CN104383270A - 一种用于冠心病的药物 - Google Patents

一种用于冠心病的药物 Download PDF

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CN104383270A
CN104383270A CN201410739321.3A CN201410739321A CN104383270A CN 104383270 A CN104383270 A CN 104383270A CN 201410739321 A CN201410739321 A CN 201410739321A CN 104383270 A CN104383270 A CN 104383270A
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heart diseases
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钱俊丽
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Jinan Shun Jing Pharmaceutical Technology Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding

Abstract

本发明公开了一种用于冠心病的药物，包括以下重量份的原料药：黄精25-30份、三七8-12份、当归15-20份、桑椹15-20份、黄芪10-15份、蒲公英5-10份、丹参5-10份、何首乌1-5份、葛根1-5份、干玛卡5-10份。本发明原料廉价易得，具有健脾补肾、益气补血、通经活络、祛瘀散结的功效，对于冠心病具有很好的治疗作用。

Description

一种用于冠心病的药物
技术领域
本发明涉及一种用于冠心病的药物，属于中药组合物技术领域。
背景技术
冠心病全称为冠状动脉粥样硬化性心脏病(CAD)，是冠状动脉血管发生动脉粥样硬化病变而引起血管腔狭窄或阻塞，造成心肌缺血、缺氧或坏死而导致的心脏病。冠状动脉粥样硬化性心脏病是心血管系统常见病、多发病，心绞痛频繁发作，且病情变化多端，极易导致心肌梗死和猝死，是世界范围内致病率和致死率居首位的复杂性疾病，我国每年死于CAD的人数超过70万，严重影响人类的身体健康和生命安全。研究发现，老年人是冠心病的高危人群，随着我国人口老龄化的加快，CAD发病率有逐年增高的趋势，其将成为危害我国人民健康和增加社会经济负担的主要疾病之一。
发明内容
本发明的目的是提供一种用于冠心病的药物，该药物对冠心病疗效显著。
本发明是通过以下措施实现的：
一种用于冠心病的药物，包括以下重量份的原料药：黄精25-30份、三七8-12份、当归15-20份、桑椹15-20份、黄芪10-15份、蒲公英5-10份、丹参5-10份、何首乌1-5份、葛根1-5份、干玛卡5-10份。
上述药物中，优选包括以下重量份的原料药：黄精28份、三七10份、当归16份、桑椹16份、黄芪12份、蒲公英6份、丹参8份、何首乌3份、葛根3份、干玛卡8份。
中医认为，冠状动脉性心脏病的致病原因是气虚血瘀、肾阳不足、经脉不通，要彻底的治疗冠心病，就必须从根本上消除该病因，本发明提供的组合物具有健脾补肾、益气补血、通经活络、祛瘀散结的功效，能够消除冠状动脉性心脏病的病因，起到很好的治疗作用。各原料药功效如下：
黄精，甘、平，具有补气养阴、健脾、润肺、益肾的功效，用于脾胃虚弱，体倦乏力，口干食少，肺虚燥咳，精血不足，内热消渴。 
三七，具有止血，散瘀，消肿，定痛的功效，用于吐血，咳血，衄血，便血，血痢，崩漏，症瘕，产后血晕，恶露不下，跌扑瘀血，外伤出血，痈肿疼痛。
当归，具有补血活血、调经止痛、润燥滑肠的功效，用于月经不调、症瘕结聚、崩漏、虚寒腹痛、痿痹、肌肤麻木、肠燥便难、赤痢后重、痈疽疮疡、跌扑损伤。
桑椹，甘、酸、寒，具有补血滋阴、生津润燥的功效，用于眩晕耳鸣，心悸失眠，须发早白，津伤口渴，内热消渴，血虚便秘。 
黄芪，甘、温 具有补气固表、利尿托毒、排脓、敛疮生肌的功效，用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴。
蒲公英，具有清热解毒、利尿散结的功效，用于急性乳腺炎、淋巴腺炎、瘰疬、疔毒疮肿、急性结膜炎、感冒发热、急性扁桃体炎、急性支气管炎、胃炎、肝炎、胆囊炎、尿路感染。
丹参，具有祛瘀、生新、活血、调经等效用，主治子宫出血、月经不调、血瘀、腹痛、经痛、经闭。
何首乌，苦、甘、涩、温，具有解毒、消脱、润肠通便的功效，用于瘰疬疮痈，风疹瘙痒，肠燥便秘、高血脂。 
葛根，具有解肌退热，生津，透疹，升阳止泻的功效，用于外感发热头痛、项背强痛，口渴，消渴，麻疹不透，热痢，泄泻，能明显的扩张冠状动脉。 
玛卡（MACA）生长在南美洲秘鲁安第斯山区海拔4000米以上的高原植物，富含高单位营养素，对人体有滋补强身的功用，能促进新陈代谢，抵抗压力和疲劳，并能提升人类及动物的性能力，生育力及乳汁分泌能力，还能消除更年期障碍、减缓老化，增进脑活力、补肾、壮阳。
本发明中药组合物可以将各原料要磨成细粉使用，也可以水煮成汤剂服用，还可以采用水提提取原料药中有效成分，然后浓缩、干燥、加入辅料制成各种剂型使用。本发明中药组合物的使用方法为：每天3次，每次3-5g。
本发明原料廉价易得，具有健脾补肾、益气补血、通经活络、祛瘀散结的功效，对于冠心病具有很好的治疗作用。
具体实施方式
下面通过具体实施例对本发明进行进一步的阐述，下述实施例如无特别说明，原料用量均为重量份。
实施例1
本发明组合物配方为：黄精28份、三七10份、当归16份、桑椹16份、黄芪12份、蒲公英6份、丹参8份、何首乌3份、葛根3份、干玛卡8份。
制备方法为：将上述配方中的各原料药混合均匀，粉碎成100目的细粉，备用。
实施例2
本发明组合物配方为：黄精25份、三七12份、当归15份、桑椹20份、黄芪10份、蒲公英10份、丹参5份、何首乌5份、葛根1份、干玛卡10份。
制备方法同实施例1。
实施例3
本发明组合物配方为：黄精30份、三七8份、当归20份、桑椹15份、黄芪15份、蒲公英5份、丹参10份、何首乌1份、葛根5份、干玛卡5份。
制备方法同实施例1。
实施例4
本发明组合物配方为：黄精30份、三七12份、当归20份、桑椹20份、黄芪15份、蒲公英5份、丹参5份、何首乌1份、葛根1份、干玛卡5份。
制备方法同实施例1。
临床试验
1、病例来源
从本市某大医院中筛选177例具有冠状动脉性心脏病的患者进行试验，其中男性77人，女性100人，高血压患者90人，高血糖患者47人，高血脂患者77人，患者年龄20～65岁，平均年龄48.7岁，病程1～10年，平均病程5.0年。
2、治疗方法
将患者平均分为3组，各组间无统计学差异。各组患者分别服用本发明实施例1、2、3的药物，每天三次，每次5g。
3、疗效判断
显效：心绞痛明显改善，基本无心绞痛或次数明显减少，心电图明显改善或恢复正常；
有效：心绞痛改善，无心绞痛次数减少，心电图改善；
无效：心绞痛基本无改善，心电图无明显改善。
4、治疗结果
各组患者连续服药1个月后，治疗效果如下表1所示：
表1

Claims (2)

1.一种用于冠心病的药物，其特征是包括以下重量份的原料药：黄精25-30份、三七8-12份、当归15-20份、桑椹15-20份、黄芪10-15份、蒲公英5-10份、丹参5-10份、何首乌1-5份、葛根1-5份、干玛卡5-10份。
2.根据权利要求1所述的药物，其特征是包括以下重量份的原料药：黄精28份、三七10份、当归16份、桑椹16份、黄芪12份、蒲公英6份、丹参8份、何首乌3份、葛根3份、干玛卡8份。
CN201410739321.3A 2014-12-08 2014-12-08 一种用于冠心病的药物 Pending CN104383270A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213778A (zh) * 2015-11-09 2016-01-06 谢桂斌 用于治疗冠心病的中药

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KR20030055127A (ko) * 2001-12-24 2003-07-02 주식회사 닥터즈메디코아 항고지혈증 조성물
CN1864738A (zh) * 2005-05-19 2006-11-22 北京燕京中科生物技术有限公司 一种治疗冠心病心绞痛的药物

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KR20030055127A (ko) * 2001-12-24 2003-07-02 주식회사 닥터즈메디코아 항고지혈증 조성물
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213778A (zh) * 2015-11-09 2016-01-06 谢桂斌 用于治疗冠心病的中药

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