CN108404044B - Compound plant incense essential oil for treating depression - Google Patents

Compound plant incense essential oil for treating depression Download PDF

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CN108404044B
CN108404044B CN201810379828.0A CN201810379828A CN108404044B CN 108404044 B CN108404044 B CN 108404044B CN 201810379828 A CN201810379828 A CN 201810379828A CN 108404044 B CN108404044 B CN 108404044B
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chinese medicine
traditional chinese
essential oil
extraction
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CN108404044A (en
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李玉洁
龚曼
李晓冰
史扬
黄婧妤
杨丽萍
张梦洋
石文博
张赢丹
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Hubei Shennong Xiangda Health Industry Co ltd
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Henan University of Traditional Chinese Medicine HUTCM
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Abstract

The invention aims to provide a compound plant incense essential oil for treating depression, which is prepared from the following raw material medicaments in part by weight: 10-30 parts of rhizoma cyperi, 10-35 parts of radix curcumae, 5-25 parts of pericarpium citri reticulatae viride, 5-20 parts of turmeric, 5-20 parts of costus root, 5-30 parts of red tangerine peel, 5-30 parts of safflower, 5-40 parts of angelica, 10-30 parts of caulis perillae, 5-20 parts of rhizoma atractylodis, 10-30 parts of chamomile and 10-50 parts of ligusticum wallichii.

Description

Compound plant incense essential oil for treating depression
Technical Field
The invention relates to a medicine, in particular to a compound plant incense essential oil for treating depression.
Background
With the development of society, the pace of life of people is accelerated, and the pressure of learning, working, living and the like is increased, the incidence of depression is continuously increased, the disease is called as 'emotional cold', and the disease is prevalent in countries, social classes and various people groups all over the world like common cold. According to WHO reports, depression is expected to become the second major disease causing human death and disability by the year 2020. With the acceptance and support of traditional medicine by the public, TCM treatment is increasingly being valued by the public. The depression belongs to the category of depression in the traditional Chinese medicine, the traditional Chinese medicine considers qi as the main part of the whole body, the heart is calm and the body is healthy if the circulation is not stopped, and the depression is the disease. Stagnation of essence and qi and obstruction of blood vessels are the root of the disease; the physicians of the past generations believe that the main location of depression is the liver, which is related to the five internal organs, and the impairment of emotion and stagnation of qi are the causes of depression, and the disorder of qi and blood in the five internal organs are the pathogenesis. Investigation shows that the former 8 common symptoms of depression in traditional Chinese medicine are liver-qi stagnation and spleen deficiency, liver-qi stagnation and qi stagnation, heart-spleen deficiency, kidney-yang deficiency, liver-kidney yin deficiency, heart-gallbladder qi deficiency, qi stagnation and blood fatigue, and heart-kidney disharmony.
At present, although there are many drugs and technical means for treating depression, the treatment is mainly psychotherapy, physical therapy and drug therapy, wherein drug therapy is the main treatment measure for the onset of depression of more than moderate degree, and clinical first-line antidepressants mainly include selective 5-hydroxytryptamine reuptake inhibitors, 5-hydroxytryptamine and norepinephrine reuptake inhibitors, norepinephrine and specific 5-hydroxytryptamine antidepressants, however, these drugs have high recurrence rate, long administration time, unsatisfactory effect, large side effect, easy drug tolerance, and the like. Therefore, improvement and innovation of the medicament for treating the depression are imperative.
Disclosure of Invention
Aiming at the situation and overcoming the defects of the prior art, the invention aims to provide the compound plant incense essential oil for treating depression, which can effectively solve the problems of medication for treating depression, improvement of curative effect and prevention of side effect.
The technical scheme of the invention is that the compound plant incense essential oil for treating depression is prepared from the following raw material medicaments in parts by weight: 10-30 parts of rhizoma cyperi, 10-35 parts of radix curcumae, 5-25 parts of pericarpium citri reticulatae viride, 5-20 parts of turmeric, 5-20 parts of costus root, 5-30 parts of red tangerine peel, 5-30 parts of safflower, 5-40 parts of angelica, 10-30 parts of caulis perillae, 5-20 parts of rhizoma atractylodis, 10-30 parts of chamomile and 10-50 parts of ligusticum wallichii, wherein, the raw material medicaments are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then preservative is added, the weight ratio of the preservative to the traditional Chinese medicine essential oil is 1-10:1000, the subcritical fluid extraction method comprises pulverizing the above medicinal materials, sieving with No. 2-6 sieve to obtain Chinese medicinal powder, placing into extraction kettle, vacuumizing, under the pressure of 0.5-1.0 MPa, adding solvent butane into an extraction kettle, extracting for 2-5 times, wherein the weight volume ratio of the traditional Chinese medicine powder solvent to the butane is 1:2-5, wherein the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 30-60 ℃ each time, the extraction time is 40-120min, the extract liquor is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into the oil layer for drying, and the yellowish-brown transparent liquid with strong aroma, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 2-5.
The invention has rich raw materials and simple preparation method, particularly adopts subcritical fluid extraction method, uses butane as solvent, can effectively extract the volatile oil component in the medicinal materials, has simple extraction method, high extraction rate, low extraction temperature, difficult damage to the effective component and good curative effect, is an innovation on medicaments for treating depression, has very strong clinical use value and has obvious economic and social benefits.
Detailed Description
The following detailed description of the embodiments of the present invention will be given with reference to the accompanying specific cases and examples.
The invention may be embodied in the form of the following examples:
example 1: is prepared from the following raw material medicaments in part by weight: 12-25 parts of rhizoma cyperi, 15-30 parts of radix curcumae, 10-20 parts of pericarpium citri reticulatae viride, 8-15 parts of turmeric, 8-15 parts of costus root, 8-20 parts of exocarpium citri rubrum, 6-25 parts of safflower, 8-30 parts of angelica, 15-25 parts of perilla stem, 10-15 parts of rhizoma atractylodis, 10-25 parts of chamomile and 15-30 parts of ligusticum wallichii, wherein, the raw material medicaments are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then preservative is added, the weight ratio of the preservative to the traditional Chinese medicine essential oil is 2-8:1000, the subcritical fluid extraction method comprises pulverizing the above medicinal materials, sieving with 3-5 mesh sieve to obtain Chinese medicinal powder, placing into extraction kettle, vacuumizing, under the pressure of 0.5-0.8 MPa, adding solvent butane into an extraction kettle, extracting for 2-4 times, wherein the weight volume ratio of the traditional Chinese medicine powder solvent to the butane is 1:2-4, wherein the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 30-50 ℃ each time, the extraction time is 40-100min, the extract liquor is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into the oil layer for drying, and the yellowish-brown transparent liquid with strong aroma, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 2-4.
Example 2: is prepared from the following raw material medicaments in part by weight: 10 parts of rhizoma cyperi, 15 parts of radix curcumae, 8 parts of pericarpium citri reticulatae viride, 6 parts of rhizoma curcumae longae, 15 parts of costus root, 10 parts of exocarpium citri rubrum, 15 parts of safflower carthamus, 10 parts of angelica, 15 parts of caulis perllae, 10 parts of rhizoma atractylodis, 12 parts of chamomile and 15 parts of ligusticum wallichii, wherein the raw material medicines are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then a preservative is added, wherein the weight ratio of the preservative to the traditional Chinese medicine essential oil is 5:1000, the subcritical fluid extraction method comprises the steps of crushing the medicinal materials, sieving the medicinal materials by a No. 5 medicine sieve to obtain traditional Chinese medicine powder, filling the traditional Chinese medicine powder into an extraction kettle, vacuumizing, adding a solvent butane into the extraction kettle under the pressure of 0.8 MPa, and: 3, the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 50 ℃ each time, the extraction time is 100min, the extract liquor is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into an oil layer for drying, and the yellowish-brown transparent liquid with strong fragrance, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 4.
Example 3: is prepared from the following raw material medicaments in part by weight: 15 parts of rhizoma cyperi, 20 parts of radix curcumae, 10 parts of pericarpium citri reticulatae viride, 10 parts of rhizoma curcumae longae, 12 parts of costus root, 8 parts of exocarpium citri rubrum, 6 parts of safflower, 15 parts of angelica, 15 parts of caulis perllae, 10 parts of rhizoma atractylodis, 25 parts of chamomile and 25 parts of ligusticum wallichii, wherein the raw material medicines are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then added with a preservative, the weight ratio of the preservative to the traditional Chinese medicine essential oil is 3:1000, the subcritical fluid extraction method comprises the steps of crushing the medicinal materials, sieving the medicinal materials by a No. 3 medicine sieve to obtain traditional Chinese medicine powder, putting the traditional Chinese medicine powder into an extraction kettle, vacuumizing, adding a solvent butane into the extraction kettle under the pressure of 0.6 MPa, and extracting for 3 times: 2, the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 40 ℃ each time, the extraction time is 60min, the extraction liquid is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into an oil layer for drying, and the yellowish-brown transparent liquid with strong fragrance, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 3.
In the medicines, the formula is the rule of treatment based on syndrome differentiation and holism, the precedent of treating depression by using blood circulation activating and stasis removing incense is created, and the multi-selectivity is provided for the means for treating depression. Musk, agilawood and cornfield, so as to reduce cost, facilitate popularization and simultaneously eliminate medicaments which have irritation to respiratory tracts, such as: semen Sinapis Albae can reduce adverse side effects, expand applicable population, and eliminate medicine without volatile components, such as: radish seeds to improve the utilization rate of each component medicament; safflower and turmeric have the functions of promoting blood circulation, promoting qi circulation and relieving pain; angelica sinensis can enrich blood and promote blood circulation; the rhizoma cyperi and the pericarpium citri reticulatae viride can soothe liver, relieve depression and regulate qi to relieve epigastric distention; the radix curcumae and the rhizoma ligustici wallichii are capable of activating blood, promoting qi circulation and relieving depression, and clearing away heart-fire and cooling blood; rhizoma atractylodis, elecampane and chrysoidine, and has the effects of eliminating dampness, strengthening spleen, regulating qi, relieving epigastric distention, reducing phlegm and dredging middle-jiao to regulate qi activity; radix aucklandiae has effects of activating qi-flowing, relieving pain, invigorating spleen, resolving food stagnation, stewing radix aucklandiae to relieve diarrhea, and adding flos Matricariae Chamomillae to enhance eyesight, nourishing heart, and clearing liver fire; the formula accords with the principle of treating depression by the traditional Chinese medicine, and the blood-activating and qi-moving medicines are mutually matched to play the functions of activating blood and resolving depression.
The depression belongs to the category of depression in the traditional Chinese medicine, and has the clinical manifestations of: the depressed mood is not matched with the situation, the depressed mood can be from sultriness to sadness, and the depressed self-body can be even pessimistic and boredom, and can have suicide attempt or behavior; even the occurrence of stupor; in some cases, there is significant anxiety and motor agitation; in severe cases, psychotic symptoms such as hallucinations and delusions may occur.
TCM holds that qi is the main of the whole body, and the disturbance of the circulation causes a healthy and healthy heart and stagnation causes diseases. Stagnation of essence and qi and obstruction of blood vessels are the root of the disease; the physicians of the past generations believe that the main location of depression is the liver, which is related to the five internal organs, and the impairment of emotion and stagnation of qi are the causes of depression, and the disorder of qi and blood in the five internal organs are the pathogenesis. Investigation shows that the former 8 common symptoms of depression in traditional Chinese medicine are liver-qi stagnation and spleen deficiency, liver-qi stagnation and qi stagnation, heart-spleen deficiency, kidney-yang deficiency, liver-kidney yin deficiency, heart-gallbladder qi deficiency, qi stagnation and blood fatigue, and heart-kidney disharmony. The traditional Chinese medicine considers that the treatment of depression is suitable for soothing the liver and strengthening the spleen, promoting qi circulation and reducing phlegm, tonifying the spleen and nourishing the heart, tonifying qi and blood, nourishing the heart and soothing the nerves, tonifying qi and invigorating yang, nourishing the liver and the kidney, promoting blood circulation and removing blood stasis, strengthening the brain and soothing the nerves and the like, so that the functions of all internal organs are normally coordinated, the qi and blood are flushed, and the diseases are not caused.
The medicine components of the invention just embody the treatment principle, and the invention uses the safflower, the turmeric and the szechuan lovage rhizome to activate blood, promote qi circulation and relieve pain, and can improve the depression symptom caused by qi stagnation and blood stasis by matching with the angelica to enrich the blood and activate the blood; the rhizoma cyperi and the pericarpium citri reticulatae viride have the effects of soothing liver-qi stagnation and regulating qi to relieve epigastric distention, and are matched with the ligusticum wallichii to promote qi circulation and relieve depression, dispel wind and remove dampness, activate blood and relieve pain, and the depression symptoms caused by liver depression and qi stagnation are improved; rhizoma atractylodis, elecampane and exocarpium citri rubrum, and has the effects of eliminating dampness, strengthening spleen, regulating qi, relieving epigastric distention, reducing phlegm, dredging middle-jiao to regulate qi activity and improve depression symptoms caused by liver depression and spleen deficiency; radix Curcumae and rhizoma Ligustici Chuanxiong have effects of promoting blood circulation, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, improving eyesight, nourishing heart, and removing liver fire, and improving depression symptoms caused by deficiency of heart and spleen, deficiency of heart and gallbladder qi, and disharmony between heart and kidney; the formula accords with the principle of treating depression by the traditional Chinese medicine, and the blood-activating and qi-moving medicines are mutually matched to play the functions of activating blood and resolving depression.
The subcritical fluid extraction method is utilized, butane is used as a solvent, the volatile oil components in the medicinal materials can be effectively extracted, the extraction method is simple, the extraction rate is high, the extraction temperature is low, the effective components are not easy to damage, the drug effect and the treatment effect are improved, and the field test and the application obtain very good beneficial technical effects:
firstly, animal experiments:
test of the Effect of Fumigation therapy on the treatment of depressed rats
The experimental method comprises the following steps:
(1) rat forced swimming combined tail suspension stimulation experiment[7]The rat model for inducing depression is firstly forced to swim, the model-made rats are placed in a bucket for forced swimming, 1 rat is filled in each bucket, independent variables such as water depth, water temperature and the like in the bucket are completely the same, and the time is recorded and fished out of water after the rat model loses the desire for survival. Tail suspension stimulation was performed on the same day: wrapping the rat tail with a rubberized fabric strip in a fixed position (one)Typically 1cm from the tail root) as a fixation, and then hanging the tail upside down with a string. The behavior of the rats was observed, and the time was recorded and allowed to return to normal after their complete loss of desire to survive, avoiding their death.
(2) The drug intervention method comprises the following steps: on the 7 th to 14 th days of the experiment, the rest groups except the normal control group are still subjected to depression molding treatment, and meanwhile, the essential oil incense group is subjected to essential oil incense therapy for 1 hour every time for three times every day. The model group and the normal group were not administered with essential oil aromatherapy, and other experimental conditions were the same.
The experimental results are as follows:
1. modern medicine considers that the cause of the onset of depression is that depression patients have lower levels of 5-HT, DA and NE in their peripheral blood than normal persons. 5-HT in rat serum is measured, and the degree of rat depression can be judged from a biochemical perspective.
The results show that: the serum 5-HT level of the rats in the model group is obviously reduced, and has extremely obvious difference compared with the normal group (P < 0.01). The 5-HT level of the serum of the rats in the essential oil incense group is obviously increased compared with that in the model group (P < 0.05).
2. Effect of essential oil aromatherapy in Tail suspension test
Rat tail suspension is a stimulation method for experiments, but is also used as a behavior index determination after being improved. Each resting time can be used as a reference for the survival desire of the rat, and the shorter the resting time for tail suspension and swimming, the lower the survival desire of the rat is, and the greater the depression degree of the rat is proved. The method comprises winding a strip of rubberized fabric around the tail of the rat in a fixed position (generally 1cm from the root of the tail), and hanging the tail upside down with a string. The behavior of the rats was observed, and the time was recorded and allowed to return to normal after their complete loss of desire to survive, avoiding their death. Tail suspension tests were performed on each group of rats at the same time daily and the comparison was recorded.
The results show that: the significance of the tail suspension resting time of the rats in the model group is reduced, and the rats have significance difference compared with the rats in the normal group (P < 0.05); the tail suspension resting time of the rats in the essential oil incense group is obviously higher than that of the model group (P < 0.05).
3. Effect of essential oil aromatherapy in rat saccharophile experiment
The depression refers to a mood disorder syndrome with the main clinical manifestations of psychomotor retardation symptoms such as depressed mood, thought retardation accompanied with decreased interest, initiative decline and the like. The intake of sugar water, namely the preference degree of the rat to sugar water, reflects the pleasure of the rat to food, and belongs to one of natural reward components. While an increase in sugar water consumption in rats reflects a relief from depression.
All rats were trained to adapt and learn to drink sugar water prior to the start of the experiment, and after 24 hours of fasting, each animal was given 1 bottle of 500ml of 2% sugar water and one bottle of 500ml of pure water, and after 2 hours both bottles were removed and the remaining liquid volume was measured with a measuring cylinder, and the degree of sugar bias was calculated: degree of preference ═ sugar water consumption/total liquid consumption ×. 100%.
The preference degree of the sweet water of each group of animals is between 66% and 80%, the preference degree of the sweet water is not greatly different, the preference degree of the sweet water of the essential oil incense group is maximum and reaches 79%, and the preference degree of the sweet water of the other groups is about 65% to 70%.
Table 1 effect of essential oil aromatherapy on serum 5-HT levels in rat model depression (n = 8)
Note: comparison with Normal group*P<0.05, **P<0.01; comparison with model group#P<0.05，##P<0.01。
Group of 5-HT (unit: ng/L) Tail suspension test (min) Degree of preference
Normal group 32.13±1.87## 35.00±16.02 69.94%
Model set 26.60±0.70** 9.00±2.65* 70.42%
Incense set 30.42±2.50# 15.33±2.07*# 79.37%
Experiments prove that the essential oil incense can raise the 5-HT level of the serum of a rat suffering from depression, and increase the tail suspension resting time and the sugar water preference degree, so that the essential oil incense therapy has a certain treatment effect on the rat suffering from depression.
II, clinical test:
on the basis of ensuring the safety of animal experiments, 58 depression patients are clinically tried out: the fumigation is carried out once in the morning and at night every day, each fumigation time is 20-30min, 15 days are a course of treatment, the statistical treatment is carried out in two courses of treatment, 30 patients with remarkable depression clinical symptoms account for 51.7 percent, 26 patients with different degrees of depression clinical symptoms account for 44.8 percent, 2 patients with no improvement or even aggravation of depression clinical symptoms account for 3.5 percent, the total effective rate is 96.5 percent, no toxic or side effect is found in the test, and the good effect is unexpected.
In a word, the invention has the advantages of rich raw materials, simple preparation method, low cost, convenient use, good effect and high curative effect, the curative effect reaches more than 96 percent, and the invention is effectively used for treating depression, the invention uses the traditional Chinese medicine to prepare the plant essential oil (smoked odor type) for improving depression symptoms, provides a new therapeutic medicine for relieving depression, is very convenient and flexible to use, can be used in offices, families and public environments, and has good prevention and improvement effects on mild depression caused by working pressure or life trouble. In addition, the essential oil prepared by the method is evaporated by a fumigator, the operation is simple and convenient, the use is convenient, the pain of a patient in long-time and continuous medicine taking is avoided, and the side effects of oral medicines on intestines and stomach and the whole body are also avoided; the method is favorable for reducing the cost burden of patients, contributes to market promotion of the product, brings considerable economic benefits for investors, and has remarkable economic and social benefits.

Claims (4)

1. A compound plant incense essential oil for treating depression is characterized in that: is prepared from the following raw material medicaments in part by weight: 10-30 parts of rhizoma cyperi, 10-35 parts of radix curcumae, 5-25 parts of pericarpium citri reticulatae viride, 5-20 parts of turmeric, 5-20 parts of costus root, 5-30 parts of red tangerine peel, 5-30 parts of safflower, 5-40 parts of angelica, 10-30 parts of caulis perillae, 5-20 parts of rhizoma atractylodis, 10-30 parts of chamomile and 10-50 parts of ligusticum wallichii, wherein, the raw material medicaments are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then preservative is added, the weight ratio of the preservative to the traditional Chinese medicine essential oil is 1-10:1000, the subcritical fluid extraction method comprises pulverizing the above medicinal materials, sieving with No. 2-6 sieve to obtain Chinese medicinal powder, placing into extraction kettle, vacuumizing, under the pressure of 0.5-1.0 MPa, adding solvent butane into an extraction kettle, extracting for 2-5 times, wherein the weight volume ratio of the traditional Chinese medicine powder solvent to the butane is 1:2-5, wherein the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 30-60 ℃ each time, the extraction time is 40-120min, the extract liquor is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into the oil layer for drying, and the yellowish-brown transparent liquid with strong aroma, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 2-5.
2. The compound plant incense essential oil for treating depression according to claim 1, which is characterized in that: is prepared from the following raw material medicaments in part by weight: 12-25 parts of rhizoma cyperi, 15-30 parts of radix curcumae, 10-20 parts of pericarpium citri reticulatae viride, 8-15 parts of turmeric, 8-15 parts of costus root, 8-20 parts of exocarpium citri rubrum, 6-25 parts of safflower, 8-30 parts of angelica, 15-25 parts of perilla stem, 10-15 parts of rhizoma atractylodis, 10-25 parts of chamomile and 15-30 parts of ligusticum wallichii, wherein, the raw material medicaments are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then preservative is added, the weight ratio of the preservative to the traditional Chinese medicine essential oil is 2-8:1000, the subcritical fluid extraction method comprises pulverizing the above medicinal materials, sieving with 3-5 mesh sieve to obtain Chinese medicinal powder, placing into extraction kettle, vacuumizing, under the pressure of 0.5-0.8 MPa, adding solvent butane into an extraction kettle, extracting for 2-4 times, wherein the weight volume ratio of the traditional Chinese medicine powder solvent to the butane is 1:2-4, wherein the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 30-50 ℃ each time, the extraction time is 40-100min, the extract liquor is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into the oil layer for drying, and the yellowish-brown transparent liquid with strong aroma, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 2-4.
3. The compound plant incense essential oil for treating depression according to claim 1, which is characterized in that: is prepared from the following raw material medicaments in part by weight: 10 parts of rhizoma cyperi, 15 parts of radix curcumae, 8 parts of pericarpium citri reticulatae viride, 6 parts of rhizoma curcumae longae, 15 parts of costus root, 10 parts of exocarpium citri rubrum, 15 parts of safflower carthamus, 10 parts of angelica, 15 parts of caulis perllae, 10 parts of rhizoma atractylodis, 12 parts of chamomile and 15 parts of ligusticum wallichii, wherein the raw material medicines are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then a preservative is added, wherein the weight ratio of the preservative to the traditional Chinese medicine essential oil is 5:1000, the subcritical fluid extraction method comprises the steps of crushing the medicinal materials, sieving the medicinal materials by a No. 5 medicine sieve to obtain traditional Chinese medicine powder, filling the traditional Chinese medicine powder into an extraction kettle, vacuumizing, adding a solvent butane into the extraction kettle under the pressure of 0.8 MPa, and: 3, the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 50 ℃ each time, the extraction time is 100min, the extract liquor is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into an oil layer for drying, and the yellowish-brown transparent liquid with strong fragrance, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 4.
4. The compound plant incense essential oil for treating depression according to claim 1, which is characterized in that: is prepared from the following raw material medicaments in part by weight: 15 parts of rhizoma cyperi, 20 parts of radix curcumae, 10 parts of pericarpium citri reticulatae viride, 10 parts of rhizoma curcumae longae, 12 parts of costus root, 8 parts of exocarpium citri rubrum, 6 parts of safflower, 15 parts of angelica, 15 parts of caulis perllae, 10 parts of rhizoma atractylodis, 25 parts of chamomile and 25 parts of ligusticum wallichii, wherein the raw material medicines are subjected to subcritical fluid extraction to obtain traditional Chinese medicine essential oil, and then added with a preservative, the weight ratio of the preservative to the traditional Chinese medicine essential oil is 3:1000, the subcritical fluid extraction method comprises the steps of crushing the medicinal materials, sieving the medicinal materials by a No. 3 medicine sieve to obtain traditional Chinese medicine powder, putting the traditional Chinese medicine powder into an extraction kettle, vacuumizing, adding a solvent butane into the extraction kettle under the pressure of 0.6 MPa, and extracting for 3 times: 2, the weight volume ratio refers to that the solid is counted by g, the liquid is counted by ml, the extraction temperature is 40 ℃ each time, the extraction time is 60min, the extraction liquid is combined, the butane is recovered under reduced pressure, the anhydrous sodium sulfate is added into an oil layer for drying, and the yellowish-brown transparent liquid with strong fragrance, namely the traditional Chinese medicine essential oil, is obtained and is stored in a sealed low-temperature dark place; the preservative is prepared by uniformly mixing sesamin and natamycin in a weight ratio of 1: 3.
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