CN113546815A - Film coating equipment for producing high-efficiency implantable biosensor - Google Patents
Film coating equipment for producing high-efficiency implantable biosensor Download PDFInfo
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- CN113546815A CN113546815A CN202110935163.9A CN202110935163A CN113546815A CN 113546815 A CN113546815 A CN 113546815A CN 202110935163 A CN202110935163 A CN 202110935163A CN 113546815 A CN113546815 A CN 113546815A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C9/00—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important
- B05C9/08—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important for applying liquid or other fluent material and performing an auxiliary operation
- B05C9/12—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important for applying liquid or other fluent material and performing an auxiliary operation the auxiliary operation being performed after the application
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
- B05B15/50—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter
- B05B15/55—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter using cleaning fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C11/00—Component parts, details or accessories not specifically provided for in groups B05C1/00 - B05C9/00
- B05C11/10—Storage, supply or control of liquid or other fluent material; Recovery of excess liquid or other fluent material
- B05C11/1002—Means for controlling supply, i.e. flow or pressure, of liquid or other fluent material to the applying apparatus, e.g. valves
- B05C11/1015—Means for controlling supply, i.e. flow or pressure, of liquid or other fluent material to the applying apparatus, e.g. valves responsive to a conditions of ambient medium or target, e.g. humidity, temperature ; responsive to position or movement of the coating head relative to the target
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C13/00—Means for manipulating or holding work, e.g. for separate articles
- B05C13/02—Means for manipulating or holding work, e.g. for separate articles for particular articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C15/00—Enclosures for apparatus; Booths
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C3/00—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material
- B05C3/02—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material
- B05C3/09—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material for treating separate articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
- B05D3/0466—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases the gas being a non-reacting gas
Abstract
The invention discloses a film coating device for producing a high-efficiency implantable biosensor, which comprises a workbench, wherein a film coating chamber is fixed on the workbench, a sensor linkage positioning mechanism, a film coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism are fixed in the film coating chamber, the film coating mechanism comprises a film coating assembly for storing liquid drop-shaped film liquid and a film coating driving assembly for driving the film coating assembly to perform film coating operation, the operation of an automatic film coating process of the implantable biosensor can be realized, the film liquid is stored in the film coating assembly in a drop-shaped manner and then performs batch film coating on the sensor linkage instead of the traditional film-shaped manner, the wrapping integrity and the uniformity and the stability of the film coating are better, and the film coating times can be reduced because the amount of the drop-shaped film liquid grabbed by a film coating cavity is far larger than that of the film-shaped film liquid, thereby greatly improving the production efficiency.
Description
Technical Field
The invention relates to the technical field of implantable biosensors, in particular to a film coating device for producing a high-efficiency implantable biosensor.
Background
Monitoring of blood glucose is very important for diabetics, and blood glucose values help to assess conditions of glucose metabolism disorders in diabetics. Currently, the detection of blood glucose can be divided into in vitro detection after blood collection and real-time detection of an implantable blood glucose sensor. When blood sugar is controlled by the method of in vitro detection after blood collection, blood collection is required to be performed for many times every day, which causes heavy burden on the spirit and the flesh of a patient, so that the method of real-time detection by an implantable blood sugar sensor is increasingly popular.
At present, the micro-sensor which is only implanted in subcutaneous tissue and can be used for clinical blood sugar continuous monitoring products and technically verified to a certain extent has the advantages of small and soft implanted biosensor, in order to improve the efficiency and facilitate the processing during the production and manufacture, a plurality of sensors which are made of the implantable biosensors are connected, and corresponding equipment is needed, for example, the invention patent of China with the patent number of CN201920221865.9 and the application date of 2019-02-22 discloses a biosensor film coating tool, which comprises a cavity, wherein a film liquid groove and a needle holding plate fixing component are arranged in the cavity, the needle holding plate fixing component is connected with a pull rod, the pull rod is externally connected with a pulling device, the pulling device controls the pull rod to drive the needle holding plate fixing component to move up and down in the cavity, a sensor is arranged on the needle holding plate fixing component, and the sensor is arranged corresponding to the film liquid groove. According to the invention, the pull rod is controlled by the lifting device to drive the needle holding plate fixing component to move up and down in the cavity, so that the sensor fixed on the needle holding plate fixing component is placed in the film liquid groove in the cavity to complete film coating, although the production efficiency is improved, the uniformity of the film coating is not good enough, and the film coating method is only suitable for preparing a sensor with a rigid special shape and a short length. Biosensors using flexible substrates are a milestone in the development of current dynamic monitoring technologies, and their flexible physical properties are important for the performance of implantable sensors, compared to rigid sensors, flexible sensors have many advantages, such as: no rigid stimulation to human tissues, no trouble of human action, free bending and the like. The production of flexible sensor must require can to fix the sensor both ends, carries out three-dimensional even operation to the sensor, just can keep in the course of working to the sensor application with even processing and coating operation, and the chinese utility model patent that publication number is CN201823669U discloses a full-automatic integral type coating machine, and it includes the base and sets up the coating room on the base, still includes horizontal motion mechanism and vertical motion mechanism, the indoor electrode holder subassembly that is provided with of coating, the electrode holder subassembly is connected with horizontal motion mechanism and vertical motion mechanism respectively. However, the utility model discloses a because the mode that uses the membrane liquid circle is filmed, can't operate the work piece that both ends are fixed wantonly in the operation process, perhaps if with the fixed condition in sensor both ends under, the circle of filming can't pass the sensor and carry out the work of filming.
The chinese patent publication No. CN104941859B discloses a sensor coating apparatus, wherein a coating film is a coating film clamp, a coating film gap for coating a workpiece with an immersion liquid can be arranged in the middle of the coating film clamp, a liquid film is formed in the coating film gap by the liquid, the liquid film has insufficient wrapping property, the amount of liquid captured by the coating film clamp is limited, the number of times of coating film is required is correspondingly increased, and finally the thickness of the liquid film is not uniform under the traction of gravity and surface tension, which is easy to be thin at the top and thick at the bottom, so that the thickness of the biological film on the surface of the sensor electrode is not uniform during coating, and the detection accuracy of the sensor electrode is greatly influenced by the small thickness difference.
Therefore, a coating apparatus for producing a highly efficient implantable biosensor is needed.
Disclosure of Invention
In order to solve the problems, the invention provides a film coating device for producing a high-efficiency implantable biosensor.
The utility model provides a production of high-efficient implantation nature biosensor is with equipment of filming, includes the workstation, be fixed with on the workstation and be used for airtight operating space that films's the room and the sensor allies oneself with the transport room, scribble the room with set up the passageway that is used for feeding and ejection of compact between the sensor allies oneself with the transport room, be fixed with the door mechanism that can overturn that is used for controlling the passageway switching on the passageway, it is fixed with the annular conveying mechanism who is used for placing and can circulate the transport sensor antithetical couplet to film indoor, is used for fixing and positioning the positioning mechanism of sensor antithetical couplet, is used for the sealed membrane liquid storage mechanism and the mechanism of filming of depositing the membrane liquid, it includes the membrane subassembly that is used for depositing the liquid droplet membrane liquid and drives the membrane subassembly that coats a film and operate to film the mechanism of filming.
Preferably, a height scanning mechanism for scanning the height of the implantable biosensor connected with the sensor and calculating the average height is fixed in the coating chamber close to the annular conveying mechanism, and the height scanning mechanism comprises a 3D scanning camera and a scanning driver for driving the 3D scanning camera to move horizontally.
Preferably, sensor allies oneself with the transport room including inclosed transport casing, offer the business turn over material mouth that is used for business turn over material on the transport casing, be fixed with the conveying mechanism who is used for the feeding and the ejection of compact in the transport casing and be used for linking the transport to appointed station's transport mechanism with the sensor, conveying mechanism passes business turn over material mouth and extends to outside the transport casing, conveying mechanism allies oneself with transport board and drive including the sensor that is used for placing the sensor and allies oneself with transport board rectilinear movement's transport drive assembly is allied oneself with to the sensor, transport mechanism is including adsorbable absorption subassembly and the drive of snatching the sensor and alliing oneself with absorption drive assembly that absorption subassembly carries out level and vertical motion.
Preferably, the channel is located above the annular conveying mechanism, the reversible bin gate mechanism comprises a bin gate which can be covered on the channel in a sealing mode, one side of the bin gate is rotatably connected into the sensor-linked carrying chamber through a rotating shaft, and the bin gate is rotatably connected with a bin gate driving assembly capable of pushing the bin gate to turn.
Preferably, the annular conveying mechanism comprises an annular base, an annular slide rail is fixed on the annular base, a plurality of sensor connection plates are connected and placed on the annular slide rail in a sliding mode, an annular driving assembly capable of driving the sensor connection plates to move along the annular slide rail is fixed on the annular base, the annular driving assembly comprises a synchronous driving gear, a synchronous driven gear and a belt for connecting the synchronous driving gear and the synchronous driven gear, the synchronous driving gear is connected with the output end of a rotating motor, and one side of the sensor connection plates is fixed on the belt.
Preferably, the positioning mechanism comprises a positioning base and a positioning driving assembly for driving the positioning base to move up and down, a pressing plate capable of pressing the edges of the fixed sensor units is fixed on the lower surface of the positioning base, the pressing plate is of a rectangular annular structure, a film coating opening convenient for a film coating operation of the film coating assembly is formed in the positioning base above the pressing plate, the upper surface of the positioning base is connected with a positioning calibration mechanism, the positioning calibration mechanism comprises a transverse positioning pushing mechanism and a longitudinal positioning pushing mechanism which are positioned on two adjacent sides of the pressing plate, the transverse positioning pushing mechanism comprises a transverse pushing assembly and a transverse driving assembly for driving the transverse pushing assembly to move transversely, the transverse driving assembly comprises a positioning rotating motor and a transverse connecting rod group fixed at the output end of the positioning rotating motor, the transverse pushing assembly comprises a first transverse pushing plate and a second transverse pushing plate which are arranged in a crossed manner, the first transverse pushing plate and the second transverse pushing plate are hinged to the transverse connecting rod group, one ends, close to the pressing plate, of the first transverse pushing plate and the second transverse pushing plate are rotatably connected with transverse pushing wheels, the transverse pushing wheels penetrate through the positioning base and extend to the lower surface of the pressing plate, a reset elastic piece is fixed at one end, far away from the pressing plate, between the first transverse pushing plate and the second transverse pushing plate, the longitudinal positioning pushing mechanism comprises a longitudinal pushing assembly and a longitudinal driving assembly for driving the longitudinal pushing assembly to move longitudinally, the longitudinal driving assembly comprises a positioning rotating motor and a longitudinal connecting rod group fixed at the output end of the positioning rotating motor, and the longitudinal pushing assembly comprises a first longitudinal pushing plate and a second longitudinal pushing plate which are arranged in a crossed manner, the first longitudinal pushing plate and the second longitudinal pushing plate are hinged to the longitudinal connecting rod set, one ends, close to the pressing plate, of the first longitudinal pushing plate and the second longitudinal pushing plate are rotatably connected with longitudinal pushing wheels, the longitudinal pushing wheels penetrate through the positioning base and extend to the lower surface of the pressing plate, and a reset elastic piece is fixed at one end, far away from the pressing plate, between the first longitudinal pushing plate and the second longitudinal pushing plate.
Preferably, the membrane liquid storage mechanism comprises a membrane liquid pool and a membrane liquid cover capable of automatically turning over and opening the membrane liquid pool, and a blowing pool for blowing and drying residual liquid on the coating assembly is further fixed in the coating chamber.
As preferred, the subassembly of filming including the installation department and the shaping in scribble membrane portion on the installation department, it has the cavity of filming that is used for depositing the liquid droplet shape membrane liquid to scribble the shaping in the membrane portion, it keeps away from to scribble membrane portion one side of installation department is offered and is used for the passageway of filming that implanted biosensor passes through, film the passageway with it is linked together to scribble membrane cavity (4), it including first portion of grabbing to scribble membrane portion, the second portion of grabbing and will first portion of grabbing and the second portion of grabbing transition connection's connecting portion of grabbing, first portion of grabbing, second portion of grabbing and grabbing connecting portion its being close to the face of one side of filming the cavity is the rough surface, installation department both sides shaping has the installation fixture block.
Preferably, the coating mechanism further comprises a coating assembly placing groove for placing, cleaning and soaking the coating assembly, a plurality of groups of clamping grooves matched with the mounting clamping blocks are formed in the coating assembly placing groove, the coating driving assembly comprises a moving seat and a three-axis servo manipulator assembly for driving the moving seat to move, and coating assembly clamping mechanisms for clamping the coating assembly are fixed on two sides of the moving seat respectively.
Preferably, a sensor coupling placing groove capable of accommodating the sensor coupling is formed in the sensor coupling placing plate, an overhead groove for enabling the implantable biosensor on the sensor coupling to be in an overhead state is formed below the sensor coupling placing groove, positioning grooves capable of accommodating the transverse pushing wheels and the longitudinal pushing wheels respectively are formed in the sensor coupling placing plate, and the positioning grooves are communicated with the sensor coupling placing groove. The invention has the beneficial effects that:
(1) the invention discloses a film coating device for producing a high-efficiency implantable biosensor, which comprises a workbench, wherein a film coating chamber is fixed on the workbench, a sensor linkage positioning mechanism, a film coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism are fixed in the film coating chamber, the film coating mechanism comprises a film coating assembly for storing liquid drop-shaped film liquid and a film coating driving assembly for driving the film coating assembly to perform film coating operation, the operation of an automatic film coating process of the implantable biosensor can be realized, the film liquid is stored in the film coating assembly in a drop-shaped manner and then performs batch film coating on the sensor linkage instead of the traditional film-shaped manner, the wrapping integrity and the uniformity and the stability of the film coating are better, and the film coating times can be reduced because the amount of the drop-shaped film liquid grabbed by a film coating cavity is far larger than that of the film-shaped film liquid, thereby greatly improving the production efficiency.
(2) The invention discloses a film coating device for producing a high-efficiency implantable biosensor, which comprises a height scanning mechanism, wherein the implantable biosensor is made of a flexible material, the height of each implantable biosensor on a sensor unit is different in height, in order to ensure the accuracy and stability of batch film coating, the height scanning mechanism acquires the heights of the implantable biosensors at different positions on each implantable biosensor before the sensor unit is coated with the film, eliminates data exceeding a limit range, calculates the average height, is convenient for controlling the film coating position height of a film coating component during film coating work, ensures the accuracy of film coating operation, improves the yield, reduces the number of defective products, and eliminates unqualified sensor units if a plurality of data exceeding the limit range exist in the data acquired by the height scanning mechanism, the quality of the finished product is further ensured.
(3) The invention discloses a film coating device for producing a high-efficiency implantable biosensor, which comprises an annular conveying mechanism, wherein an annular driving assembly capable of driving a plurality of sensor combined placing plates to move along an annular sliding rail is fixed on an annular base, when a sensor pair enters from the sensor combined placing plate close to a turnover bin gate mechanism and is conveyed to a positioning mechanism along the conveying direction of the annular conveying mechanism for film coating operation, and finally the sensor pair moves to the position close to the turnover bin gate mechanism for discharging along a conveying route, the annular conveying mechanism not only provides waiting time for the sensor pair, but also provides residence time in a THF (tetrahydrofuran) atmosphere for the sensor pair just after the film coating operation is finished, the whole process flow is annularly buckled, the production efficiency is improved, the function of controlling the beat time is realized, and meanwhile, the process parameter adjustment is convenient.
(4) The invention discloses a film coating device for producing a high-efficiency implantable biosensor, which comprises a positioning mechanism, wherein the effect of pressing a sensor unit in the film coating operation process can be realized through a pressing plate, and meanwhile, the positioning and calibrating mechanism realizes the transverse and longitudinal quick and accurate positioning of the sensor unit needing film coating, so that the film coating accuracy, the working efficiency and the yield of the sensor unit are ensured.
Drawings
FIG. 1 is a perspective view of a film coating assembly of the present invention;
FIG. 2 is an enlarged view of the point A in FIG. 1;
FIG. 3 is another shape of the coating film portion of the present invention;
FIG. 4 is a schematic view of a sensor assembly of the present invention;
FIG. 5 is a perspective view of a platen member of the present invention;
FIG. 6 is a perspective view of a coating apparatus for manufacturing a highly efficient implantable biosensor according to the present invention;
FIG. 7 is a schematic view of the internal structure of a coating apparatus for producing a highly efficient implantable biosensor according to the present invention;
FIG. 8 is a schematic structural diagram of a conveying mechanism and a carrying mechanism according to the present invention;
FIG. 9 is a schematic view of the reversible door mechanism of the present invention;
FIG. 10 is a schematic view of the construction of the endless conveyor mechanism of the present invention;
FIG. 11 is an enlarged view of FIG. 10 at A;
FIG. 12 is a schematic view of the height scanning mechanism of the present invention;
FIG. 13 is a schematic view of the positioning mechanism of the present invention;
FIG. 14 is a schematic view of another angle of view of the positioning mechanism of the present invention;
FIG. 15 is a schematic structural view of the membrane liquid deposition mechanism of the present invention;
FIG. 16 is a schematic structural view of a coating mechanism according to the present invention;
fig. 17 is a schematic structural view of a sensor mounting plate according to the present invention.
In the figure: a mounting portion 1; a film coating section 2; a connecting part 3; a coating cavity 4; a unit frame 5; a unit frame 51; an implantable biosensor 52; an electrode portion 53; a flexibility detection portion 54; a coating channel 6; a first grasping portion 7; a second grasping portion 8; a grabbing connecting part 9; mounting the fixture block 10; a platen 12; film coating assembly a 41; a film coating chamber a1, a sensor combined carrying chamber a2, a conveying mechanism a22, a carrying mechanism a23, an adsorption component a23, an adsorption driving component a23, a conveying driving component a23, a reversible door mechanism a23, a door driving component a23, an annular conveying mechanism a23, an annular driving component a23, a belt a23, an annular base a23, a limit bump a23, a limit telescopic cylinder a23, a limit slot a23, a positioning mechanism a23, a film coating port a23, a transverse positioning pushing mechanism a23, a longitudinal positioning pushing mechanism a23, a positioning rotating motor a23, a transverse pushing wheel a23, a longitudinal pushing wheel a23, a positioning driving component a23, a transverse third connecting rod a521, a transverse fifth connecting rod a522, a longitudinal third connecting rod a523, a longitudinal fifth connecting rod a film liquid, a film liquid storing mechanism a23, a film coating mechanism 23, a height scanning mechanism 23 a23, a camera scanning mechanism 23D, a23 a scanning sensor combined scanning sensor 23 a and a23 a placing and a sensor combined scanning plate 23 a23 An overhead groove a92, a positioning groove a93, a membrane liquid pool a61, an air blowing pool a62, a coating film assembly placing groove a71, a coating film driving assembly a72, a three-axis servo manipulator assembly a73, an atmosphere pool a10 and an atmosphere cover a 11.
Detailed Description
The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first", "second", may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In order to improve the production efficiency, the invention adopts a mass production mode for the production mode of an implantable biosensor, the implantable biosensor is made into a sensor unit, the sensor unit comprises a unit frame 5, the unit frame 5 comprises a unit frame 51, a plurality of implantable biosensors 52 (three or more) are fixedly connected on the unit frame 51 side by side, the upper surface of each implantable biosensor 52 keeps the same plane with the upper surface of the unit frame 51, each implantable biosensor 52 comprises an electrode part 53 and a flexible detection part 54, the implantable biosensor 52 is introduced in the subcutaneous tissue internal sensor device with controllable implantation angle of the prior patent CN201310724053.3, and therefore, the description is not repeated in the present case, one end of the electrode part 53 of the implantable biosensor 52, which is far away from the flexible detection part 54, is connected with the unit frame 51, the end of the flexible detection part 54 of the implantable biosensor 52 away from the electrode part 53 is connected to the unit frame 51, i.e., both ends of the implantable biosensor 52 are fixed to the unit frame 51. The pressing plate 12 is used for pressing the unit frame 51 in the invention, and the purpose of the pressing plate is to fix the sensor unit and expose the implanted biosensor 52 needing film coating to the outside for film coating, and the outer edge of the pressing plate 12 is 1-3 mm smaller than that of the sensor unit, so that the positioning mechanism a5 can perform positioning calibration conveniently when the pressing plate 12 presses the sensor unit.
The existing sensor coating mode generally adopts an immersion mode, for example, Chinese patent with patent No. CN201920221865.9 and application date 2019-02-22 discloses a biosensor coating tool, which immerses a sensor into a coating liquid in a liquid tank for coating, and then pulls up the sensor after coating, and such an operation mode firstly has the problem that the coating efficiency is not high enough, because the sensor needs to be pulled up after coating in the coating liquid, the pulling up process is slow, because once the speed is too fast, the effect of the coating is influenced, the uniformity of the coating is influenced, secondly, because the sensor is vertically arranged, the coating liquid is influenced by gravity, the accumulation of the coating liquid can occur in the slow pulling process, the effect of the coating is influenced, the non-uniformity of the sensor coating is caused, and finally, the mode of annular coating is adopted, such a method is suitable for a needle-shaped sensor having one end fixed, and therefore, the needle-shaped sensor must have high rigidity, not be bent by resistance during passing through a coating film, be usable only when the one end is fixed, and have a certain limit in the length of the sensor to be processed.
For example, chinese patent publication No. CN104941859B discloses a sensor coating apparatus, in which a coating film is a coating film holder, a coating film gap for coating a workpiece with immersion liquid can be provided in the middle of the coating film holder, and a liquid film formed in the coating film gap by the liquid is not enough to wrap the liquid film, and the amount of liquid captured by the coating film holder is limited, so that the number of times of coating film is required is correspondingly increased, and finally the thickness of the liquid film is not uniform under the traction of gravity and surface tension, so that the thickness of the liquid film is not uniform, and the thickness of the biological film itself on the surface of the sensor electrode is thin, and the small thickness difference may greatly affect the detection accuracy of the sensor electrode.
A coating device for producing a high-efficiency implantable biosensor comprises a workbench, wherein a coating chamber a1 and a sensor joint conveying chamber a2 which are used for sealing a coating operation space are fixed on the workbench, a channel for feeding and discharging is formed between the coating chamber a1 and the sensor joint conveying chamber a2, a reversible bin gate mechanism a3 used for controlling the opening and closing of the channel is fixed on the channel, an annular conveying mechanism a4 used for placing and circularly conveying the sensor joint, a positioning mechanism a5 used for fixing and positioning the sensor joint, a membrane liquid storage mechanism a6 used for hermetically storing the membrane liquid and a coating mechanism a7 are fixed in the coating chamber a1, and the coating mechanism a7 comprises a coating assembly a41 used for storing the membrane liquid and a coating driving assembly a72 used for driving the coating assembly a41 to perform coating operation.
Specifically, a height scanning mechanism a8 for scanning the height of the implantable biosensor 52 on the sensor set and calculating the average height is fixed in the coating chamber a1 near the annular conveying mechanism a4, the height scanning mechanism a8 includes a 3D scanning camera a81 and a scanning driver a82 for driving the 3D scanning camera a81 to move horizontally, the scanning driver a82 may be a single-axis robot, because the implantable biosensor 52 is made of a flexible material, there is a height difference in the height of each implantable biosensor 52 on the sensor set, in order to ensure the accuracy and stability of batch coating, the height scanning mechanism a8 collects the height of the implantable biosensor 52 at different positions on each implantable biosensor 52 before the coating mechanism a7 coats the sensor set, and rejects data exceeding the limit range, and calculating the average height, then controlling the film coating assembly a41 to descend by the film coating mechanism a7, so that the film coating cavity 4 of the film coating assembly a41 is exactly located at the central position corresponding to the average height, the accuracy of film coating operation is ensured, the yield is improved, the number of defective products is reduced, if a plurality of data exceeding the limit range exist in the data acquired by the height scanning mechanism a8, the unqualified sensors are rejected, and the quality of finished products is further ensured.
Specifically, the sensor joint conveying chamber a2 includes a closed conveying shell, the arrangement of the conveying shell further ensures the tightness in the coating operation process, prevents volatile gas from volatilizing, a feeding and discharging port for feeding and discharging is provided on the conveying shell, a conveying mechanism a22 for feeding and discharging and a conveying mechanism a23 for conveying the sensor joint to a designated station are fixed in the conveying shell, the conveying mechanism a22 penetrates through the feeding and discharging port and extends to the outside of the conveying shell, the conveying mechanism a22 includes a sensor joint conveying plate for placing the sensor joint and a conveying driving component a26 for driving the sensor joint conveying plate to move linearly, the conveying driving component a26 can be a linear slide rail, the conveying mechanism a23 includes an adsorption component a24 capable of adsorbing and grabbing the sensor joint and an adsorption driving component a25 for driving the adsorption component a24 to move horizontally and vertically, adsorb drive assembly a25 can be triaxial servo manipulator, adsorb assembly a24 including adsorbing the flat board, be fixed with a plurality of absorption portions on the adsorption flat board, the absorption portion is located including breather pipe, cover absorption compression spring on the breather pipe and with the sucking disc of breather pipe intercommunication, after the sucking disc allies oneself with the contact with the sensor, utilize the adsorption affinity of its production to realize snatching of sensor antithetical couplet, absorption compression spring's setting has guaranteed to be elastic contact when alling oneself with the contact with the sensor, and does not produce great impact, guarantees that the sensor allies oneself with can not damaged, has also guaranteed the stability when carrying the sensor antithetical couplet.
Specifically, the reversible door mechanism a3 includes a door a31 that can be sealed and covered on the channel, the channel is located above the annular conveying mechanism a4, one side of the door a31 is rotatably connected in the sensor-linked carrying chamber a2 through a rotating shaft, the door a31 is rotatably connected with a door driving component a32 that can push the door a31 to turn, the door driving component a32 can be a telescopic cylinder, and the reversible door mechanism a3 is used for ensuring the sealing property in the film coating chamber a 1.
Specifically, the annular conveying mechanism a4 includes an annular base a44, an annular slide rail is fixed on the annular base a44, a plurality of sensor coupling placement plates a9 are slidably connected to the annular slide rail, the sensor coupling placement plates a9 are used for placing sensor couplings, a sensor coupling placement groove a91 for accommodating the sensor couplings is formed on the sensor coupling placement plate a9, an overhead groove a92 for enabling the implantable biosensor 52 on the sensor coupling to be in an overhead state is formed below the sensor coupling placement groove a91, a positioning groove a93 for respectively accommodating a transverse pushing wheel a55 and a longitudinal pushing wheel a56 is formed on the sensor coupling placement plate a9, and the positioning groove a93 is communicated with the sensor coupling placement groove a 91. The annular base a44 is fixed with an annular driving assembly a42 which can drive the sensor jointly-placed plate a9 to move along an annular slide rail, the annular driving assembly a42 comprises a synchronous driving gear, a synchronous driven gear and a belt a43 which is connected with the synchronous driving gear and the synchronous driven gear, the synchronous driving gear is connected with the output end of a rotating motor, one side of the sensor jointly-placed plate a9 is fixed on the belt a43, the synchronous driving gear drives the belt a43 to rotate on the synchronous driving gear and the synchronous driven gear, so that the belt a43 drives the sensor jointly-placed plate a9 to move along the annular slide rail, a limit bump a45 is fixed on the sensor jointly-placed plate a9 close to the outer edge of the annular base, a limit assembly is fixed on the outer edge of the annular base and close to the position of the positioning mechanism a5, and the limit assembly comprises a limit base fixed on the outer edge of the annular base, and a limiting telescopic cylinder a46 is fixed on the limiting base, and a limiting clamping groove a47 is fixed at the telescopic end of the limiting telescopic cylinder a46, so that the limiting base is used for fixing the position of the sensor joint placing plate a9 and placing the sensor joint placing plate on the annular sliding rail to slide when the film coating operation is performed. The sensor placing plate a9 is located at a position close to the positioning mechanism a5 and is a film coating station, a waiting station is located before the rotation direction of the film coating station, and a staying and drying station is located after the rotation direction of the film coating station.
Specifically, the positioning mechanism a5 is located on one side of the annular conveying mechanism a4 away from the turnable cabin door mechanism a3, and includes a positioning base and a positioning driving component a57 for driving the positioning base to move up and down, the positioning driving component a57 may be a telescopic cylinder, the lower surface of the positioning base is fixed with a pressing plate 12 capable of pressing and fixing the peripheral edge of a sensor link, the pressing plate 12 is a rectangular ring structure, the positioning base is provided with a film coating port a51 above the pressing plate 12 for facilitating the film coating operation of the film coating component a41, the upper surface of the positioning base is connected with a positioning calibration mechanism, the positioning calibration mechanism includes a transverse positioning pushing mechanism a52 and a longitudinal positioning pushing mechanism a53 located on two adjacent sides of the pressing plate 12, referring to fig. 5, the invention is set that the direction parallel to the long side of the pressing plate 12 is transverse, the direction parallel to the short side of the pressing plate 12 is longitudinal, the transverse positioning pushing mechanism a52 comprises a transverse pushing component and a transverse driving component for driving the transverse pushing component to move transversely, the transverse driving component comprises a positioning rotating motor a54 and a transverse connecting rod group fixed at the output end of the positioning rotating motor a54, the transverse pushing component comprises a first transverse pushing plate and a second transverse pushing plate which are arranged in a crossed manner, the first transverse pushing plate and the second transverse pushing plate are hinged on the transverse connecting rod group, one ends of the first transverse pushing plate and the second transverse pushing plate close to the pressing plate 12 are rotatably connected with a transverse pushing wheel a55, the transverse pushing wheel a55 penetrates through the positioning base and extends to the lower surface of the pressing plate 12, and a reset elastic piece is fixed at one end between the first transverse pushing plate and the second transverse pushing plate far away from the pressing plate 12, the longitudinal positioning pushing mechanism a53 comprises a longitudinal pushing assembly and a longitudinal driving assembly for driving the longitudinal pushing assembly to move longitudinally, the longitudinal driving assembly comprises a positioning rotating motor a54 and a longitudinal connecting rod group fixed at the output end of the positioning rotating motor a54, the longitudinal pushing assembly comprises a first longitudinal pushing plate and a second longitudinal pushing plate which are arranged in a crossed manner, the first longitudinal pushing plate and the second longitudinal pushing plate are hinged on the longitudinal connecting rod group, one ends of the first longitudinal pushing plate and the second longitudinal pushing plate, which are close to the pressing plate 12, are rotatably connected with a longitudinal pushing wheel a56, the longitudinal pushing wheel a56 penetrates through the positioning base and extends to the lower surface of the pressing plate 12, a reset elastic piece is fixed at one end between the first longitudinal pushing plate and the second longitudinal pushing plate, which is far away from the pressing plate 12, the transverse connecting rod group comprises a transverse first connecting rod fixed with the positioning rotating motor a54, a transverse second connecting rod is fixed at one end of the transverse first connecting rod far away from the positioning rotating motor a54, a transverse third connecting rod a521 is hinged at the other end of the transverse second connecting rod, the transverse third connecting rod a521 can longitudinally slide in a longitudinally arranged slide rail, a transverse fourth connecting rod is hinged at one end of the transverse third connecting rod a521 far away from the transverse second connecting rod, a transverse fifth connecting rod a522 is hinged at the other end of the transverse fourth connecting rod, one end of the transverse fifth connecting rod a522 far away from the transverse fourth connecting rod is hinged with the first transverse pushing plate and the second transverse pushing plate, the transverse fifth connecting rod a522 can transversely slide in the transversely arranged slide rail, the fir direction connecting rod group comprises a fir direction first connecting rod fixed with the positioning rotating motor a54, and a longitudinal second connecting rod is fixed at one end of the fir direction first connecting rod far away from the positioning rotating motor a54, the other end of the longitudinal second connecting rod is hinged with a longitudinal third connecting rod a523, the longitudinal third connecting rod a523 can slide transversely in a transversely arranged slide rail, one end, far away from the longitudinal second connecting rod, of the longitudinal third connecting rod a523 is hinged with a longitudinal fourth connecting rod, the other end of the longitudinal fourth connecting rod is hinged with a longitudinal fifth connecting rod a524, one end, far away from the longitudinal fourth connecting rod, of the longitudinal fifth connecting rod a524 is hinged with the first longitudinal pushing plate and the second longitudinal pushing plate, and the longitudinal fifth connecting rod a524 can slide longitudinally in the longitudinally arranged slide rail.
Specifically, the membrane-liquid storing mechanism a6 comprises a membrane-liquid pool a61 and a membrane-liquid cover capable of automatically turning over and opening on the membrane-liquid pool a61, the automatic opening and closing of the membrane liquid cover a61 is fixed by a membrane liquid rotating motor fixed with the membrane liquid cover a61, the membrane liquid cover is opened or closed by a control system, namely, the membrane liquid cover is automatically opened when the membrane material needs to be taken, the structure is favorable for the sealed preservation of the membrane liquid, the consumption of the membrane liquid due to the volatility of the membrane liquid is reduced, a blowing pool a62 for drying residual liquid on the film coating assembly a41 is also fixed in the film coating chamber a1, the air blowing pool a62 comprises an air blowing pool body for accommodating the film coating component a41, a plurality of air blowing openings are arranged on the inner wall of one side of the air blowing pool body, the air blowing port is communicated with an air inlet pipe, and the arrangement of the air blowing pool a62 is used for blowing the cleaning liquid on the film coating assembly a41 by the impact force of air flow.
Specifically, the coating assembly a41 includes an installation part 1, a coating part for capturing membrane liquid in a droplet shape is formed on the installation part 1, a coating cavity 4 for storing the droplet-shaped membrane liquid is formed on the coating part 2, a coating channel 6 through which the implantable biosensor 52 passes is formed on one side of the coating part 2 away from the installation part 1, and the coating channel 6 is communicated with the coating cavity 4, so that the implantable biosensor 52 enters from the coating channel 6 and passes through the droplet-shaped membrane liquid stored in the coating cavity 4 from bottom to top, and the implantable biosensor 52 is wrapped in an integrity manner by the droplet-shaped membrane liquid; coating portion 2 is including first portion 7 that snatchs, the second snatchs portion 8 and snatchs connecting portion 9 with first portion 7 and the second 8 transitional couplings that snatch, snatch connecting portion 9 and can prevent the drop shape membrane liquid deformation of snatching because implanted biosensor 52 produces an upwards extruded power to the membrane liquid from the supreme in-process of passing down, if do not have and snatch connecting portion 9, the membrane liquid can also have tension because of self to can be crowded or warp upwards. The grabbing connecting part 9 is in a shape of circular arc, triangle, wave-shaped circular arc, trapezoid, etc., the first grabbing part 7 can be in a shape of straight line, wave-shaped line, arc, etc., the second grabbing part 8 is in a shape of straight line, wave-shaped, arc, etc., the coating parts 2 are in a combination of any shapes as long as the coating liquid can be present in the coating cavity 4 in a drop shape, fig. 3 is a schematic view of another shape, the surfaces of the first grabbing part 7, the second grabbing part 8 and the grabbing connecting part 9 close to one side of the coating cavity 4 are rough surfaces, due to roughness, friction force can be generated to overcome the gravity of the coating liquid, the number of the coating parts 2 is 3 or more, a plurality of the coating parts 2 are arranged on the mounting part 1, the number of the coating parts 2 is arranged at one-step intervals to match with the implanted biosensor 52 on the sensor unit, scribble membrane portion 2 through connecting portion 3 with 1 transitional coupling of installation department, the shaping of 1 both sides of installation department has installation fixture block 10, the placing of the subassembly of scribbling of being convenient for, as long as will install fixture block 10 card and can realize the placing of the subassembly of scribbling in the draw-in groove.
Specifically, the film coating mechanism a7 further comprises a film coating assembly placing groove a71 for placing, cleaning and soaking the film coating assembly a41, a cleaning solution for cleaning the film coating assembly a41 is contained in the film coating assembly placing groove a71, the solution may be tetrahydrofuran, a plurality of sets of clamping grooves matched with the mounting fixture blocks 10 are formed in the film coating assembly placing groove a71, the film coating driving assembly a72 comprises a moving seat and a three-axis servo manipulator assembly a73 for driving the moving seat to move, film coating assembly clamping mechanisms for clamping the film coating assemblies are respectively fixed on two sides of the moving seat, the film coating assembly clamping mechanisms may be grabbing cylinders, a plurality of sets of clamping grooves matched with the mounting fixture blocks 10 are formed in the film coating assembly placing groove a71, and the film coating assembly placing groove a71 is connected with an external container containing the cleaning solution through a liquid inlet injection pump and a liquid outlet injection pump, the cleaning liquid in the coating module placing groove a71 is pumped into the container by a liquid outlet injection pump, and the cleaning liquid in the container is pumped into the coating module placing groove a71 by a liquid inlet injection pump, so that the cleaning liquid in the coating module placing groove a71 is in a flowing state, and the membrane liquid on the coating module can be washed clean.
Specifically, an atmosphere pool a10 is fixed in the coating chamber a1, a THF solution is placed in the atmosphere pool a10, the implanted biosensor 52 needs to be coated for a plurality of times during the coating process, the coating process needs to stay in the THF atmosphere for at least 0.5min, and the atmosphere pool a10 is connected with a container containing the THF solution through an inlet liquid injection pump and an outlet liquid injection pump. The top of the coating chamber a1 is also provided with an atmosphere cover a11 for realizing the functions of atmosphere keeping and atmosphere exhausting.
The specific operation process comprises the following steps:
the first step is as follows: feeding; the working personnel scans the sensor coupling needing film coating through the scanning gun, records the information of the sensor coupling (because each sensor coupling has the label, the staff can trace each link of the sensor coupling in the production process), then the sensor unit is placed on the sensor unit transportation plate, the transportation driving assembly a26 transports the sensor unit transportation plate from the outside of the sensor unit transportation chamber a2 to the inside of the sensor unit transportation chamber a2, the transportation mechanism adsorbs and captures the sensor unit, the turnover bin gate mechanism a3 turns over the bin gate, opens the channel, the conveying mechanism places the sensor on the sensor placing plate a9, and turns over the bin gate to close the channel by the turnover bin gate mechanism a3, thereby effectively ensuring the sealing property in the film coating chamber a1, preventing the volatile gas from being emitted, further reducing the loss caused by the volatility and saving the film coating material;
the second step is that: and (4) carrying out annular conveying. The corresponding angle of rotating electrical machines rotation to belt a43 drives the sensor of first step and allies oneself with placing board a9 and moves to the station of filming, and spacing telescopic cylinder a46 moves, promotes spacing draw-in groove a47 and moves and block spacing lug a45 to spacing lug a45 direction, thereby realizes that the sensor allies oneself with the fixed of placing board a 9.
The third step: scanning, namely acquiring the heights of the implantable biosensors 52 at different positions of each implantable biosensor 52 on the sensor unit by a height scanning mechanism a8, eliminating data exceeding a limit range, and calculating an average height;
the fourth step: the film coating machine is precisely positioned, after the third scanning step, the positioning driving assembly a57 acts to drive the positioning base to move towards the sensor linkage placing plate a9 direction until the pressing plate 12 presses the sensor linkage to be coated (the pressing plate 12 can play a role in fixing the sensor linkage, so that the sensor linkage is smoother, and because the sensor linkage is made of flexible materials, the sensor linkage is easy to bend and unsmooth, the pressing plate 12 presses the sensor linkage to flatten the sensor linkage, so that the film coating effect is better facilitated), meanwhile, the positioning and calibrating mechanism acts, and the transverse positioning pushing mechanism a52 and the longitudinal positioning pushing mechanism a53 push the long edge and the short edge of the sensor linkage to be coated to be precisely positioned;
the fifth step: coating, the coating driving assembly a72 drives the moving seat to move above the coating assembly placing groove a71, the coating assembly clamping mechanism clamps the coating assembly a41 and moves above the membrane liquid storage mechanism a6 under the driving of the coating driving assembly a72, the membrane liquid rotating motor operates to open the membrane liquid cover, the coating assembly a41 moves to the membrane liquid pool a61 to pick up the membrane liquid, the membrane liquid is stored in the coating cavity 4 in a dripping shape, the membrane liquid cover is automatically closed, the driving coating assembly a41 of the coating driving assembly a72 moves above a sensor assembly to be coated, and moves downwards towards the sensor coupling direction, passes through the film coating port a51, and continues to move downwards to the average height calculated in the third step, at this time, the film liquid completely wraps the implantable biosensor 52 due to the self tension, and finally, the film coating driving assembly a72 drives the film coating assembly a41 to perform film coating operation on the implantable biosensor 52;
and a sixth step: drying in a THF (tetrahydrofuran) atmosphere, after coating is finished, actuating a limiting telescopic cylinder a46 to push a limiting clamping groove a47 to move towards the direction far away from a limiting bump a45, loosening the limiting bump a45 by the limiting clamping groove a47, continuously rotating a rotary motor by a corresponding angle, moving a sensor combined placing plate a9 passing through the coating towards a3 direction of a reversible bin gate mechanism to enter a staying and drying station, while in a waiting state, allowing the sensor combined placing plate a9 to enter the coating station along with the movement of a belt a43, repeating the operations of the second step to the fifth step, and allowing the sensor which is positioned at the staying and drying station and is coated to be connected in the THF atmosphere for drying;
the seventh step: cleaning the coating module a41, moving the coating module a41 subjected to coating in the fifth step into an air blowing pool a62 under the driving of a72, drying the residual membrane liquid, finally moving the coating module to a coating module placing groove a71, clamping the coating module a41 into the clamping groove, and further soaking and cleaning the coating module in a 71;
eighth step: and discharging, when the sensor combined placing plate a9 in the staying drying station moves to the position of the turnable door mechanism a3, the turnable door mechanism a3 turns over the door, a channel is opened, the conveying mechanism adsorbs and grabs the sensor combined placing plate a9 and moves to the sensor combined conveying plate, the turnable door mechanism a3 turns over the door to close the channel, and finally the conveying driving component a26 conveys the sensor combined conveying plate from the sensor combined conveying chamber a2 to the outside of the sensor combined conveying chamber a2 to realize discharging.
A coating device for producing an efficient implantable biosensor realizes the operation of an automatic coating process of the implantable biosensor, and membrane liquid is stored in a coating component a41 in a dripping form and then is used for coating the sensor assembly in batches instead of the traditional membrane form, so that the coating integrity, the coating uniformity and the coating stability are better, and meanwhile, the quantity of the dripping membrane liquid grabbed by a coating cavity is far greater than that of the membrane liquid, so that the coating frequency can be reduced, and the production efficiency is greatly improved.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The utility model provides a production of high-efficient implantation biosensor is with equipment of filming, includes the workstation, its characterized in that: a film coating chamber (a1) and a sensor-linked carrying chamber (a2) which are used for sealing a film coating operation space are fixed on the workbench, a channel for feeding and discharging is formed between the film coating chamber (a1) and the sensor-linked carrying chamber (a2), a reversible bin gate mechanism (a3) which is used for controlling the channel to be opened and closed is fixed on the channel, an annular conveying mechanism (a4) which is used for placing and circularly conveying the sensor link, a positioning mechanism (a5) which is used for fixing and positioning the sensor link, a film liquid storage mechanism (a6) and a film coating mechanism (a7) which are used for hermetically storing the film liquid are fixed in the film coating chamber (a1), and the film coating mechanism (a7) comprises a film coating assembly (a41) which is used for grabbing the film liquid in a drop-shaped form and a film coating driving assembly (a72) which drives the film coating assembly (a41) to perform film coating operation.
2. The coating apparatus for producing a highly efficient implantable biosensor according to claim 1, wherein: a height scanning mechanism (a8) for scanning the height of the implantable biosensor (52) connected with the sensor and calculating the average height is fixed in the coating chamber (a1) close to the annular conveying mechanism (a4), and the height scanning mechanism (a8) comprises a 3D scanning camera (a81) and a scanning driver (a82) for driving the 3D scanning camera (a81) to move horizontally.
3. The coating apparatus for producing a highly efficient implantable biosensor according to claim 1, wherein: sensor allies oneself with transport room (a2) is including inclosed transport casing, offer the business turn over material mouth that is used for business turn over material on the transport casing, be fixed with conveying mechanism (a22) that are used for the feeding and the ejection of compact in the transport casing and be used for carrying sensor allies oneself with transport to appointed station's transport mechanism (a23), conveying mechanism (a22) pass business turn over material mouth and extend to outside the transport casing, conveying mechanism (a22) is including being used for placing sensor allies oneself with transport board and drive the transport drive assembly (a26) of sensor allies oneself with transport board rectilinear movement, transport mechanism (a23) is including adsorbable absorption component (a24) and the drive that snatchs sensor allies oneself with absorption component (a24) carry out horizontal and vertical motion's absorption drive assembly (a 25).
4. The coating apparatus for producing a highly efficient implantable biosensor according to claim 1, wherein: the channel is located above the annular conveying mechanism (a4), the reversible door mechanism (a3) comprises a door (a31) which can be sealed and covered on the channel, one side of the door (a31) is rotatably connected into the sensor-linked carrying chamber (a2) through a rotating shaft, and the door (a31) is rotatably connected with a door driving component (a32) which can push the door (a31) to turn.
5. The coating apparatus for producing a highly efficient implantable biosensor according to claim 3, wherein: annular conveying mechanism (a4) is including annular base (a44), be fixed with annular slide rail on annular base (a44), sliding connection has a plurality of sensors to ally oneself with and places board (a9) on the annular slide rail, be fixed with on annular base (a44) and drive sensor ally oneself with places board (a9) and along annular drive assembly (a42) of annular slide rail removal, annular drive assembly (a42) is including synchronous driving gear, synchronous driven gear and belt (a43) of connecting synchronous driving gear and synchronous driven gear, the synchronous driving gear is connected with the output of rotating electrical machines, sensor allies oneself with and places board (a9) one side and is fixed in on the belt (a 43).
6. The coating apparatus for producing a highly efficient implantable biosensor according to claim 3, wherein: positioning mechanism (a5) is including location base and drive the location drive assembly that the location base reciprocated, location base lower surface is fixed with and can pushes down clamp plate (12) that fixed sensor allies oneself with all edges, clamp plate (12) are rectangle loop configuration, be located on the location base clamp plate (12) top is seted up and is convenient for film coating subassembly (a41) carry out the film coating mouth (a51) of filming operation, location base upper surface is connected with the location alignment mechanism, the location alignment mechanism is including being located horizontal location pushing mechanism (a52) and longitudinal direction location pushing mechanism (a53) of the adjacent both sides of clamp plate (12), horizontal location pushing mechanism (a52) is including horizontal pushing assembly and drive horizontal pushing assembly lateral shifting's lateral drive subassembly, horizontal drive assembly is including location rotating electrical machines (a54) and be fixed in the horizontal even of location rotating electrical machines (a54) output is even The transverse pushing assembly comprises a first transverse pushing plate and a second transverse pushing plate which are arranged in a crossed mode, the first transverse pushing plate and the second transverse pushing plate are hinged to the transverse connecting rod assembly, one ends, close to the pressing plate (12), of the first transverse pushing plate and the second transverse pushing plate are rotatably connected with transverse pushing wheels (a55), the transverse pushing wheels (a55) penetrate through the positioning base and extend to the lower surface of the pressing plate (12), one ends, far away from the pressing plate (12), of the first transverse pushing plate and the second transverse pushing plate are fixedly provided with reset elastic pieces, the longitudinal positioning pushing mechanism (a53) comprises a longitudinal pushing assembly and a longitudinal driving assembly for driving the longitudinal pushing assembly to move longitudinally, the longitudinal driving assembly comprises a positioning rotating motor (a54) and a longitudinal connecting rod assembly fixed at the output end of the positioning rotating motor (a54), the longitudinal pushing assembly comprises a first longitudinal pushing plate and a second longitudinal pushing plate which are arranged in a crossed mode, the first longitudinal pushing plate and the second longitudinal pushing plate are hinged to the longitudinal connecting rod group, one ends, close to the pressing plate (12), of the first longitudinal pushing plate and the second longitudinal pushing plate are rotatably connected with longitudinal pushing wheels (a56), the longitudinal pushing wheels (a56) penetrate through the positioning base and extend to the lower surface of the pressing plate (12), and a reset elastic piece is fixed at one end, far away from the pressing plate (12), of the first longitudinal pushing plate and the second longitudinal pushing plate.
7. The coating apparatus for producing a highly efficient implantable biosensor according to claim 1, wherein: the membrane liquid storage mechanism (a6) comprises a membrane liquid pool (a61) and a membrane liquid cover capable of automatically turning over and opening on the membrane liquid pool (a61), and an air blowing pool (a62) for drying residual liquid on the membrane coating assembly (a41) is further fixed in the membrane coating chamber (a 1).
8. The coating apparatus for producing a highly efficient implantable biosensor according to claim 1, wherein: the coating film component (a41) comprises a mounting part (1) and a coating film part (2) formed on the mounting part (1), a coating cavity (4) for storing the dripping film liquid is formed on the coating part (2), a coating channel (6) for an implanted biosensor (52) to pass through is arranged on one side of the coating part (2) far away from the mounting part (1), the film coating channel (6) is communicated with the film coating cavity (4), the film coating part (2) comprises a first grabbing part (7), a second grabbing part (8) and a grabbing connecting part (9) which connects the first grabbing part (7) and the second grabbing part (8) in a transition way, first portion (7), the second portion (8) of snatching and snatch connecting portion (9) its face that is close to one side of filming cavity (4) is the rough surface, installation department (1) both sides shaping has installation fixture block (10).
9. The coating apparatus for producing a highly efficient implantable biosensor according to claim 8, wherein: the film coating mechanism (a7) further comprises a film coating assembly placing groove (a71) used for placing, cleaning and soaking the film coating assembly (a41), a plurality of groups of clamping grooves matched with the mounting clamping blocks (10) are formed in the film coating assembly placing groove (a71), the film coating driving assembly (a72) comprises a moving seat and a three-axis servo manipulator assembly (a73) driving the moving seat to move, and film coating assembly clamping mechanisms (a63) used for clamping the film coating assembly (a41) are respectively fixed on two sides of the moving seat.
10. The coating apparatus for producing a highly efficient implantable biosensor according to claim 6, wherein: the sensor is connected with the place board (a9) and is formed with the sensor and is connected with the place slot (a91) that can hold the sensor, the sensor is connected with the place slot (a92) that is opened under the place slot (a91) and makes the implanted biosensor (52) on the sensor to be in the overhead state, the sensor is connected with the place board (a9) and is opened with the constant head tank (a93) that can hold the horizontal pushing wheel (a55) and the vertical pushing wheel (a56), the constant head tank (a93) is connected with the place slot (a91) of the sensor.
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| CN202110935163.9A CN113546815B (en) | 2021-08-16 | 2021-08-16 | Film coating equipment for producing high-efficiency implantable biosensor |
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