CN101451097A - Liver and health preserving wine containing low polyxylose and preparation method thereof - Google Patents
Liver and health preserving wine containing low polyxylose and preparation method thereof Download PDFInfo
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- CN101451097A CN101451097A CNA2007101505484A CN200710150548A CN101451097A CN 101451097 A CN101451097 A CN 101451097A CN A2007101505484 A CNA2007101505484 A CN A2007101505484A CN 200710150548 A CN200710150548 A CN 200710150548A CN 101451097 A CN101451097 A CN 101451097A
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Abstract
The invention relates to liver-protecting health-care wine, which is prepared from traditional Chinese medicines, namely 5 to 100 milligrams of resveratrol, 20 to 100 milligrams of rhizoma gastrodiae, 30 to 200 milligrams of kudzu and 1 to 200 milligrams of xylo-oligosaccharide, as raw materials and through the prior soaking method of white wine (more than 50 DEG). The health-care wine has gentle medicine property and proper mouthfeel. The invention eliminates body fatigue and pain when simultaneously meeting the drinking demand of people, can obviously lighten the harm of free radicals generated by ethanol in the wine to human body, and provides the health-care wine for protecting the body health.
Description
Technical field
The invention belongs to the technical field of protective foods, relate to a kind of contain xylo-oligosaccharide protect the liver health wine and preparation method thereof.
Technical background
Liquor is a kind of liquor of tool individual style in the world, is a kind of alcoholic beverage that Chinese consumed thousand, is that people entertain, one of most important drink when celebrating.Liquor becomes virtually that people keep up a friendship, mutual a kind of instrument of exchange and conmmunication in various social lives.The tradition of the culture of the Chinese wine that continues thousand and " it is not a banquet without wine " custom of drinking, still the live and work to current people is producing tremendous influence, owing to contain ethanol in the liquor, can stimulate appetite after drinking on a small quantity, the secretion of promoting digestion liquid and blood circulation make the people in high spirits.Can stimulate stomach mucous membrane but drinking white spirit is excessive, unfavorable digestion, the lighter is overexcited, and dermohemia is clouding of consciousness, and people's controllability reduces; Symptoms such as weight person's unconsciousness, lethargic sleep.Particularly for the crowd because of the frequent drinking white spirit of requirements of one's work, long-term drinking liquor, alcohol have caused infringement to its liver more or less, and therefore, preventing or alleviating alcohol is crucial problem to the problem of the infringement of liver.
Liver is the body of gland of human body maximum, it all plays important effect in people's metabolism, bile generation, detoxifcation, blood coagulation, immunity, heat generation and water and electrolytical adjusting, be intravital one huge " chemical plant " of people. the metabolism and the degradation production of some harmful wastes that produced in the body metabolism process and external poisonous substance, toxin medicine, all at liver detoxification.When the excessive consumption of alcohol liver function sustains damage for a long time, will fatty liver appear, alcoholic liver causes hepatocellular injury.Therefore in liquor, dissolve in herbal medicine and can prevent and reduce the damaging action of alcohol liver with protection liver.
Summary of the invention
The objective of the invention is to adopt advanced extracting technique of Chinese medicine to add xylo-oligosaccharide, produce pure taste, can relieve the effect of alcohol, detoxify can protect the liver, protect liver again protect the liver health wine.
The various active ingredient of Chinese herbs that protect the liver in the health wine of the present invention derive from be food be again trans-resveratrol, rhizoma Gastrodiae, the Radix Puerariae of the integration of drinking and medicinal herbs of medicine.Particularly add by the functional polymerization sugar xylo-oligosaccharide of 2-7 wood sugar molecule, strengthened liver-protective function more with the strong be combined into of β (1-4) glucosides.Technical scheme of the present invention is as follows:
A kind of health wine that protects the liver is characterized in that, it is to be raw material with trans-resveratrol 5～100mg, rhizoma Gastrodiae 20～100mg, Radix Puerariae 30～200mg, xylo-oligosaccharide 1～200mg Chinese medicine, makes with the conventional immersion process of liquor.The present invention has kept original taste of liquor through the prescription of science.
The health wine that protects the liver of the present invention is characterized in that the proportioning (w/v) of trans-resveratrol, rhizoma Gastrodiae, Radix Puerariae, xylo-oligosaccharide and liquor is 10mg～450mg/500ml.
In one embodiment of the invention, contain trans-resveratrol 20～80mg, rhizoma Gastrodiae 25～75mg, Radix Puerariae 30～150mg, xylo-oligosaccharide 10～60mg in the 500ml liquor.
In a preferred embodiment of the invention, it is characterized in that, contain trans-resveratrol 25～75mg, rhizoma Gastrodiae 30～60mg, Radix Puerariae 30～120mg, xylo-oligosaccharide 15～60mg in the 500ml liquor.
The health wine that protects the liver of the present invention, the liquor number of degrees are 50～65.
The method that protects the liver health wine of the present invention comprises the steps:
1) preparation of trans-resveratrol: when extracting trans-resveratrol, select 75% ethanol to make extraction solvent, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent extracts with 10 times of volumes of acetic acid ethyl esters, extracting solution concentrate ethyl acetate extract, pass through macroporous resin column, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains white crystalline powder;
2) preparation of rhizoma Gastrodiae: select 60%～80% ethanol to make extraction solvent, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent passes through macroporous resin column, elder generation's water is eluted to colourless, use 8 times of column volume 25%～50% ethanol elutions again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains white crystalline powder;
3) preparation of Radix Puerariae: use water extraction, extracting solution adds small diluted amount after being concentrated into and being equivalent to the medicinal material charging capacity, diluent is by macroporous resin column, and first water is eluted to colourless, uses 30%～60% ethanol elution again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains the crystallinity powder;
4) above-mentioned crystalline powder and xylo-oligosaccharide are dissolved in the 500ml liquor by prescription, make and protect the liver health wine.
What need be illustrated especially is that the extract of a lot of medicinal materials all has commercially available product, so active ingredient of Chinese herbs of the present invention also can be replaced with corresponding commercially available extract; The proportioning of extract is that the content according to index components is converted to the proportioning that is equivalent to described active ingredient of Chinese herbs, and these all belong to protection scope of the present invention.
The quality of medicinal material standard that the present invention uses all meets " the Chinese people are state's officinal relevant regulations altogether ", and the physico-chemical property and the pharmacological effect that protect the liver used medicinal material in the health wine are described below:
" the Chinese pharmacopoeia record, rhizoma Gastrodiae has " tool is calming the liver to stop the wind, the effect of expelling wind for relieving convulsion, is used to have a dizzy spell numb limbs and tense tendons, infantile convulsion, epilepsy, hypertension, aural vertigo "." national herbal medicine compilation " record, rhizoma Gastrodiae " cures mainly diseases such as hypertension, dizzy, headache, facial hemiparalysis, numb limbs and tense tendons, infantile convulsion ".Some well-known doctors are summed up as the effect of rhizoma Gastrodiae " three anti-, three towns, a benefit ", i.e. anti-epileptic, anticonvulsion, rheumatism, calmness, antispastic, analgesia, qi-restoratives.
Trans-resveratrol is a white powder, in water and ethanol certain dissolubility is arranged.Studies have shown that liver injury has significant protective effect to trans-resveratrol to Con A inductive, comparatively obvious with middle dosage (10mg/kg) group effect, show as that Serum ALT and AST actively reduce, the liver injury pathological change alleviates; Three dosage of trans-resveratrol big (20mg/kg), in the content of (10mg/kg), little (5mg/kg) group mice serum NO all significantly reduce, the active of heavy dose of, middle dosage group hepatic tissue SOD obviously raises, MDA content significantly reduces, with the model group comparing difference significance meaning is arranged, the mechanism of protecting the liver of making veratryl alcohol clear and the damage of its anti peroxidation of lipid and to suppress the generation of NO closely related, thus theoretical basis provided for diseases such as trans-resveratrol treatment hepatitis B and immunity, liver injuries.
The Radix Puerariae chemical ingredients contains multiple flavones ingredient, is mainly big legumin (daidzein), Daidzin (daidzin), puerarin (puerarin), puerarin-7-xyloside (puerarin-7-xyloside) etc.Function cures mainly to induce sweat brings down a fever, and promotes the production of body fluid, and promoting eruption rises positive antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, have loose bowels.The flavones that proposes in the root of kudzu vine can increase brain and crown vascular flow amount.Behind the anesthesia dog internal carotid artery injection Radix Puerariae flavone, cerebral blood flow (CBF) increases, the corresponding reduction of vascular resistance, effect was kept 2～20 minutes, as intravenous injection, then the cerebral blood flow (CBF) increase is lighter, can not remove suprarenin and norepinephrine and shrink cerebrovascular effect, but then can improve cerebral circulation to the hypertensive arteriosclerosis patient, its action temperature and.Radix Puerariae flavone and kudzuvine root wine medicinal extract are injected in coronary artery and the vein of dog, and the coronary vasodilator volume of blood flow is increased, and vascular resistance reduces.To the crystallization that proposes in rat abdominal cavity and subcutaneous injection kudzuvine root wine medicinal extract and its water decoction of abdominal injection and the root of kudzu vine, caused heart ischemia reaction all has provide protection to Pituitrin.
It is of the present invention that to protect the liver the xylo-oligosaccharide that health wine added be to have prevention and alleviate the activeconstituents of alcohol to the infringement of liver.This protects the liver the characteristics that the health bartender has held liquor, and the mouse liver oxidative damage that ethanol is caused has significant protective effect simultaneously.Solved the colony that custom is drunk for a long time, the low polyxylose alcohol that can intangibly will have liver protection function when drinking is sent into intravital problem, reaches the purpose that effectively prevents or control alcoholic liver, fatty liver.
Drinking method: each cuvette, noon and evening respectively once also can increase the amount of drinking according to the capacity for liquor of oneself slightly, are as the criterion up to taking effect, and adhere to drinking resistibility and healthy being beneficial to health.
Through clinical experiment, the present invention can reduce total cholesterol and triglyceride level in the rat model liver, compares with model group to have significant difference, and the fatty liver rat model is presented significant hepatoprotective effect.And can obviously reduce the total cholesterol and the triglyceride level of Golden Hamster high blood lipid model.This product both can prevent fat accumulation in the liver, removed superabundant fat in the liver, again can the blood fat reducing level, and the protection liver is an active drug of preventing and treating the fatty liver disease.Jiang protects the liver health wine and has carried out the contrast of rabbit cerebral blood flow.The ear vein administration, 0.24 gram/kilogram, rabbit rheoencephalogram wave amplitude changes identical, causes that all wave amplitude reduces, and prompting has vasoconstriction to reduce the effect of volume of blood flow.
Actual effect of the present invention mainly is to taste experiment by people, and the real reaction effect of prolonged application, similar compare is verified.On probation through people more than 100, effect is obvious, and it is happy to drink back spirit, obviously alleviates dizziness, headache, feels sick, symptom such as vomiting, and can obviously improve liver function, and for original Huang, after weak illness crowd takes, feel that generally health is comfortable.The health wine that protects the liver that contains various compositions simultaneously shows through acute toxicity test and long term toxicity test: the trans-resveratrol that comprises among the present invention, rhizoma Gastrodiae, Radix Puerariae, xylo-oligosaccharide and liquor compatibility are without any side effects, safe and reliable.In different crowds, try out and obtained extraordinary result of treatment.
Drink its health wine according to required standard quantity of the present invention, according to the different situations of body constitution, emphasis has carried out the effect experiment to 50 examples of suffering from sub-health state in various degree: number: 50 people are the male sex 38 people wherein, women 12 people; 30 years old of age minimum, maximum 80 years old.Symptom: apocleisis, abdomen rises, and uncomfortable liver area is weak, and the complexion jaundice is uncomfortable.Effect: through length, in, short-term drinks and occurred the different somatic reaction of situation either large or smallly, the curative effect that has is fairly obvious.As drinking of said product person's actual effect having been carried out the follow-up study situation of half a year and 1-2, then 50 examples being drunk effect assesses, experiment shows the health wine of drinking compatibility of the present invention, treat efficient 95.8%, symptom, sign improvement rate answer 98.5%, quality of life raising rate reaches 99%, and improvement rate 100%. effects can be proved by following representative instance;
Open * *, man 60 years old has apocleisis, and abdomen rises, uncomfortable liver area, symptom such as weak, drinking of said product one month, above-mentioned symptom obviously alleviates, and continues drinking of said product 3 months, and readme is felt good, and now still adheres to drinking.
The king * *, man 78 years old, over seventy years of age, dull mind, the face Huang is black and thin, and not strong this long-term drinking of appetite protects the liver health wine (15-30g every day), and miracle occurs, this gloss of having rosy cheeks, reaction is quick, and the mental status is good.
Embodiment
Following examples only are used to illustrate the present invention, but are not used for limiting protection scope of the present invention.Embodiment 1 protects the liver the preparation method of health wine:
1) preparation of trans-resveratrol: trans-resveratrol 5g, select 75% ethanol to make extraction solvent, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent extracts with 10 times of volumes of acetic acid ethyl esters, extracting solution concentrate ethyl acetate extract, by the D301 macroporous resin column, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains white crystalline powder.
2) preparation of rhizoma Gastrodiae: rhizoma Gastrodiae 2g, select 60% ethanol to make extraction solvent, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent is by the D301 macroporous resin column, and first water is eluted to colourless, uses 8 times of column volume 50% ethanol elutions again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains crystalline powder.
3) preparation of Radix Puerariae: Radix Puerariae 30g water extraction, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent is by the D301 macroporous resin column, elder generation's water is eluted to colourless, use 60% ethanol elution again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains the crystallinity powder.
4) above-mentioned crystalline powder 5mg, rhizoma Gastrodiae 20mg, Radix Puerariae 300mg, xylo-oligosaccharide are dissolved in the 500ml liquor, make and protect the liver health wine.
Embodiment 2:
In 500ml liquor (50%), dissolve in trans-resveratrol 100mg, rhizoma Gastrodiae 100mg, Radix Puerariae 200mg, xylo-oligosaccharide 100mg that method for preparing obtains, measure content through the HPLC method, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine.
Embodiment 3:
In 500ml liquor (62%), dissolve in trans-resveratrol 80mg, rhizoma Gastrodiae 60mg, Radix Puerariae 75mg, xylo-oligosaccharide 50mg that method for preparing obtains, measure content, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine through the HPLC method.
Embodiment 4:
In 500ml liquor (55%), dissolve in trans-resveratrol 50mg, rhizoma Gastrodiae 70mg, Radix Puerariae 150mg, xylo-oligosaccharide 100mg that method for preparing obtains, measure content through the HPLC method, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine.
Embodiment 5:
In 500ml liquor (57%), dissolve in trans-resveratrol 80mg, rhizoma Gastrodiae 60mg, Radix Puerariae 75mg, xylo-oligosaccharide 50mg that method for preparing obtains, measure content, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine through the HPLC method.
Embodiment 6:
In 500ml liquor (57%), dissolve in trans-resveratrol 75mg, rhizoma Gastrodiae 30mg, Radix Puerariae 120mg, xylo-oligosaccharide 60mg, measure content, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine through the HPLC method.
Embodiment 7
In 500ml liquor (45%), dissolve in 25mg, rhizoma Gastrodiae 60mg, Radix Puerariae 30mg, xylo-oligosaccharide 15mg.Measure content through the HPLC method, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine.
Embodiment 8
In 500ml liquor (38%), dissolve in 55mg, rhizoma Gastrodiae 50mg, Radix Puerariae 80mg, xylo-oligosaccharide 45mg.Measure content through the HPLC method, make sweet-smelling, liver protecting health care wine stable and controllable for quality with wine.
Claims (6)
1, a kind of contain xylo-oligosaccharide protect the liver health wine and preparation method thereof.It is characterized in that it is to be raw material with trans-resveratrol 5～100mg, rhizoma Gastrodiae 20～100mg, Radix Puerariae 30～200mg, xylo-oligosaccharide 1～200mg Chinese medicine, make with the conventional immersion process of liquor.
2, the health wine that protects the liver as claimed in claim 1 is characterized in that the proportioning (w/v) of trans-resveratrol, rhizoma Gastrodiae, Radix Puerariae, xylo-oligosaccharide and liquor is 10mg～450mg/500ml.
3, the health wine that protects the liver as claimed in claim 1 or 2 is characterized in that, contains trans-resveratrol 20～80mg, rhizoma Gastrodiae 25～75mg, Radix Puerariae 30～150mg, xylo-oligosaccharide 10～60mg in the 500ml liquor.
4, the health wine that protects the liver as claimed in claim 1 or 2 is characterized in that, contains trans-resveratrol 25～75mg, rhizoma Gastrodiae 30～60mg, Radix Puerariae 30～120mg, xylo-oligosaccharide 15～60mg in the 500ml liquor.
5,, it is characterized in that the liquor number of degrees are 50～65 as the described health wine that protects the liver of claim 1-4.
6, a kind of described method that protects the liver health wine of claim 1 for preparing comprises the steps:
1) preparation of trans-resveratrol: when extracting trans-resveratrol, select 75% ethanol to make extraction solvent, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent extracts with 10 times of volumes of acetic acid ethyl esters, extracting solution concentrate ethyl acetate extract, pass through macroporous resin column, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains white crystalline powder;
2) preparation of rhizoma Gastrodiae: select 60%～80% ethanol to make extraction solvent, after extracting solution is concentrated into and is equivalent to the medicinal material charging capacity, add small diluted amount, diluent passes through macroporous resin column, elder generation's water is eluted to colourless, use 8 times of column volume 25%～50% ethanol elutions again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains white crystalline powder;
3) preparation of Radix Puerariae: use water extraction, extracting solution adds small diluted amount after being concentrated into and being equivalent to the medicinal material charging capacity, diluent is by macroporous resin column, and first water is eluted to colourless, uses 30%～60% ethanol elution again, collect elutriant, through decolouring, concentrate, freeze-drying promptly obtains the crystallinity powder;
4) above-mentioned crystalline powder and xylo-oligosaccharide are dissolved in the 500ml liquor by prescription, make and protect the liver health wine.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101505484A CN101451097A (en) | 2007-11-28 | 2007-11-28 | Liver and health preserving wine containing low polyxylose and preparation method thereof |
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| CNA2007101505484A CN101451097A (en) | 2007-11-28 | 2007-11-28 | Liver and health preserving wine containing low polyxylose and preparation method thereof |
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| CN101451097A true CN101451097A (en) | 2009-06-10 |
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| CNA2007101505484A Pending CN101451097A (en) | 2007-11-28 | 2007-11-28 | Liver and health preserving wine containing low polyxylose and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856383A (en) * | 2010-06-09 | 2010-10-13 | 广东神农烟科技术有限公司 | Liver-protecting white spirit and preparation method thereof |
| CN106617052A (en) * | 2016-11-23 | 2017-05-10 | 天津市益倍建生物技术有限公司 | Composition with effects of protecting liver and dispelling effect of alcohol and application thereof |
-
2007
- 2007-11-28 CN CNA2007101505484A patent/CN101451097A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856383A (en) * | 2010-06-09 | 2010-10-13 | 广东神农烟科技术有限公司 | Liver-protecting white spirit and preparation method thereof |
| CN106617052A (en) * | 2016-11-23 | 2017-05-10 | 天津市益倍建生物技术有限公司 | Composition with effects of protecting liver and dispelling effect of alcohol and application thereof |
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Open date: 20090610 |