CN113633641A - 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 - Google Patents
用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 Download PDFInfo
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- CN113633641A CN113633641A CN202110874748.4A CN202110874748A CN113633641A CN 113633641 A CN113633641 A CN 113633641A CN 202110874748 A CN202110874748 A CN 202110874748A CN 113633641 A CN113633641 A CN 113633641A
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- tetrahydro
- thioxo
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- purin
- pyrimidin
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| CN200880111701A Pending CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
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| CN200880111701A Pending CN101873857A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
| CN201610055826.7A Pending CN105687199A (zh) | 2007-08-23 | 2008-08-22 | 用于治疗亨廷顿舞蹈病和多系统萎缩的mpo抑制剂 |
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| WO2016178113A1 (en) | 2015-05-05 | 2016-11-10 | Pfizer Inc. | 2-thiopyrimidinones |
| MX2019015578A (es) * | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
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| US20240067651A1 (en) * | 2019-10-10 | 2024-02-29 | Biohaven Therapeutics Ltd. | Prodrugs of myeloperoxidase inhibitors |
| WO2021178734A1 (en) * | 2020-03-05 | 2021-09-10 | Biohaven Therapeutics Ltd. | Method of treating amyotrophic lateral sclerosis with myeloperoxidase inhibitor |
| EP4146219A4 (en) * | 2020-05-06 | 2024-05-22 | Biohaven Therapeutics Ltd. | PROCESS FOR PREPARING VERDIPERSTAT |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
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| WO2024163892A1 (en) * | 2023-02-02 | 2024-08-08 | University Of Virginia Patent Foundation | Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah) |
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| WO2006062465A1 (en) * | 2004-12-06 | 2006-06-15 | Astrazeneca Ab | Novel pyrrolo [3, 2-d] pyrimidin-4-one derivatives and their use in therapy |
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