CN113559027A - Toothpaste containing honeysuckle extract and preparation method thereof - Google Patents

Toothpaste containing honeysuckle extract and preparation method thereof Download PDF

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Publication number
CN113559027A
CN113559027A CN202110819594.9A CN202110819594A CN113559027A CN 113559027 A CN113559027 A CN 113559027A CN 202110819594 A CN202110819594 A CN 202110819594A CN 113559027 A CN113559027 A CN 113559027A
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parts
extract
honeysuckle extract
paste
lauryl sulfate
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高双
黄瑞
张佳佳
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention belongs to the field of toothpaste, in particular to a toothpaste containing honeysuckle extract and a preparation method thereof, aiming at the problem of poor antibacterial and anti-inflammatory effects of the existing toothpaste, the invention provides the following scheme, which comprises the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 1-5 parts of sodium carboxymethylcellulose, 5-10 parts of sodium lauryl sulfate, 1-5 parts of calcium hydrophosphate, 5-10 parts of honeysuckle extract, 1-5 parts of fructus forsythiae, 0.1-0.5 part of folium isatidis, 0.5-1 part of radix isatidis, 1-3 parts of dandelion, 2-4 parts of coptis chinensis, 1-5 parts of andrographis paniculata and 0.5-1 part of houttuynia cordata, and the preparation method comprises the following steps: s1, adding calcium carbonate, sodium carboxymethylcellulose, sodium lauryl sulfate and calcium hydrogen phosphate into the paste making pot, and mixing uniformly for 10 min.

Description

Toothpaste containing honeysuckle extract and preparation method thereof
Technical Field
The invention relates to the field of toothpaste, in particular to toothpaste containing honeysuckle extract and a preparation method thereof.
Background
Toothpaste is one of tooth cleaning products, generally in a gel shape, and is usually applied to a toothbrush, and the mechanical friction of the toothbrush is used for cleaning the surfaces of teeth, cleaning the teeth and the periphery of the teeth and purifying and refreshing the oral cavity. Tooth cleaning is of utmost importance for tooth aesthetics, protection of gum health and prevention of bad breath. Toothpaste has become a necessity in human daily life.
The existing toothpaste has poor antibacterial and anti-inflammatory effects, so that a toothpaste containing honeysuckle extract and a preparation method thereof are provided for solving the problems.
Disclosure of Invention
The invention aims to solve the defect of poor antibacterial and anti-inflammatory effects of toothpaste in the prior art, and provides a toothpaste containing honeysuckle extract and a preparation method thereof.
The invention provides a toothpaste containing honeysuckle extract, which comprises the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 1-5 parts of sodium carboxymethylcellulose, 5-10 parts of sodium lauryl sulfate, 1-5 parts of calcium hydrophosphate, 5-10 parts of honeysuckle extract, 1-5 parts of fructus forsythiae, 0.1-0.5 part of folium isatidis, 0.5-1 part of radix isatidis, 1-3 parts of dandelion, 2-4 parts of coptis chinensis, 1-5 parts of andrographis paniculata, 0.5-1 part of houttuynia cordata, 0.1-0.5 part of azone, 0.1-0.5 part of menthol, 0.5-1 part of liquorice, 0.5-1 part of clove, 0.5-1 part of ligusticum wallichii extract and 0.5-1 part of angelica sinensis.
Preferably, the feed comprises the following raw materials in parts by weight: 32-38 parts of calcium carbonate, 2-4 parts of sodium carboxymethylcellulose, 6-9 parts of sodium lauryl sulfate, 2-4 parts of calcium hydrophosphate, 6-9 parts of honeysuckle extract, 2-4 parts of fructus forsythiae, 0.2-0.4 part of folium isatidis, 0.6-0.9 part of radix isatidis, 1.5-2.5 parts of dandelion, 2.5-3.5 parts of coptis chinensis, 2-4 parts of andrographis paniculata, 0.6-0.9 part of houttuynia cordata, 0.2-0.4 part of azone, 0.2-0.4 part of menthol, 0.6-0.9 part of liquorice, 0.6-0.9 part of clove, 0.6-0.9 part of ligusticum wallichii extract and 0.6-0.9 part of angelica sinensis.
Preferably, the feed comprises the following raw materials in parts by weight: 35 parts of calcium carbonate, 3 parts of sodium carboxymethylcellulose, 7 parts of sodium lauryl sulfate, 3 parts of calcium hydrophosphate, 7 parts of honeysuckle extract, 3 parts of fructus forsythiae, 0.3 part of folium isatidis, 0.7 part of radix isatidis, 2 parts of dandelion, 3 parts of coptis chinensis, 3 parts of andrographis paniculata, 0.7 part of houttuynia cordata, 0.3 part of azone, 0.3 part of menthol, 0.7 part of liquorice, 0.7 part of clove, 0.7 part of ligusticum wallichii extract and 0.7 part of angelica sinensis.
The invention also provides a preparation method of the toothpaste containing the honeysuckle extract, which comprises the following steps:
s1, adding calcium carbonate, sodium carboxymethyl cellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing;
s2, preparing fructus forsythiae, folium isatidis, radix isatidis, dandelion, coptis chinensis, andrographis paniculata and houttuynia cordata into powder, and uniformly mixing the powder with the honeysuckle extract to obtain the antibacterial and anti-inflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, and inspecting to obtain the toothpaste containing the honeysuckle extract.
Preferably, in the S4, during the kneading and grinding processes, vacuum pumping is performed until the vacuum degree reaches-0.096 MPa, and the time is 50 minutes.
Preferably, in S4, after the paste is qualified, the paste is put into a storage pot for aging, and the paste is naturally cooled to normal temperature, where the aging time is 120 minutes.
Preferably, in the step S1, calcium carbonate, sodium carboxymethyl cellulose, sodium lauryl sulfate, and calcium hydrogen phosphate are added into a paste making pot, and are uniformly mixed for 10-15 min.
Preferably, in S2, the antibacterial and anti-inflammatory agent is prepared by making fructus forsythiae, folium isatidis, radix isatidis, dandelion, coptis chinensis, andrographis paniculata and houttuynia cordata into powder, and mixing the powder with the honeysuckle extract uniformly for 30-35 min.
Licorice root: glycyrrhizin, sodium glycyrrhetinate, dipotassium glycyrrhetinate and disodium glycyrrhetinate succinate separated from Glycyrrhrizae radix have effect of promoting absorption of medicine mucosa
The invention has the beneficial effects that:
the honeysuckle extract is used as the raw material, has the functions of resisting bacteria and enhancing the immunologic function, and the forsythia is used as the raw material, has the functions of resisting microorganisms, inhibiting phosphodiesterase and lipoxygenase, stopping vomiting, resisting liver injury, resisting inflammation, inhibiting the activity of elastase and reducing spontaneous hypertension;
the indigowoad leaf is taken as a raw material, so that the indigowoad leaf can clear away heat and toxic materials, cool blood and clear away speckles, and the indigowoad root has the effects of resisting bacteria, viruses, endotoxin, cancers, immunity enhancement and the like; herba Taraxaci has heat and toxic materials clearing away and antibacterial effects, Coptidis rhizoma has heat and toxic materials clearing away, dampness eliminating, pathogenic fire purging and toxic materials removing effects, herba Andrographitis has heat and toxic materials clearing away, blood cooling and detumescence effects, and herba Houttuyniae has antibacterial, antiviral and immunity enhancing effects;
the azone has the function of promoting the absorption of the medicine, the menthol can stimulate mucous membrane and promote the absorption, the liquorice has the function of promoting the absorption of the medicine mucous membrane, and the ligusticum wallichii extract, the clove and the angelica have the function of promoting the absorption, can promote the absorption of the antibacterial and anti-inflammatory medicine of a human body and improve the antibacterial and anti-inflammatory effects;
the invention can promote the absorption of the antibacterial and anti-inflammatory medicine by human body and improve the antibacterial and anti-inflammatory effect.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example one
The invention provides a toothpaste containing honeysuckle extract, which comprises the following raw materials in parts by weight: 30 parts of calcium carbonate, 1 part of sodium carboxymethylcellulose, 5 parts of sodium lauryl sulfate, 1 part of calcium hydrophosphate, 5 parts of honeysuckle extract, 1 part of fructus forsythiae, 0.1 part of folium isatidis, 0.5 part of radix isatidis, 1 part of dandelion, 2 parts of coptis chinensis, 1 part of andrographis paniculata, 0.5 part of houttuynia cordata, 0.1 part of azone, 0.1 part of menthol, 0.5 part of liquorice, 0.5 part of clove, 0.5 part of ligusticum wallichii extract and 0.5 part of angelica;
the preparation method comprises the following steps:
s1, adding calcium carbonate, sodium carboxymethylcellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing for 10 min;
s2, preparing fructus forsythiae, folium Isatidis, radix Isatidis, herba Taraxaci, Coptidis rhizoma, herba Andrographitis, and herba Houttuyniae into powder, mixing with flos Lonicerae extract uniformly for 30min to obtain antibacterial and antiinflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, vacuumizing until the vacuum degree reaches-0.096 Mpa in the kneading and grinding processes, and aging in a storage pot for 120 minutes after the paste is qualified.
Example two
The invention provides a toothpaste containing honeysuckle extract, which comprises the following raw materials in parts by weight: 32 parts of calcium carbonate, 2 parts of sodium carboxymethylcellulose, 6 parts of sodium lauryl sulfate, 2 parts of calcium hydrophosphate, 6 parts of honeysuckle extract, 2 parts of fructus forsythiae, 0.2 part of folium isatidis, 0.6 part of radix isatidis, 1.5 parts of dandelion, 2.5 parts of coptis chinensis, 2 parts of andrographis paniculata, 0.6 part of houttuynia cordata, 0.2 part of azone, 0.2 part of menthol, 0.6 part of liquorice, 0.6 part of clove, 0.6 part of ligusticum wallichii extract and 0.6 part of angelica;
the preparation method comprises the following steps:
s1, adding calcium carbonate, sodium carboxymethylcellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing for 11 min;
s2, preparing fructus forsythiae, folium Isatidis, radix Isatidis, herba Taraxaci, Coptidis rhizoma, herba Andrographitis, and herba Houttuyniae into powder, mixing with flos Lonicerae extract uniformly for 31min to obtain antibacterial and antiinflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, vacuumizing until the vacuum degree reaches-0.096 Mpa in the kneading and grinding processes, and aging in a storage pot for 120 minutes after the paste is qualified.
EXAMPLE III
The invention provides a toothpaste containing honeysuckle extract, which comprises the following raw materials in parts by weight: 34 parts of calcium carbonate, 3 parts of sodium carboxymethylcellulose, 7 parts of sodium lauryl sulfate, 3 parts of calcium hydrophosphate, 7 parts of honeysuckle extract, 3 parts of fructus forsythiae, 0.3 part of folium isatidis, 0.7 part of radix isatidis, 2 parts of dandelion, 3 parts of coptis chinensis, 3 parts of andrographis paniculata, 0.7 part of houttuynia cordata, 0.3 part of azone, 0.3 part of menthol, 0.7 part of liquorice, 0.7 part of clove, 0.7 part of ligusticum wallichii extract and 0.7 part of angelica;
the preparation method comprises the following steps:
s1, adding calcium carbonate, sodium carboxymethylcellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing for 12 min;
s2, preparing fructus forsythiae, folium Isatidis, radix Isatidis, herba Taraxaci, Coptidis rhizoma, herba Andrographitis, and herba Houttuyniae into powder, mixing with flos Lonicerae extract uniformly for 32min to obtain antibacterial and antiinflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, vacuumizing until the vacuum degree reaches-0.096 Mpa in the kneading and grinding processes, and aging in a storage pot for 120 minutes after the paste is qualified.
Example four
The invention provides a toothpaste containing honeysuckle extract, which comprises the following raw materials in parts by weight: 38 parts of calcium carbonate, 4 parts of sodium carboxymethylcellulose, 9 parts of sodium lauryl sulfate, 4 parts of calcium hydrophosphate, 9 parts of honeysuckle extract, 4 parts of fructus forsythiae, 0.4 part of folium isatidis, 0.9 part of radix isatidis, 2.5 parts of dandelion, 3.5 parts of coptis chinensis, 4 parts of andrographis paniculata, 0.9 part of houttuynia cordata, 0.4 part of azone, 0.4 part of menthol, 0.9 part of liquorice, 0.9 part of clove, 0.9 part of ligusticum wallichii extract and 0.9 part of angelica;
the preparation method comprises the following steps:
s1, adding calcium carbonate, sodium carboxymethylcellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing for 14 min;
s2, preparing fructus forsythiae, folium Isatidis, radix Isatidis, herba Taraxaci, Coptidis rhizoma, herba Andrographitis, and herba Houttuyniae into powder, mixing with flos Lonicerae extract uniformly for 34min to obtain antibacterial and antiinflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, vacuumizing until the vacuum degree reaches-0.096 Mpa in the kneading and grinding processes, and aging in a storage pot for 120 minutes after the paste is qualified.
EXAMPLE five
The invention provides a toothpaste containing honeysuckle extract, which comprises the following raw materials in parts by weight: 40 parts of calcium carbonate, 5 parts of sodium carboxymethylcellulose, 10 parts of sodium lauryl sulfate, 5 parts of calcium hydrophosphate, 10 parts of honeysuckle extract, 5 parts of fructus forsythiae, 0.5 part of folium isatidis, 1 part of radix isatidis, 3 parts of dandelion, 4 parts of coptis chinensis, 5 parts of andrographis paniculata, 1 part of houttuynia cordata, 0.5 part of azone, 0.5 part of menthol, 1 part of liquorice, 1 part of clove, 1 part of ligusticum wallichii extract and 1 part of angelica sinensis-1;
the preparation method comprises the following steps:
s1, adding calcium carbonate, sodium carboxymethylcellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing for 15 min;
s2, preparing fructus forsythiae, folium Isatidis, radix Isatidis, herba Taraxaci, Coptidis rhizoma, herba Andrographitis, and herba Houttuyniae into powder, mixing with flos Lonicerae extract for 35min to obtain antibacterial and antiinflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, vacuumizing until the vacuum degree reaches-0.096 Mpa in the kneading and grinding processes, and aging in a storage pot for 120 minutes after the paste is qualified.
Comparative example 1
The difference from the first embodiment is that: the feed comprises the following raw materials in parts by weight: 30 parts of calcium carbonate, 1 part of sodium carboxymethylcellulose, 5 parts of sodium lauryl sulfate, 1 part of calcium hydrophosphate, 5 parts of honeysuckle extract, 1 part of fructus forsythiae, 0.1 part of folium isatidis, 0.5 part of radix isatidis, 1 part of dandelion, 2 parts of coptis chinensis, 1 part of andrographis paniculata, 0.5 part of houttuynia cordata, 0.1 part of azone, 0.1 part of menthol and 0.5 part of liquorice; s3, mixing azone, Mentholum, and radix Glycyrrhizae uniformly to obtain the absorption promoting material.
Comparative example No. two
The difference from the first embodiment is that: the feed comprises the following raw materials in parts by weight: 30 parts of calcium carbonate, 1 part of sodium carboxymethylcellulose, 5 parts of sodium lauryl sulfate, 1 part of calcium hydrophosphate, 5 parts of honeysuckle extract, 1 part of fructus forsythiae, 0.1 part of folium isatidis, 0.5 part of radix isatidis, 1 part of dandelion, 2 parts of coptis chinensis, 1 part of andrographis paniculata, 0.5 part of houttuynia cordata, 0.5 part of liquorice, 0.5 part of clove, 0.5 part of ligusticum wallichii extract and 0.5 part of angelica sinensis, and S3.
The antibacterial and anti-inflammatory effects of the ointments prepared in the first to fifth examples and the first and second comparative examples are improved in percentage as follows:
example one Example two EXAMPLE III Example four EXAMPLE five Comparative example 1 Comparative example No. two
90.25％ 91.37％ 91.76％ 91.45％ 91.83％ 85.15％ 84.23％
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (8)

1. The toothpaste containing the honeysuckle extract is characterized by comprising the following raw materials in parts by weight: 30-40 parts of calcium carbonate, 1-5 parts of sodium carboxymethylcellulose, 5-10 parts of sodium lauryl sulfate, 1-5 parts of calcium hydrophosphate, 5-10 parts of honeysuckle extract, 1-5 parts of fructus forsythiae, 0.1-0.5 part of folium isatidis, 0.5-1 part of radix isatidis, 1-3 parts of dandelion, 2-4 parts of coptis chinensis, 1-5 parts of andrographis paniculata, 0.5-1 part of houttuynia cordata, 0.1-0.5 part of azone, 0.1-0.5 part of menthol, 0.5-1 part of liquorice, 0.5-1 part of clove, 0.5-1 part of ligusticum wallichii extract and 0.5-1 part of angelica sinensis.
2. The toothpaste containing the honeysuckle extract as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 32-38 parts of calcium carbonate, 2-4 parts of sodium carboxymethylcellulose, 6-9 parts of sodium lauryl sulfate, 2-4 parts of calcium hydrophosphate, 6-9 parts of honeysuckle extract, 2-4 parts of fructus forsythiae, 0.2-0.4 part of folium isatidis, 0.6-0.9 part of radix isatidis, 1.5-2.5 parts of dandelion, 2.5-3.5 parts of coptis chinensis, 2-4 parts of andrographis paniculata, 0.6-0.9 part of houttuynia cordata, 0.2-0.4 part of azone, 0.2-0.4 part of menthol, 0.6-0.9 part of liquorice, 0.6-0.9 part of clove, 0.6-0.9 part of ligusticum wallichii extract and 0.6-0.9 part of angelica sinensis.
3. The toothpaste containing the honeysuckle extract as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight: 35 parts of calcium carbonate, 3 parts of sodium carboxymethylcellulose, 7 parts of sodium lauryl sulfate, 3 parts of calcium hydrophosphate, 7 parts of honeysuckle extract, 3 parts of fructus forsythiae, 0.3 part of folium isatidis, 0.7 part of radix isatidis, 2 parts of dandelion, 3 parts of coptis chinensis, 3 parts of andrographis paniculata, 0.7 part of houttuynia cordata, 0.3 part of azone, 0.3 part of menthol, 0.7 part of liquorice, 0.7 part of clove, 0.7 part of ligusticum wallichii extract and 0.7 part of angelica sinensis.
4. The preparation method of the toothpaste containing the honeysuckle extract is characterized by comprising the following steps:
s1, adding calcium carbonate, sodium carboxymethyl cellulose, sodium lauryl sulfate and calcium hydrophosphate into a paste making pot, and uniformly mixing;
s2, preparing fructus forsythiae, folium isatidis, radix isatidis, dandelion, coptis chinensis, andrographis paniculata and houttuynia cordata into powder, and uniformly mixing the powder with the honeysuckle extract to obtain the antibacterial and anti-inflammatory material;
s3, mixing azone, Mentholum, radix Glycyrrhizae, flos Caryophylli, rhizoma Chuanxiong extract, and radix Angelicae sinensis to obtain absorption promoting material;
s4, adding the antibacterial and anti-inflammatory material and the absorption promoting material into a paste making pot, stirring, homogenizing, stirring, kneading, grinding to obtain paste, and inspecting to obtain the toothpaste containing the honeysuckle extract.
5. The method of claim 4, wherein the step of S4, during the kneading and grinding process, is performed by vacuum pumping until the vacuum reaches-0.096 MPa for 50 min.
6. The method of claim 4, wherein in step S4, after the paste is qualified, the paste is put into a storage pot for aging, and the paste is naturally cooled to normal temperature for 120 minutes.
7. The method for preparing toothpaste containing honeysuckle extract according to claim 4, wherein in S1, calcium carbonate, sodium carboxymethyl cellulose, sodium lauryl sulfate and calcium hydrogen phosphate are added into a paste making pot and mixed uniformly for 10-15 min.
8. The method of claim 4, wherein in S2, the antibacterial and anti-inflammatory agent is prepared by pulverizing fructus forsythiae, folium Isatidis, radix Isatidis, herba Taraxaci, Coptidis rhizoma, herba Andrographitis, and herba Houttuyniae into powder, and mixing with the flos Lonicerae extract for 30-35 min.
CN202110819594.9A 2021-07-20 2021-07-20 Toothpaste containing honeysuckle extract and preparation method thereof Pending CN113559027A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115068534A (en) * 2022-06-10 2022-09-20 赵蔚萍 Oral traditional Chinese medicine preparation for treating acute periodontitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115068534A (en) * 2022-06-10 2022-09-20 赵蔚萍 Oral traditional Chinese medicine preparation for treating acute periodontitis

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