CN113648257A - 一种美白祛斑组合物及其制备方法和应用 - Google Patents
一种美白祛斑组合物及其制备方法和应用 Download PDFInfo
- Publication number
- CN113648257A CN113648257A CN202111084582.2A CN202111084582A CN113648257A CN 113648257 A CN113648257 A CN 113648257A CN 202111084582 A CN202111084582 A CN 202111084582A CN 113648257 A CN113648257 A CN 113648257A
- Authority
- CN
- China
- Prior art keywords
- whitening
- removing composition
- phase
- skin
- freckle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 230000000694 effects Effects 0.000 claims abstract description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 8
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000839 emulsion Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003974 emollient agent Substances 0.000 claims abstract description 5
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 5
- 239000003381 stabilizer Substances 0.000 claims abstract description 5
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 4
- 229960000458 allantoin Drugs 0.000 claims abstract description 4
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 4
- 239000003755 preservative agent Substances 0.000 claims abstract description 4
- 230000002335 preservative effect Effects 0.000 claims abstract description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 4
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 3
- 229960005150 glycerol Drugs 0.000 claims abstract description 3
- 239000000419 plant extract Substances 0.000 claims abstract description 3
- 239000012071 phase Substances 0.000 claims description 21
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 4
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 4
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 4
- 229960003415 propylparaben Drugs 0.000 claims description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 3
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical group CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 3
- 229940075529 glyceryl stearate Drugs 0.000 claims description 3
- 229940100460 peg-100 stearate Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- -1 polydimethylsiloxane Polymers 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 26
- 206010014970 Ephelides Diseases 0.000 abstract description 4
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 abstract description 4
- 229960000401 tranexamic acid Drugs 0.000 abstract description 4
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 abstract description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract description 2
- 229940089468 hydroxyethylpiperazine ethane sulfonic acid Drugs 0.000 abstract description 2
- 229940101267 panthenol Drugs 0.000 abstract description 2
- 235000020957 pantothenol Nutrition 0.000 abstract description 2
- 239000011619 pantothenol Substances 0.000 abstract description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 229960004063 propylene glycol Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 45
- 239000000047 product Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 8
- 230000007794 irritation Effects 0.000 description 6
- 230000037303 wrinkles Effects 0.000 description 5
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 229920000832 Cutin Polymers 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000005562 fading Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 208000001382 Experimental Melanoma Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010027146 Melanoderma Diseases 0.000 description 1
- 206010034277 Pemphigoid Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 206010048245 Yellow skin Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229940059958 centella asiatica extract Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229940051810 licorice root extract Drugs 0.000 description 1
- 235000020725 licorice root extract Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
本发明提供一种美白祛斑组合物及其制备方法和应用，涉及护肤品技术领域。本发明的美白祛斑组合物，由以下原料制成：乳化剂、润肤剂、乳化稳定剂、透明质酸钠、尿囊素、甘油、丙二醇、羟乙基哌嗪乙烷磺酸、烟酰胺、泛醇、凝血酸、植物提取物、美白剂、抗氧化剂、防腐剂、水。本发明的组合物通过各成分之间的相互配合可以抑制黑色素的产生，达到美白祛斑的效果。
Description
技术领域
本发明涉及护肤品技术领域，特别是涉及一种美白祛斑组合物及其制备方法和应用。
背景技术
皮肤是人体最大的器官，皮肤状态是表达人体健康和衰老程度的标志。当皮肤代谢旺盛、血液循环畅通、营养供给充足时，皮肤会呈现细腻、光滑、柔嫩、富有弹性的状态，且不易出现皱纹和色斑；反之，则皮肤会呈现灰暗、衰老等状态，且易产生皱纹和色斑。
黑色素在表皮基底层黑色素细胞中的黑色素体中生物合成，正常生理状态下，皮肤中黑色素可以保护皮肤免受紫外线伤害，当外部侵害、激素失调、老化或其他因素造成黑色素合成代谢机制障碍时，易使表皮基底层的黑色素增多，导致皮肤色泽加深，引起雀斑、黄褐斑、妊娠斑、老年斑、黑色素瘤等色素沉着类皮肤病。
现代人生活节奏快、生活压力大、饮食不规律，加之环境污染、手机电脑辐射，导致很多人出现皮肤暗黄、色斑等，影响人们心情和生活质量。因此有必要提供一种安全有效的美白祛斑护肤品。
发明内容
基于此，有必要针对上述问题，提供一种美白祛斑组合物，具有较好的美白祛斑效果，而且对人体刺激小，安全有效。
一种美白祛斑组合物，由以下重量百分比的原料制成：
上述组合物，通过各成分之间的相互配合可以加快皮肤更新，更好地抑制黑色素的产生，使皮肤变得白皙的同时降低产品的刺激性，舒缓皮肤炎症，从而使产品达到强效、低刺激的美白祛斑效果。
透明质酸钠作为天然的保湿剂，可以在皮肤上形成一种粘弹性透明水化膜，增加皮肤角质层的水分，同时还可以渗透到真皮层，调节皮肤新陈代谢，起到抗皱防皱的效果。
尿囊素可作用于角蛋白，增加和促进角质层水合能力，使其结合水的能力增加，减少水分损失，同时可溶角蛋白，达到软化角蛋白的作用，使皮肤变得光滑、润湿何柔韧，可缓解和治疗皮肤干燥症，滋润皮肤同时可促进皮肤细胞再生，加快伤口愈合，减轻皮肤刺激的作用。
羟乙基哌嗪乙烷磺酸具有软化角质、促进老旧角质剥离、柔软肌肤，提亮肤色的作用，而且作用非常温和，在产品中能较长时间控制恒定的pH范围，保护活性物同时促进活性成分的吸收，在UVA波段和可见光波段有吸收可协同防晒。
烟酰胺分子量较小，能够快速渗透到肌肤深处，参与黑色素转运，加速细胞新陈代谢，加速皮肤更换导致黑色素的脱落，从而起到美白淡斑的作用，同时可以修复受损的角质层，提高肌肤抵御病菌的能力；对于痤疮和天疱疮样病变有一定的抗炎作用，对脂溢性皮炎和湿疹有效，且通过消除自由基而具有抗氧化作用。
泛醇(原维生素B5)可提高皮肤的保湿能力，刺激皮肤再生，可预防炎症和瘙痒症。
凝血酸(又名传明酸、氨甲环酸)能抑制黑斑部位的表皮细胞机能的混乱，抑制黑色素增强因子群，断绝因为紫外线照射而形成的黑色素发生的途径。阻止皮肤黑色素的产生，从而能有效地防止和改善皮肤的色素沉积，同时在后端干扰黑色素从黑色素细胞向周围细胞扩散。作用于皮肤时有淡斑、美白及均衡整体肤色白皙感的功效，还可以改善整体肤色透明感和局部肤块的暗沉。
在其中一个实施例中，所述乳化剂选自：鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷、甘油硬脂酸酯/PEG-100硬脂酸酯、鲸蜡硬脂醇中的一种或两种以上。
在其中一个实施例中，所述润肤剂选自：肉豆蔻酸异丙酯、辛酸/癸酸甘油三酯和聚二甲基硅氧烷中的一种或两种以上。
在其中一个实施例中，所述乳化稳定剂选自：卡波姆和黄原胶中的一种或两种。
在其中一个实施例中，所述植物提取物选自：甘草根提取物和积雪草提取物中的一种或两种。
在其中一个实施例中，所述美白剂为4-丁基间苯二酚。
4-丁基间苯二酚通过抑制络氨酸酶和B16黑色素瘤细胞的活性抑制络氨酸酶的合成，从而对黑色素产生抑制作用，且不会引起细胞毒性；作为络氨酸酶和过氧化酶的强效抑制剂，是有效的皮肤增白剂和增色剂，能够有效对抗皮肤斑点的生成，对过氧化氢引起的DNA损伤有很强的保护效果，同时具有抗糖化的效果。
在其中一个实施例中，所述抗氧化剂为维生素E。
维生素E是一种脂溶性维生素，具有抗氧化保护机体细胞免受自由基毒害的作用，从而延缓衰老，有效减少皱纹的产生；同时可以保护皮肤免受紫外线和污染的伤害，减少疤痕和色素的沉积，加速伤口的愈合。
在其中一个实施例中，所述防腐剂选自：苯氧乙醇、羟苯甲酯、羟苯乙酯、羟苯丙酯中的一种或两种以上。
在其中一个实施例中，所述防腐剂选用苯氧乙醇/羟苯甲酯/羟苯乙酯/羟苯丙酯。
在其中一个实施例中，所述美白祛斑组合物由以下重量百分比的原料制成：
本发明还提供一种上述美白祛斑组合物的制备方法，包括以下步骤：
制备乳化相：将乳化剂和润肤剂混合，加热，得到A相；
制备水相：将乳化稳定剂、透明质酸钠、尿囊素、甘油和水混合，加热，得到B相；
均质：将B相加入A相，均质，均质完成后降温，加入其余原料，混合均匀后，即得美白祛斑组合物。
在其中一个实施例中，所述制备乳化相中，加热温度为80-85℃。
在其中一个实施例中，所述制备水相中，加热温度为80-85℃。
在其中一个实施例中，所述均质步骤中，均质时间为4-6min，均质速度为2700-2900rpm，均质后降温至35-45℃。
本发明还提供一种上述美白祛斑组合物在制备护肤品中的应用。
与现有技术相比，本发明具有以下有益效果：
本发明的组合物，通过各成分之间的相互配合可以加快皮肤更新，更好地抑制黑色素的产生，使皮肤变得白皙的同时降低产品的刺激性，舒缓皮肤炎症，从而使产品达到强效、低刺激的美白祛斑效果。本发明的组合物可应用于制备护肤品，达到美白祛斑、不刺激的效果。
具体实施方式
为了便于理解本发明，下面将结合较佳的实施例对本发明进行更全面的描述。但是，本发明可以以许多不同的形式来实现，并不限于本文所描述的实施例。相反地，提供这些实施例的目的是使对本发明的公开内容的理解更加透彻全面。
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。
以下实施例和对比例中所涉及的原料均为市售购得。其中，鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷为法国赛比克MONTANOVTM68，甘油硬脂酸酯/PEG-100硬脂酸酯为法国赛比克SIMULSOLTM165，甘草根提取物为江苏天晟药业生产的甘草根提取物，积雪草提取物为美国SABINSA生产的积雪草提取物，苯氧乙醇/羟苯甲酯/羟苯乙酯/羟苯丙酯为英国托尔PM3。
实施例1
一种美白祛斑组合物，其原料和各组分用量(质量百分数)如表1所示，该组合物通过以下方法制备得到：
(1)将表中A相的原料加入乳化锅中，加热至80℃，使其完全融化，得到A相。
(2)将表中B相的原料混合，50rpm下搅拌分散均匀，加热至80℃，使原料溶解，保温30min，得到B相。
(3)将B相加入到A相中，2800rpm转速下均质5min，均质完成后，降低转速至50rpm，降温至40℃；
(4)将表中C相的原料混合，加热至完全溶解，加入表中D的原料，搅拌均匀，出料，即得。
实施例2
一种美白祛斑组合物，其原料和各组分用量如表1所示，该组合物的制备方法与实施例1相同。
实施例3
一种美白祛斑组合物，其原料和各组分用量如表1所示，该组合物的制备方法与实施例1相同。
对比例1
一种美白祛斑组合物，其原料和各组分用量如表1所示，该组合物的制备方法与实施例1相同。
表1.实施例和对比例原料种类和配比表(质量百分数％)
实验例1
将实施例和对比例的产品进行保湿性测试、皮肤颜色测试、抗氧化测试，同时设置空白对照组。
(1)保湿性能测试
对受试者使用分别使用实施例和对比例的样品，测试皮肤水分流失情况，皮肤水分流失(TEWL)数值越小，表示皮肤保湿性能越好，测试结果如表2所示。
表2.皮肤水分流失(TEWL)情况
(2)皮肤颜色测试
对受试者分别使用实施例和对比例的样品，测定使用四周后的ITA值，ITA值是基于CIE L*a*b-颜色空间建立的皮肤颜色测量指标，ITA值越大，皮肤颜色越白，测试结果如表3所示。
表3.ITA值变化
| 初始ITA值 | 四周后ITA值 | 变化率％ | |
| 空白组 | 18.2 | 18.3 | 0.55 |
| 实施例1 | 17.6 | 23.7 | 34.66 |
| 实施例2 | 18.1 | 23.1 | 27.62 |
| 实施例3 | 19.6 | 24.3 | 23.98 |
| 对比例1 | 17.5 | 20.4 | 16.57 |
(3)抗氧化测试
将实施例和对比例的样品分别进行DPPH测试，计算自由基抑制率，测试结果如表4所示。
表4.DPPH测试
| 空白组 | 实施例1 | 实施例2 | 实施例3 | 对比例1 | |
| 自由基抑制率 | 0 | 15％ | 13.5％ | 13.0％ | 12.0％ |
以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。
Claims (10)
1.一种美白祛斑组合物，其特征在于，由以下重量百分比的原料制成：
2.根据权利要求1所述的美白祛斑组合物，其特征在于，所述乳化剂选自：鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷、甘油硬脂酸酯/PEG-100硬脂酸酯、鲸蜡硬脂醇中的一种或两种以上；所述润肤剂选自：肉豆蔻酸异丙酯、辛酸/癸酸甘油三酯和聚二甲基硅氧烷中的一种或两种以上。
3.根据权利要求1所述的美白祛斑组合物，其特征在于，所述乳化稳定剂选自：卡波姆和黄原胶中的一种或两种。
4.根据权利要求1所述的美白祛斑组合物，其特征在于，所述植物提取物选自：甘草根提取物和积雪草提取物中的一种或两种。
5.根据权利要求1所述的美白祛斑组合物，其特征在于，所述美白剂为4-丁基间苯二酚，所述抗氧化剂为维生素E。
6.根据权利要求1所述的美白祛斑组合物，其特征在于，所述防腐剂选自：苯氧乙醇、羟苯甲酯、羟苯乙酯、羟苯丙酯中的一种或两种以上。
7.根据权利要求1-6任一项所述的美白祛斑组合物，其特征在于，由以下重量百分比的原料制成：
8.根据权利要求1-7任一项所述的美白祛斑组合物的制备方法，其特征在于，包括以下步骤：
制备乳化相：将乳化剂和润肤剂混合，加热，得到A相；
制备水相：将乳化稳定剂、透明质酸钠、尿囊素、甘油和水混合，加热，得到B相；
均质：将B相加入A相，均质，均质完成后降温，加入其余原料，混合均匀后，即得美白祛斑组合物。
9.根据权利要求8所述的制备方法，其特征在于，所述制备乳化相中，加热温度为80-85℃；所述制备水相中，加热温度为80-85℃；所述均质步骤中，均质时间为4-6min，均质速度为2700-2900rpm，均质后降温至35-45℃。
10.一种权利要求1-7任一项所述的美白祛斑组合物在制备护肤品中的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111084582.2A CN113648257A (zh) | 2021-09-16 | 2021-09-16 | 一种美白祛斑组合物及其制备方法和应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111084582.2A CN113648257A (zh) | 2021-09-16 | 2021-09-16 | 一种美白祛斑组合物及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113648257A true CN113648257A (zh) | 2021-11-16 |
Family
ID=78494059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111084582.2A Pending CN113648257A (zh) | 2021-09-16 | 2021-09-16 | 一种美白祛斑组合物及其制备方法和应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113648257A (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504516A (zh) * | 2022-03-01 | 2022-05-17 | 国妆(广州)科技有限公司 | 一种祛斑型的美白霜 |
| CN115770196A (zh) * | 2022-11-30 | 2023-03-10 | 广州市婷采化妆品有限公司 | 一种多效美白祛斑护肤品及其制备方法及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434707A (zh) * | 2014-12-30 | 2015-03-25 | 罗友群 | 美白祛斑精华 |
| CN111671685A (zh) * | 2020-06-15 | 2020-09-18 | 广州市科昂贸易有限公司 | 一种美白祛斑组合物与美白祛斑霜及其制备方法 |
| CN112675100A (zh) * | 2021-02-05 | 2021-04-20 | 广州瑞嘉精细化工有限公司 | 一种美白护肤组合物及其制备方法 |
-
2021
- 2021-09-16 CN CN202111084582.2A patent/CN113648257A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434707A (zh) * | 2014-12-30 | 2015-03-25 | 罗友群 | 美白祛斑精华 |
| CN111671685A (zh) * | 2020-06-15 | 2020-09-18 | 广州市科昂贸易有限公司 | 一种美白祛斑组合物与美白祛斑霜及其制备方法 |
| CN112675100A (zh) * | 2021-02-05 | 2021-04-20 | 广州瑞嘉精细化工有限公司 | 一种美白护肤组合物及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 佚名: "相宜本草红景天莹透幼白精华乳", 《COSDNA》 * |
| 彭冠杰等: "《美白化妆品科学与技术》", 30 June 2019, 中国轻工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504516A (zh) * | 2022-03-01 | 2022-05-17 | 国妆(广州)科技有限公司 | 一种祛斑型的美白霜 |
| CN115770196A (zh) * | 2022-11-30 | 2023-03-10 | 广州市婷采化妆品有限公司 | 一种多效美白祛斑护肤品及其制备方法及其应用 |
| CN115770196B (zh) * | 2022-11-30 | 2023-11-21 | 广州市婷采化妆品有限公司 | 一种多效美白祛斑护肤品及其制备方法及其应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111000783B (zh) | 一种美白舒缓抗衰精华及其制备方法 | |
| MXPA04000002A (es) | Agente con un contenido de gasa (aceite), que contiene un extracto de cebolla su preparacion y su utilizacion para el cuidado, la prevencion o el tratamiento de un tejido cutaneo danado, en particular de cicatrices. | |
| CN106860088B (zh) | 一种美白祛疤护肤品及其制备方法 | |
| US11654099B2 (en) | Producing a topical solution composition | |
| CN113648257A (zh) | 一种美白祛斑组合物及其制备方法和应用 | |
| CN107456415B (zh) | 一种美白增亮组合物 | |
| CN104434707A (zh) | 美白祛斑精华 | |
| Rathod et al. | Cosmeceuticals and Beauty Care Products: Current trends with future prospects | |
| CN110917051A (zh) | 一种美白精华液及其制备方法 | |
| CN111671685A (zh) | 一种美白祛斑组合物与美白祛斑霜及其制备方法 | |
| CN111067838A (zh) | 一种美白祛斑组合物，美白祛斑霜及其制备方法 | |
| KR101382112B1 (ko) | 편백다당체를 함유하는 피부 외용제 조성물 | |
| KR20160148174A (ko) | 프로폴리스 복합 추출물을 함유하는 화장료 조성물 | |
| KR20090129928A (ko) | 인삼 꽃 추출물을 함유하는 피부 외용제 조성물 | |
| CN112006958A (zh) | 脱毛膏及制备方法 | |
| CN114748367A (zh) | 一种保湿修复精华及其制备方法 | |
| CN110693778A (zh) | 一种面霜及其生产工艺 | |
| US11918666B2 (en) | Topical formulations comprising strontium and methylsulfonylmethane (MSM) and methods of treatment | |
| KR101639578B1 (ko) | 바실씨앗 추출물을 함유하는 화장료 조성물 | |
| CN111166707B (zh) | 一种面部抗衰修复护理组合物及其制备方法和应用 | |
| KR20120139222A (ko) | 탄시논ⅱａ를 유효성분으로 함유하는 피부 외용제 조성물 | |
| CN109453088B (zh) | 美白紧致霜及其制备方法和酪氨酸酶抑制剂 | |
| CN112168772A (zh) | 一种淡斑精华乳及其制备方法 | |
| CN113693966B (zh) | 一种美白淡斑亮采霜及其制备方法 | |
| CN108653144B (zh) | 一种美白化妆品 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211116 |
|
| RJ01 | Rejection of invention patent application after publication |