered under reduced pressure in combining extraction liquid, in oil
Anhydrous sodium sulfate drying is added in layer, obtains the yellowish-brown transparency liquid with strong fragranced, i.e. essential oil of traditional Chinese medicine, seals low temperature
It is kept in dark place；The preservative is sesamin and natamycin, with weight ratio 1:The ratio of 2-5 is uniformly mixed and is made.
Abundant raw material of the present invention, preparation method is simple, in particular with subcritical fluid extraction method, using butane as molten
Agent can effectively extract volatile oil component in above-mentioned medicinal material, and extracting method is simple, and recovery rate is high, and Extracting temperature is low, it is not easy to destroy
Active ingredient, good effect are the innovations in medicament for treatment of depression, have very strong Clinical practice value, there is significant economy
And social benefit.
Specific implementation mode
It elaborates to the specific implementation mode of the present invention below in conjunction with concrete condition and embodiment.
The present invention can be provided in specific implementation by following embodiment：
Embodiment 1：It is made of the material medicine of following components by weight percent meter：12-25 parts of rhizoma cyperi, 15-30 parts of Radix Curcumae, green peel
10-20 parts, 8-15 parts of turmeric, 8-15 parts of costus root, 8-20 parts of Exocarpium Citri Rubrum, 6-25 parts of safflower, 8-30 parts of Radix Angelicae Sinensis, the sub- 15-25 of caulis perllae
Part, 10-15 parts of rhizoma atractylodis, 10-25 parts of chamomile, 15-30 parts of Rhizoma Chuanxiong, wherein material medicine is used into subcritical fluid extraction method
Essential oil of traditional Chinese medicine, add preservative, the weight ratio of preservative and essential oil of traditional Chinese medicine is 2-8:1000, subcritical fluids extraction
Following the example of is, by above-mentioned pulverizing medicinal materials, crosses 3-5 medicines sieve, obtains traditional Chinese medicine powder, be fitted into extraction kettle, vacuumize, in pressure 0.5-
Under 0.8MPa, solvent butane is added in extraction kettle, extracts 2-4 times, the w/v of each Chinese medicine powder solvent and butane is
1：2-4, w/v refer to solid in terms of g, and liquid is in terms of ml, 30-50 DEG C of each extraction temperature, extraction time 40-
Butane is recovered under reduced pressure in 100min, combining extraction liquid, and anhydrous sodium sulfate drying is added in oil reservoir, obtains having strong fragranced
Yellowish-brown transparency liquid, i.e. essential oil of traditional Chinese medicine, sealing keep in dark place at low temperature；The preservative be sesamin and natamycin,
With weight ratio 1:The ratio of 2-4 is uniformly mixed and is made.
Embodiment 2：It is made of the material medicine of following components by weight percent meter：10 parts of rhizoma cyperi, 15 parts of Radix Curcumae, 8 parts of green peel, ginger
6 parts yellow, 15 parts of costus root, 10 parts of Exocarpium Citri Rubrum, 15 parts of safflower, 10 parts of Radix Angelicae Sinensis, 15 parts of caulis perllae, 10 parts of rhizoma atractylodis, 12 parts of chamomile, river
15 parts of rhizome of chuanxiong, wherein material medicine is obtained into essential oil of traditional Chinese medicine using subcritical fluid extraction method, adds preservative, preservative is in
The weight ratio of medicine essential oil is 5:1000, the subcritical fluid extraction method is, by above-mentioned pulverizing medicinal materials, No. 5 medicine sieves to be crossed, in obtaining
Medicinal powder is fitted into extraction kettle, is vacuumized, and at pressure 0.8MPa, solvent butane is added in extraction kettle, extracts 4 times, in each
The w/v of medicinal powder solvent and butane is 1：3, w/v refers to solid in terms of g, and liquid is in terms of ml, extraction temperature every time
50 DEG C of degree, butane is recovered under reduced pressure in extraction time 100min, combining extraction liquid, and anhydrous sodium sulfate drying is added in oil reservoir, obtains
To the yellowish-brown transparency liquid with strong fragranced, i.e. essential oil of traditional Chinese medicine, sealing is kept in dark place at low temperature；The preservative is sesame
Numb element and natamycin, with weight ratio 1:4 ratio is uniformly mixed and is made.
Embodiment 3：It is made of the material medicine of following components by weight percent meter：15 parts of rhizoma cyperi, 20 parts of Radix Curcumae, 10 parts of green peel,
10 parts of turmeric, 12 parts of costus root, 8 parts of Exocarpium Citri Rubrum, 6 parts of safflower, 15 parts of Radix Angelicae Sinensis, caulis perllae 15 parts, 10 parts of rhizoma atractylodis, 25 parts of chamomile,
25 parts of Rhizoma Chuanxiong, wherein material medicine is obtained into essential oil of traditional Chinese medicine using subcritical fluid extraction method, adds preservative, preservative with
The weight ratio of essential oil of traditional Chinese medicine is 3:1000, the subcritical fluid extraction method is, by above-mentioned pulverizing medicinal materials, to cross No. 3 medicine sieves, obtain
Traditional Chinese medicine powder is fitted into extraction kettle, is vacuumized, at pressure 0.6MPa, the addition solvent butane in extraction kettle, and extraction 3 times, every time
The w/v of Chinese medicine powder solvent and butane is 1：2, w/v refers to solid in terms of g, and liquid is extracted every time in terms of ml
40 DEG C of temperature, butane is recovered under reduced pressure in extraction time 60min, combining extraction liquid, and anhydrous sodium sulfate drying is added in oil reservoir,
The yellowish-brown transparency liquid with strong fragranced is obtained, i.e. essential oil of traditional Chinese medicine, sealing is kept in dark place at low temperature；The preservative is
Sesamin and natamycin, with weight ratio 1:3 ratio is uniformly mixed and is made.
In said medicine, above-mentioned prescription be using diagnosis and treatment and organic conception therapy then, started promoting blood circulationization
Stasis of blood class stacte treats the beginning of depression, provides sneakerization in the means for the treatment of depression, the present invention uses Rhizoma Chuanxiong, with enhancing
The effect of blood-activating and qi-promoting, wind-expelling pain-stopping, using the chamomile that volatile oil content is abundant, enhancing improving eyesight, irascibility of refreshing oneself, move back work(
Effect, using the component of low cost, such as：Moschus, agalloch eaglewood, hillside plot are conducive to promote to reduce cost, meanwhile, exclusion has respiratory tract
Irritating drug, such as：Semen brassicae expands target user's range, and exclude the medicine for not having volatile ingredient to reduce side effect
Object, such as：Radish seed, to improve each utilization rate for forming drug；Safflower, the analgesic of turmeric blood-activating and qi-promoting；Chinese angelica blood supplementing, promoting blood circulation；
Rhizoma cyperi, green peel soothing liver-qi stagnation, regulating the flow of QI to ease the stomach；Radix Curcumae, Rhizoma Chuanxiong blood-activating and qi-promoting are opened strongly fragrant, and clear away heart-fire cool blood；Rhizoma atractylodis, root of Aucklandia lappa Decne, Exocarpium Citri Rubrum, eliminating dampness
Invigorating the spleen, regulating the flow of QI to ease the stomach, resolving sputum, dredge profit in coke with harmonizing the functional activities of vital QI；Costus root promoting qi circulation and relieving pain, reinforcing spleen to promote digestion, roasted RADIX AUCKLANDIAE reality intestines antidiarrheal,
Addition chamomile enhancing improving eyesight, moves back the effect of irascibility at nourishing heart；Prescription meets the principle of Chinese traditional treatment depression, blood-activating drug and row
Gas medicine is used in conjunction with each other, and plays the work(of Huoxue Jieyu altogether.
Depression is in traditional Chinese medicine category melancholia scope, clinical manifestation：Mental state is low unbecoming with its situation, mood it is downhearted
Can be from depressed to extremely grieved, depression of feeling oneself inferior or even pessimistic and worldweary can have conamen or behavior；Wood even occurs
It is stiff；Some cases have apparent anxiety and motility intense；Severe patient may occur in which the psychotic symptoms such as illusion, vain hope.
Chinese medicine thinks that gas is the master of the whole body, flows round without stopping, and body of feeling at ease is strong, and stasis is then disease.Vital essence pent-up, blood vessels are obstructed
It is the root of disease；Ancient Chinese medicine doctor thinks that the main sick position of depression is liver, is related to the five internal organs, is hindered with feelings will, depression and stagnation of QI is suppression
Strongly fragrant disease because using qi activity disturbance, the five internal organs disorder of qi and blood as the interpretation of the cause, onset and process of an illness.Investigation finds that 8 are before the common tcm syndrome of depression
The tired card of syndrome of stagnation of liver qi and spleen deficiency, Liver depression and Qi stagnation, syndrome of deficiency of both heart and spleen, insufficiency of the kidney yang card, syndrome of yin deficiency of liver and kidney, heart and gallbladder syndrome of qi deficiency, stagnation of the circulation of vital energy blood,
Syndrome of disharmony between heart and kidney.Chinese medicine thinks the suitable soothing liver and strengthening spleen of the treatment of depression, promoting the circulation of qi resolving sputum, tonifying spleen nourishing heart, tonifying Qi and blood, nourishing heart peace
God, benefiting qi and raising yang, nourishing the liver and kidney, promoting blood circulation and removing blood stasis, invigorating brain and relieving mental uneasiness etc. make each viscera function normally coordinate, this is qi and blood punching and ten thousand
Disease is not raw.
The drug component of the present invention just embodies this principle of reatment, is had been given above-mentioned, present invention safflower, ginger
Yellow, Rhizoma Chuanxiong blood-activating and qi-promoting analgesic, cooperation Chinese angelica blood supplementing, promoting blood circulation can improve depressive symptom caused by qi depression to blood stasis；Rhizoma cyperi, green peel
Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, Rhizoma Chuanxiong promote breath and open depression of arranging in pairs or groups dispel pathogenic wind and remove dampness, and promoting blood circulation and stopping pain improves depression caused by stagnation of QI due to depression of the liver
Shape；Rhizoma atractylodis, root of Aucklandia lappa Decne, Exocarpium Citri Rubrum, drying damp and strengthening spleen, regulating the flow of QI to ease the stomach, resolving sputum, dredge coke in profit improves stagnation of liver-QI with deficiency of the spleen institute extremely with harmonizing the functional activities of vital QI
Depressive symptom；Radix Curcumae, Rhizoma Chuanxiong blood-activating and qi-promoting are opened strongly fragrant, and clear away heart-fire cool blood, and collocation chamomile enhancing improving eyesight, moves back the effect of irascibility at nourishing heart,
Improve the depressive symptom caused by the insufficiency of heart and spleen, the heart and gallbladder deficiency of vital energy and breakdown of the normal physiological coordination between the heart and the kidney；Prescription meets the principle of Chinese traditional treatment depression, living
Blood medicine is used in conjunction with each other with qi-activating drug, plays the work(of Huoxue Jieyu altogether.
Using subcritical fluid extraction method, using butane as solvent, volatile oil component in above-mentioned medicinal material can be effectively extracted,
Extracting method is simple, and recovery rate is high, and Extracting temperature is low, it is not easy to destroy active ingredient, improve drug effect and therapeutic effect, and through reality
Ground is tested and application, achieves extraordinary advantageous effects：
One, animal experiment：
Test effect of the stacte therapy to treatment depression rat treatment
Experimental method：
(1) it uses rat forced swimming to combine and hangs tail stimulation test[7]Inducing depression rat model, is forced first
Modeling rat is put into forced swimming in bucket by swimming, and each bucket fills 1 rat, and the irrelevant variables such as the depth of water, water temperature are complete in bucket
It is exactly the same, it records the time after desire is sought survival in its forfeiture and is pulled out from water.Outstanding anal spine is carried out on the same day to swash：It is entangled in adhesive tape
Then it is projecting to hang tail as fixation with cord for the fixed position (generally apart from tail base 1cm) of rat tail.Observe rat
Behavior, the time is recorded after it completely loses and seeks survival desire and it is made to restore normal, avoids its death.
(2) pharmaceutical intervention method is as follows：In experiment the 7th~14 day, in addition to Normal group, remaining group still carried out depression
Disease modeling is handled, while essential oil stacte group is given three times a day, the essential oil stacte therapy of each 1h.Model group is not given with normal group
Essential oil stacte therapy is given, other experiment conditions are identical.
Experimental result：
1. modern medicine thinks that the reason of depression is that the level of patients with depression peripheral blood 5-HT, DA and NE are less than
Normal person.The 5-HT in rat blood serum is measured, the degree of Depression in Rats is may determine that from biochemical angle.
As a result it shows：The horizontal conspicuousnesses of model group rats serum 5-HT reduce, and have pole significant difference compared with normal group
(P<0.01).Essential oil stacte group rat blood serum 5-HT levels are with model group than more significant raising (P<0.05).
2. effect of the essential oil stacte therapy in outstanding tail test
Rat tail suspension belongs to a kind of stimulating method of experiment, still, by improving also as the measurement of behavioral indicator.Often
Secondary quiescent time can be used as rat and seek survival the reference of desire, hangs tail and swimming quiescent time is shorter, rat lust for life is lower, it was demonstrated that
Rat Degree of Depression is bigger.Method is entangled in the fixed position (generally apart from tail base 1cm) of rat tail with adhesive tape as follows,
As fixation, it is projecting then tail to be hanged with cord.The behavior for observing rat records the time simultaneously after it completely loses and seeks survival desire
So that it is restored normal, avoids its death.The daily same time carries out outstanding tail test and Record Comparison to the rat of each of each group.
As a result it shows：Model group rats, which hang tail quiescent time conspicuousness, to be reduced, with the normal more significant difference (P of group<
0.05)；Essential oil stacte group rat tail suspension quiescent time increases (P than model group conspicuousness<0.05).
3. effect of the essential oil stacte therapy in the thermophilic sugar experiment of rat
Depression refers to depressed, retardation of thinking and slow with psychomotor activities such as interest attenuating, initiative declines
Stagnant symptom is a kind of mood disorder syndrome of main clinical manifestation.Syrup intake, i.e. rat are to the partially thermophilic degree of syrup, instead
Pleasant sensation of the rat to food is reflected, one kind of natural award ingredient is belonged to.And the increase of rat syrup consumption reflects depression
Alleviate.
All rats of training adapt to and learn to drink syrup before experiment starts, and after fasting 24 hours, give every 1 bottle of animal
The pure water of 2% syrup 500ml and one bottle of 500ml takes two bottles away and measures remaining liq volume with graduated cylinder, calculates after 2 hours
The partially thermophilic degree of syrup：Partially thermophilic degree=syrup consumption/total liquid-consumed * 100%.
Each group animal syrup preference is between 66%-80%, and the difference of syrup preference is little, essential oil stacte group
Syrup preference is maximum, reaches 79%, remaining each group is in 65%-70% or so.
Influence (n=8) of the 1 essential oil stacte therapy of table to rat model of depression serum 5-HT levels
Note：Compared with normal group*P<0.05,**P<0.01；Compared with model group#P<0.05,##P<0.01。
It is demonstrated experimentally that essential oil stacte can increase, depression rat blood serum 5-HT is horizontal, and tail quiescent time and syrup are hanged in increase
Preference illustrates that essential oil stacte therapy has depression rat certain therapeutic effect.
Two, clinical test：
On the basis of animal experiment ensures safety, and clinic trial clinically is carried out to 58 patients with depression：Often
It once in the morning and once at night, each fumigation time 20-30min, 15 days as one therapeutic course, two courses for the treatment of count curative effects, are statistically analyzed,
30 people of the depression clinical symptoms person of significantly improving, accounts for 51.7%, and 26 people of the depression clinical symptoms person of being improved in varying degrees accounts for
44.8%, depression clinical symptoms even have 2 people of trend person of exacerbation without improving, and account for 3.5%, total effective rate 96.5%, and
Toxic side effect is found no in test, getting well for effect was not expected.
In short, abundant raw material of the present invention, preparation method is simple, at low cost, easy to use, and effect is good, and curative effect is high, and curative effect reaches
96% or more, effective for treatment depression, Chinese medicine selected by the present invention prepares plants essential oil (stacte type) for improving depression
Symptom provides new medicine to alleviate depression, very easy to use, flexible, can be in office, family, public environment
Middle use has prevention and improvement result well for the minor depressive caused by operating pressure or little nothings of life.In addition originally
The made essential oil of patent is evaporated by fumigator, easy to operate, easy to use, is avoided patient's long-time, is persistently taken medicine
The pain of object, while also avoiding side effect of the oral drugs to stomach and whole body；And be conducive to mitigate the expense of many patients
With burden, contribute to the marketing of this product, brings considerable economic benefit, economic and social benefit notable for investor.
Claims (4)
1. a kind of compound plant stacte essential oil of Huoxue Jieyu, it is characterized in that：It is by the material medicine system of following components by weight percent meter
At：10-30 parts of rhizoma cyperi, 10-35 parts of Radix Curcumae, 5-25 parts of green peel, 5-20 parts of turmeric, 5-20 parts of costus root, 5-30 parts of Exocarpium Citri Rubrum, safflower
5-30 parts, 5-40 parts of Radix Angelicae Sinensis, caulis perllae be 10-30 parts sub-, 5-20 parts of rhizoma atractylodis, 10-50 parts of 10-30 parts of chamomile and Rhizoma Chuanxiong, wherein will
Material medicine obtains essential oil of traditional Chinese medicine using subcritical fluid extraction method, adds preservative, the weight ratio of preservative and essential oil of traditional Chinese medicine
For 1-10:1000, the subcritical fluid extraction method is, by above-mentioned pulverizing medicinal materials, to cross 2-6 medicines sieve, obtain traditional Chinese medicine powder, be packed into
It in extraction kettle, vacuumizes, at pressure 0.5-1.0 MPa, solvent butane is added in extraction kettle, extracts 2-5 times, each Chinese medicine
The w/v of powder solvent and butane is 1：2-5, w/v refer to solid in terms of g, and liquid is in terms of ml, extraction temperature every time
30-60 DEG C of degree, butane is recovered under reduced pressure in extraction time 40-120min, combining extraction liquid, and anhydrous sodium sulfate is added in oil reservoir
It is dry, the yellowish-brown transparency liquid with strong fragranced is obtained, i.e. essential oil of traditional Chinese medicine, sealing is kept in dark place at low temperature；Described is anti-
Rotten agent is sesamin and natamycin, with weight ratio 1:The ratio of 2-5 is uniformly mixed and is made.
2. the compound plant stacte essential oil of Huoxue Jieyu according to claim 1, it is characterized in that：It is by following components by weight percent
The material medicine of meter is made：12-25 parts of rhizoma cyperi, 15-30 parts of Radix Curcumae, 10-20 parts of green peel, 8-15 parts of turmeric, 8-15 parts of costus root,
8-20 parts of Exocarpium Citri Rubrum, 6-25 parts of safflower, 8-30 parts of Radix Angelicae Sinensis, caulis perllae be 15-25 parts sub-, 10-15 parts of rhizoma atractylodis, 10-25 parts of chamomile, Rhizoma Chuanxiong
15-30 parts, wherein material medicine is obtained into essential oil of traditional Chinese medicine using subcritical fluid extraction method, adds preservative, preservative is in
The weight ratio of medicine essential oil is 2-8:1000, the subcritical fluid extraction method is, by above-mentioned pulverizing medicinal materials, to cross 3-5 medicines sieve,
Traditional Chinese medicine powder is obtained, is fitted into extraction kettle, vacuumizes, at pressure 0.5-0.8 MPa, solvent butane, extraction are added in extraction kettle
2-4 times, the w/v of each Chinese medicine powder solvent and butane is 1：2-4, w/v refer to solid in terms of g, liquid with
Ml is counted, and 30-50 DEG C of each extraction temperature, extraction time 40-100min, butane is recovered under reduced pressure in combining extraction liquid, in oil reservoir
Anhydrous sodium sulfate drying is added, obtains the yellowish-brown transparency liquid with strong fragranced, i.e. essential oil of traditional Chinese medicine, seals low-temperature dark
It preserves；The preservative is sesamin and natamycin, with weight ratio 1:The ratio of 2-4 is uniformly mixed and is made.
3. the compound plant stacte essential oil of Huoxue Jieyu according to claim 1, it is characterized in that：It is by following components by weight percent
The material medicine of meter is made：10 parts of rhizoma cyperi, 15 parts of Radix Curcumae, 8 parts of green peel, 6 parts of turmeric, 15 parts of costus root, 10 parts of Exocarpium Citri Rubrum, safflower 15
Part, 15 parts of 10 parts of Radix Angelicae Sinensis, caulis perllae, 10 parts of rhizoma atractylodis, 12 parts of chamomile, 15 parts of Rhizoma Chuanxiong, wherein by material medicine using subcritical
Fluids extraction obtains essential oil of traditional Chinese medicine, adds preservative, and the weight ratio of preservative and essential oil of traditional Chinese medicine is 5:1000, the Asia is faced
Boundary's fluids extraction is, by above-mentioned pulverizing medicinal materials, to cross No. 5 medicine sieves, obtain traditional Chinese medicine powder, be fitted into extraction kettle, vacuumize, in pressure
Under 0.8 MPa, solvent butane is added in extraction kettle, extracts 4 times, the w/v of each Chinese medicine powder solvent and butane is 1：
3, w/v refers to solid in terms of g, and liquid is in terms of ml, 50 DEG C, extraction time 100min of each extraction temperature, merges extraction
Liquid is taken, butane is recovered under reduced pressure, anhydrous sodium sulfate drying is added in oil reservoir, obtains the yellowish-brown transparent liquid with strong fragranced
Body, i.e. essential oil of traditional Chinese medicine, sealing are kept in dark place at low temperature；The preservative is sesamin and natamycin, with weight ratio 1:4 ratio
Example is uniformly mixed and is made.
4. the compound plant stacte essential oil of Huoxue Jieyu according to claim 1, it is characterized in that：It is by following components by weight percent
The material medicine of meter is made：15 parts of rhizoma cyperi, 20 parts of Radix Curcumae, 10 parts of green peel, 10 parts of turmeric, 12 parts of costus root, 8 parts of Exocarpium Citri Rubrum, safflower 6
Part, 15 parts of 15 parts of Radix Angelicae Sinensis, caulis perllae, 10 parts of rhizoma atractylodis, 25 parts of chamomile, 25 parts of Rhizoma Chuanxiong, wherein by material medicine using subcritical
Fluids extraction obtains essential oil of traditional Chinese medicine, adds preservative, and the weight ratio of preservative and essential oil of traditional Chinese medicine is 3:1000, the Asia is faced
Boundary's fluids extraction is, by above-mentioned pulverizing medicinal materials, to cross No. 3 medicine sieves, obtain traditional Chinese medicine powder, be fitted into extraction kettle, vacuumize, in pressure
Under 0.6 MPa, solvent butane is added in extraction kettle, extracts 3 times, the w/v of each Chinese medicine powder solvent and butane is 1：
2, w/v refers to solid in terms of g, and liquid is in terms of ml, 40 DEG C, extraction time 60min of each extraction temperature, merges extraction
Liquid is taken, butane is recovered under reduced pressure, anhydrous sodium sulfate drying is added in oil reservoir, obtains the yellowish-brown transparent liquid with strong fragranced
Body, i.e. essential oil of traditional Chinese medicine, sealing are kept in dark place at low temperature；The preservative is sesamin and natamycin, with weight ratio 1:3 ratio
Example is uniformly mixed and is made.
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