CN113633722A - 一种治疗冠心病、心律失常的中药组合物及其制备方法 - Google Patents
一种治疗冠心病、心律失常的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂技术领域,尤其是一种治疗冠心病、心律失常的中药组合物及其制备方法,解决了现有技术中采用西药治疗冠心病,治标不治本且副作用大的问题,所述治疗冠心病、心律失常的中药组合物,包括以下原料:甘松100‑200份、桂枝100‑150份、西洋参100‑150份、丹参100‑150份、三七100‑150份、山楂100‑150份、天麻100‑150份、瓜蒌壳100‑150份、黄精80‑120份、制首乌40‑80份、葛根80‑120份、辅料20‑40份。本发明对于治疗高血压、冠心病、心肌缺血、常见类型心律失常、不稳定心绞痛、高脂血症、心脑血管动脉硬化有显著疗效。
Description
技术领域
本发明涉及中药制剂技术领域,尤其涉及一种治疗冠心病、心律失常的中药组合物及其制备方法。
背景技术
冠心病是威胁人类生命健康且发病率极高的疾病之一,具体指冠状动脉粥样硬化导致心肌缺血、缺氧而引起的心脏病,属于中医学“厥心痛”、“真心痛”、“胸痹”的范畴。其表现主要是胸部憋闷疼痛,甚则胸痛彻背,气短喘息,不得安卧。病位主要在心,但与肝、脾、肾也有一定联系。中医辨证常见有气滞血淤证、痰浊阻塞证、阴寒凝滞证、气阴两虚证、阳气虚衰证。冠心病为动脉粥样硬化导致器官病变的最常见类型。由于心肌的缺血缺氧, 不但发生心绞痛或心肌梗塞, 还可影响心肌细胞的自律性 、兴奋性和传导性, 从而发生各种心律失常。心律失常是冠心病最严重的并发症和死亡的主要原因 。因此, 积极防治心律失常是治疗冠心病的重要措施。
目前治疗冠心病对采用西药,主要是通过扩张心脏冠状动脉增加心肌供血治疗冠心病,但是心脏的冠状动脉是不能无限扩张的,长期服用西药,冠状动脉就会产生耐药性,所起的作用会越来越小。所以西药虽然见效快,但达不到根治的目的。另一方面西药副作用较大,长期应用会损害身体的其它器官。基于上述陈述,本发明提出了一种治疗冠心病、心律失常的中药组合物及其制备方法。
发明内容
本发明的目的是为了解决现有技术中采用西药治疗冠心病,治标不治本且副作用大的问题,而提出的一种治疗冠心病、心律失常的中药组合物及其制备方法。
一种治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松100-200份、桂枝100-150份、西洋参100-150份、丹参100-150份、三七100-150份、山楂100-150份、天麻100-150份、瓜蒌壳100-150份、黄精80-120份、制首乌40-80份、葛根80-120份、辅料20-40份。
优选的,所述治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松120-180份、桂枝110-140份、西洋参110-140份、丹参110-140份、三七110-140份、山楂110-140份、天麻110-140份、瓜蒌壳110-140份、黄精90-110份、制首乌50-70份、葛根90-110份、辅料25-35份。
优选的,所述治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松150份、桂枝120份、西洋参120份、丹参120份、三七120份、山楂120份、天麻120份、瓜蒌壳120份、黄精100份、制首乌60份、葛根100份、辅料30份。
优选的,所述辅料由质量比为2-5:1:1-3的硬脂酸镁、羟基磷石灰和甘露醇组成。
本发明还提出了一种治疗冠心病、心律失常的中药组合物的制备方法,包括以下步骤:
S1、按重量份计,优选中药材甘松100-200份、桂枝100-150份、西洋参100-150份、丹参100-150份、三七100-150份、山楂100-150份、天麻100-150份、瓜蒌壳100-150份、黄精80-120份、制首乌40-80份、葛根80-120份、辅料20-40份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量5-7倍的去离子水,搅拌分散均匀后,升温煎煮3-5h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理20-40min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
优选的,所述步骤S2中细粉的粒径为0.05-1mm。
优选的,所述步骤S3中煎煮液、乙醇和水的质量比为1-2:3-4:1-5。
本发明提出的一种治疗冠心病、心律失常的中药组合物,具有以下有益效果:
1、本发明采用甘松、桂枝、丹参、天麻、三七、山楂、西洋参、瓜蒌壳、何首乌、黄精、葛根等中药材与辅料压片组成。配方中丹参活血祛淤,养血安神,凉血消肿;天麻平肝降压,息风止痉;田七散淤止血,消肿定痛;山楂消食化积,调脂减肥;西洋参补气养阴,清热生津;瓜蒌壳宽胸散结;何首乌补肝肾,益精血,乌须发,调血脂;甘松芳香开郁,平复焦虑,调节心律;桂枝辛甘化阳,通阳复脉;黄精补脾益气,滋肾填精;葛根扩管降压,改善微循环;上述中药材合用,具有活血祛淤、行气止痛、养血安神、降压调脂等作用。本发明对于治疗高血压、冠心病、心肌缺血、常见类型心律失常、不稳定心绞痛、高脂血症、心脑血管动脉硬化有显著疗效。
2、本发明配方科学、配比严谨,将选用的中药材西洋参、三七、山楂和葛根共同制细粉;将中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同煎煮回收挥发油,微波提取有效药物成分后制药粉,最后将细粉、挥发油和药粉在辅料的作用下混合、压片,制得所需的治疗冠心病、心律失常的中药组合物;本发明制备方法简单,制备条件温和,极大程度的保证了药物有效成分保留率,所得中药组合物药物有效成分吸收利用率高,治疗冠心病效果显著。
本发明药物中所用的原料均采用常见的中草药,药源丰富、易于取得。配方中各味中草药原料的属性及功效如下:
甘松:味辛、甘,性温;归脾、胃经。功效是理气止痛,开郁醒脾,外用祛湿消肿;用于脘腹胀满,食欲不振,呕吐;外用治牙痛,脚气肿毒。
桂枝:味辛、甘,性温;归肺、心、膀胱经。功效是发汗解表、散寒止痛、通阳化气;用于风寒感冒、寒凝血滞诸痛症、痰饮、蓄水证、心悸。
西洋参:味甘微苦,性凉;归心、肺、肾经。中医认为西洋参具有补气养阴,清热生津的功效;用于气虚阴亏,虚热,咳喘痰血,虚热烦倦,消渴,VI燥咽干。 现代医学研究认为西洋参有抗疲劳、抗氧化、抗应激、抑制血小板聚集、降低血液凝固性的作用,另外,对糖尿病患者还有调节血糖的作用。
丹参:味苦微寒;归心、肝经;丹参具有活血祛瘀,通经止痛,清心除烦,凉血消痈之功效;用于胸痹心痛,脘腹胁痛,症瘕积聚,热痹疼痛,心烦不眠,月经不调,痛经经闭,疮疡肿痛。
三七:味苦微甘,性温;归肝、胃经。功效是止血,散瘀,消肿,止痛;主治:治吐血,咳血,衄血(就是鼻子出血),便血,血痢,崩漏,症瘕, 产后血晕,恶露小下,跌扑瘀血,外伤出血,痈肿疼痛等。
山楂:味酸、甘,微温;归脾、胃、肝经。功效是消食健胃,行气散瘀,化浊降脂;用于肉食积滞,胃脘胀满,泻痢腹痛,瘀血经闭,产后瘀阻,心腹刺痛,胸痹心痛,疝气疼痛,高脂血症。焦山楂消食导滞作用增强。用于肉食积滞,泻痢不爽。
天麻:味甘,性平;归肝经。具有息风止痉,平抑肝阳,祛风通络的功效;主治肝风内动,惊痫抽搐,眩晕,头痛,肢体麻木,手足不遂,风湿痹痛等。
瓜蒌壳:味甘,性寒;归肺、胃、大肠经。功效是润肺、化痰、定喘、宽胸理气;用于痰热咳嗽,咽喉肿痛,胸痛,消疮痈肿毒,便秘,凉血出现咳血、鼻子出血、呕血等病症。
黄精:味甘,性平;归脾、肺、肾经。具有补气养阴,健脾,润肺,益肾的功效;用于脾胃气虚,体倦乏力,胃阴不足,口干食少,肺虚燥咳,劳嗽咳血,精血不足,腰膝酸软,须发早白,内热消渴。
制首乌:苦、甘、涩,温;归肝、心、肾经。具有补肝肾,益精血,乌须发,强筋骨功效;用于血虚萎黄,眩晕耳鸣,须发早白,腰膝酸软,肢体麻木,崩漏带下,久疟体虚;高血脂。
葛根:味甘、辛,性凉;归肺、胃经。具有解肌退热,透疹,生津止渴,升阳止泻的功效;用于表证发热,项背强痛,麻疹不透,热病口渴,阴虚消渴,热泻热痢,脾虚泄泻。
具体实施方式
下面结合具体实施例对本发明作进一步解说。
实施例一
本发明提出的一种治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松100份、桂枝100份、西洋参100份、丹参100份、三七100份、山楂100份、天麻100份、瓜蒌壳100份、黄精80份、制首乌40份、葛根80份、辅料20份;其中辅料由质量比为2:1:1的硬脂酸镁、羟基磷石灰和甘露醇组成。
其制备方法,包括以下步骤:
S1、按重量份计,优选中药材甘松100份、桂枝100份、西洋参100份、丹参100份、三七100份、山楂100份、天麻100份、瓜蒌壳100份、黄精80份、制首乌40份、葛根80份、辅料20份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成粒径为0.05mm的细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量5倍的去离子水,搅拌分散均匀后,升温煎煮3h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、按质量比1:3:1,将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理20min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
实施例二
本发明提出的一种治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松110份、桂枝110份、西洋参110份、丹参110份、三七110份、山楂110份、天麻110份、瓜蒌壳110份、黄精90份、制首乌50份、葛根90份、辅料25份;其中辅料由质量比为2.5:1:1.5的硬脂酸镁、羟基磷石灰和甘露醇组成。
其制备方法,包括以下步骤:
S1、按重量份计,优选中药材甘松110份、桂枝110份、西洋参110份、丹参110份、三七110份、山楂110份、天麻110份、瓜蒌壳110份、黄精90份、制首乌50份、葛根90份、辅料25份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成粒径为0.06mm的细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量5.5倍的去离子水,搅拌分散均匀后,升温煎煮3.5h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、按质量比1.2:3:2,将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理25min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
实施例三
本发明提出的一种治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松150份、桂枝120份、西洋参120份、丹参120份、三七120份、山楂120份、天麻120份、瓜蒌壳120份、黄精100份、制首乌60份、葛根100份、辅料30份;其中辅料由质量比为3:1:2的硬脂酸镁、羟基磷石灰和甘露醇组成。
其制备方法,包括以下步骤:
S1、按重量份计,优选中药材甘松150份、桂枝120份、西洋参120份、丹参120份、三七120份、山楂120份、天麻120份、瓜蒌壳120份、黄精100份、制首乌60份、葛根100份、辅料30份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成粒径为0.08mm的细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量6倍的去离子水,搅拌分散均匀后,升温煎煮4h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、按质量比1.5:3.5:3,将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理30min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
实施例四
本发明提出的一种治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松180份、桂枝140份、西洋参140份、丹参140份、三七140份、山楂140份、天麻140份、瓜蒌壳140份、黄精110份、制首乌70份、葛根110份、辅料35份;其中辅料由质量比为4:1:2.5的硬脂酸镁、羟基磷石灰和甘露醇组成。
其制备方法,包括以下步骤:
S1、按重量份计,优选中药材甘松180份、桂枝140份、西洋参140份、丹参140份、三七140份、山楂140份、天麻140份、瓜蒌壳140份、黄精110份、制首乌70份、葛根110份、辅料35份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成粒径为0.8mm的细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量6.5倍的去离子水,搅拌分散均匀后,升温煎煮4.5h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、按质量比1.8:3.8:4,将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理35min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
实施例五
本发明提出的一种治疗冠心病、心律失常的中药组合物,包括以下重量份的原料:甘松200份、桂枝150份、西洋参150份、丹参150份、三七150份、山楂150份、天麻150份、瓜蒌壳150份、黄精120份、制首乌80份、葛根120份、辅料40份;其中辅料由质量比为5:1:3的硬脂酸镁、羟基磷石灰和甘露醇组成。
其制备方法,包括以下步骤:
S1、按重量份计,优选中药材甘松200份、桂枝150份、西洋参150份、丹参150份、三七150份、山楂150份、天麻150份、瓜蒌壳150份、黄精120份、制首乌80份、葛根120份、辅料40份份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成粒径为1mm的细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量7倍的去离子水,搅拌分散均匀后,升温煎煮5h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、按质量比2:4:5,将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理40min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
发明人选取了心内科门诊确诊为冠心病的病人180例,其中男、女各90例,年龄分布在30-70岁之间,病程分布在1-3年。
随机将180例患者分成了治疗组1-5和对照组1,每组30例,治疗组1中患者服用本发明实施例一中制备的中药组合物,以此类推,治疗组2-5中患者分别服用本发明实施例二-五中制备的中药组合物,每日2次,一次1片(60mg);对照组1中患者口服硝苯地平缓释片,每日2次,一次1片(20mg)。两组均4周为1个疗程,比较治疗组1-5和对照组1的临床疗效,结果如下表所示:
表:
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (7)
1.一种治疗冠心病、心律失常的中药组合物,其特征在于,包括以下重量份的原料:甘松100-200份、桂枝100-150份、西洋参100-150份、丹参100-150份、三七100-150份、山楂100-150份、天麻100-150份、瓜蒌壳100-150份、黄精80-120份、制首乌40-80份、葛根80-120份、辅料20-40份。
2.根据权利要求1所述的一种治疗冠心病、心律失常的中药组合物,其特征在于,包括以下重量份的原料:甘松120-180份、桂枝110-140份、西洋参110-140份、丹参110-140份、三七110-140份、山楂110-140份、天麻110-140份、瓜蒌壳110-140份、黄精90-110份、制首乌50-70份、葛根90-110份、辅料25-35份。
3.根据权利要求1或2所述的一种治疗冠心病、心律失常的中药组合物,其特征在于,包括以下重量份的原料:甘松150份、桂枝120份、西洋参120份、丹参120份、三七120份、山楂120份、天麻120份、瓜蒌壳120份、黄精100份、制首乌60份、葛根100份、辅料30份。
4.根据权利要求3所述的一种治疗冠心病、心律失常的中药组合物,其特征在于,所述辅料由质量比为2-5:1:1-3的硬脂酸镁、羟基磷石灰和甘露醇组成。
5.根据权利要求3所述的一种治疗冠心病、心律失常的中药组合物的制备方法,其特征在于,包括以下步骤:
S1、按重量份计,优选中药材甘松100-200份、桂枝100-150份、西洋参100-150份、丹参100-150份、三七100-150份、山楂100-150份、天麻100-150份、瓜蒌壳100-150份、黄精80-120份、制首乌40-80份、葛根80-120份、辅料20-40份,备用;
S2、将步骤S1中准备的中药材西洋参、三七、山楂和葛根共同加入到中药粉碎机中,粉碎成细粉;
S3、将步骤S1中准备的中药材甘松、桂枝、丹参、天麻、瓜蒌壳、黄精和制首乌共同加入到提取罐中,加入罐中中药材总量5-7倍的去离子水,搅拌分散均匀后,升温煎煮3-5h,同时回收挥发油,煎煮完成过滤煎煮液;
S4、将步骤S3中的煎煮液加乙醇和水搅拌混合均匀后,微波处理20-40min,静置离心后喷雾干燥得药粉;
S5、将步骤S2中细粉、步骤S3中挥发油、步骤S4中的药粉和辅料依次加入到制片机中,混合、压片即得治疗冠心病、心律失常的中药组合物。
6.根据权利要求5所述的一种治疗冠心病、心律失常的中药组合物的制备方法,其特征在于,所述步骤S2中细粉的粒径为0.05-1mm。
7.根据权利要求5所述的一种治疗冠心病、心律失常的中药组合物的制备方法,其特征在于,所述步骤S3中煎煮液、乙醇和水的质量比为1-2:3-4:1-5。
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