CN113693966B - 一种美白淡斑亮采霜及其制备方法 - Google Patents
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Abstract
本发明属于日化领域。一种美白淡斑亮采霜,包括以下组分:鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷、甘油硬脂酸酯/PEG‑100硬脂酸酯、角鲨烯、辛酸/葵酸甘油三酯、生育酚、1618醇、红没药醇、植物甾醇、甘油、丙二醇、汉生胶、尿囊素、透明质酸钠、水杨酸、β环糊精、葡萄糖、传明酸、生物复合酶、环五聚二甲基硅氧烷/环己硅氧烷、肉豆蔻酸异丙酯、甘草类黄酮、二甲基甲氧基苯并二氢吡喃醇、1,3‑丁二醇、甘草根提取物、Vc及其衍生物、光甘草定;以及余量的水。本发明淡斑霜基于仿生学原理,主要以天然亲近人体的成分为主温和无刺激,安全无毒副作用,无依赖性,用后肌肤不过敏,不红肿,不脱皮。
Description
技术领域
本发明属于日化领域,具体涉及一种美白淡斑亮采霜及其制备方法。
背景技术
大量黑色素积聚、色素沉着,会引发黄褐斑、雀斑和老年斑等色素沉着性疾病。色斑的致病因素分为内源性因素和外源性因素,内源性因素包括:①压力:如果长期受到压力,过度疲劳,精神功能絮乱人体新陈代谢的平衡就会遭到破坏,皮肤所需的营养供应趋于缓慢,肾上腺皮脂功能下降,导致酪氨酸酶的活跃性增强,以至色素沉着;②内分泌失调、新陈代谢缓慢:肝脏新陈代谢功能不正常或卵巢功能减退时都易长斑,新陈代谢、内分泌失调会加剧色素沉着;④疾病:皮肤疾病如暗疮、粉刺等引发的色素沉着;⑤肌肤酸碱度、维生素含量和角质层含水量等也会影响黑色素形成。外源性因素包括紫外线照射,以及清洁不当或外部刺激引发的肌肤敏感。在紫外线照射和肌肤敏感时,人体为了保护皮肤,黑色素细胞会分泌很多麦拉宁色素,皮肤加速老化,色素过度沉积,易引发肌肤问题。
祛斑存在几个误区:①长斑初期盲目祛斑,随意使用具有祛斑功效的化妆品,导致长斑越来越严重,治疗难度越来越大,耽误了祛斑的最佳时机;②分斑不分治,每种肌肤产生斑的原因和治疗的方法不同,在祛斑的过程中如不区分肤质,将针对油性的祛斑产品用于干性肌肤或敏感肌肤,则易出现皮肤过敏等刺激性症状,造成色斑加重;③依赖高效的祛斑手段,如剥脱法祛斑或短期漂白肤质祛斑,导致皮肤表层损害严重,肌肤免疫力减弱,经紫外线照射易形成晒斑和真皮班等顽固色斑,后期更难治愈;④认为色斑无法治愈。
目前市场上的祛斑产品和祛斑技术包括①含铅汞的霜或膜粉祛斑:味道重,毒副作用强,对皮肤伤害很大,皮肤红肿脆弱,长期使用,汞元素沉淀于皮肤会形成汞斑;②化学剥脱:破环角质层,皮肤发红、肿胀、刺痛,皮肤变薄,脆弱敏感,红血丝裸露,免疫力和抵抗力下降,无法抵御外界刺激;③激光祛斑:皮肤易灼伤留下疤痕,皮肤出现红肿或轻微灼热感,要经历结痂脱皮等过程,皮肤脆弱受刺激后易造成色素回流,形成真皮斑;④激素:依赖性强,产期使用皮肤易敏感,抑制新陈代谢和蛋白质合成,破环肌肤皮张,肌肤潮红,干燥起皮,毛细血管爆裂,真菌感染率,易引发皮炎;⑤中药成分:中药材污染严重,成分复杂,刺激性强,易引起过敏,见效周期长;⑥化学成分:对苯二酚刺激性强,易引发皮炎;熊果苷会释放一种对苯二酚的前体药物,毒性强;L-抗坏血酸对光和热敏感,易变质;M-鞣花酸不溶于水,可利用性差。因此,需要一种温和无刺激、安全无毒副作用、见效快效果好的祛斑产品。
发明内容
本发明所要解决的技术问题是提供一种美白淡斑亮采霜,该淡斑霜基于仿生学原理,主要以天然亲近人体的成分为主温和无刺激,安全无毒副作用,无依赖性,用后肌肤不敏感,不红肿,不脱皮。
本发明美白淡斑亮采霜可美白亮肤,祛皱抗衰,抑菌消炎,清除自由基,抗紫外线延缓光衰老,赋活细胞,提高细胞活性,促进细胞生长修复更新,加速新陈代谢,营养激活肌肤,提高肌肤免疫力,通过肌肤自身的修复能力抵御色斑形成,抑制类人酪氨酸酶的活性,抑制酪氨酸的氧化过程,实现抑制黑色素细胞活性,减缓黑色素体的合成,淡化分解黑色素,美白净化肌肤,可有效修复、淡化、去除晒斑、表皮斑、黄褐斑、真皮斑、反弹斑和敏感斑,祛斑见效快,祛斑效果持久,有效避免了色斑反复发作。
本发明的技术方案如下:
一种美白淡斑亮采霜,包括以下按质量百分比计算的组分:
A相:鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷1-4%、甘油硬脂酸酯/PEG-100硬脂酸酯1-3.5%、角鲨烯3-6%、辛酸/葵酸甘油三酯1-5%、生育酚0.3-0.5%、1618醇2-4%、红没药醇0.1-0.3%、植物甾醇0.5-2%;
B相:甘油2-6%、丙二醇1-5%、汉生胶0.1-0.3%、尿囊素0.6-1.5%、透明质酸钠0.02-0.2%、水杨酸0.5-2%、β环糊精1-6%、葡萄糖0.1-0.5%、传明酸0.3-3%、生物复合酶0.15-1%;
C相:环五聚二甲基硅氧烷/环己硅氧烷2-6%、肉豆蔻酸异丙酯1-5%、甘草类黄酮0.03-1%、二甲基甲氧基苯并二氢吡喃醇0.2-1%;
D相:1,3-丁二醇4-16%、甘草根提取物0.05-1%;
E相:Vc及其衍生物0.1-1%、光甘草定0.01-0.1%;
以及余量的水。
A.生物复合酶
生物复合酶由多种酶组合而成,可实现多种酶的催化功效:抑菌消炎,清除自由基,抗衰老,修复肌肤和粘膜屏障。通过其接触上皮细胞,利用细胞自身的代谢物H2O,脱氢集氧,能够使细胞的含氧量迅速提升,并能够激活沉睡和亚休眠状态的细胞,促进细胞更新和组织代谢,促进细胞进行囊泡转运,当皮肤的微循环打通后,皮肤清除自由基和运输养料的通道更加通畅,根本解决肌肤的主动吸收问题,当皮肤的微循环打通后可促进上皮细胞得到修复增生,解决因细胞缺水缺氧造成的一系列皮肤问题。
B.二甲基甲氧基苯并二氢吡喃醇
二甲基甲氧基苯并二氢吡喃醇作为一种酪氨酸酶和过氧化酶的强抑制剂,可抑制内源性人酪氨酸酶和过氧化氢酶的活性,对黑色素细胞显示出明显剂量依赖性和黑色素的淡化功效,调节肤色,可有效美白色素沉着肌肤,美白效果比熊果苷、曲酸和抗坏血酸磷酸酯镁更为显著,与氢醌等具有明显细胞毒性的美白剂相比具有更高的安全性,吡喃美白剂没有任何的细胞毒性。具有良好的光保护作用,可使肌肤免受UV伤害,有效对抗黄褐斑,对H2O2诱导的DNA损伤具有很强的保护作用,抗糖化效果好。
C.Vc多肽
Vc多肽在光、热、酸碱、金属离子等氧化条件下均具有较高的稳定性,Vc多肽作用于肌肤时在α-多肽酶的作用下逐渐释放Vc,使Vc的有效活性得以长期保存,与天然Vc相比,Vc多肽在见光状态下可至少保持24个月不变色不失活。Vc和Vc多肽均可通过抑制黑素细胞的黑色素合成来防止皮肤的色素沉淀,减少皮肤中黑色素含量,进而减轻皮肤色素沉淀。可促进溶酶体生成巨嗜细胞,在皮肤斑点形成处包覆、吞噬、溶解黑色素细胞,有效消除淡化色斑、提亮肤色。Vc多肽缓慢释放的Vc具有强抗氧化作用,能有效清除自由基和净化紫外线辐射,Vc多肽缓慢释放的多肽对紫外线有极强的能量吸收,提高肌肤的抗紫外线能力。在PH=5-6.5的微酸环境下,小分子多肽可直接被皮肤细胞吞噬,用以加快再生表皮和真皮细胞的新陈代谢,从而有效减少细纹、皱纹和皮肤粗糙程度,紧致肌肤,延缓衰老。
D.尿囊素
尿囊素具有避光、杀菌防腐、止痛、抗氧化作用,能使皮肤保持水分、滋润和柔软,具有促进细胞生长、加快伤口愈合、软化角质蛋白等生理功能,加速细胞增殖分化,迅速形成表皮层,实现肌肤修复、诱导新生、细腻嫩肤的效果。但尿囊素水溶性差,于一般的护肤品中添加量仅为0.3%,超过该剂量就会析出,水剂产品会呈现出针状凝结物,结晶等。申请人经大量实验证明了:低浓度的尿囊素对肌肤的护理和修复来说是远远不够的,因而限制了尿囊素在护肤品和药品中的应用。实验证明在护肤品中尿囊素添加量达0.6%及以上,其优异的护肤新能才能显现。本发明尿囊素的添加量为0.6-1.5%,在分子上接入易溶于水的结构相似物,从而大大地改善了尿囊素的水溶性,可清除外层角质,疏通毛囊,促进微循环,改善和均匀肤色;促进细胞组织生长,加快伤口愈合;具有优异的抗过敏作用,增强肌肤免疫力;能够长效补水保湿,维持皮肤湿度,调节肌肤水油平衡。
E.光甘草定
光甘草定是一种黄酮类物质,活性高,可深入肌肤内部,美白抗氧化,可抑制黑色素生成过程中多种酶的活性,特别是抑制酪氨酸酵素活性,有效抑制黑色素,具有美白抗衰、抑菌抗炎抗氧化、紧致肌肤、抗皱防粗糙的效果。
F.水杨酸
水杨酸可去除角质、杀菌消炎,可温和的去除皮肤表面的死皮细胞,调节皮肤角质层活性,帮助肌肤抵御外界细菌侵袭,预防皮肤炎症,修复受损肌肤,软化去除老化角质层,促进表皮细胞快速更新,表皮细胞新鲜、活力强,可使肌肤恢复光滑细嫩,有效淡化色素斑,缩小毛孔,去除细小皱纹,改善日晒引起的肌肤老化。
进一步的,还包括防腐剂。
进一步的,所述防腐剂为丙醇0.1-0.2%、甲酯0.1-0.2%、辛酰羟肟酸0.1-0.4%、乙基己基甘油0.01-0.5%、己二醇0.01-1%。
进一步的,所述生物复合酶为蛋白酶、超氧歧化酶、辅酶Q10、溶菌酶和过氧化酶。
进一步的,所述蛋白酶、超氧歧化酶、辅酶Q10、溶菌酶和过氧化酶的质量比为1:1-3:1-3:1-3:1-3。
进一步的,所述Vc衍生物为Vc多肽。
一种所述的美白淡斑亮采霜的制备方法,包括以下步骤:
S1.将水和B相原料加入乳化锅中加热至85-90℃,备用;
S2.将A相原料加入油相搅拌锅中加热至80-85℃搅拌均匀,备用;
S3.开启真空,把溶解后的A相原料抽入乳化锅中,与B相混合,加入C相开启均质,乳化5-15min,恒温85-90℃搅拌10-30min后降温;
S4.降温至40-45℃时加入溶解好的D相原料;
S5.降温至35-39℃时加入溶解好的E相原料和防腐剂,搅拌均匀;
S6.降温至34℃后停止搅拌,静置降温至室温。
本发明美白淡斑亮采霜的制备采用了微囊包括缓释技术,由β-环糊精和葡萄糖形成的囊材,具有良好的生物相容性、包覆能力、控释能力,可将有效成分包裹于微囊中,既保证了有效成分的高活性,又避免了有效成分直接作用于肌肤上的强刺激性,微囊包裹缓慢释放,作用效果持久。
本发明具有如下有益效果:
本发明选用的甘草根提取物、VC及其衍生物和光甘草定,可抑制中胚层酪氨酸酶活性并减少黑色素的合成量,减缓合成速度,酪氨酸酶在氧自由基的催化作用下酪氨酸逐步氧化形成黑色素,选用的光甘草定、甘草类黄酮、二甲基甲氧基苯并二氢吡喃醇,可抑制氧自由基,竞争性的抑制酪氨酸酶活性,氧自由基是引起机体老化的原因之一,本发明可破坏、清除皮肤底层的氧自由基,延缓机体衰老。选用的红没药醇可抑制炎症,减缓黑色素细胞的大量增殖,修复细胞免疫功能。
选用角鲨烯、辛酸/葵酸甘油三酯、生育酚(维生素E)、植物甾醇、甘油和丙二醇等成分复配,可长效补水保湿,有效锁水6小时以上,锁水技术复配皮肤保护技术能让肌肤长时间处于水润状态,角质层含水量高可有效过滤折射部分光线,避免光线直射,避免肌肤晒伤。选用的生物复合酶可对角质层表面的色素细胞进行吞噬、分解脱落、加速代谢,可促进上皮组织细胞更新,激活肌肤免疫增强肌肤自我修复能力,修复肌肤屏障,肌肤免疫力提高,配合抗紫外线技术,提高了肌肤抗敏能力,肌肤不易损伤和病变。本发明淡斑霜每日涂膜2-3次,明显可见美白遮瑕效果,7-10天可有效淡化晒斑等表皮斑,12-15天可有效去除表皮斑,1个月可淡化40%以上的色斑,2个月可去除70%以上的色斑。
附图说明
图1为本发明晒斑祛斑效果测试中某志愿者使用前后对比图;
图2为本发明黄褐斑祛斑效果测试中患者甲受试期间面部变化图;
图3为本发明黄褐斑祛斑效果测试中患者乙受试期间面部变化图。
具体实施方式
下面结合实施例对本发明进行详细的说明,实施例仅是本发明的优选实施方式,不是对本发明的限定。
实施例
下表为本发明美白淡斑亮采霜3个实施例的配方表(单位:%):
对比例
下表为本发明美白淡斑亮采霜3个对比例的配方表(单位:%):
上述美白淡斑亮采霜实施例和对比例的制备方法,包括以下步骤:
S1.将水和B相原料加入乳化锅中加热至85℃,备用;
S2.将A相原料加入油相搅拌锅中加热至80℃搅拌均匀,备用;
S3.开启真空,把溶解后的A相原料抽入乳化锅中,与B相混合,加入C相开启均质,乳化5-15min,恒温85℃搅拌10-30min后降温;
S4.降温至40-45℃时加入溶解好的D相原料;
S5.降温至39℃时加入溶解好的E相原料和防腐剂,搅拌均匀;
S6.降温至34℃后停止搅拌,静置降温至室温。
以下是对实施例和对比例技术效果的实验验证数据:
一、美白、亮肤、补水、保湿、紧致等功效的测试
1、测试项目:皮肤黑色素含量、皮肤白度、皮肤明亮度、水分含量、水分流失、光泽度、皮肤弹性。
2、测试仪器:CKMPA580皮肤测试仪、Mexameter皮肤黑色素和血红素测试探头、Colormeter皮肤颜色测试探头、Corneometer水分测试探头、Tewameter水分流失探头、Glossymeter光泽度测试探头、Cutometer皮肤弹性测试探头。
3、受试对象:筛选无色斑的合格志愿者,选择面部作为测试部位。根据Chardon分组法,基础皮肤明亮度ITA°在Ⅱ~Ⅳ级之间。实施例1-3、对比例1-3每组各20名受试者。
4、测试周期:测试周期为28天,在使用样品前1天和使用后第14、28天使用仪器测试各项指标。在使用后的测试中,志愿者在测试当天不能涂抹样品,需要测试完成后再使用样品。
5、样品使用:测试前1周为洗脱期,此期间受试者使用不含任何活性物的基础保湿水和保湿乳。在测试期间不能使用其他美白产品。受试者连续28天使用样品,每天早晨、晚上睡前洗脸后在面部涂抹样品,涂抹量约为0.2g。测试黑色素含量、白度、明亮度以颈部作为自身对照用。
6、测试过程:使用前数据采集:测试前,在温度为24±1℃、湿度为55±5%RH的恒温恒湿室内静坐20分钟。用Colormeter皮肤颜色测试探头、Mexameter皮肤黑色素和血红素测试探头、Corneometer水分测试探头、Tewameter水分流失探头、Glossymeter光泽度测试探头、Cutometer皮肤弹性测试探头在测试部位进行使用前数据的采集。对各测试部位的各测试点循环测试4次,取平均值作为对应部位的使用前数据。
7、使用后第7、14、28天的数据采集,步骤同使用前数据采集。
8、测试结果
(1)皮肤黑色素含量变化率:
时间(天) | 实施例1 | 实施例2 | 实施例3 | 对比例1 | 对比例2 | 对比例3 |
7 | -14.56% | -15.62% | -16.14% | -10.63% | -13.87% | -15.21% |
14 | -19.01% | -18.32% | -19.29% | -12.44% | -15.52% | -17.74% |
28 | -22.57% | -23.55% | -24.35% | -15.86% | -20.97% | -21.63% |
(2)皮肤白度变化率:
时间(天) | 实施例1 | 实施例2 | 实施例3 | 对比例1 | 对比例2 | 对比例3 |
7 | 1.76% | 1.82% | 1.91% | 1.15% | 1.63% | 1.85% |
14 | 1.85% | 1.92% | 2.03% | 1.28% | 1.75% | 1.96% |
28 | 2.13% | 2.25% | 2.32% | 1.54% | 1.98% | 2.23% |
(3)皮肤明亮度变化率:
时间(天) | 实施例1 | 实施例2 | 实施例3 | 对比例1 | 对比例2 | 对比例3 |
7 | 9.54% | 9.72% | 10.16% | 6.07% | 7.69% | 9.53% |
14 | 17.18% | 18.63% | 19.47% | 13.82% | 16.53% | 17.85% |
28 | 20.35% | 21.59% | 22.27% | 16.26% | 19.74% | 21.17% |
(4)水分含量变化率:
时间(天) | 实施例1 | 实施例2 | 实施例3 | 对比例1 | 对比例2 | 对比例3 |
7 | 27.53% | 29.32% | 30.07% | 24.61% | 24.76% | 28.94% |
14 | 36.96% | 37.27% | 38.42% | 34.15% | 32.63% | 36.28% |
28 | 46.81% | 47.15% | 49.28% | 42.76% | 42.90% | 47.52% |
(5)水分流失变化率:
时间(天) | 实施例1 | 实施例2 | 实施例3 | 对比例1 | 对比例2 | 对比例3 |
7 | -13.44% | -14.91% | -15.31% | -11.83% | -11.62% | -14.13% |
14 | -15.82% | -16.47% | -16.99% | -13.65% | -13.84% | -15.35% |
28 | -17.46% | -18.34% | -19.15% | -15.12% | -15.37% | -17.89% |
(6)光泽度变化率:
时间(天) | 实施例1 | 实施例2 | 实施例3 | 对比例1 | 对比例2 | 对比例3 |
7 | 8.32% | 8.81% | 9.25% | 5.13% | 6.50% | 8.55% |
14 | 9.49% | 9.96% | 10.38% | 6.27% | 7.33% | 9.72% |
28 | 15.02% | 16.57% | 17.13% | 11.54% | 14.91% | 15.48% |
(7)皮肤弹性变化率:
可见,本发明淡斑霜可显著的降低皮肤黑色素含量,提高皮肤白皙度和明亮度,以及增加皮肤水分含量,增强皮肤屏障功能,提高皮肤光泽度的效果。
二、祛斑功效的测试
(1)筛选10名脸上有晒斑的志愿者,选择面部作为测试部位。测试周期为15天,在使用样品前1天和使用后第7、10、12、15天,观察志愿者面部晒斑消退情况。测试前1周为洗脱期,此期间受试者使用不含任何活性物的基础保湿水和保湿乳,在测试期间不能使用其他美白产品。受试者连续15天使用实施例1,每天早晨、晚上睡前洗脸后在面部涂抹样品,涂抹量约为0.2g,重点部位取0.1g重复涂抹。测试结果见下表:
时间 | 结果 |
7d | 9人晒斑淡化; |
10d | 2人斑完全消退,8人晒斑淡化,全员面部均有代谢物体出现; |
12d | 6人斑完全消退,全员面部更为弹性嫩白; |
15d | 9人晒斑完全消退,1人晒斑消退90%以上,该名志愿者使用前后的对比图如图1所示。 |
可见,本发明淡斑霜对晒斑的祛斑效果显著,7-10d可有效淡化晒斑,12-15天可有效去除晒斑。
(2)选取两名脸上有黄褐斑的女性患者,选择面部作为测试部位。测试前1周为洗脱期,此期间患者使用不含任何活性物的基础保湿水和保湿乳,在测试期间不能使用其他美白产品。患者甲(年龄41岁)使用实施例2,患者乙(年龄44岁)实施例3,连续28天使用样品,每天早晨、晚上睡前洗脸后在面部涂抹样品,涂抹量约为0.2g,重点部位取0.1g重复涂抹。测试周期为28天,在使用样品前1天和使用后第14、28天,用照片记录患者的变化过程,患者的任何不良反应都由患者随时进行报告:患者甲受试期间的面部变化如图2所示,图2(a)为受试前,图2(b)为受试后2d,图2(c)为受试后14d,图2(d)为为受试后28d;患者乙受试期间的面部变化如图3所示,图3(a)为受试前,图3(b)为受试后2d,图3(c)为受试后14d,图3(d)为为受试后28d。使用(MX-18;Cour三次连续测量他们的皮肤最黑的地方的黑色素指数(MI)。从每半边脸中获得的数据计算平均值,测试结果见下表。
黑色素指数(MI) | 0d | 14d | 28d |
患者甲 | 221.33 | 215.33 | 210.33 |
患者乙 | 223.00 | 189.33 | 189.33 |
可见,本发明淡斑霜对黄褐斑的祛斑效果显著,1个月可淡化40%以上的黄褐斑,2个月可去除70%以上的黄褐斑。
本发明美白淡斑亮采霜可美白亮肤,祛皱抗衰,抑菌消炎,清除自由基,抗紫外线延缓光衰老,赋活细胞,提高细胞活性,促进细胞生长修复更新,加速新陈代谢,营养激活肌肤,提高肌肤免疫力,通过肌肤自身的修复能力抵御色斑形成,抑制类人酪氨酸酶的活性,抑制酪氨酸的氧化过程,实现抑制黑色素细胞活性,减缓黑色素体的合成,淡化分解黑色素,美白净化肌肤,可有效修复、淡化、去除晒斑、表皮斑、黄褐斑、真皮斑、反弹斑和敏感斑,祛斑见效快,祛斑效果持久,有效避免了色斑反复发作。
Claims (2)
1.一种美白淡斑亮采霜,其特征在于,由以下按质量百分比计算的组分组成:
A相:鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷1-4%、甘油硬脂酸酯/PEG-100硬脂酸酯1-3.5%、角鲨烯3-6%、辛酸/葵酸甘油三酯1-5%、生育酚0.3-0.5%、1618醇2-4%、红没药醇0.1-0.3%、植物甾醇0.5-2%;
B相:甘油2-6%、丙二醇1-5%、汉生胶0.1-0.3%、尿囊素0.6-1.5%、透明质酸钠0.02-0.2%、水杨酸0.5-2%、β环糊精1-6%、葡萄糖0.1-0.5%、传明酸0.3-3%、生物复合酶0.15-1%;
C相:环五聚二甲基硅氧烷/环己硅氧烷2-6%、肉豆蔻酸异丙酯1-5%、甘草类黄酮0.03-1%、二甲基甲氧基苯并二氢吡喃醇0.2-1%;
D相:1,3-丁二醇4-16%、甘草根提取物0.05-1%;
E相:Vc及其衍生物0.1-1%、光甘草定0.01-0.1%;
防腐剂:丙醇0.1-0.2%、甲酯0.1-0.2%、辛酰羟肟酸0.1-0.4%、乙基己基甘油0.01-0.5%、己二醇0.01-1%;
以及余量的水;
所述生物复合酶为蛋白酶、超氧歧化酶、辅酶Q10、溶菌酶和过氧化酶;
所述蛋白酶、超氧歧化酶、辅酶Q10、溶菌酶和过氧化酶的质量比为1:1-3:1-3:1-3:1-3;
所述Vc衍生物为Vc多肽。
2.一种权利要求1所述的美白淡斑亮采霜的制备方法,其特征在于,包括以下步骤:
S1.将水和B相原料加入乳化锅中加热至85-90℃,备用;
S2.将A相原料加入油相搅拌锅中加热至80-85℃搅拌均匀,备用;
S3.开启真空,把溶解后的A相原料抽入乳化锅中,与B相混合,加入C相开启均质,乳化5-15min,恒温85-90℃搅拌10-30min后降温;
S4.降温至40-45℃时加入溶解好的D相原料;
S5.降温至35-39℃时加入溶解好的E相原料和防腐剂,搅拌均匀;
S6.降温至34℃后停止搅拌,静置降温至室温。
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Publication number | Priority date | Publication date | Assignee | Title |
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US9468597B1 (en) * | 2013-03-16 | 2016-10-18 | Dr. Perry Skindustries, LLC | Stabilized L-ascorbic acid skin serum |
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CN107714539A (zh) * | 2017-10-27 | 2018-02-23 | 广州君研生物科技有限公司 | 美白祛斑霜 |
CN108743468A (zh) * | 2018-06-16 | 2018-11-06 | 赖辉武 | 一种可养颜调肤清痘祛斑护肤霜的配方及其制作方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN107496190A (zh) * | 2017-10-15 | 2017-12-22 | 广州汀兰生物科技有限公司 | 一种美白祛斑组合物及其应用 |
CN107714539A (zh) * | 2017-10-27 | 2018-02-23 | 广州君研生物科技有限公司 | 美白祛斑霜 |
CN108743468A (zh) * | 2018-06-16 | 2018-11-06 | 赖辉武 | 一种可养颜调肤清痘祛斑护肤霜的配方及其制作方法 |
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