CN113646432A - 用血管生成素样7(angptl7)抑制剂治疗眼科疾病 - Google Patents

用血管生成素样7(angptl7)抑制剂治疗眼科疾病 Download PDF

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CN113646432A
CN113646432A CN202080022870.2A CN202080022870A CN113646432A CN 113646432 A CN113646432 A CN 113646432A CN 202080022870 A CN202080022870 A CN 202080022870A CN 113646432 A CN113646432 A CN 113646432A
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seq
angptl7
position corresponding
nucleic acid
molecule
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K·普拉文
C·舒尔曼
L·古尔斯基
T·T·多斯塔尔
G·阿贝卡西斯
A·巴拉斯
G·科波拉
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Regeneron Pharmaceuticals Inc
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CN202080022870.2A 2019-01-23 2020-01-21 用血管生成素样7(angptl7)抑制剂治疗眼科疾病 Pending CN113646432A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962795665P 2019-01-23 2019-01-23
US62/795,665 2019-01-23
US201962880609P 2019-07-30 2019-07-30
US62/880,609 2019-07-30
US201962902683P 2019-09-19 2019-09-19
US62/902,683 2019-09-19
US201962909573P 2019-10-02 2019-10-02
US62/909,573 2019-10-02
PCT/US2020/014373 WO2020154268A2 (en) 2019-01-23 2020-01-21 Treatment of ophthalmic conditions with angiopoietin-like 7 (angptl7) inhibitors

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KR (1) KR20210132045A (enExample)
CN (1) CN113646432A (enExample)
AU (1) AU2020210630B2 (enExample)
CA (1) CA3126476A1 (enExample)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL284700B2 (en) 2019-01-23 2025-10-01 Regeneron Pharma Treating eye conditions with angiopoietin-like 7 inhibitors
US11845989B2 (en) 2019-01-23 2023-12-19 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
AU2020285639A1 (en) 2019-05-24 2021-12-23 Empirico Inc. Treatment of angiopoietin like 7 (ANGPTL7) related diseases
WO2022072356A1 (en) * 2020-09-29 2022-04-07 Empirico Inc. Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases
EP4251753A4 (en) * 2020-11-24 2025-08-06 Empirico Inc TREATMENT OF DISEASES AND DISORDERS RELATED TO SOS2
CA3210480A1 (en) 2021-02-26 2022-09-01 Regeneron Pharmaceuticals, Inc. Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors
KR20240099232A (ko) * 2021-09-30 2024-06-28 리제너론 파마슈티칼스 인코포레이티드 Rho 구아닌 뉴클레오타이드 교환 인자 12[Rho Guanine Nucleotide Exchange Factor 12, ARHGEF12] 억제제를 이용한 녹내장 치료
WO2023122656A1 (en) * 2021-12-22 2023-06-29 Regeneron Pharmaceuticals, Inc. Treatment of kidney diseases with angiopoietin like 3 (angptl3) inhibitors

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1781787T1 (sl) 2004-08-23 2017-08-31 Sylentis S.A.U. Zdravljenje očesnih nepravilnosti, kakakterističnih za povišan očesni tlak s sirna
JP2009542201A (ja) 2006-07-05 2009-12-03 オリエントバイオ カンパニーリミテッド メチル移行領域のメチル化を測定してがんの有無を判別する方法
US20110020312A1 (en) 2009-05-11 2011-01-27 Niven Rajin Narain Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
EP3093029A1 (en) 2009-07-27 2016-11-16 Baxalta GmbH Blood coagulation protein conjugates
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
JP5909755B2 (ja) 2009-07-27 2016-04-27 リポクセン テクノロジーズ リミテッド 非血液凝固タンパク質の糖ポリシアル酸化
SG178141A1 (en) 2009-07-27 2012-03-29 Baxter Int Blood coagulation protein conjugates
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
WO2011051276A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Colon and rectal tumor markers and methods of use thereof
CA3256492A1 (en) 2010-01-11 2025-11-29 Genomic Health, Inc. Method to use gene expression to determine likelihood of clinical outcome of renal cancer
EP2397559A1 (en) 2010-06-17 2011-12-21 Max-Delbrück-Centrum Für Molekulare Medizin Stage-specific biomarkers for the diagnosis of acute kidney injury
WO2012006589A2 (en) 2010-07-08 2012-01-12 Infinity Pharmaceuticals, Inc. Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling
WO2012016131A1 (en) 2010-07-30 2012-02-02 Baxter International Inc. Nucleophilic catalysts for oxime linkage
DK2654794T3 (da) 2010-12-22 2020-06-08 Baxalta GmbH Materialer og fremgangsmåder til konjugering af et vandopløseligt fedtsyrederivat til et protein
PL2710375T3 (pl) 2011-05-18 2019-07-31 Baxalta GmbH Testy aktywności zależne od modyfikacji
AU2012328524B2 (en) 2011-10-28 2017-05-18 Excelse Bio, Inc. Protein formulations containing amino acids
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
AU2013204754C1 (en) 2012-05-16 2018-10-11 Takeda Pharmaceutical Company Limited Nucleophilic Catalysts for Oxime Linkage
US20130310546A1 (en) 2012-05-16 2013-11-21 Bater Healthcare Sa Nucleophilic catalysts for oxime linkage and use of nmr analyses of the same
US20150174203A1 (en) 2012-05-30 2015-06-25 Icahn School Of Medicine At Mount Sinai Compositions And Methods For Modulating Pro-Inflammatory Immune Response
CN104755627A (zh) 2012-09-21 2015-07-01 英特盖根公司 用于肝样本的分类和局灶性结节不典型增生、肝细胞腺瘤和肝细胞癌的诊断的新方法
US9206423B2 (en) 2012-12-30 2015-12-08 The Regents Of The University Of California Methods of modulating compliance of the trabecular meshwork
WO2014167529A1 (en) 2013-04-10 2014-10-16 Institut De Cardiologie De Montreal Methods and compositions for preventing and treating atherosclerosis
WO2015132303A1 (en) * 2014-03-04 2015-09-11 Sylentis Sau Sirnas and their use in methods and compositions for the treatment and/or prevention of eye conditions
WO2015179633A1 (en) 2014-05-22 2015-11-26 Fred Hutchinson Cancer Research Center Lilrb2 and notch-mediated expansion of hematopoietic precursor cells
CN108603188A (zh) 2015-11-24 2018-09-28 联邦科学技术研究组织 在细胞培养物中产生病毒
AU2016361454A1 (en) 2015-11-24 2018-06-21 Commonwealth Scientific And Industrial Research Organisation Production of viruses in avian eggs
WO2017168348A1 (en) 2016-03-31 2017-10-05 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
JP7050215B2 (ja) * 2016-08-19 2022-04-08 ツールゲン インコーポレイテッド 人工的に操作された血管新生調節系
US10995146B2 (en) * 2016-08-30 2021-05-04 Regeneron Pharmaceuticals, Inc. Methods of treating severe insulin resistance by interfering with glucagon receptor signaling
WO2018067991A1 (en) 2016-10-07 2018-04-12 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
JP2019535263A (ja) 2016-11-14 2019-12-12 メモリアル スローン ケタリング キャンサー センター 幹細胞由来シュワン細胞を使用する薬物発見のための方法
WO2018174861A1 (en) 2017-03-21 2018-09-27 Mprobe Inc. Methods and compositions for detecting early stage breast cancer with rna-seq expression profiling
EP3600108A4 (en) 2017-03-23 2021-01-06 The Regents of the University of California STIMULATION OF HAIR GROWTH BY SENESCENT CELLS AND THE SECRETORY PHENOTYPE ASSOCIATED WITH SENESCENCE
JP6779164B2 (ja) * 2017-03-28 2020-11-04 ヤンマーパワーテクノロジー株式会社 作業車両の自律走行システム
JP2018164442A (ja) * 2017-03-28 2018-10-25 国立大学法人 熊本大学 皮膚有棘細胞癌の判定、予防又は治療方法
EP3630981A4 (en) 2017-05-31 2021-03-03 Commonwealth Scientific and Industrial Research Organisation CHARACTERISTICS SELECTION IN BIRDS
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US20210122819A1 (en) 2018-01-18 2021-04-29 Adanate, Inc. Anti-lilrb antibodies and uses thereof
GB201806118D0 (en) 2018-04-13 2018-05-30 Univ Edinburgh Macrophage use
IL284700B2 (en) 2019-01-23 2025-10-01 Regeneron Pharma Treating eye conditions with angiopoietin-like 7 inhibitors
AU2020285639A1 (en) 2019-05-24 2021-12-23 Empirico Inc. Treatment of angiopoietin like 7 (ANGPTL7) related diseases
WO2022072356A1 (en) 2020-09-29 2022-04-07 Empirico Inc. Compositions and methods for the treatment of angiopoietin like 7 (angptl7) related diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GUHAN RAM VENKATARAMAN: "Bayesian model comparison for rare variant association studies", 《BIORXIV》, 14 April 2018 (2018-04-14), pages 1 - 31 *
NU´ RIA COMES等: "Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma", 《GENES TO CELLS》, vol. 16, no. 3, 31 December 2011 (2011-12-31), pages 243 - 259 *

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