CN113616774A - 一种含植物干细胞的抑菌组合物、养护抑菌液及其制备方法 - Google Patents
一种含植物干细胞的抑菌组合物、养护抑菌液及其制备方法 Download PDFInfo
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- CN113616774A CN113616774A CN202111061387.8A CN202111061387A CN113616774A CN 113616774 A CN113616774 A CN 113616774A CN 202111061387 A CN202111061387 A CN 202111061387A CN 113616774 A CN113616774 A CN 113616774A
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Abstract
本申请涉及医疗卫生领域,具体公开了一种含植物干细胞的抑菌组合物、养护抑菌液及其制备方法,该抑菌组合物由包含以下重量份的原料制得:狄伟草提取物、苦参碱、蒲公英、卡琪花蒂玛、份芦荟、青黛、红花、当归、燕麦提取物、洋甘菊提取物、山茱萸、乙酰基六肽‑8和苹果干细胞冻干粉;养护抑菌液包括所述的抑菌组合物和保湿剂,水补足;养护抑菌液的制备方法包括以下步骤:浸膏制备;基液制备;养护液制备:将浸膏溶解与基液混合,加入狄伟草提取物、保湿剂和乙酰基六肽‑8,得到滤液;取部分水溶解苹果干细胞冻干粉,然后加入滤液中,搅拌,加入剩余水,调pH值,得养护抑菌液。本申请具有提供抑菌效果更好的抑菌产品特点。
Description
技术领域
本申请涉及医疗卫生技术领域,更具体地说,它涉及一种含植物干细胞的抑菌组合物、养护抑菌液及其制备方法。
背景技术
妇科炎症是女性的常见疾病,是由于许多人对妇科疾病缺乏应有的认识,缺乏对身体的保健,加上各种不良生活习惯带来的疾病,最终阴道内部藏匿着众多的毒素和细菌,使阴道内环境失调所导致。常见的妇科炎症有女性外阴炎、阴道炎、宫颈炎等。临床上妇科炎症主要表现为阴道分泌物增多且伴有异味、外阴瘙痒,白带增多,灼热肿痛等症状,给正常生活、工作带来极大的不便。因此养护抑菌液对于预防和缓解妇科炎症具有重要意义。
目前我国针对妇科炎症主要用药包括抗生素、西药和中药几种,抗生素容易产生耐药性,而一旦人体内产生耐药菌株,即使不断增加药品剂量,病情也得不到有效的控制,而且抗生素易破坏阴道菌群平衡,使用后炎症复发率高;而西药主要利用化学成分的杀菌治标,虽然见效快,但是刺激性、依赖性等毒副作用相对较大,因此目前采用中草药在抑菌产品中被广泛应用,如蛇床子、苦参和黄柏等具有清热解毒、止痒功效成分,但是目前的阴道抑菌产品抑菌效果不够理想。
发明内容
为了提供抑菌效果更好地抑菌养护产品,本申请提供一种含植物干细胞的抑菌组合物、养护抑菌液及其制备方法。
第一方面,本申请提供的一种含植物干细胞的抑菌组合物采用如下的技术方案:
一种含植物干细胞的抑菌组合物,由包含以下重量份的原料制得:3-8份狄伟草提取物、0.2-0.5份苦参碱、3-7份蒲公英、3-8份卡琪花蒂玛、3-7份芦荟、3-8份青黛、3-8份红花、3-7份当归、0.5-1.5份燕麦提取物、1-4份洋甘菊提取物、3-8份山茱萸、1-3份乙酰基六肽-8和0.5-1份植物干细胞冻干粉。
通过采用上述技术方案,本申请中苦参碱具有杀菌消炎作用,对于阴道内的真菌感染有不同的抑制作用,还具有清热、利尿、去湿作用,蒲公英具有光谱的抑菌作用,对于革兰阳性菌、革兰阴性菌、真菌抑菌均具有一定的作用,且不产生耐药,具有优异的抑菌作用。
申请人发现抑菌组合物中加入狄伟草提取物和乙酰基六肽-8的时候可以显著提高抑菌组合物的抑菌作用,可能是由于妇科炎症形成是综合性过程,据研究发现妇女在绝经后由于雌激素减少,上皮萎缩,鳞状细胞层消失,只保留了营养不良且绒毛易掉的基底层和副基底层细胞,这种情况下阴道粘膜易受细菌感染和有毒代谢物渗透,而且容易形成小裂伤造成感染。
可能是狄伟草提取物中的狄伟草皂苷分子和人体天然黄体素的分子非常接近,对于人体内部激素具有一定的影响,可以提升身体机能,而乙酰基六肽-8的添加可能会保护表皮粘膜不受细菌侵害,申请人发现将狄伟草提取物与乙酰基六肽-8复配使用可以有效抑制阴道内相关细菌的滋生,得到的抑菌组合物具有更好的抑菌作用。苹果干细胞冻干粉的添加进一步提高抑菌组合物的抑菌作用,最终得到抑菌效果更好的养护抑菌产品,对于妇科炎症的治疗和预防具有更好的效果。
山茱萸和芦荟具有一定的抑菌作用,卡琪花蒂玛性温,可以活血化瘀,调经止痛,减少白带;红花具有活血通经、散淤止痛的作用;当归具有补血活血,调经止痛作用;青黛具有清凉解热、凉血消斑效果,山茱萸补益肝肾,收敛固涩,还具有一定的抑菌作用,芦荟具有一定的消炎止痒止痛的功效。燕麦提取物具有一定的减少皮肤瘙痒、消炎功效。
本申请中上述物质可能是由于当归、红花等物质具有活血通经等作用,再加上狄伟草提取物对于激素的调节,而苦参碱等抑菌物质,还具有杀菌消炎等物质,通过上述多种物质共同作用,具有良好的抑菌效果,而且不仅针对妇科炎症起到杀菌消毒的作用,还可以具有消炎止痒、止痛、减少白带等作用,还可以在阴道粘膜表面形成保护性菌膜门,有效防止微生物在阴道内滋生,促进阴道的自然防御功能维持或恢复,起到标本兼治的功效。而且通过活血调经等物质的作用,从根源上作用降低妇科炎症概率,实现从妇科炎症产生根源条件调节到后期杀菌和修复等多个路径进行作用,从而起到养护抑菌的功效。
可选的,所述抑菌组合物还包括3-8份珍珠粉和1-4份银耳多糖。
通过采用上述技术方案,珍珠粉可以增强免疫力,具有杀菌生肌等功效,银耳多糖可以增强人体细胞免疫和体液免疫作用,而且具有优良的保湿性能,使得皮肤具有良好的滑爽感和湿润感,改善阴道干燥,进一步加强养护抑菌液的养护抑菌功效。
第二方面,本申请提供的一种养护抑菌液采用如下的技术方案:
一种养护抑菌液,包括所述抑菌组合物和6-15份保湿剂,水补足至100份。
通过采用上述技术方案,本申请中制得的养护抑菌液用于阴道清洁和养护,起到优异的抑菌作用,不仅对于阴道炎等妇科炎症具有一定的作用,还对于阴道粘膜上皮细胞层具有一定的修复作用,有助于阴道阴道的自然防御功能维持或恢复,而且还可以作为女性阴道的养护液,起到清洁养护功效,防止细菌滋生,通过妇科炎症产生根源条件调节到后期杀菌和修复等多个路径进行作用,从而起到养护抑菌的功效。
可选的,所述保湿剂选用质量比为1:(0.8-1.2)的甘油和透明质酸钠。
通过采用上述技术方案,保湿剂的添加不仅对于养护抑菌液起到一定的锁水功效,而且还可以改善阴道干燥现象,对于阴道润滑改善具有一定的作用,而且对于人体刺激小,而且甘油具有促乳化作用,可以促进各原料之间的互溶。
可选的,所述养护抑菌液还包括1-2份尼泊金乙酯、6-10份十二烷基硫酸钠和3-5份
吐温-80。
通过采用上述技术方案,尼泊金乙酯的添加对于抑菌防护液起到杀菌防腐作用,而且使用后对于阴道受细菌和真菌感染也起到一定的防护作用,十二烷基硫酸钠作为增溶剂和乳化剂,不仅可以增加原料在水中的溶解以及相互溶解,形成均质液体,而且还可以起到促进渗透作用,吐温-80的添加也可以起到增溶剂和分散剂的作用,有利于原料在水中的分散溶解,有助于形成均质的养护液,本申请中添加十二烷基硫酸钠和吐温-80,促进各个原料在水中的分散溶解,而且还具有优异的抑菌性能,防止吐温-80添加量过多导致养护液抑菌效果降低。
第三方面,本申请提供的一种养护抑菌液的制备方法采用如下的技术方案:
一种养护抑菌液的制备方法,包括以下步骤:
浸膏制备:将蒲公英、红花、芦荟、当归、青黛、山茱萸和卡琪花蒂玛煎煮、浓缩得浸膏;基液制备:乙醇溶解苦参碱,得基液;
养护液制备:将浸膏溶解与基液混合,然后加入狄伟草提取物、洋甘菊提取物、燕麦提取物、保湿剂和乙酰基六肽-8,得到滤液;
取部分水溶解苹果干细胞冻干粉得到干细胞冻干粉水溶液;
将干细胞冻干粉水溶液加入滤液中,搅拌,加入剩余水,调pH值,得养护抑菌液。
通过采用上述技术方案,将抑菌组合物制备为液体,吸收更为迅速,吸收效果更好,起到优异的抑菌效果。
可选的,所述养护抑菌液还包括3-8份珍珠粉和1-4份银耳多糖,珍珠粉于浸膏制备步骤中与蒲公英共同加入;银耳多糖于养护液制备步骤中与狄伟草提取物共同加入。
可选的,所述养护抑菌液还包括1-2份尼泊金乙酯、6-10份十二烷基硫酸钠和3-5份吐温-80;
尼泊金乙酯和吐温-80于基液制备步骤中加入;
十二烷基硫酸钠于养护液制备步骤中加入干细胞冻干粉水溶液加入后加入。
可选的,浸膏制备的具体操作为:将上述原料加水煎煮两次,过滤,除去滤渣,合并两次滤液,然后加热浓缩至60℃下相对密度为1.1-1.2的浸膏;然后向浸膏中加入乙醇,使浸膏中的含醇量达到75%,搅拌,静置23-24h,取上清液回收乙醇至无醇味,得浸膏。
综上所述,本申请具有以下有益效果:
1、本申请中制得的养护抑菌液用于阴道清洁和养护,起到优异的抑菌作用,不仅对于阴道炎等妇科炎症具有一定的作用,还对于阴道粘膜上皮细胞层具有一定的修复作用,有助于阴道阴道的自然防御功能维持或恢复,而且还可以作为女性阴道的养护液,起到清洁养护功效,防止细菌滋生,通过妇科炎症产生根源条件调节到后期杀菌和修复等多个路径进行作用,从而起到养护抑菌的功效;
2、本申请中可能是由于狄伟草提取物对于人体内部激素具有一定作用,提升身体机能,乙酰基六肽-8的添加可能会保护表皮粘膜不受细菌侵害,发现将狄伟草提取物与乙酰基六肽-8复配使用可以有效抑制阴道内相关细菌的滋生,得到的抑菌组合物具有更好的抑菌作用;
3、本申请中珍珠粉可以增强免疫力,具有杀菌生肌等功效,银耳多糖可以增强人体细胞免疫和体液免疫作用,而且具有优良的保湿性能,使得皮肤具有良好的滑爽感和湿润感,改善阴道干燥,进一步加强养护抑菌液的养护抑菌功效;
4、本申请养护抑菌液中保湿剂的添加不仅对于养护抑菌液起到一定的锁水功效,而且还可以改善阴道干燥现象,对于阴道润滑改善具有一定的作用,而且对于人体刺激小;
5、本申请养护抑菌液中甘油、十二烷基硫酸钠和吐温-80的添加可以起到增溶的作用,还起到乳化分散作用,有助于原料之间的互溶以及在水中的溶解分散,最终形成均匀的养护液。
具体实施方式
以下结合实施例对本申请作进一步详细说明,予以特别说明的是:以下实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行,以下实施例中所用原料除特殊说明外均可来源于普通市售。
本申请中的苹果干细胞冻干粉可以采用本领域常规方法制得,也可以是来源于西安泽郎生物科技有限公司的普通市售。
本申请提供的抑菌组合物可以用于养护抑菌液或养护抑菌膏等不同的剂型,本申请实施例中以养护抑菌液剂型为例进行阐述。
实施例
实施例1
一种养护抑菌液的制备方法,包括以下步骤:
浸膏制备:将原料30g蒲公英、30g红花、30g芦荟、30g当归、30g青黛、30g山茱萸和30g卡琪花蒂玛加入上述原料之和8倍量(质量倍数)的水中,煎煮1.5h,过滤,收集滤液;将滤渣加入6倍量(质量倍数)的水中,煎煮1h,过滤,收集滤液;合并两次收集到的滤液,浓缩为60℃下相对密度为1.1的浸膏,然后向浸膏中加入乙醇,使浸膏中的含醇量达到75%,搅拌,静置24h,取上清液回收乙醇至无醇味,得浸膏,备用;
基液制备:将2g苦参碱和10g尼泊金乙酯溶解于6质量倍数的乙醇中,然后添加30g吐温-80,搅拌,得基液;
养护液制备:将浸膏溶解于3质量倍数的水中,然后与基液混合,然后加入30g狄伟草提取物、60g保湿剂和10g乙酰基六肽-8以及10g洋甘菊提取物和5g燕麦提取物,得到滤液,保湿剂包括质量比为1:0.8的透明质酸钠和甘油;
将5g苹果干细胞冻干粉溶解于2质量倍数的水中得到干细胞冻干粉水溶液;
将干细胞冻干粉水溶液加入滤液中,搅拌,然后加入60g十二烷基硫酸钠,搅拌,加水补充至1000g,滴加三乙醇胺调pH值至6.5,搅拌均匀,得养护抑菌液。
实施例2
一种养护抑菌液的制备方法,包括以下步骤:
浸膏制备:将原料50g蒲公英、50g红花、50g芦荟、50g当归、50g青黛、50g山茱萸和50g卡琪花蒂玛加入上述原料之和8倍量(质量倍数)的水中,煎煮1.5h,过滤,收集滤液;将滤渣加入6倍量(质量倍数)的水中,煎煮1h,过滤,收集滤液;合并两次收集到的滤液,浓缩为60℃下相对密度为1.1的浸膏,然后向浸膏中加入乙醇,使浸膏中的含醇量达到75%,搅拌,静置24h,取上清液回收乙醇至无醇味,得浸膏,备用;
基液制备:将3g苦参碱和15g尼泊金乙酯溶解于6质量倍数的乙醇中,添加40g吐温-80,搅拌,得基液;
养护液制备:将浸膏溶解于3质量倍数的水中,然后与基液混合,然后加入50g狄伟草提取物、100g保湿剂和20g乙酰基六肽-8以及20g洋甘菊提取物和10g燕麦提取物,得到滤液,保湿剂包括质量比为1:1的透明质酸钠和甘油;
将8g苹果干细胞冻干粉溶解于2质量倍数的水中得到干细胞冻干粉水溶液;
将得到的干细胞冻干粉水溶液加入滤液中,搅拌,然后加入80g十二烷基硫酸钠,搅拌,加水补充至1000g,滴加三乙醇胺调pH值至7,搅拌均匀,得养护抑菌液。
实施例3
一种养护抑菌液的制备方法,包括以下步骤:
浸膏制备:将原料70g蒲公英、80g红花、70g芦荟、70g当归、80g青黛、80g山茱萸和80g卡琪花蒂玛加入上述原料之和8倍量(质量倍数)的水中,煎煮1.5h,过滤,收集滤液;将滤渣加入6倍量(质量倍数)的水中,煎煮1h,过滤,收集滤液;合并两次收集到的滤液,浓缩为60℃下相对密度为1.1的浸膏,然后向浸膏中加入乙醇,使浸膏中的含醇量达到75%,搅拌,静置24h,取上清液回收乙醇至无醇味,得浸膏,备用;
基液制备:将5g苦参碱和20g尼泊金乙酯溶解于7质量倍数的乙醇中,添加50g吐温-80,搅拌,得基液;
养护液制备:将浸膏溶解于4质量倍数的水中,然后与得到的基液混合,然后加入80g狄伟草提取物、120g保湿剂和30g乙酰基六肽-8以及40g洋甘菊提取物和15g燕麦提取物,得到滤液,保湿剂包括质量比为1:1.2的透明质酸钠和甘油;
将10g苹果干细胞冻干粉溶解于3质量倍数的水中得到干细胞冻干粉水溶液;
将干细胞冻干粉水溶液加入滤液中,搅拌,然后加入100g十二烷基硫酸钠,搅拌,加水补充至1000g,滴加三乙醇胺调pH值至7,搅拌均匀,得养护抑菌液。
实施例4
一种养护抑菌液的制备方法,按照实施例5中的方法进行,不同之处在于:浸膏制备步骤中,加入蒲公英的同时,还添加有30g珍珠粉,第一次煎煮时添加的水为上述添加原料之和的8倍量,第二次煎煮时添加的水为上述添加原料之和的6倍量;其余步骤与实施例2中相同;养护液制备步骤中,加入狄伟草提取物的同时还添加有10g银耳多糖。
实施例5
一种养护抑菌液的制备方法,按照实施例5中的方法进行,不同之处在于:浸膏制备步骤中,加入蒲公英的同时,还添加有50g珍珠粉,第一次煎煮时添加的水为上述添加原料之和的8倍量,第二次煎煮时添加的水为上述添加原料之和的6倍量;其余步骤与实施例2中相同;养护液制备步骤中,加入狄伟草提取物的同时还添加有20g银耳多糖。
实施例6
一种养护抑菌液的制备方法,按照实施例5中的方法进行,不同之处在于:浸膏制备步骤中,加入蒲公英的同时,还添加有80g珍珠粉,第一次煎煮时添加的水为上述添加原料之和的8倍量,第二次煎煮时添加的水为上述添加原料之和的6倍量;其余步骤与实施例2中相同;养护液制备步骤中,加入狄伟草提取物的同时还添加有40g银耳多糖。
实施例7
一种养护抑菌液的制备方法,按照实施例5中的方法进行,不同之处在于,吐温-80等量替换十二烷基硫酸钠。
对比例
对比例1
一种养护抑菌液的制备方法,按照实施例2中的方法进行,不同之处在于:养护液制备步骤中,未添加乙酰基六肽-8和狄伟草提取物。
对比例2
一种养护抑菌液的制备方法,按照实施例2中的方法进行,不同之处在于:养护液制备步骤中,乙酰基六肽-8等量替换狄伟草提取物。
对比例3
一种养护抑菌液的制备方法,按照实施例2中的方法进行,不同之处在于:养护液制备步骤中,狄伟草提取物等量替换乙酰基六肽-8。
对比例4
一种养护抑菌液的制备方法,按照实施例2中的方法进行,不同之处在于:养护液制备步骤中,未添加苹果干细胞冻干粉。
对比例5
一种养护抑菌液的制备方法,按照实施例2中的方法进行,不同之处在于:养护液制备步骤中,乙酰基六肽-8和狄伟草提取物等量替换苹果干细胞冻干粉,且乙酰基六肽-8和狄伟草提取物的质量比为1:2.5。
对比例6
一种养护抑菌液的制备方法,按照实施例2中的方法进行,不同之处在于,浸膏制备步骤中,未添加青黛、山茱萸和卡琪花蒂玛。
本申请提供的养护抑菌液使用方法为:使用前清洗双手及外阴,取本品一支平躺后借助辅助器将液体吸收后推入阴部,静趟片刻。
性能检测
1、抑菌试验测试
以本申请实施例中制得的养护抑菌液作为试验样品,采用本申请对比例中制得的养护抑菌液作为对照样品,参照GB15979-2002《一次性使用卫生用品卫生标准》C4部分,分别检测对大肠杆菌、金黄色葡萄球菌和白色念珠菌的平均抑菌率,其中作用5min和20min时的抑菌率检测结果记录如下表1和表2所示,表1为实施例的检测结果,表2为对比例检测结果。
表1实施例检测结果
由上表1中检测结果可以看出,本申请中制得的养护抑菌液具有优良的抑菌性能。
表2:对比例检测结果
结合上表1和表2中的检测结果,可以看出,对比例1中未添加乙酰基六肽-8和狄伟草提取物时,制得的养护抑菌液的抑菌性能远低于实施例2中的检测结果;再结合对比例2和对比例3的检测结果,可以看出,养护液中仅添加有乙酰基六肽-8或狄伟草提取物的时候,其抑菌性能较差,实施例2中同时添加有乙酰基六肽-8和狄伟草提取物的时候,显著提升其抑菌性能;再参照对比例4和对比例5的检测结果,可以看出,养护液中未添加有苹果干细胞冻干粉的时候,其抑菌性能稍有所降低。
2、阴道粘膜刺激试验
依据卫生部2002年版《消毒技术规范》中的方法进行阴道粘膜刺激试验,试验动物为由西安交通大学医学院实验动物中心提供日本大耳白家兔,雌性,体重2.0-2.5kg,受试物剂量为2g/只,试验方法为:试验时动物仰卧固定,受试物组经阴道注入受试物2g/只,对照组给予同容积生理盐水,动物仰卧固定4小时,使受试物与阴道粘膜充分接触。试验结束后动物放回笼内饲养,24小时后处死动物取出阴道组织,肉眼仔细观察粘膜变性、分泌物、血管充血、水肿等现象,以注入生理盐水动物的粘膜变性、分泌物、血管充血、水肿状况计0分,其余动物与注入生理盐水动物做对比打分,分值0-5分,分值越大表示受损越严重。试验结果如下表3所示。
表3阴道粘膜刺激试验
由上表3可以看出,本申请实施例中制得的养护抑菌液对于阴道粘膜均没有刺激性,对比例2中乙酰基六肽-8等量替换狄伟草提取物的时候,会有轻微刺激性,而对比例5中将苹果干细胞冻干粉等量替换为狄伟草提取物与乙酰基六肽-8的时候,也具有轻微刺激性,可以看出,可能是由于在对比例2和对比例5中乙酰基六肽-8添加量过多,或者是狄伟草提取物可以降低刺激性,本申请实施例中添加乙酰基六肽-8和狄伟草提取物的时候对于阴道粘膜没有刺激性。
本具体实施例仅仅是对本申请的解释,其并不是对本申请的限制,本领域技术人员在阅读完本说明书后可以根据需要对本实施例做出没有创造性贡献的修改,但只要在本申请的权利要求范围内都受到专利法的保护。
Claims (10)
1.一种含植物干细胞的抑菌组合物,其特征在于,由包含以下重量份的原料制得:3-8份狄伟草提取物、0.2-0.5份苦参碱、3-7份蒲公英、3-8份卡琪花蒂玛、3-7份芦荟、3-8份青黛、3-8份红花、3-7份当归、0.5-1.5份燕麦提取物、1-4份洋甘菊提取物、3-8份山茱萸、1-3份乙酰基六肽-8和0.5-1份植物干细胞冻干粉,所述植物干细胞冻干粉为苹果干细胞冻干粉。
2.根据权利要求1所述的一种含植物干细胞的抑菌组合物,其特征在于:所述抑菌组合物还包括3-8份珍珠粉和1-4份银耳多糖。
3.一种养护抑菌液,其特征在于:以重量份数计,包括如权利要求1中所述的抑菌组合物和6-12份保湿剂,水补足至100份。
4.根据权利要求3所述的一种养护抑菌液,所述保湿剂选用质量比为1:(0.8-1.2)的甘油和透明质酸钠。
5.根据权利要求3所述的一种养护抑菌液,其特征在于:所述抑菌组合物还包括3-8份珍珠粉和1-4份银耳多糖。
6.根据权利要求3所述的一种养护抑菌液,其特征在于:所述养护抑菌液还包括1-2份尼泊金乙酯、6-10份十二烷基硫酸钠和3-5份吐温-80。
7.一种如权利要求3中所述的养护抑菌液的制备方法,其特征在于:包括以下步骤:
浸膏制备:将蒲公英、红花、芦荟、当归、青黛、山茱萸和卡琪花蒂玛煎煮、浓缩得浸膏;
基液制备:乙醇溶解苦参碱,得基液;
养护液制备:将浸膏溶解与基液混合,然后加入狄伟草提取物、洋甘菊提取物、燕麦提取物、保湿剂和乙酰基六肽-8,得到滤液;
取部分水溶解苹果干细胞冻干粉得到干细胞冻干粉水溶液;
将干细胞冻干粉水溶液加入滤液中,搅拌,加入剩余水,调pH值,得养护抑菌液。
8.根据权利要求7所述的一种养护抑菌液的制备方法,其特征在于:
所述养护抑菌液还包括3-8份珍珠粉和1-4份银耳多糖,珍珠粉于浸膏制备步骤中与蒲公英共同加入;银耳多糖于养护液制备步骤中与狄伟草提取物共同加入。
9.根据权利要求7或8所述的一种养护抑菌液的制备方法,其特征在于:所述养护抑菌液还包括1-2份尼泊金乙酯、6-10份十二烷基硫酸钠和3-5份吐温-80;
尼泊金乙酯和吐温-80于基液制备步骤中加入;
十二烷基硫酸钠于养护液制备步骤中加入干细胞冻干粉水溶液加入后加入。
10.根据权利要求7所述的一种养护抑菌液的制备方法,其特征在于:浸膏制备的具体操作为:将上述原料加水煎煮两次,过滤,除去滤渣,合并两次滤液,然后加热浓缩至60℃下相对密度为1 .1-1 .2的浸膏;然后向浸膏中加入乙醇,使浸膏中的含醇量达到75%,搅拌,静置23-24h,取上清液回收乙醇至无醇味,得浸膏。
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