CN109350632A - A kind of Chinese medicine composition for antipyretic-antalgic - Google Patents
A kind of Chinese medicine composition for antipyretic-antalgic Download PDFInfo
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- CN109350632A CN109350632A CN201811493557.8A CN201811493557A CN109350632A CN 109350632 A CN109350632 A CN 109350632A CN 201811493557 A CN201811493557 A CN 201811493557A CN 109350632 A CN109350632 A CN 109350632A
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- chinese medicine
- radix angelicae
- angelicae sinensis
- antipyretic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The present invention relates to a kind of Chinese medicine compositions for antipyretic-antalgic, with Radix Angelicae Sinensis, Rhizoma Chuanxiong extract for effective medicinal ingredient, collectively constitute with acceptable auxiliary adding ingredient in drug.Active drug ingredient Radix Angelicae Sinensis, Rhizoma Chuanxiong respectively by its extract quite with raw material crude drug Radix Angelicae Sinensis, Rhizoma Chuanxiong parts by weight in terms of ratio be 0.1~5:0.2~10.The Chinese medicine composition is suitable for fever, and effective to the fever of many reasons, the present invention not only has good refrigeration function, the also toxic side effect without aspirin due to its Antipyretic Mechanism is different from aspirin；There are also apparent analgesic activity, analgesic activities to be substantially better than brufen for the Chinese medicine composition, can be used for courbature, arthralgia caused by the Muscular stiffness as caused by flu or other reasons, has broad application prospects.
Description
Technical field
The invention belongs to field of medicaments more particularly to a kind of Chinese medicine compositions for antipyretic-antalgic.
Background technique
Common cold (referred to as catching a cold) is the most common acute infections of respiratory tract disease, which drawn by virus
It rises, rhinovirus is to cause the most common pathogen of catching a cold.This disease is self-limited disease, but easily merges bacterium infection, leads to disease
Feelings aggravate to delay and can produce serious complication, or even threaten patient vitals.Serious person is outer except fever, can feel discomfort out of strength,
Chilly has aches in the limbs, has a headache and the constitutional symptoms such as loss of appetite.Due to causing the rhinovirus blood serum subtype caught a cold, there are more than 140
It plants, and often morphs, therefore, doctor trained in Western medicine clinical treatment does not advocate the therapy based on the antiviral and antibiotic of use, but
Frequently with symptomatic treatment, analgesic-antipyretic (non-steroid anti-inflammatory drug) such as aspirin, paracetamol are such as used.Chinese patent drug
Then suggest clear using GANMAO QINGRE KELI, " Zhengcaihu Drink ", Chailian oral liquor, YINQIAO JIEDU KELI, curing cold capsule, lily feet
Hot glue capsule, dispelling wind detoxicating capsule, dripping pills of andrographolide, Reduning injection, Shuanhuanglian injection, Tanreqing, almond perilla anti-cough
Particle, SUNJU GANMAO PIAN, ageratum class, Yupingfeng Granules etc..
According to statistics, the Western medicine of anti-flu only has 20 kinds in China's medical insurance directory in 2017, and related to flu in Chinese patent drug
Diaphoretic recipes have 52 kinds, according to market survey report display, 2009~2013 years, Beijing, Shanghai, 3 urban retail terminal sense of Guangzhou
It emits medicine marketing scale 2013 Chinese patent drugs that grow steadily and occupies the half of the country of flu medication with 55.9% share, take a fancy on surface
Patent medicine is obviously dominant in the market in cold drug, but fine analysis can find that Market of Chinese Materia Medica in the market of cold drug is very little: having
The selling market that people has extracted more than 20 forward a cold drug kinds of home sale share is analyzed, as a result, it has been found that: it is pressing
Sales volume, two kinds of the sales volume top 10s to sort are in totally 13 kinds of drugs, none is Chinese patent drug, all chemicals.In total
In 13 kinds of drugs, joint brand has crack, compound paracetamol and zinc gluconate tablets, New contac capsule, morning-night, Tylenol, Bufferin, panadol, Voltarol, sweet smell
Must, totally 10 kinds, sales volume, sales volume account for total sales volume, the 61% of sales volume, 75% respectively.Domestic brand has new speed to reach
Common cold tablet, sense health, 3 kinds of chlorphene yellow sensitive tablets, sales volume, sales volume account for total sales volume, the 39% of sales volume, 25% respectively.
Currently, at least the kind of more than half is multiple for Chinese and Western medicine in the Chinese patent drug of the treatment flu in medical insurance directory
Square preparation is added to a large amount of chemical drug composition in these compound preparations: such as Antipyretics object aspirin, to acetyl ammonia
Base phenol etc., Loratadine such as Fei Nading, diphenhydramine etc. cause vessel retraction, congested mitigation oedema class drug such as Chinese ephedra
Alkali and pseudoephedrine etc., central antibechic or excited medicament, such as dextromethorphan, pentoxyverine, antiviral drugs such as Buddha's warrior attendant
Alkanamine etc..On the one hand the addition of these Western medicine is no doubt to significantly increase curative effect, but also significantly increase security risk simultaneously.
On April 30,1 day~2010 January in 2004, in the case report data base of national drug adverse reaction monitoring center
Case report number in relation to vitamin C Yinqiao tablet total 1885, adverse reaction/event mainly involve maincenter and peripheral neverous system,
Digestive system, skin and appendicle etc..Wherein the report of vitamin C Yinqiao tablet several cases is 48 total, accounts for about all reports
2.55%.The adverse reaction of other Chinese patent drugs also when have been reported that: as curing cold capsule can cause acute myelogenous reduce, regeneration barrier
Impenetrability anaemia, decrease of platelet, blood urine etc.；Lingyangganmao Capsules can cause allergy, fash；Swap buffers lozenge can lead to nauseous hardly possible
Bear, whole body shiver with cold, then upper abdomen paroxysmal colic, frequently vomits, sweat all over；Shuanhuanglian injection then easily causes infusion
Reaction and allergic reaction.Including severe allergic shock, expiratory dyspnea, exfoliative dermatitis, or even death；Antitoxic bolus of honeysuckle flower and forsythia
Can cause it is nervous, uncomfortable in chest, feel suffocated, have difficulty in breathing, sweat all over, pale complexion, dark and dim eyesight, the allergic reaction of nausea and vomiting
And anaphylactic shock；Zhongganling tablets: allergy and drowsiness, out of strength etc.；Bupleurum injection can then cause allergic reaction, and anaphylaxis is stopped
Gram, acute pulmonary edema or even death；Multi-arch retaining structure can cause gastrointestinal discomfort, abdominal distension, diarrhea；HuoXiangZhengQiShui can cause
The allergic reactions such as drug rash, purpura, shock and intestinal obstruction, upper gastrointestinal bleeding, pediatric hypoglycemia disease.
Although current many Chinese medicines show good effect in terms for the treatment of flu, mostly decoction is for clinic.Cause
This, exploitation has good social value and economic value with non-toxic or low-toxic cold medicine.
Rhizoma Chuanxiong, warm-natured, acrid flavour, slight bitter have effects that blood-activating and qi-promoting wind-expelling pain-stopping.Cure mainly menstruation caused by stagnation of QI and blood
It is uncomfortable, dysmenorrhea amenorrhoea, stagnation of QI due to depression of the liver and the sternal rib pain for causing hematogenous blockage, headache, wind-cold-dampness arthralgia, the diseases such as treating swelling and pain by traumatic injury.Face
Bed is mainly used for treating the disease of cardiovascular and cerebrovascular, breathing, urinary system and gynecology.Modern studies have found that Rhizoma Chuanxiong contains largely
Volatile oil, main component are phthalide analog compounds, account for about the 31.53%~74.47% of entire volatile oil, with Z- Ligustilide
Based on etc., and phthalide analog compound is divided into three categories type: alkyl phthalide, hydroxyl phthalide and phthalide dimer.The identification such as Wu Qi
62 compounds in rhizoma chuanxiong volatile oil, account for the 87.36% of volatile oil total amount, wherein with Bdph, 4,5- bis-
- 3 β of hydrogen-butylphthalide, 4,5- dihydro -3a- butylphthalide, Z- Ligustilide, E- Ligustilide, 3,1'- dihydroxy
Base -3- butylphthalide, 4,5- dihydro -3,1'- dihydroxy -3- butylphthalide and 4,5- dihydro -3,1'- dihydroxy
Base -3- amyl phthalide content is higher, accounts for the 43.45% of volatile oil total amount.The obtained volatile oil of Rhizoma Chuanxiong steam distillation into
GC-MS combination analysis is gone, wherein main component is Ligustilide, cnidiumlactone, neocindilide, senkyunolide, 3-
Butylphthalide, 3- butylidenephthalide, in addition there are also a variety of terpenes and a variety of aliphatic esters such as sabinene, australene, laurene.
There is document to point out that the extraction of steam distillation long-time heating can make heat-sensitive materials therein that the reactions such as oxidation polymerization occur and cause
Denaturation.Document records the researcher of Beijing Pharmaceutical Ind. Inst. in isolated ligustrazine, rye from Rhizoma Chuanxiong in 1977
Potash, l-Isoleucine-Valine acid anhydride.Cao Fengyin etc. gets 1- β-ethyl acrylate -7- aldehyde radical-from Rhizoma Chuanxiong
B-carboline, 1- acetyl group-B-carboline, L- valyl-Valine acid anhydride, trimethylamine, choline, uracil.Wang Yixiong etc.
Isolated adenine and adenosine from Rhizoma Chuanxiong.Wherein the content of ligustrazine is very low, 60 μ g is contained only in every gram of crude drug, less than very much
One of.There is scholar to determine high-volume Ligusticum chuanxiong Hort and medicine materical crude slice using HPLC-UV-MS method, does not all detect ligustrazine, phenol
Acid and organic acid, measure the acid in Rhizoma Chuanxiong contain ferulic acid, sedanoic acid, vanillic aldehyde, vanillic acid, palmitinic acid, linoleic acid, to hydroxyl
Yl benzoic acid, Chrysophanol, caffeic acid, protocatechuic acid etc..Wherein ferulic acid is principle active component, accounts for about crude drug ingredient
0.1%~0.2%.It measures and contains Palmiticacid in Rhizoma Chuanxiong.Rhizoma Chuanxiong triterpene, spainulenol, cupreol, sucrose and
A kind of fatty glyceride, gas-chromatography prove the glyceride of two linoleic acid and a palmitinic acid.
Sodium ferulate in modern pharmacological research discovery Rhizoma Chuanxiong can inhibit platelet aggregation, inhibit intra platelet free calcium 5-HT,
It prevents the outer aberrant angiogenesis of encephalic from shrinking, blocks the vicious circle of the easypro contracting of aberrant angiogenesis, reach treatment and prevention migraine.Ferulic acid
Sodium can also alleviate rabbit and isolated rat aorta spasmodic contraction, increase guinea pig heart perfusion flow and reduce rat whole blood viscosity etc.
Effect.Piperazine ferulate can obviously increase coronary flow, and the blood that vasoconstriction caused by antagonism adrenaline and ADP are induced is small
Plate aggregation, delays the conduction of Single Cardiac Cell, increases myocardial contractive power, improves blood circulation.Ligustrazine, vanillic aldehyde,
Chrysophanol may act on cardiac muscle membrane acceptor, and ligustrazine is possible to act on α receptor, vanillic aldehyde be possible to act on β by
Body.Ligustrazine can expand coronary artery and block the coronary artery contraction of Endothelin, to prevent myocardial ischemia.
Ligustrazine can be quickly through blood-brain barrier, so it fights nervous centralis ischemic injuries, improves learning and memory, inhibits
Epileptic attack has certain effect.Ligustrazine is to using diabetes as the concurrent central nervous system of the metabolic disease of representative, surrounding
Nervous system and eyeground optic neuropathy all have certain protective role, Central nervous cellular defense mechanism are as follows: thin to nerve
Born of the same parents and vascular endothelial cell play Anti-G value, inhibit the reaction of nerve cell inflammation, antioxidation, calcium channel retardance
Effect promotes the expression of nervous centralis trophic factors, protects axoneure tigroid body and promotes maincenter vascular endothelial growth
Deng.Volatile oil and water decoction contained by Rhizoma Chuanxiong have sedation, and water decoction can fight the excitation of caffeine.Ligustrazine carries on the back mouse
Root ganglion neuron ATP activated current has non-competitive inhibition.Speculate that its mechanism of action may pass through with ligustrazine to gland
The gated ion channel receptor of purine nucleotides is acted on and the phosphorylation at the position this receptor N-terminal phosphokinase C is promoted to be produced
Raw other structure adjusting is related, shows that ligustrazine has certain analgesic activity.The effect ligustrazine of digestive system can significantly reduce
MDA in rat blood serum glutamic-pyruvic transaminase, malonaldehyde, hyaluronic acid, III procollagen type (PC III) and hepatic tissue；It improves in hepatic tissue
Superoxide dismutase (SOD) activity, significant to mitigate liver collagen fiber hyperplasia degree, i.e. ligustrazine is made with anti-hepatic fibrosis
With, ligustrazine can fight the synthesis and activity of thromboxane A2, inhibit the anomalous variation of lactic dehydrogenase, thus substantially reduced mouse,
The diseases such as the reperfusion injury of rabbit hepatic ischemia and anti-oxidant, anti-senile dementia.
Radix Angelicae Sinensis, alias is dry to return, and is the root of San Hang section plant Radix Angelicae Sinensis Angelica sinensis (Oliv.) Diele.It is warm-natured,
Converge to heart and liver channels have the effect of replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels, clinically for treating irregular menstruation, moisturizing cunning
The diseases such as intestines, defaecation obtain significant curative effect.Modern research shows that Radix Angelicae Sinensis contains volatile oil part and fixed oil part.Wherein wave
It mainly include senkyunolide, 3- Diligustilide, Z- Ligustilide, a variety of chemistry such as phthalide-type noval chemical compound in hair oil composition
Ingredient.Organic acid and polysaccharide compound are mainly contained in Radix Angelicae Sinensis fixed oil.Organic acid compound organic acid chemical combination
The main component of object is the organic acids compounds such as ferulic acid, niacin, anisic acid, succinic acid.Also contain Radix Angelicae Sinensis polysaccharide and Huang
The substances such as legumin, flavones and vitamin A.Modern pharmacological research Radix Angelicae Sinensis and its extract have good protection to the heart, the cerebrovascular
Effect, while also having and relievining asthma, diastole smooth muscle, promote Cutaneous permeation, improve gastrointestinal function, analgesic and anti-inflammatory effects etc..
Rhizoma Chuanxiong and Radix Angelicae Sinensis are traditional Chinese medicines, the medicine of composition to be apply in common compatibility form.Rhizoma Chuanxiong and Radix Angelicae Sinensis compatibility
" rhizome of chuanxiong returns soup ", be just documented in Song Dynasty " formulary of peaceful benevolent dispensary ", modern development be relax the glad dripping pill of brain, have reason
The effect of gas promoting blood circulation, blood-activating analgetic.Clinically to headache caused by cerebral insufficiency, dizziness, blurring of vision, insomnia, amnesia, partially
Headache, hemiplegia and sequela etc. have significant curative effect.Szechuan lovage rhizome-angelica medicine is very extensive to applying in tcm prescription, according to river
Rhizome of chuanxiong-Radix Angelicae Sinensis medicine analyzes the application in TCM data of different ratio, (is derived from " tcm prescription voluminous dictionary ") from tcm prescription database
In retrieve the 1242 first prescriptions containing Rhizoma Chuanxiong, Radix Angelicae Sinensis simultaneously.In addition it is also widely used in modern traditional Chinese patent medicine, as blood-nourishing is clear
Brain particle, ZHENGTIAN WAN, tonifying kidneys and nourishing brain ball etc..
Modern studies have found that the conjunction decocting liquid of different proportion Rhizoma Chuanxiong, Radix Angelicae Sinensis, can inhibit or promote the dissolution of certain ingredients, but
Not new compound generates.Therefore, szechuan lovage rhizome-angelica medicine closes compatibility and decocts, and compared with simple, it is molten that effective component can be improved
Out, but mechanism of action is still not clear, and needs further to study.
Rhizoma Chuanxiong and Radix Angelicae Sinensis proportion compatibility and extraction side's Rhizoma Chuanxiong and Radix Angelicae Sinensis proportion compatibility and extracting method change, to drug effect
The dissolution of effect and effective component has certain influence.Radix Angelicae Sinensis-Rhizoma Chuanxiong medicine is analyzed to the application in TCM data of different ratio, is passed through
Tcm prescription database is retrieved, in the 1242 first prescriptions containing Radix Angelicae Sinensis, Rhizoma Chuanxiong, the formula frequency of occurrence of the two ratio 1: 1 is most
It is more, account for the 68.06% of sum.Under Radix Angelicae Sinensis, Rhizoma Chuanxiong different ratio and Different Extraction Method, wherein 7 kinds of active constituent (3 kinds of virtues
Fragrant acid, 4 kinds of phthalide analog compounds) recovery rate all change.It is mentioned simultaneously with water, 3 kinds of alcohol extracting and different proportion water alcohol extracting mention
Method is taken to return medicine to extracting rhizome of chuanxiong, rhizome of chuanxiong returns common water extract compared with single medicinal material water mentions, aromatic acid and phthalide-type chemical combination
The dissolution of object all increased；Radix Angelicae Sinensis is returned in rhizome of chuanxiong and Rhizoma Chuanxiong alcohol extracting or water-alcohol extract, and the recovery rate of total acid is with Rhizoma Chuanxiong ratio
Increase and increases；Total phthalide analog compound recovery rate in rhizome of chuanxiong water extract is returned to increase with Rhizoma Chuanxiong ratio and increase.On the other hand, will
Water mentions the Radix Angelicae Sinensis Rhizoma Chuanxiong of different ratio respectively, 50% alcohol extracting and Xian Shui propose rear alcohol extracting, measures antioxidant activity (the OH freedom of medical fluid
Base clearance rate), the antioxidant activity proportion optimized are as follows: water extract 1: 1,50% alcohol extract are 1: 1.5, after first water mentions
Alcohol extract is 2: 1.These are studies have shown that the active constituent of Radix Angelicae Sinensis and Rhizoma Chuanxiong under different ratio and extracting method, in extract
Amount and its pharmacological activity are all different, and best proportion compatibility can be found by condition optimizing, reaches best drug therapy
Effect.Research in this respect at present, which is concentrated mainly on, makees smooth muscle cell proliferation inhibiting effect, vascular endothelial cell protection
With, to the effect of blood stasis, thrombus, the influence to brain stem c-fos gene mRNA expression etc..
Currently, and having no that it is used for the research and relevant report in antipyretic analgesia field.Our early-stage studies discovery Radix Angelicae Sinensis,
Rhizoma Chuanxiong is applied alone with good refrigeration function, and the Radix Angelicae Sinensis of research discovery now, Rhizoma Chuanxiong are shared under certain condition in antipyretic, analgesia side
Face shows good synergistic function.
Summary of the invention
The Chinese medicine composition that the object of the present invention is to provide a kind of antipyretic-antalgic effects is good, has no toxic side effect.
The purpose of the present invention is what is be achieved through the following technical solutions, a kind of Chinese medicine composition for antipyretic-antalgic, with
Radix Angelicae Sinensis, Rhizoma Chuanxiong primary crude drug and angelica extract are effective medicinal ingredient, assist adding ingredient with acceptable in drug
It collectively constitutes.
Further, the auxiliary adding ingredient is disintegrating agent, excipient, lubricant or adhesive.
Further, effective medicinal ingredient Radix Angelicae Sinensis, Rhizoma Chuanxiong quite use raw material crude drug Radix Angelicae Sinensis, Rhizoma Chuanxiong respectively with its extract
The ratio of parts by weight meter is 0.1~5:0.2~10.
Further, Rhizoma Chuanxiong extract is 50~100% ethyl alcohol water extracts.
Further, Rhizoma Chuanxiong extract is rhizoma chuanxiong volatile oil, and the content of Ligustilide must not be lower than 20%, Ligustilide
40% must not be lower than with the total amount of Senkyunolide A.
Further, ferulic acid must not be lower than 1%, and the total amount of Ligustilide and Senkyunolide A must not be lower than 5%.
Further, the angelica extract is the 0-100% ethanol solution extract of Radix Angelicae Sinensis.
Further, the mass content of the ferulic acid of the angelica extract is greater than or equal to 1%, and the matter of Ligustilide
It measures content and is greater than or equal to 3.0%.
Further, the angelica extract is Chinese angelica volatile oil, and the mass content of Ligustilide is greater than or equal to
30%.
Further, the Chinese medicine composition is oral type pharmaceutical preparation or external preparation.
Compared with prior art, the invention has the following advantages: the Chinese medicine composition is suitable for fever, to a variety of originals
The fever of cause is effective, and the present invention not only has good refrigeration function, also because its Antipyretic Mechanism is different from aspirin
And the toxic side effect without aspirin；There are also apparent analgesic activity, analgesic activities to be substantially better than Bu Luo for the Chinese medicine composition
Sweet smell can be used for courbature, arthralgia caused by the Muscular stiffness as caused by flu or other reasons, before wide application
Scape.
Specific embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book is understood other advantages and efficacy of the present invention easily.
Embodiment 1
Ligusticum chuanxiong Hort is taken, crushes, is added 8 times of 70% ethyl alcohol of amount, soaked overnight, heating and refluxing extraction 3 times, merging filtrate,
Recovered alcohol is concentrated, dry, and measuring its Ligustilide content is 4.1%, and Senkyunolide A content is 1.9%.
Embodiment 2
Radix Angelicae Sinensis medicinal material is taken, crushes, is added 8 times of 50% ethyl alcohol of amount, soaked overnight, heating and refluxing extraction 3 times, merging filtrate,
Recovered alcohol is concentrated, dry, measures its ferulic acid 1.5%, and Ligustilide content is 3.0%.
Embodiment 3
Radix Angelicae Sinensis medicinal material 5kg, Ligusticum chuanxiong Hort 5kg are taken, is crushed, 8 times of 10% ethyl alcohol of amount, soaked overnight, heating are added after mixing
Refluxing extraction 3 times, merging filtrate, recovered alcohol is concentrated, dry.Capsule is routinely made.
Embodiment 4
Example 1 and the resulting extract of embodiment 2, in Radix Angelicae Sinensis crude drug in whole: Rhizoma Chuanxiong crude drug in whole=1:10 ratio is mixed
It closes, tablet is routinely made.
Embodiment 5
Buy rhizoma chuanxiong volatile oil, Ligustilide content 28.5%, Senkyunolide A content 15.9% in market；Commercially available Radix Angelicae Sinensis
Volatile oil, measuring its Ligustilide content is 31.5%.In Radix Angelicae Sinensis crude drug in whole: the mixing of Rhizoma Chuanxiong crude drug in whole=5:2 ratio (according to
Yield conversion), dripping pill is routinely made.
Embodiment 6
Rhizoma chuanxiong volatile oil is bought in market, and using molecular distillation technique, separation makes its Ligustilide content after purification
50.1%, Senkyunolide A content is 18.9%；Commercially available Chinese angelica volatile oil, measuring its Ligustilide content is 51.5%.By working as
Return crude drug in whole: Rhizoma Chuanxiong crude drug in whole=1:1 ratio mixes (converting according to yield), is routinely prepared into soft capsule.
Influence of the embodiment to fever rat model
1, medicinal material and reagent are tested
Dry ferment: Angel Yeast Co., Ltd's production, is made into required concentration with physiological saline before use by 5g/ bags
Suspension is spare.
Aspirin enteric coated tablet: the production of Bayer.S.p.A company is dispensed, production date by Bayer HealthCare Co
Phase: 2016.04.01, batch number: BJ30648, validity period 60 months.
2, laboratory apparatus
Electronic scale: model: YP1201, specification: MAX=1200g e=1g d=0.1g, upper current chart level instruments and meters are limited
Company's production.
Electronic balance: model: JA1003A, specification: MAX=100g d=1mg e=10d, the upper sub- instrument of Nereid's atmospheric electricity have
The production of limit company.
Electronic thermometer: model: MC-347, Omron (Dalian) Co., Ltd, lot number: 20100830UF.
3, experimental animal
Rat
4, experimental method
4.1 pairs of yeast cause rat fever solution to model heat effect research
SD rat, all-male, 180~220g of weight are placed in experimental situation and adapt to 3 days, daily before formal experiment to survey anus temperature 2
Secondary, morning and afternoon is each primary, and continuous 2 days.Body Temperature changing is selected from no more than 0.5 DEG C, body temperature is big in 36.5~38.2 DEG C
Mouse is tested.The same day surveys body temperature 2 times before experiment, is spaced 1h, the basal body temperature as experimental rat.When experiment, control group is removed
It is subcutaneously injected outside physiological saline 20ml/kg, 20% sterilised yeast suspension 20ml/kg is subcutaneously injected in remaining animal, in injection yeast juice
5h measures anus temperature afterwards, and the rat that Thermal preference increases 0.8 DEG C or more is grouped at random by table 1, and gastric infusion is primary, and control group is given
Isometric solvent.Then it is measured at 1,3 hour after gastric infusion and records body temperature (anus temperature), and it is opposite to find out each measurement moment
Temperature changing value before administration, for statistical analysis with Temperature changing value, as a result see Table 1 for details.
The different embodiments of table 1 cause the influence of rat fever to dry ferment
As seen from Table 1, rat is 5 hours after injecting dry ferment, and body temperature significantly increases, and difference has compared with the control group
Statistical significance.Radix Angelicae Sinensis, Rhizoma Chuanxiong have the function of certain reduction to the rat model body temperature, but weaker due to acting on, with mould
Type group comparing difference has statistical difference.And Radix Angelicae Sinensis+Rhizoma Chuanxiong and other embodiments have the raising of yeast rat temperature
Significant antagonism has statistical significance with model group comparing difference, wherein best with the effect of embodiment 6.It grinds simultaneously
Studying carefully result also prompts Radix Angelicae Sinensis and Rhizoma Chuanxiong to share at antipyretic aspect with significant synergistic function.
4.2 Dichlorodiphenyl Acetates cause the influence of mouse writhing reaction
SPF grades of KM mouse are taken, half male and half female adaptable fed 2 days, is grouped, gastric infusion at random by table 2,2 times a day,
It is administered 3 times altogether, administered volume 0.1ml/10g, model group gives the solvent of respective volume, each group mouse after 1h after the last administration
0.7% glacial acetic acid 0.1mL/10g is injected intraperitoneally.Observe writhing number of the mouse after glacial acetic acid is injected intraperitoneally in 5-20min.It turns round
Precursor reactant performance occurs to count once simultaneously with abdominal retraction, body distortion, hindlimb extension, and as a result see Table 2 for details.
The different embodiment Dichlorodiphenyl Acetates of table 2 cause the influence of mouse writhing reaction
As seen from Table 2, after injecting acetic acid significant, a large amount of writhing number occurs for mouse.Radix Angelicae Sinensis, Rhizoma Chuanxiong individually make
Used time has the tendency that reducing acetic acid causes mouse writhing reaction, but weaker due to acting on, poor without statistics with model group comparing difference
It is different.And Radix Angelicae Sinensis+Rhizoma Chuanxiong and other embodiments can significantly inhibit acetic acid and cause mouse writhing reaction, have with model group comparing difference
It is statistically significant, wherein best with the effect of embodiment 6.Result of study also prompts Radix Angelicae Sinensis and Rhizoma Chuanxiong to share in analgesia side simultaneously
Face has significant synergistic function.
The influence of 4.3 paraxylene cause mouse ear swelling
Taking weight is the male mice of 18~22g, is grouped at random by table 3, gastric infusion, model group is then given isometric molten
Matchmaker.Only, 30min puts to death mouse to the left 20 μ l/ of ear even spread dimethylbenzene of 40min each group mouse after modeling, takes a left side after the last administration
Auris dextra piece removes the weighing of left and right auricle with the punch that diameter is 8mm, using left and right auricle weight difference as swelling.It the results are shown in Table
3。
The different embodiment paraxylene of table 3 cause the influence of mouse ear swelling model
As seen from Table 3, after instillation dimethylbenzene, significant swelling occurs mouse for auricle.When Radix Angelicae Sinensis, Rhizoma Chuanxiong are used alone
Have the tendency that reducing xylene-induced ear swelling in mice, but weaker due to acting on, with model group comparing difference no difference of science of statistics.And
Radix Angelicae Sinensis+Rhizoma Chuanxiong and other embodiments can significantly inhibit xylene-induced ear swelling in mice, have system with model group comparing difference
Meter learns meaning, wherein best with the effect of embodiment 6.Result of study also prompts Radix Angelicae Sinensis and Rhizoma Chuanxiong to share in anti-inflammatory aspect tool simultaneously
There is significant synergistic function.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for antipyretic-antalgic, which is characterized in that with the extraction of Radix Angelicae Sinensis, Rhizoma Chuanxiong primary crude drug and Radix Angelicae Sinensis
Object is effective medicinal ingredient, is collectively constituted with acceptable auxiliary adding ingredient in drug.
2. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 1, which is characterized in that the auxiliary adds
Addition point is disintegrating agent, excipient, lubricant or adhesive.
3. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 1, which is characterized in that effective medicinal ingredient
Radix Angelicae Sinensis, Rhizoma Chuanxiong respectively by its extract quite with raw material crude drug Radix Angelicae Sinensis, Rhizoma Chuanxiong parts by weight in terms of ratio be 0.1~5:0.2~
10。
4. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 3, which is characterized in that Rhizoma Chuanxiong extract is
50~100% ethyl alcohol water extracts.
5. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 3, which is characterized in that Rhizoma Chuanxiong extract is
The content of rhizoma chuanxiong volatile oil, Ligustilide must not be lower than 20%, and the total amount of Ligustilide and Senkyunolide A must not be lower than
40%.
6. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 4, which is characterized in that ferulic acid must not be low
In 1%, the total amount of Ligustilide and Senkyunolide A must not be lower than 5%.
7. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 3, which is characterized in that the Radix Angelicae Sinensis extracts
Object is the 0-100% ethanol solution extract of Radix Angelicae Sinensis.
8. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 7, which is characterized in that the Radix Angelicae Sinensis extracts
The mass content of the ferulic acid of object is greater than or equal to 1%, and the mass content of Ligustilide is greater than or equal to 3.0%.
9. a kind of Chinese medicine composition for antipyretic-antalgic according to claim 1, which is characterized in that the Radix Angelicae Sinensis extracts
Object is Chinese angelica volatile oil, and the mass content of Ligustilide is greater than or equal to 30%.
10. a kind of Chinese medicine composition for antipyretic-antalgic described in -9 any one according to claim 1, which is characterized in that
The Chinese medicine composition is oral type pharmaceutical preparation or external preparation.
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| CN112730670A (en) * | 2020-12-23 | 2021-04-30 | 天津中新药业集团股份有限公司第六中药厂 | Method for detecting Shunaoxin dropping pills |
| CN114699436A (en) * | 2022-05-13 | 2022-07-05 | 四川省中医药科学院 | Traditional Chinese medicine extract composition for preventing and treating influenza as well as preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112730670A (en) * | 2020-12-23 | 2021-04-30 | 天津中新药业集团股份有限公司第六中药厂 | Method for detecting Shunaoxin dropping pills |
| CN112730670B (en) * | 2020-12-23 | 2023-05-30 | 津药达仁堂集团股份有限公司第六中药厂 | Detection method of sulbactam sodium dripping pill |
| CN114699436A (en) * | 2022-05-13 | 2022-07-05 | 四川省中医药科学院 | Traditional Chinese medicine extract composition for preventing and treating influenza as well as preparation method and application thereof |
| CN114699436B (en) * | 2022-05-13 | 2023-08-25 | 四川省中医药科学院 | Application of traditional Chinese medicine extract composition for preventing and treating influenza in preparation of medicines for inhibiting death caused by influenza virus and inhibiting lung injury caused by influenza virus |
| WO2023216514A1 (en) * | 2022-05-13 | 2023-11-16 | 四川省中医药科学院 | Traditional chinese medicine extract composition for preventing and treating influenza, preparation method therefor and use thereof |
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Application publication date: 20190219 |