CN113633735A - Traditional Chinese medicine composition for treating autism and application thereof - Google Patents

Traditional Chinese medicine composition for treating autism and application thereof Download PDF

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Publication number
CN113633735A
CN113633735A CN202111028081.2A CN202111028081A CN113633735A CN 113633735 A CN113633735 A CN 113633735A CN 202111028081 A CN202111028081 A CN 202111028081A CN 113633735 A CN113633735 A CN 113633735A
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parts
traditional chinese
wild
chinese medicine
medicine composition
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张慧琴
林阳炎
曾诚齐
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating autism and application thereof. The traditional Chinese medicine composition comprises the following components in parts by mass: 1-3 parts of saffron, 28-32 parts of chrysanthemum, 18-22 parts of wild mint, 18-22 parts of wild liquorice, 18-22 parts of wrinkled gianthyssop, 18-22 parts of mulberry leaf and 1-3 parts of galangal. The Chinese medicinal composition is prepared into a bath agent, and can effectively treat patients with autism.

Description

Traditional Chinese medicine composition for treating autism and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating autism and application thereof.
Background
Autism is a developmental disorder disease, also known as autism, and is a representative disease of Pervasive Developmental Disorder (PDD). The disease starts in the infant stage and is mainly manifested as language development disorder, interpersonal interaction disorder, narrow interests and stereotyped behavior patterns of different degrees.
The existing method for treating autism is a rehabilitation method, the method only has a correction effect on autism children and cannot completely cure the autism children, and the method is high in cost and can cause certain economic burden to families. Therefore, the prior art urgently needs a medicine which has low cost and can completely cure the autism to meet the defects of the prior art.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition capable of effectively treating autism and application thereof.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for treating autism, which comprises the following components in parts by mass: 1-3 parts of saffron, 28-32 parts of chrysanthemum, 18-22 parts of wild mint, 18-22 parts of wild liquorice, 18-22 parts of wrinkled gianthyssop, 18-22 parts of mulberry leaf and 1-3 parts of galangal.
Preferably, the composition comprises the following components in parts by mass: 1.5-2.5 parts of saffron, 29-31 parts of chrysanthemum, 19-21 parts of wild mint, 19-21 parts of wild liquorice, 19-21 parts of wrinkled gianthyssop, 19-21 parts of mulberry leaf and 1.5-2.5 parts of galangal.
Preferably, the composition comprises the following components in parts by mass: 2 parts of saffron, 30 parts of chrysanthemum, 20 parts of wild mint, 20 parts of wild liquorice, 20 parts of wrinkled gianthyssop herb, 20 parts of mulberry leaf and 2 parts of galangal.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating autism.
Preferably, the medicament is a bath agent.
Preferably, the preparation method of the bathing agent comprises the following steps: firstly, the agastache rugosus and the galangal are decocted in water for 20-30 min, then the saffron, the chrysanthemum, the wild mint, the wild liquorice and the mulberry leaves are added for further decoction for 20-30 min, and the filtrate is taken to obtain the bath agent.
Preferably, the volume mass ratio of water to agastache rugosus during decoction is 200-300 ml: 1g of the total weight of the composition.
Preferably, the bathing agent is used by the following method: mixing the bathing agent with water, and bathing.
Preferably, the volume ratio of the bathing agent to the water is 1-1.2: 100.
Preferably, the frequency of bathing is 1-2 times per day, and the bathing time is 30-40 min.
The invention provides a traditional Chinese medicine composition capable of effectively treating autism. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, cooling blood and detoxifying, and resolving stagnation; flos Chrysanthemi with effects of suppressing hyperactive liver and improving eyesight; radix Glycyrrhizae Indici with effects of clearing heat, promoting diuresis, removing toxic substance and relieving swelling; herba Menthae with exterior syndrome relieving, heat clearing away, analgesic, antitussive, and expectorant effects; rhizoma Alpiniae Officinarum with effects of warming stomach, relieving vomit, dispelling cold and relieving pain; folium Mori has effects in dispelling pathogenic wind and heat, clearing lung-heat, moistening dryness, removing liver fire, and improving eyesight; after the herba agastaches with the effects of dispelling wind and cold, eliminating dampness, sweating and resisting bacteria is reasonably matched, the effects of clearing heat and removing toxicity, clearing and activating the channels and collaterals, calming the liver and improving eyesight of the formula are fully exerted, so that the autism is more effectively treated.
The traditional Chinese medicine composition disclosed by the invention is reasonable and safe in formula, and when the traditional Chinese medicine composition is prepared into a bath agent, the resistance of children to oral traditional Chinese medicines is solved, the autism can be effectively treated, and the effective rate can reach 90%.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating autism, which comprises the following components in parts by mass: 1-3 parts of saffron, preferably 1.5-2.5 parts, and more preferably 2 parts; 28-32 parts of chrysanthemum, preferably 29-31 parts of chrysanthemum, and further preferably 30 parts of chrysanthemum; 18-22 parts of wild mint, preferably 19-21 parts of wild mint, and more preferably 20 parts of wild mint; 18-22 parts of licorice root, preferably 19-21 parts, and more preferably 20 parts; 18-22 parts of agastache rugosus, preferably 19-21 parts of agastache rugosus, and further preferably 20 parts of agastache rugosus; 18-22 parts of mulberry leaves, preferably 19-21 parts of mulberry leaves, and more preferably 20 parts of mulberry leaves; 1 to 3 parts of galangal, preferably 1.5 to 2.5 parts, and more preferably 2 parts.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating autism.
In the present invention, the medicament is a bathing agent.
In the invention, the preparation method of the bath agent comprises the following steps: firstly, the agastache rugosus and the galangal are decocted in water for 20-30 min, preferably 25min, then the saffron, the chrysanthemum, the wild mint, the wild liquorice and the mulberry leaves are added, and the decoction is continued for 20-30 min, preferably 25min, and the filtrate is taken to obtain the bath agent.
In the invention, the volume-mass ratio of water to agastache rugosus during decoction is 200-300 ml: 1g, preferably 250 ml: 1g of the total weight of the composition.
In the invention, the use method of the bathing agent comprises the following steps: mixing the bathing agent with water, and bathing.
In the invention, the volume ratio of the bathing agent to water is 1-1.2: 100, preferably 1.1: 100.
In the invention, the number of times of bathing is 1-2 times per day, and the bathing time is 30-40 min, preferably 35 min.
In the embodiment of the present invention, the criteria for determining the therapeutic effect are:
and (3) curing: the symptoms of autism disappear completely;
the effect is shown: the symptoms of autism are obviously relieved;
and (4) invalidation: the symptoms of autism were not significantly improved.
In the embodiment of the present invention, the total efficient calculation method includes: [ cure number + significant number)/total population ]. times.100%.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
Adding 5.4g of wrinkled gianthyssop herb and 0.9g of galangal into 1080ml of water for decoction, and after the water is boiled and timing for 20min, adding 0.3g of saffron, 8.4g of chrysanthemum, 6.6g of mentha haplocalyx, 5.4g of glycyrrhiza uralensis and 6.6g of mulberry leaves for further decoction for 30min to obtain 845ml of the bath lotion of the example 1.
The disease course of the autism is 1-12 months, including 22 sick children of 1 month and 12 months, wherein 16 boys and 6 girls are selected, and the average age is 5.21 years. Before treatment, the manifestations are language disorder and expression preference, which is alone in the corner and the vision is dull. The bathing agent of the embodiment 1 is prepared according to the volume ratio of the bathing agent to water of 1:100, and then the patient is kept to take a bath for 30min every day for 1 time. 4 weeks is 1 course of treatment, and the condition of the infant patient is observed after 3 courses of treatment.
The results show that: in 22 children, no allergy or physical discomfort symptoms appeared. The symptoms of the patients disappear in 2 cases, the disease course of the autism is 6 months and 8 months respectively, and the 2 cases are girls. The communication can be properly made and there are 19 patients interested in some transactions starting, 4 of them and 15 of them. After continuing to adhere to the treatment for 1 course, 9 cases of symptoms disappeared. In the remaining 10 cases, the symptoms completely disappeared after a total of 5 treatment courses and in 4 cases after a total of 6 treatment courses.
After adherence to 3 courses for 1 patient, although there was interest in some transactions, there was no significant improvement. Finally, the treatment of example 1 was discontinued.
By calculation, when the bath agent of the embodiment 1 is used for treating the sick children with the disease course of 1-12 months, the total effective rate after 3 treatment courses is 95.45%, and the cure rate is 9.09%. The cure rate of 6 courses of treatment of children patients with disease duration of 1-12 months by using the bath agent of the embodiment 1 is as follows: 95.45 percent and the inefficiency rate is 4.5 percent.
Example 2
Adding 8.8g of wrinkled gianthyssop herb and 0.4g of galangal into 2640ml of water for decoction, starting to time 30min after the water is boiled, adding 1.2g of saffron, 12.8g of chrysanthemum, 7.2g of wild mint, 8.8g of wild licorice and 8.8g of mulberry leaves, and continuing to decoct for 20min to obtain 2075ml of the bath lotion of the embodiment 2.
20 patients with autism course of 12 months to 5 years are selected, wherein 15 patients have boys and 5 patients have girls, and the average age is 6.71 years. Before treatment, severe autism symptoms were shown, and there was self-disabling behavior in addition to language disorders, in corners alone. After the bathing agent of the present example 2 was prepared in a volume ratio of the bathing agent to water of 1.2:100, the patient was bathed 2 times a day for 40min each time. 4 weeks is 1 course of treatment, and the condition of the infant patient is observed after 3 courses of treatment.
The results show that: after 20 children had used the bath agent of example 2, no symptoms of allergy or physical discomfort appeared in the body. After 20 patients were treated with the bathing agent of example 2, 18 patients with significantly reduced autism symptoms were treated, and 2 patients had no significant improvement in symptoms. The final 2 patients with insignificant improvement of symptoms automatically abandon the treatment of this example 2. And 18 patients continue to be treated, wherein the symptoms of 3 children disappear after 6 treatment courses, the symptoms of 6 patients disappear after 8 treatment courses, the symptoms of autism of 8 patients disappear after 10 treatment courses, and the symptoms of 1 patient disappear after 12 treatment courses.
Through calculation, when the bath lotion of the embodiment 2 is used for treating the sick children with the disease course of 12 months to 5 years, the total effective rate after 3 treatment courses is 90%. The cure rate after 12 treatment courses is 90 percent, and the failure rate is 10 percent.
From the above embodiments, the invention provides a traditional Chinese medicine composition capable of effectively treating autism. After the traditional Chinese medicine composition is prepared into the bath lotion, the pain of oral medicines to children is relieved, and the autism can be effectively treated.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for treating the autism is characterized by comprising the following components in parts by mass: 1-3 parts of saffron, 28-32 parts of chrysanthemum, 18-22 parts of wild mint, 18-22 parts of wild liquorice, 18-22 parts of wrinkled gianthyssop, 18-22 parts of mulberry leaf and 1-3 parts of galangal.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by mass: 1.5-2.5 parts of saffron, 29-31 parts of chrysanthemum, 19-21 parts of wild mint, 19-21 parts of wild liquorice, 19-21 parts of wrinkled gianthyssop, 19-21 parts of mulberry leaf and 1.5-2.5 parts of galangal.
3. The traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following components in parts by mass: 2 parts of saffron, 30 parts of chrysanthemum, 20 parts of wild mint, 20 parts of wild liquorice, 20 parts of wrinkled gianthyssop herb, 20 parts of mulberry leaf and 2 parts of galangal.
4. Use of the Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicament for treating autism.
5. The use according to claim 4, wherein the medicament is a bath preparation.
6. The use according to claim 5, wherein the bathing agent is prepared by a process comprising the steps of: firstly, the agastache rugosus and the galangal are decocted in water for 20-30 min, then the saffron, the chrysanthemum, the wild mint, the wild liquorice and the mulberry leaves are added for further decoction for 20-30 min, and the filtrate is taken to obtain the bath agent.
7. The use according to claim 6, wherein the volume mass ratio of water to agastache rugosus is 200-300 ml: 1g of the total weight of the composition.
8. The use according to any one of claims 5 to 7, wherein the bathing agent is used by a method comprising: mixing the bathing agent with water, and bathing.
9. The use according to claim 8, wherein the volume ratio of the bathing agent to water is 1-1.2: 100.
10. The use of claim 9, wherein the number of bathing is 1-2 times per day, and the bathing time is 30-40 min.
CN202111028081.2A 2021-09-02 2021-09-02 Traditional Chinese medicine composition for treating autism and application thereof Pending CN113633735A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105833003A (en) * 2016-05-18 2016-08-10 孙新永 Traditional Chinese medicine composition for treating autism
CN107789545A (en) * 2017-12-07 2018-03-13 李艳阳 A kind of auxiliary Chinese medicine when being used for paediatrics self-closing disease rehabilitation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105833003A (en) * 2016-05-18 2016-08-10 孙新永 Traditional Chinese medicine composition for treating autism
CN107789545A (en) * 2017-12-07 2018-03-13 李艳阳 A kind of auxiliary Chinese medicine when being used for paediatrics self-closing disease rehabilitation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
南天一尤-481-231转载: "小儿自闭症的食疗", 《新浪微博，HTTP://BLOG.SINA.COM.CN/S/BLOG_64D78A190102VVEC.HTML》 *
张奇文，朱锦善主编: "《实用中医儿科学》", 31 August 2016 *

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