CN115703097A - Film coating equipment for production of implantable biosensor - Google Patents

Abstract

The invention discloses a film coating device for producing an implantable biosensor, which comprises a workbench, wherein a film coating chamber is fixed on the workbench, a sensor linkage positioning mechanism, a film coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism are fixed in the film coating chamber, the film coating mechanism comprises a film coating assembly for storing a liquid drop-shaped film liquid and a film coating driving assembly for driving the film coating assembly to perform film coating operation, the operation of an automatic film coating process of the implantable biosensor can be realized, the film liquid is stored in the film coating assembly in a drop-shaped manner and then the sensor linkage is subjected to batch film coating instead of the traditional film-shaped manner, the wrapping integrity and the uniformity and the stability of the film coating are better, and meanwhile, the number of film coating times can be reduced because the amount of the drop-shaped film liquid captured by a film coating cavity is far larger than that of the film-shaped film liquid, so that the production efficiency is greatly improved.

Description

Film coating equipment for production of implantable biosensor

Technical Field

The invention relates to the technical field of implantable biosensors, in particular to a film coating device for producing an implantable biosensor.

Background

Monitoring of blood glucose is very important for diabetics, and blood glucose values help to assess conditions of glucose metabolism disorders in diabetics. Currently, the detection of blood glucose can be divided into in vitro detection after blood collection and real-time detection of an implantable blood glucose sensor. When blood sugar is controlled by the method of in vitro detection after blood collection, blood collection is required to be performed for many times every day, and heavy burden is imposed on the spirit and the flesh of a patient, so that the method of real-time detection by an implantable blood sugar sensor is increasingly popular.

At present, the biosensor which can be used for clinical blood sugar continuous monitoring products and is technically verified to a certain extent only has a micro sensor implanted in subcutaneous tissue, and due to the characteristics of small size and softness of an implantable biosensor, in order to improve efficiency and facilitate processing during production and manufacturing, a plurality of implantable biosensors are manufactured into a sensor unit, and corresponding equipment is needed at this time, for example, chinese invention patents with patent numbers of CN201920221865.9 and application dates of 2019-02-22 disclose a biosensor film coating tool which comprises a cavity, a film liquid groove and a needle holding plate fixing component are arranged in the cavity, a pull rod is connected with the needle holding plate fixing component, a pulling device is externally connected with the pull rod, the pulling device controls the pull rod to drive the needle holding plate fixing component to move up and down in the cavity, a sensor is arranged on the needle holding plate fixing component, and the sensor is arranged corresponding to the film liquid groove. According to the invention, the pulling device is used for controlling the pulling rod to drive the needle holding plate fixing component to move up and down in the cavity, so that the sensor fixed on the needle holding plate fixing component is placed in the film liquid tank in the cavity to complete film coating, although the production efficiency is improved, the uniformity of the film coating is not good, the film coating is only suitable for preparing sensors with rigid special shapes and short lengths, the coated sensor has to have high rigidity, cannot be bent due to resistance in the process of penetrating through the film coating, can be used only under the condition that one end of the coated sensor is fixed, and the length of the processed sensor is limited to a certain extent, so that the equipment and the principle cannot be applied to the industrial production process of common sensors. The biosensor adopting the flexible substrate is a milestone in the development of the current dynamic monitoring technology, the flexible physical property of the biosensor is important for the use performance of the implantable sensor, and compared with a rigid sensor, the flexible sensor has many advantages, such as: no rigid stimulation to human tissues, no trouble of human action, free bending and the like. The production of flexible sensor must require can to fix the sensor both ends, carries out three-dimensional even operation to the sensor, just can keep in the course of working to the sensor to apply with even processing and coating operation, and chinese utility model patent that publication number is CN201823669U discloses full-automatic integral type coating machine, and it includes the base and sets up the coating room on the base, still includes horizontal motion mechanism and vertical motion mechanism, the indoor electrode holder subassembly that is provided with of coating, the electrode holder subassembly is connected with horizontal motion mechanism and vertical motion mechanism respectively. However, the utility model discloses a because the mode that uses the membrane liquid circle is filmed, can't operate the work piece that both ends are fixed wantonly in the operation process, perhaps if with the fixed condition in sensor both ends under, the circle of filming can't pass the sensor and carry out the work of filming.

The chinese patent publication No. CN104941859B discloses a sensor film coating apparatus, wherein a film coating clamp is used as a film coating, a film coating gap for coating a workpiece after immersion is arranged in the middle of the film coating clamp, a film-like liquid film is formed in the film coating gap by liquid, the wrapping property of the liquid film is not enough, the liquid amount grabbed by the film coating clamp is limited, so that the number of times of film coating is correspondingly increased, and finally the thickness of the liquid film is not uniform under the traction of gravity and surface tension, which is easy to be thin at the top and thick at the bottom, so that the film thickness on the surface of a sensor electrode is not uniform during film coating, while the thickness of a biological film on the surface of the electrode is thin, and a small thickness difference may greatly affect the detection accuracy of the sensor electrode.

Therefore, a coating apparatus for manufacturing an implantable biosensor is needed.

Disclosure of Invention

In order to solve the problems, the invention provides a film coating device for producing an implantable biosensor.

The coating equipment comprises a workbench, wherein a coating chamber used for sealing a coating operation space is arranged on the workbench, a sensor joint positioning mechanism used for positioning and fixing a sensor joint, a membrane liquid storage mechanism used for storing membrane liquid in a sealing manner and a coating mechanism are fixedly arranged in the coating chamber, and the coating mechanism comprises a coating assembly used for storing liquid dripping membrane liquid and a coating driving assembly used for driving the coating assembly to perform coating operation.

Preferably, the coating assembly comprises an installation part and a coating part formed on the installation part, a coating cavity for storing the droplet-shaped membrane liquid is formed on the coating part, a coating channel for the implantable biosensor to pass through is formed on one side of the coating part, which is far away from the installation part, and the coating channel is communicated with the coating cavity.

Preferably, the film coating driving assembly comprises a driving support, a cross sliding table is fixed on the driving support, a moving seat is connected to the cross sliding table in a sliding mode, and a film coating assembly clamping mechanism for clamping and moving the film coating assembly and a sensor linkage adsorption mechanism for adsorbing and moving the sensor linkage are fixed at two ends of the moving seat respectively.

Preferably, the sensor linkage positioning mechanism comprises a positioning seat for accommodating the sensor linkage, the positioning seat is provided with a fixed positioning mechanism and a synchronous positioning mechanism matched with the fixed positioning mechanism, the fixed positioning mechanism comprises a transverse positioning baffle and a longitudinal positioning baffle which are fixed at two adjacent sides of the positioning seat, and the synchronous positioning mechanism comprises a transverse positioning pushing mechanism matched with the transverse positioning baffle, a longitudinal positioning pushing mechanism matched with the longitudinal positioning baffle and a positioning driving mechanism for driving the transverse positioning pushing mechanism and the longitudinal positioning pushing mechanism to act.

Preferably, the membrane liquid storage mechanism comprises a membrane liquid pool and a membrane liquid cover hinged to the membrane liquid pool.

Preferably, a cleaning mechanism is fixed in the film coating chamber, and the cleaning mechanism comprises a stirring cleaning pool and an air blowing pool which are arranged and fixed with the film liquid pool.

Preferably, a material storage mechanism is fixed on the coating chamber, the material storage mechanism comprises a movable material storage base and a material driving mechanism for driving the material storage base to move out of or into the coating chamber, and a material storage bin and a material discharge bin are fixed on the material storage base.

Preferably, the film coating part comprises a first grabbing part, a second grabbing part and a grabbing connecting part, the grabbing connecting part is used for connecting the first grabbing part with the second grabbing part in a transition mode, the surfaces of the first grabbing part, the second grabbing part and the grabbing connecting part, which are close to one side of the film coating cavity, are rough surfaces, and mounting clamping blocks are formed on two sides of the mounting part.

Preferably, the film coating mechanism comprises a film coating assembly placing groove for placing and cleaning the film coating assembly, and a plurality of groups of clamping grooves matched with the mounting clamping blocks are formed in the film coating assembly placing groove.

Preferably, the transverse positioning pushing mechanism comprises a transverse connecting block fixed with the positioning driving mechanism, a transverse pushing plate is hinged to the transverse connecting block, a transverse pushing wheel is hinged to the transverse pushing plate, the longitudinal positioning pushing mechanism comprises a longitudinal connecting block fixed with the positioning driving mechanism, a longitudinal pushing plate is hinged to the longitudinal connecting block, and a longitudinal pushing wheel is hinged to the longitudinal pushing plate. The beneficial effects of the invention are:

(1) The invention discloses a film coating device for producing an implantable biosensor, which comprises a workbench, wherein a film coating chamber is fixed on the workbench, a sensor connection positioning mechanism, a film coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism are fixed in the film coating chamber, the film coating mechanism comprises a film coating assembly for storing liquid drop-shaped film liquid and a film coating driving assembly for driving the film coating assembly to perform film coating operation, the automatic film coating process operation of the implantable biosensor can be realized, the film liquid is stored in the film coating assembly in a drop-shaped manner and then performs batch film coating on the sensor connection instead of the traditional film-shaped manner, the wrapping integrity and the film coating uniformity and stability are better, and meanwhile, the number of film coating times can be reduced because the amount of the drop-shaped film liquid grabbed by a film coating cavity is far greater than that of the film-shaped film liquid, so that the production efficiency is greatly improved.

(2) The invention discloses a film coating device for production of an implantable biosensor, which comprises a sensor joint positioning mechanism, wherein the sensor joint positioning mechanism comprises a positioning seat for accommodating a sensor joint, a fixed positioning mechanism and a synchronous positioning mechanism matched with the fixed positioning mechanism are arranged on the positioning seat, and the synchronous positioning mechanism is matched with the fixed positioning mechanism so as to realize quick and accurate positioning of the sensor joint and ensure the efficiency and effect of a sensor joint film coating process.

(3) The invention discloses a film coating device for production of an implantable biosensor, which comprises a cleaning mechanism, wherein the cleaning mechanism is used for cleaning a film coating component, so that the cleanliness of the film coating component during each film coating operation is ensured, and film liquid is not influenced.

(4) The invention discloses a film coating device for producing an implantable biosensor, which comprises a material storage mechanism, wherein a sensor unit can be stacked on a base, the sealing performance of a film coating chamber cannot be influenced by frequent feeding and discharging, the automatic feeding and discharging of the sensor unit in batches are realized, a first sealing plate and a second sealing plate are formed on two sides of the base, the sealing performance of the film coating chamber is effectively ensured, the loss of a film coating due to volatility is further reduced, and the film coating material is saved.

Drawings

FIG. 1 is a perspective view of a film coating assembly of the present invention;

FIG. 2 is an enlarged schematic view of the point A in FIG. 1;

FIG. 3 is another shape of the coating film portion of the present invention;

FIG. 4 is a schematic view of a sensor assembly of the present invention;

FIG. 5 is a perspective view of a coating apparatus for manufacturing an implantable biosensor according to the present invention;

FIG. 6 is a schematic view showing the internal structure of a coating apparatus for manufacturing an implantable biosensor according to the present invention;

FIG. 7 is a schematic perspective view of a sensor linkage positioning mechanism according to the present invention;

FIG. 8 is a perspective view of the material storage mechanism of the present invention;

FIG. 9 is a schematic perspective view of the membrane liquid storage mechanism according to the present invention;

FIG. 10 is a perspective view of the film coating driving assembly of the present invention;

FIG. 11 is a perspective view of the placement groove of the filming assembly of the present invention;

FIG. 12 is a schematic perspective view of a sensor-coupling adsorption mechanism according to the present invention;

fig. 13 is a perspective view of the pressure plate member of the present invention.

In the figure: a mounting portion 1; a film coating section 2; a connecting part 3; a coating cavity 4; a unit frame 5; a unit frame 51; an implantable biosensor 52; an electrode portion 53; a flexibility detection portion 54; a coating passage 6; a first grasping portion 7; a second grasping portion 8; a grabbing connecting part 9; installing a fixture block 10; a platen 12; a work table a1; a coating chamber a2; a sensor linkage positioning mechanism a3; a positioning seat a31; a fixed positioning mechanism a32; a synchronous positioning mechanism a33; a transverse positioning baffle a34; a longitudinal positioning baffle a35; a lateral positioning pushing mechanism a36; a transverse connecting block a361; pushing plate a362 laterally; a transverse pushing wheel a363; a longitudinal positioning pushing mechanism a37; a longitudinal connecting block a371; a longitudinal pushing plate a372; a longitudinal pushing wheel a373; (ii) a A coating mechanism a4; a film coating component a41; a coating film driving unit a42; a film coating component placing groove a43; a membrane liquid storage mechanism a5; a membrane liquid pool a51; a drive bracket a6; a cross slide a61; a moving seat a62; a film coating unit gripping mechanism a63; a sensor-associated adsorption mechanism a64; adsorption plate a641; a vent tube a642; an adsorption compression spring a643; suction cup a644; a cleaning mechanism a7; a stirring and cleaning pool a71; the blowing tank a72; a material storage mechanism a8; a material storage base a81; a material driving mechanism a82; a storage bin a83; a discharge bin a84; a first seal plate a85; a second seal plate a86; a return spring a39; the extension block a391 is limited.

Detailed Description

The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations or positional relationships based on those shown in the drawings, merely for convenience of description and simplification of the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, features defined as "first" and "second" may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In order to improve the production efficiency, the invention adopts a mass production mode for the production mode of an implantable biosensor, and the implantable biosensor is made into a sensor assembly, wherein the sensor assembly comprises a unit frame 5, the unit frame 5 comprises a unit frame 51, a plurality of implantable biosensors 52 (three or more) are fixedly connected to the unit frame 51 side by side, the upper surface of each implantable biosensor 52 is kept in the same plane with the upper surface of the unit frame 51, each implantable biosensor 52 comprises an electrode part 53 and a flexible detection part 54, the implantable biosensor 52 is introduced in the subcutaneous tissue internal sensor device with controllable implantation angle in the prior patent CN 201724053.3, so that the description is not carried out in the present case, one end of the electrode part 53 of the implantable biosensor 52, which is far away from the flexible detection part 54, is connected with the unit frame 51, and one end of the flexible detection part 54 of the implantable biosensor 52, which is far away from the electrode part 53, is connected with the unit frame 51, namely, two ends of the implantable biosensors 52 are both fixed on the unit frame 51. The size and shape of the pressing plate 12 are matched with the size and shape of the unit frame 51, and the pressing plate 12 is used for fixing two ends of the implantable biosensor 52 when the film coating assembly performs the film coating operation on the implantable biosensor 52.

The prior art of coating a film on a sensor generally adopts an immersion type, for example, chinese patent No. CN201920221865.9, filed as 2019-02-22 discloses a biosensor coating tool, which is used for coating a film by immersing a sensor in a coating solution in a liquid tank, and then pulling up the sensor after coating, and the operation method has the problems that firstly, the efficiency of coating is not high enough, the sensor needs to be pulled up again after coating in the coating solution, the pulling up process is slow, the effect of coating is affected once the speed is too fast, the uniformity of coating is affected, secondly, the coating solution is vertically arranged, the accumulation of the coating solution occurs in the slow pulling process due to the influence of gravity, the effect of coating is affected, the coating film of the sensor is not uniform, and finally, the annular coating method is adopted, and is suitable for a needle-shaped sensor with one end fixed, so that the needle-shaped sensor needs to have high rigidity, the needle-shaped sensor is not bent due to the resistance in the passing process, and the length of the sensor can be limited under the condition of fixing.

The traditional sensor film coating mode adopts the principle that a sensor penetrates through a liquid film to coat a film, for example, chinese patent publication No. CN104941859B discloses a sensor film coating device, wherein a film coating clamp is used for coating a film on a workpiece after immersion, a film coating gap for coating the workpiece after immersion is arranged in the middle of the film coating clamp, and a film-shaped liquid film is formed in the film coating gap by liquid.

A coating device for producing an implantable biosensor is used for coating sensors in batches by using liquid drop-shaped membrane liquid, the coating degree of the coating is better, the stability and the uniformity of the coated membrane layer are better, the coating times can be reduced, and the production efficiency is greatly improved. A coating device for producing an implantable biosensor comprises a workbench a1, wherein a coating chamber a2 for sealing a coating operation space is arranged on the workbench a1, and a sensor linkage positioning mechanism a3, a coating mechanism a4, a membrane liquid storage mechanism a5, a cleaning mechanism a7 and a material storage mechanism a8 are fixed in the coating chamber a 2.

Specifically, the sensor linkage positioning mechanism a3 is used for positioning and fixing a sensor linkage, so that the sensor linkage can be quickly and accurately positioned, and the speed and the effect of a sensor linkage coating film are ensured, the sensor linkage positioning mechanism includes a positioning seat a31 for accommodating the sensor linkage, the positioning seat a31 is provided with a fixed positioning mechanism a32 and a synchronous positioning mechanism a33 matched with the fixed positioning mechanism a32, the fixed positioning mechanism a32 includes a transverse positioning baffle a34 and a longitudinal positioning baffle a35 fixed on two adjacent sides of the positioning seat a31, the synchronous positioning mechanism a33 includes a transverse positioning pushing mechanism a36 matched with the transverse positioning baffle a34, a longitudinal positioning pushing mechanism a37 matched with the longitudinal positioning baffle a35, and a positioning driving mechanism a38 for driving the transverse positioning pushing mechanism a36 and the longitudinal positioning pushing mechanism a37 to move, the positioning driving mechanism a38 may be a four-jaw cylinder, and the four-jaw cylinder is a conventional technology in the field, so that no more details are given. The transverse positioning baffle a34 positions the transverse direction of the sensor unit, the longitudinal positioning baffle a35 positions the longitudinal direction of the sensor unit, the transverse positioning pushing mechanism a36 includes a transverse connecting block a361 fixed with the positioning driving mechanism a38, a transverse pushing plate a362 is hinged on the transverse connecting block a361, a transverse pushing wheel a363 is connected to the transverse pushing plate a362 in a rotating manner, the positioning driving mechanism 38 drives the transverse pushing plate a362 to move in the direction of a positioning seat a31 where the sensor unit is placed through the transverse connecting block a361, the transverse pushing wheel a363 rotates to push the sensor unit to move in the direction of the transverse positioning baffle a34 to further perform transverse accurate positioning, the longitudinal positioning pushing mechanism a37 includes a longitudinal connecting block a371 fixed with the positioning driving mechanism a38, a longitudinal pushing plate a372 is hinged on the longitudinal connecting block a, a longitudinal pushing wheel 373 is hinged on the longitudinal pushing plate a372, the positioning driving mechanism 38 places a longitudinal connecting block a371 which drives the longitudinal pushing plate a371 to move in the direction of the positioning seat 372 a31 a where the sensor unit, and the longitudinal pushing plate a35 a further moves in the direction of the longitudinal positioning pushing plate a. The number of the transverse pushing plates a362 and the number of the longitudinal pushing plates a372 are two, and the return springs a39 are fixed between the two transverse pushing plates a362 and between the two longitudinal pushing plates a372, so that the reset effect can be achieved, and the rotation angle of the transverse pushing plates a362 can be limited. One end of the transverse connecting block a361, which is far away from the positioning seat a31, and one end of the longitudinal connecting block a371, which is far away from the positioning seat a31, are both formed with limiting extension blocks a391 for limiting the moving range of the four-jaw cylinder, so that the moving positions of the transverse pushing plate a362 and the longitudinal pushing plate a372 can be limited, the accurate positioning is realized, excessive extrusion cannot be generated on the sensor joint, and the sensor joint is protected.

Specifically, the coating mechanism a4 comprises a coating module a41 for storing the droplet-shaped coating solution, a coating driving module a42 for driving the coating module a41 to perform a coating operation, and a coating module placing groove a43 for placing and cleaning the coating module a41;

the coating assembly a41 comprises an installation part 1, a coating part for grabbing membrane liquid in a drop shape is formed on the installation part 1, a coating cavity 4 for storing the drop-shaped membrane liquid is formed on the coating part 2, a coating channel 6 for the implantable biosensor 52 to pass through is formed on one side of the coating part 2, which is far away from the installation part 1, and the coating channel 6 is communicated with the coating cavity 4, so that the implantable biosensor 52 enters from the coating channel 6 and passes through the drop-shaped membrane liquid stored in the coating cavity 4 from bottom to top, and the drop-shaped membrane liquid wraps the implantable biosensor 52 completely;

the coating film driving assembly a42 comprises a driving support a6, a cross sliding table a61 is fixed on the driving support a6, a moving seat a62 is connected on the cross sliding table a61 in a sliding manner, and a coating film assembly clamping mechanism a63 for clamping and moving the coating film assembly a41 and a sensor linkage adsorption mechanism a64 for adsorbing and moving a sensor linkage are respectively fixed at two ends of the moving seat a62;

the coating assembly placing groove a43 is internally provided with a cleaning solution for cleaning the coating assembly a41, the solution can be tetrahydrofuran, the coating assembly placing groove a43 is provided with a plurality of groups of clamping grooves matched with the mounting clamping blocks 10, when the coating assembly is placed in the coating assembly placing groove a43, the coating assembly is further soaked and cleaned, the coating assembly placing groove a43 is communicated with an external container containing the cleaning solution through an injection pump, the cleaning solution in the coating assembly placing groove a43 is continuously replaced, and the cleaning solution in the coating assembly placing groove a43 is in a flowing state, so that the cleaning degree is more beneficial to cleaning.

Specifically, the coating portion 2 includes a first grabbing portion 7, a second grabbing portion 8 and a grabbing connecting portion 9 connecting the first grabbing portion 7 and the second grabbing portion 8 in a transition manner, the grabbing connecting portion 9 can prevent deformation of the grabbed dripping-shaped membrane liquid, because the implanted biosensor 52 generates an upward extrusion force to the membrane liquid in the process of passing through from bottom to top, if the grabbing connecting portion 9 does not exist, the membrane liquid can be extruded upwards or deformed due to tension of the membrane liquid itself. The grabbing connecting portion 9 is arc-shaped, triangular, wavy arc-shaped, trapezoidal and the like, the first grabbing portion 7 can be linear, wavy, arc-shaped and the like, the second grabbing portion 8 is linear, wavy, arc-shaped and the like, the coating portion 2 can be any combination of shapes which can enable membrane liquid to be present in the coating cavity 4 in a drop shape, fig. 3 is a schematic diagram of another shape, the surfaces of the first grabbing portion 7, the second grabbing portion 8 and the grabbing connecting portion 9, which are close to one side of the coating cavity 4, are rough surfaces, due to roughness, friction force can be generated to overcome gravity of the membrane liquid, the number of the coating portions 2 is 3 or more than 3, a plurality of the coating portions 2 are arranged on the mounting portion 1, the number of the coating portions 2 is matched with the implantable biosensor 52 on the sensor unit at one-level arrangement intervals, the coating portions 2 are in transitional connection with the coating cavity 1 through the connecting portions 3, the mounting portions 10 are formed on two sides of the mounting portion 1, so that the placement of the fixture block assembly can be conveniently placed in parallel to achieve the placement of the fixture block assembly.

Specifically, the film coating assembly clamping mechanism a63 and the sensor-coupled adsorption mechanism a64 are both fixedly connected to the moving seat a62 through a vertical driving mechanism, which may be an air cylinder, or a driving mechanism that drives a screw rod pair or the like through a motor so long as the driving mechanism can drive the film coating assembly clamping mechanism a63 or the sensor-coupled adsorption mechanism a64 to move up and down.

Specifically, the filming assembly clamping mechanism a63 can clamp or unclamp the filming assembly, and the filming operation on the implantable biosensor 52 is realized by conveying and displacing the filming assembly, the filming assembly clamping mechanism a63 includes a pneumatic clamping jaw and a clamping plate fixed to the pneumatic clamping jaw, and the clamping and unclamping actions are realized by two clamping plates, and the pneumatic clamping jaw is a conventional technology in the field, so that the description is omitted. The sensor coupling adsorption mechanism a64 comprises an adsorption flat plate a641, a plurality of adsorption parts are fixed on the adsorption flat plate a641, each adsorption part comprises a vent pipe a642, an adsorption compression spring a643 sleeved on the vent pipe a642 and a sucker a644 communicated with the vent pipe a642, after the sucker a644 is contacted with the sensor coupling or the pressing plate 12, the displacement and the transportation of the sensor coupling or the pressing plate 12 are realized by utilizing the adsorption force generated by the sucker a644, and the arrangement of the adsorption compression spring a643 ensures that the sucker a is in elastic contact with the sensor coupling or the pressing plate 12 without generating relatively large impact when in contact with the sensor coupling or the pressing plate 12, thereby ensuring that the sensor coupling is not damaged and ensuring the stability when the sensor coupling or the pressing plate 12 is transported.

Specifically, the membrane liquid storage mechanism a5 comprises a membrane liquid pool a51 and a membrane liquid cover hinged to the membrane liquid pool a51, wherein the membrane liquid cover is opened or closed through a control system, namely, the membrane liquid cover is automatically opened when a membrane material needs to be taken.

Specifically, the cleaning mechanism a7 includes a stirring cleaning pool a71 and a blowing pool a72 which are arranged and fixed with the membrane liquid pool a51, the stirring cleaning pool a71 includes a magnetic stirrer, the magnetic stirrer continuously stirs the cleaning liquid in the stirring cleaning pool a71 to enable the cleaning liquid to flow greatly, so as to wash and clean the membrane assembly, and improve cleaning cleanliness and cleaning efficiency, the stirring cleaning pool a71 is communicated with an external container filled with the cleaning liquid through an injection pump, so that the cleaning liquid in the stirring cleaning pool a71 can flow, the cleaning liquid continuously enters the clean cleaning liquid, and the unclean cleaning liquid flows out. The air blowing pool a72 comprises an air blowing pool body used for accommodating the film coating assembly, a plurality of air blowing ports are formed in the inner wall of one side of the air blowing pool body and communicated with an air inlet pipe, and the air blowing pool a72 is arranged to flush residual cleaning liquid or film liquid on the film coating assembly through the impact force of air flow.

Specifically, the material storage mechanism a8 includes a movable material storage base a81 and a material driving mechanism a82 for driving the material storage base a81 to move out of or into the coating chamber a2, the material driving mechanism a82 may be a linear slide rail, a storage bin a83 for storing a sensor assembly to be coated and a discharge bin a84 for storing a sensor assembly and a pressure plate 12 for coating, which are completed, are formed on the material storage base a81, a first sealing plate a85 and a second sealing plate a86 are formed on two sides of the base a81 perpendicular to the moving direction, the size and shape of the first sealing plate a85 and the second sealing plate a86 are matched with the size and shape of a discharge port formed on the coating chamber a2, the first sealing plate a85 seals the coating chamber a2 under the condition of no discharge, and when the coating chamber a2 is manually discharged or discharged, the second sealing plate a86 seals the coating chamber a2, so that the sealing performance of the coating chamber a2 is effectively ensured, the loss of the coating due to its own volatility is prevented, the loss of the coating material is further reduced, and the amount of the coating material is saved.

The specific operation process comprises the following steps:

the first step is as follows: discharging; stacking a plurality of sensor units and the pressing plate 12 which need to be coated at intervals and storing the sensor units and the pressing plate 12 in a storage bin a83, namely stacking one sensor unit on one pressing plate 12 to form a group for stacking;

the second step is that: taking a sensor couple, wherein the coating driving assembly a42 drives the sensor couple adsorption mechanism a64 to move right above the storage bin a83, then the vertical driving mechanism drives the sensor couple adsorption mechanism a64 to move downwards, the sensor couple needing coating is adsorbed and fixed, the coating driving assembly a42 drives the sensor couple adsorption mechanism a64 to move to the position above the sensor couple positioning mechanism a3 again, and the adsorbed sensor couple is placed in the positioning seat a31;

the third step: taking a press plate 12, driving a sensor linkage adsorption mechanism a64 to move right above a material storage bin a83 by a coating driving assembly a42, driving the sensor linkage adsorption mechanism a64 to move downwards by a vertical driving mechanism, adsorbing and fixing the press plate 12, driving the sensor linkage adsorption mechanism a64 to move above a sensor linkage positioning mechanism a3 again by the coating driving assembly a42, and placing the adsorbed press plate 12 on the sensor linkage (the press plate 12 can play a role of fixing the sensor linkage, so that the sensor linkage is smoother, and because the sensor linkage is made of flexible materials, the situation of bending and irregularity is easy to occur, the press plate 12 is placed on the sensor linkage to flatten the sensor linkage, thereby being more beneficial to the effect of coating);

the fourth step: the positioning driving mechanism a38 drives the synchronous positioning mechanism a33 to move towards the fixed positioning mechanism a32, and pushes the sensor unit arranged at the positioning seat a31 and the pressing plate 12 to move towards the fixed positioning mechanism a32, so as to perform accurate positioning;

the fifth step: grabbing the coating film assembly a41 and coating, wherein the coating film driving assembly a42 drives the coating film assembly clamping mechanism a63 to move to the position above the coating film assembly placing groove a43, then the vertical driving mechanism drives the coating film assembly clamping mechanism a63 to move downwards, the coating film assembly a41 is grabbed and moved into the air blowing pool a72 under the driving of the coating film driving assembly a42, the cleaning liquid on the coating film assembly a41 is blown away by air flow, the coating film assembly a41 is moved to the position above the membrane liquid storing mechanism a5, the membrane liquid cover is automatically opened after the sensor senses, the coating film assembly a41 is moved into the membrane liquid pool a51 to be dipped, the membrane liquid is stored in the coating film cavity 4 in a dripping form, the membrane liquid cover is automatically closed, the membrane liquid cover is finally moved to the position above the sensor combined adsorption mechanism a64, the coating film assembly a63 moves downwards under the driving of the vertical driving mechanism, the implantable biosensor 52 enters the coating film channel 6, the coating film clamping mechanism a63 continues to move downwards, the implantable biosensor 52 enters the coating film cavity 4, and the implantable biosensor 52 can be completely wrapped due to detect the direction of the implanted biosensor from the coating film assembly moving mechanism 54;

and a sixth step: cleaning the coating assembly a41, driving the coating assembly clamping mechanism a63 to move above the stirring and cleaning tank a71 by the coating driving assembly a42, driving the coating assembly clamping mechanism a63 to repeatedly move up and down by the vertical driving mechanism for a plurality of times, oscillating and cleaning the residual membrane liquid, moving the residual membrane liquid into the air blowing tank a72 by the combined action of the coating driving assembly a42 and the vertical driving mechanism, blowing away the residual liquid, finally clamping the coating assembly a41 into the clamping groove a44, and further soaking and cleaning the coating assembly in the coating assembly placing groove a43;

the seventh step: storing materials, namely placing the pressing plate 12 in a material placing bin a84 through a sensor coupling adsorption mechanism a64 under the common drive of the coating driving assembly a42 and the vertical driving mechanism, and then placing the sensor which is coated in a material placing bin a84 through the sensor coupling adsorption mechanism a64 under the common drive of the coating driving assembly a42 and the vertical driving mechanism;

eighth step: and repeating the second step to the seventh step.

The invention discloses a film coating device for an implantable biosensor, which comprises a sensor coupling positioning mechanism, a film coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism, wherein the film coating mechanism comprises a film coating assembly for storing liquid drop-shaped film liquid and a film coating driving assembly for driving the film coating assembly to perform film coating operation, so that the automatic film coating process operation of the implantable biosensor can be realized, the film liquid is stored in the film coating assembly in a drop-shaped manner and then is subjected to batch film coating on the sensor coupling instead of the traditional film form, the coating integrity is realized, the film coating uniformity and stability are better, and meanwhile, the film drop-shaped film liquid amount grabbed by a film coating cavity is far greater than the film liquid amount, so that the film coating times can be reduced, and the production efficiency is greatly improved.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made to the present invention by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A coating apparatus for producing an implantable biosensor, comprising a table (a 1), wherein a coating chamber (a 2) for sealing a coating operation space is provided on the table (a 1), characterized in that: and a sensor coupling positioning mechanism (a 3) for positioning and fixing a sensor coupling, a membrane liquid storage mechanism (a 5) for hermetically storing membrane liquid and a coating mechanism (a 4) are fixed in the coating chamber (a 2), and the coating mechanism (a 4) comprises a coating assembly (a 41) for storing the liquid dripping membrane liquid and a coating driving assembly (a 42) for driving the coating assembly (a 41) to perform coating operation.

2. The coating apparatus for the production of an implantable biosensor according to claim 1, wherein: the coating assembly (a 41) comprises an installation part (1) and a coating part (2) formed on the installation part (1), a coating cavity (4) used for storing liquid drop-shaped membrane liquid is formed on the coating part (2), the coating part (2) is far away from one side of the installation part (1) and is provided with a coating channel (6) used for an implantable biosensor (52) to pass through, and the coating channel (6) is communicated with the coating cavity (4).

3. The coating apparatus for the production of an implantable biosensor according to claim 1, wherein: the coating driving assembly (a 42) comprises a driving support (a 6), a cross sliding table (a 61) is fixed on the driving support (a 6), a moving seat (a 62) is connected to the cross sliding table (a 61) in a sliding mode, and two ends of the moving seat (a 62) are respectively fixed with a coating assembly clamping mechanism (a 63) for clamping and moving the coating assembly (a 41) and a sensor linkage adsorption mechanism (a 64) for adsorbing and moving a sensor linkage.

4. The coating apparatus for the production of an implantable biosensor according to claim 1, wherein: the sensor allies oneself with positioning mechanism (a 3) is including being used for holding positioning seat (a 31) that the sensor allies oneself with, be provided with fixed position mechanism (a 32) on positioning seat (a 31) and with fixed position mechanism (a 32) matched with synchronous positioning mechanism (a 33), fixed position mechanism (a 32) including be fixed in horizontal location baffle (a 34) and vertical location baffle (a 35) of the adjacent both sides of positioning seat (a 31), synchronous positioning mechanism (a 33) including with horizontal location pushing mechanism (a 36) of horizontal location baffle (a 34) matched with, with vertical location pushing mechanism (a 37) of vertical location baffle (a 35) matched with and drive horizontal location pushing mechanism (a 36) and vertical location actuating mechanism (38) of pushing mechanism (a 37) action.

5. The coating apparatus for the production of an implantable biosensor according to claim 1, wherein: the membrane liquid storage mechanism (a 5) comprises a membrane liquid pool (a 51) and a membrane liquid cover which is hinged to the membrane liquid pool (a 51).

6. The coating apparatus for the production of an implantable biosensor according to claim 5, wherein: a cleaning mechanism (a 7) is fixed in the film coating chamber (a 2), and the cleaning mechanism (a 7) comprises a stirring cleaning pool (a 71) and an air blowing pool (a 72) which are fixedly arranged with the film liquid pool (a 51).

7. The coating apparatus for the production of an implantable biosensor according to claim 1, wherein: the coating chamber (a 2) is fixed with a material storage mechanism (a 8), the material storage mechanism (a 8) comprises a movable material storage base (a 81) and a material driving mechanism (a 82) for driving the material storage base (a 81) to move out of or into the coating chamber (a 2), and a storage bin (a 83) and a storage bin (a 84) are formed on the material storage base (a 81).

8. The coating apparatus for the production of an implantable biosensor according to claim 2, wherein: scribble membrane portion (2) including first portion (7) of snatching, the second snatchs portion (8) and snatchs portion (7) and second with first portion (8) of snatching and snatchs connecting portion (9) of portion (8) transitional coupling, first portion (7) of snatching, the second snatchs portion (8) and snatchs connecting portion (9) its being close to the face of one side of filming cavity (4) is the rough surface, installation department (1) both sides shaping has installation fixture block (10).

9. The coating apparatus for the production of an implantable biosensor according to claim 8, wherein: the film coating mechanism (a 4) comprises a film coating assembly placing groove (a 43) used for placing and cleaning the film coating assembly (a 41), and a plurality of groups of clamping grooves (a 44) matched with the mounting clamping blocks (10) are formed in the film coating assembly placing groove (a 43).

10. The coating apparatus for the production of an implantable biosensor according to claim 4, wherein: the transverse positioning pushing mechanism (a 36) comprises a transverse connecting block (a 361) fixed with the positioning driving mechanism (38), a transverse pushing plate (a 362) is hinged to the transverse connecting block (a 361), a transverse pushing wheel (a 363) is connected to the transverse pushing plate (a 362) in a rotating mode, the longitudinal positioning pushing mechanism (a 37) comprises a longitudinal connecting block (a 371) fixed with the positioning driving mechanism (38), a longitudinal pushing plate (a 372) is hinged to the longitudinal connecting block (a 371), and a longitudinal pushing wheel (a 373) is connected to the longitudinal pushing plate (a 372) in a rotating mode.

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