CN113546016B - Water-in-oil type scar repairing microemulsion and preparation method thereof - Google Patents
Water-in-oil type scar repairing microemulsion and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A61K8/04—Dispersions; Emulsions
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a water-in-oil type scar repairing microemulsion and a preparation method thereof. The scar repairing microemulsion comprises an emulsifier, a solvent, a centella asiatica extract and a vegetable oil active ingredient. The preparation method comprises the steps of uniformly mixing the active ingredients of the vegetable oil and the emulsifier at room temperature to obtain an oil phase, dissolving the centella extract in a solvent to obtain a water phase, and adding the water phase into the oil phase under the stirring condition to obtain the water-in-oil type scar repairing microemulsion. The scar repairing microemulsion prepared by the invention has triple skin care effects of removing scar tissues, nourishing skin and lightening pigment, and overcomes the defects of poor solubility and small application range of the centella asiatica extract. The microemulsion prepared by the invention is a water-in-oil system, has better stability, can be used independently, can also be added into oil type cosmetics, and has convenient use, simple process and easy production.
Description
Technical Field
The invention relates to a water-in-oil type scar repairing microemulsion and a preparation method thereof, belonging to the technical field of cosmetics and medicines.
Background
Scars, which are fibrous tissues that replace normal skin after human skin injury, are a general term for morphological and histopathological changes of normal skin tissues and are also a necessary result of wound healing. Scars not only damage the beauty of the body surface, but also may affect the function of the relevant tissues or organs, and even more serious ones may cause deformities. With the increase of attention of people to personal appearance, skin wound repair becomes a hot point of attention in the cosmetic industry and the plastic industry.
The essential oil of Lavender mainly comprises linalool, camphora, linalyl acetate, lavender alcohol, eucalyptol, etc. The lavender essential oil has a certain protection effect on wound healing, and researches prove that the lavender essential oil has the effects of resisting inflammation, relieving pain, reducing scar tissue hyperplasia, promoting wound tissue repair and shortening healing time.
Patchouli oil is essential oil extracted from patchouli, is volatile, has pungent smell and has various pharmacological activities, and can fade scars left by acne, wounds, measles, pox marks or furuncles or reduce the scars as much as possible.
Centella asiatica extract is widely used in the fields of medicine and cosmetology, has the function of promoting wound healing, and is used for treating trauma, operation wound, burn, keloid and scleroderma. However, in cosmetics, because the molecular weight of the active ingredients of centella asiatica is relatively large, the water solubility of the active ingredients in the cosmetics is poor, precipitates are easy to separate out and the like, and the application of the active ingredients in the cosmetics is influenced, so that the active ingredients are generally added in the form of extraction extract, and the real efficacy is difficult to exert.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the poor water solubility of centella asiatica leads to the problem of limited use in cosmetics.
In order to solve the technical problems, the invention provides a water-in-oil type scar repairing microemulsion, wherein an oil phase comprises an emulsifier and a vegetable oil active ingredient, and a water phase comprises a centella asiatica extract and a solvent, wherein the emulsifier is at least one of polyglycerol polyricinoleate, tween-80 and span-80, the vegetable oil active ingredient is patchouli oil and/or lavender essential oil, and the solvent is at least one of 1, 3-butanediol, 1, 3-propanediol and polyethylene glycol-400.
Preferably, the mass ratio of the vegetable oil active ingredient to the emulsifier in the oil phase is 9.
Preferably, the mass ratio of the centella asiatica extract to the solvent in the aqueous phase is 0.2-0.4: 15 to 20.
Preferably, the mass ratio of the oil phase to the water phase is 1:0.1 to 0.3.
Preferably, the active ingredients of the vegetable oil are the combination of patchouli oil and lavender essential oil, and the mass ratio of the patchouli oil to the lavender essential oil is 1.
The invention also provides a preparation method of the water-in-oil type scar repairing microemulsion, which comprises the following steps:
step 1: mixing the active ingredients of the vegetable oil and the emulsifier in proportion at room temperature, stirring uniformly, and then placing in a constant temperature oscillator for emulsification treatment to obtain a uniform oil phase;
and 2, step: weighing a centella extract in a solvent at room temperature, and heating for dissolving to obtain a clear and transparent water phase;
and step 3: and weighing the water phase, adding the water phase into the oil phase, and stirring and mixing to obtain the water-in-oil type scar repairing microemulsion.
Preferably, the temperature of the emulsification treatment in the step 1 is 20-30 ℃ and the time is 12-24 h.
Preferably, the temperature for heating and dissolving in the step 2 is 50-70 ℃.
Preferably, the conditions for stirring and mixing in the step 3 are as follows: the temperature is 20-30 ℃, and the stirring speed is 500-2000r/min.
The brief introduction of the part of the raw materials involved in the scar repairing composition of the invention is as follows:
the main components of lavender essential oil include linalool, camphor, linalyl acetate, lavender alcohol, eucalyptol, etc. The lavender essential oil has a certain protection effect on wound healing, and researches prove that the lavender essential oil has the effects of resisting inflammation, relieving pain, reducing scar tissue hyperplasia, promoting wound tissue repair and shortening healing time.
Patchouli oil is essential oil extracted from patchouli, is volatile, has pungent smell and has various pharmacological activities, and can fade scars left by acne, wounds, measles, pox marks or furuncles or reduce the scars as much as possible.
Centella asiatica extract is widely used in the fields of medicine and cosmetology, has the function of promoting wound healing, and is used for treating trauma, operation wound, burn, keloid and scleroderma.
Compared with the prior art, the invention has the beneficial effects that:
1. the scar repairing microemulsion is prepared by selecting ingredients such as lavender essential oil, patchouli oil and centella extract, and the like, and the active ingredients are matched with each other in a synergistic manner, so that the effect of repairing scars is favorably improved, the substances are all natural extracts, the skin is not easy to be stimulated, the scar repairing microemulsion is suitable for sensitive skin, and the application range is wider;
2. the invention can effectively solve the problem of poor solubility of the asiatic pennywort herb extract, and the asiatic pennywort herb extract can exert real effect by effectively solubilizing the asiatic pennywort herb extract;
3. the microemulsion prepared by the invention is a water-in-oil system, has better stability, can be used independently, can also be added into oil type cosmetics, and has convenient use, simple process and easy production.
Detailed Description
In order that the invention may be more readily understood, preferred embodiments will now be described in detail.
The specifications of the raw materials and information on the manufacturer used in the following examples are shown in table 1:
table 1 raw material information
Starting materials | Reagent specifications | Manufacturer of the product |
Centella asiatica extract | -- | Shanghai green butterfly industries Ltd |
1, 3-butanediol | Analytical purity | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
Polyethylene glycol-400 | Analytical purity | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
1, 3-propanediol | Analytical purity | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
Polyglycerol ricinol ester | Analytical purity | Shandong Youso chemical technology Co Ltd |
Calcium chloride | Analytical purity | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
Tween-80 | Analytical purity | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
Span-80 | Analytical purity | SINOPHARM CHEMICAL REAGENT Co.,Ltd. |
Lavender essential oil | -- | Jiangxi Baolin Natural spices Limited |
Patchouli oil | -- | Hubei Jusheng science and technology Co Ltd |
The model and manufacturer information of the instruments used in the following examples are shown in Table 2:
TABLE 2 Instrument Equipment information
Instrumentation and equipment | Type number | Manufacturer of the product |
Electronic balance | PL 403 | METTLER TOLEDO |
Manual liquid transfer device | 100μL | Mettler-toledo group |
Constant temperature magnetic stirrer | 524G | Shanghai Meiglupu Instrument and Meter manufacturing Co., ltd |
Constant temperature oscillator | SHZ-B | Shanghai Bo news medical biological instruments GmbH |
Example 1
A water-in-oil type microemulsion for repairing scar comprises an oil phase including emulsifier and vegetable oil active ingredient, and a water phase including herba Centellae extract and solvent, wherein polyglycerol polyricinoleate is used as emulsifier, lavender essential oil is used as vegetable oil active ingredient, and polyethylene glycol-400 and 1, 3-propylene glycol are used as solvent.
The preparation method of the water-in-oil type scar repairing microemulsion specifically comprises the following steps:
(1) Mixing the active ingredients of the vegetable oil and the emulsifier according to a certain proportion at room temperature, stirring uniformly, fully mixing the oil phase and the emulsifier, transferring to a container, placing on a constant temperature oscillator, and continuously shaking for 12h at the temperature of 25 ℃ to obtain a phase A;
wherein the dosage of the active ingredients of the vegetable oil and the emulsifier is calculated according to the mass ratio of 5: the dosage of the polyglycerol polyricinoleate is calculated according to the mass ratio of 5;
(2) Weighing 0.2g of centella asiatica extract powder, dissolving in 10mL of solvent at room temperature, placing a beaker in a 60 ℃ water bath kettle, heating, stirring and dissolving until a clear and transparent solution is obtained, thus obtaining a phase B;
wherein, the volume ratio of the solvent polyethylene glycol-400 to the 1, 3-propylene glycol is 7;
(3) Controlling the stirring speed of a magnetic stirrer to be 500r/min, and adding the phase B into the phase A at 25 ℃ to obtain water-in-oil type scar repairing microemulsion;
wherein the mass ratio of the phase A to the phase B is 1.
Example 2
A water-in-oil type microemulsion for repairing scar comprises oil phase including emulsifier and vegetable oil active ingredient, and water phase including herba Centellae extract and solvent, wherein span-80 is used as emulsifier, lavender essential oil and oleum Pogostemonis are used as vegetable oil active ingredient, and 1, 3-butanediol is used as solvent.
The preparation method of the water-in-oil type scar repairing microemulsion specifically comprises the following steps:
(1) Mixing the active ingredient of the vegetable oil and the emulsifier according to a certain proportion at room temperature, stirring uniformly, fully mixing the active ingredient of the vegetable oil and the emulsifier, transferring to a container, placing on a constant temperature oscillator, and continuously shaking for 12h at the temperature of 25 ℃ to obtain phase A;
wherein, the dosage of the vegetable oil active ingredient and the emulsifier is calculated according to the mass ratio of 5; the active ingredients of the vegetable oil are compounded by lavender essential oil and patchouli oil according to the mass ratio of 4;
(2) Weighing 0.2g of centella asiatica extract powder at room temperature, dissolving in 10mL of solvent, placing a beaker in a 60 ℃ water bath kettle, heating, stirring and dissolving until a clear and transparent solution is obtained, and obtaining a phase B;
(3) Controlling the stirring speed of a magnetic stirrer to be 500r/min, and adding the phase B into the phase A at 25 ℃ to obtain water-in-oil type scar repairing microemulsion;
wherein the mass ratio of the phase A to the phase B is 1.
Example 3
A water-in-oil type microemulsion for repairing scar is prepared from oil phase including emulsifier and vegetable oil as active components, and water phase including herba Centellae extract and solvent, wherein polyglycerol polyricinoleate is used as emulsifier, lavender essential oil and oleum Pogostemonis are used as vegetable oil as active components, and polyethylene glycol-400 and 1, 3-propylene glycol are used as solvent.
The preparation method of the water-in-oil type scar repairing microemulsion specifically comprises the following steps:
(1) Mixing the active ingredients of the vegetable oil and the emulsifier according to a certain proportion at room temperature, stirring uniformly, fully mixing the active ingredients of the vegetable oil and the emulsifier, transferring the mixture into a container, placing the container on a constant-temperature oscillator, and continuously shaking for 12 hours at the temperature of 25 ℃ to obtain a phase A;
wherein, the dosage of the vegetable oil active ingredient and the emulsifier is calculated according to the mass ratio of 5; the active ingredients of the vegetable oil are compounded by lavender essential oil and patchouli oil according to the mass ratio of 4;
(2) Weighing 0.2g of centella asiatica extract powder, dissolving in 10mL of solvent at room temperature, placing a beaker in a 60 ℃ water bath kettle, heating, stirring and dissolving until a clear and transparent solution is obtained, thus obtaining a phase B;
wherein the volume ratio of the solvent polyethylene glycol-400 to the 1, 3-propylene glycol is 7;
(3) Controlling the stirring speed of a magnetic stirrer to be 500r/min, and adding the phase B into the phase A at 25 ℃ to obtain water-in-oil type scar repairing microemulsion;
wherein the mass ratio of the phase A to the phase B is 1.
Example 4
A water-in-oil type scar repairing microemulsion comprises an oil phase and a water phase, wherein the oil phase comprises an emulsifier and a vegetable oil active component, the water phase comprises a centella asiatica extract and a solvent, span-80 and tween-80 are used as the emulsifier, lavender essential oil and patchouli oil are used as the vegetable oil active component, and polyethylene glycol-400 and 1, 3-propylene glycol are used as the solvent.
The preparation method of the water-in-oil type scar repairing microemulsion specifically comprises the following steps:
(1) Mixing the active ingredients of the vegetable oil and the emulsifier according to a certain proportion at room temperature, stirring uniformly, fully mixing the active ingredients of the vegetable oil and the emulsifier, transferring the mixture into a container, placing the container on a constant temperature oscillator, and continuously shaking for 12 hours at the temperature of 25 ℃ to obtain a phase A;
wherein, the dosage of the vegetable oil active ingredient and the emulsifier is calculated according to the mass ratio of 5; the active ingredients of the vegetable oil are compounded by lavender essential oil and patchouli oil according to the mass ratio of 4; the emulsifier comprises span-80 and tween-80 in a mass ratio of 1;
(2) Weighing 0.2g of centella asiatica extract powder, dissolving in 10mL of solvent at room temperature, placing a beaker in a 60 ℃ water bath kettle, heating, stirring and dissolving until a clear and transparent solution is obtained, thus obtaining a phase B;
wherein the volume ratio of the solvent polyethylene glycol-400 to the 1, 3-propylene glycol is 7;
(3) Controlling the stirring speed of a magnetic stirrer to be 600r/min, and adding the phase B into the phase A at 25 ℃ to obtain water-in-oil type scar repairing microemulsion;
wherein the mass ratio of the phase A to the phase B is 1.
The solubility of the centella extract in the microemulsion reaches 2.700mg/mL, and the microemulsion is a clear and transparent solution, so that the centella extract is effectively solubilized, and the application range of the microemulsion is enlarged. (the solubilities of asiatic acid and asiaticoside in water were 0.100mg/mL and 0.305mg/mL (25 ℃ C.) respectively).
Comparative example 1
A scar repairing microemulsion is prepared from span-80 and Tween-80 as emulsifier, lavender essential oil and oleum herba Pogostemonis as active ingredients of vegetable oil, and polyethylene glycol-400 and 1, 3-propylene glycol as solvent.
The preparation of the scar repairing microemulsion comprises the following steps:
(1) Mixing the active ingredients of the vegetable oil and the emulsifier according to a certain proportion at room temperature, stirring uniformly, fully mixing the active ingredients of the vegetable oil and the emulsifier, transferring the mixture into a container, placing the container on a constant temperature oscillator, and continuously shaking for 12 hours at the temperature of 25 ℃ to obtain a phase A;
wherein, the dosage of the vegetable oil active ingredient and the emulsifier is calculated according to the mass ratio of 5; the active ingredients of the vegetable oil are compounded by lavender essential oil and patchouli oil according to the mass ratio of 4; the emulsifier is composed of span-80 and tween-80 in a mass ratio of 1;
(2) Mixing polyethylene glycol-400 and 1, 3-propylene glycol according to the volume ratio of 7;
(3) Controlling the stirring speed of a magnetic stirrer to be 600r/min, and adding the phase B into the phase A at 25 ℃ to obtain the water-in-oil type scar repairing microemulsion;
wherein the mass ratio of the phase A to the phase B is 1.
Test experiments:
1. stability test
Stability tests were performed on the microemulsion for scar repair prepared in examples 1 to 4 and comparative example 1, and the test subjects were observed after being placed in an environment of-5 ℃, 25 ℃ and 45 ℃ at room temperature for one month, respectively, and the standards of no discoloration, no precipitation, and no odor were adopted. Specific test results are shown in table 3.
Table 3 stability test results of scar repair microemulsions of examples and comparative examples
-5℃ | Room temperature 25 deg.C | 45℃ | |
Example 1 | Clear and transparent | Clear and transparent | Clear and transparent |
Example 2 | Clear and transparent | Clear and transparent | Clear and transparent |
Example 3 | Clear and transparent | Clear and transparent | Clear and transparent |
Example 4 | Clear and transparent | Clear and transparent | Clear and transparent |
Comparative example 1 | Clear and transparent | Clear and transparent | Clear and transparent |
The experimental results are as follows: after 1 month observation, the scar repair microemulsions obtained in examples 1-4 and comparative example 1 are clear and transparent. Therefore, the water-in-oil type scar repairing microemulsion prepared by the invention has good stability.
2. Evaluation of efficacy
The efficacy of the microemulsion for scar repair prepared in examples 1 to 4 and comparative example 1 was evaluated. Test objects: 50 volunteers are selected in total, 10 volunteers are selected in each experimental group, the age is 18-55 years old, cosmetics can be used according to the standard, evaluation work can be completed according to requirements by matching with workers, certain expression capability is realized, and the feeling after use can be truly reflected; test area: scars on the skin; use of: the ointment is used once in the morning and evening every day for 45 days continuously, and a proper amount of the ointment is uniformly smeared on the surface of a scar when the ointment is used; evaluation criteria: effective, effective and ineffective, wherein the skin scar is basically eliminated or obviously lightened to be effective; the skin scar phenomenon is effectively relieved; if the skin scar is not changed or the remission is not obvious, the skin scar is judged to be invalid. The specific test results are shown in table 4.
TABLE 4 scar repair test evaluation chart
Show effect | Is effective | Nullification | |
Example 1 | 1 | 4 | 5 |
Example 2 | 2 | 6 | 2 |
Example 3 | 2 | 5 | 3 |
Example 4 | 3 | 6 | 1 |
Comparative example 1 | 1 | 4 | 5 |
From the results in table 4, it can be seen that: the examples 1-4 and the comparative example 1 of the invention can play a certain role in repairing and lightening scars on the skin. Wherein the fading repair rate of the composition containing the centella extract, the patchouli oil and the lavender essential oil on scars reaches more than 70%. As can be seen from comparison of the efficacy tests of example 1 and examples 2-4, the combination of lavender essential oil and patchouli oil has better efficacy in repairing scars than the use of lavender essential oil alone; as can be seen from the comparison of the efficacy test of example 4 with the efficacy test of comparative example 1, the obtained composition has a better promoting effect on the repair of scars due to the significant synergistic effect of the centella asiatica extract, the lavender essential oil and the patchouli oil.
The above-described embodiments are only preferred embodiments of the present invention, and are not intended to limit the present invention in any way and substantially, it should be noted that those skilled in the art may make several modifications and additions without departing from the scope of the present invention, which should also be construed as a protection scope of the present invention.
Claims (5)
1. The water-in-oil type scar repairing microemulsion is characterized in that an oil phase comprises an emulsifier and a vegetable oil active ingredient, and a water phase comprises a centella asiatica extract and a solvent, wherein the emulsifier is at least one of polyglycerol ricinol and span-80, the vegetable oil active ingredient is a combination of patchouli oil and lavender essential oil, the mass ratio of the patchouli oil to the lavender essential oil is 1;
the mass ratio of the vegetable oil active ingredient to the emulsifier in the oil phase is 9 to 5;
the mass ratio of the asiatic pennywort herb extract to the solvent in the water phase is 0.2 to 0.4:15 to 20;
the mass ratio of the oil phase to the water phase is 1:0.1 to 0.3.
2. The method for preparing the microemulsion of water-in-oil type scar repair according to claim 1, comprising the steps of:
step 1: mixing the active ingredients of the vegetable oil with an emulsifier in proportion at room temperature, uniformly stirring, and then putting the mixture into a constant-temperature oscillator for emulsification treatment to obtain a uniform oil phase;
and 2, step: weighing herba Centellae extract at room temperature, dissolving in solvent under heating to obtain clear and transparent water phase;
and 3, step 3: and weighing the water phase, adding the water phase into the oil phase, and stirring and mixing to obtain the water-in-oil type scar repairing microemulsion.
3. The preparation method of the water-in-oil type scar repair microemulsion according to claim 2, wherein the temperature of the emulsification treatment in the step 1 is 20 to 30 ℃ and the time is 12 to 24h.
4. The preparation method of the microemulsion for water-in-oil scar repair according to claim 2, wherein the temperature for heating and dissolving in step 2 is 50 to 70 ℃.
5. The method for preparing a water-in-oil type scar repair microemulsion of claim 2, wherein the conditions for stirring and mixing in step 3 are: the temperature is 20 to 30 ℃, and the stirring speed is 500 to 2000r/min.
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