CN102552565A - Oil-in-water compound grape seed oil nanoemulsion breast enlargement preparation and preparation method thereof - Google Patents
Oil-in-water compound grape seed oil nanoemulsion breast enlargement preparation and preparation method thereof Download PDFInfo
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- CN102552565A CN102552565A CN2012100365868A CN201210036586A CN102552565A CN 102552565 A CN102552565 A CN 102552565A CN 2012100365868 A CN2012100365868 A CN 2012100365868A CN 201210036586 A CN201210036586 A CN 201210036586A CN 102552565 A CN102552565 A CN 102552565A
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Abstract
The invention discloses an oil-in-water compound grape seed oil nanoemulsion breast enlargement preparation and a preparation method thereof. The preparation consists of the following raw materials in percentage by mass: 20 to 35 percent of surfactant, 2 to 15 percent of cosurfactant, 1 to 5 percent of oil phase, 0.1 to 5 percent of grape seed oil, 0.1 to 3 percent of rose oil, 0.1 to 3 percent of sage oil, 0.1 to 2 percent of ylang ylang oil, 0.1 to 2 percent of evening primrose oil, and the balance of distilled water. According to the preparation, several kinds of essential oil are compounded together; and the preparation is used as a nanoemulsion liniment which has an obvious effect and high safety, can enlarge breast and beautify the breast, and does not have side effects.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of compound recipe compound grape-seed oil nanometer emulsion breast enlargement preparation, be specifically related to a kind of oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation and preparation method thereof.
Background technology
[0002] present stage, breast enlarging method has a lot, but all has certain defective.The hormones product that is used for breast enlargement contains artificial estradiol usually, can cause suffering from the risk of cancer, gets fat, and stops using to be prone to bounce-back; Instrument breast enlargement cost of investment is high, and part crowd can rebound; Motion breast enlargement DeGrain, the time is long, is difficult for adhering to; Diet breast enlargement effect is slow; Injection breast enlargement safety is low, and cell or skin histology around the material of injection possibly invaded damage human body; The operation expense height of enlarging the bosom has rejection easily, can damage human body.Therefore seek a kind of safe, effectively, the breast enlarging method that do not rebound is to need the problem that solves at present.
Summary of the invention
Some problems that the breast enlargement product mentioned more than the objective of the invention is to be directed against exists, provide a kind of can be well by skin absorbs, effect is remarkable, easy to use, cost of investment is low and the compound grape-seed oil nanometer emulsion breast enlargement preparation that has no side effect.
The effect and the mechanism thereof of the U.S. breasts of five kinds of quintessence oil breast enlargements have been detailed in the background technology, with they compound nano-emulsion preparations that is prepared into, better skin permeation, and can also coordinate each other between five kinds of quintessence oils, complement each other, reinforced effects.Concrete breast enlargement effect will detail in Test Example.
The technical scheme that realizes the foregoing invention purpose is an oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation, and each amounts of components is for all to have effect preferably in following weight percentage ranges:
Surfactant 20%～35%
Cosurfactant 2%～15%
Oil phase 1%～5%
Oleum Vitis viniferae 0.1%～5%
Rose oil 0.1%～3%
Sage oil 0.1%～3%
Cananga odorata oil 0.1%～2%
Radix Oenotherae erythrosepalae oil 0.1%～2%
Surplus is a distilled water, and the mass percent sum of above-mentioned raw materials is 100%.
The formula optimization weight percentage ranges of preparation medicine of the present invention is:
Surfactant 25%～32%
Cosurfactant 4%～10%
Oil phase 2%～4%
Oleum Vitis viniferae 0.1%～4%
Rose oil 0.1%～2%
Sage oil 0.1%～2%
Cananga odorata oil 0.1%～1.5%
Radix Oenotherae erythrosepalae oil 0.1%～1.5%
Surplus is a distilled water, and the mass percent sum of above-mentioned raw materials is 100%.
The prescription optimum weight percentage of preparation medicine of the present invention is:
Tween-80 30%, ethanol 6%, isopropyl myristate 4%, Oleum Vitis viniferae 3%, rose oil 1.5%, sage oil 1.5%, Cananga odorata oil 1%, Radix Oenotherae erythrosepalae oil 1%, distilled water 52%;
Described surfactant is the mixture of any or several kinds among polyoxyethylene ether (40) castor oil hydrogenated (RH-40), tween 80 and the EL-40.
Described cosurfactant is an ethanol, 1, any in 2-propylene glycol, glycerin, the 1,3 butylene glycol or several kinds of mixture.
Said oil is the mixture of any or several kinds in isopropyl myristate, Jojoba oil, liquid paraffin, the ethyl oleate.
On surfactant selection, the present invention selects the nonionic surfactant of avirulence and good biocompatibility for use.Available surfactant has the mixture of any or several kinds among polyoxyethylene ether (40) castor oil hydrogenated, tween 80 and the EL-40.
In the selection of cosurfactant; The HLB of cosurfactant ability reconciliation statement surface-active agent; And can reduce oil water interfacial tension, nano-emulsion multiselect short chain alcohol and medium chain alcohol are cosurfactant, and the cosurfactant that the present invention selects for use is an ethanol, 1; In 2-propylene glycol, glycerin, the 1,3 butylene glycol any or several kinds of mixture.
The present invention is according to when the HLB of the required surfactant of emulsifying oil phase is close with surfactant; The principle that formed emulsion is stable, the oils and fats of selecting for use have the mixture of any or several kinds in isopropyl myristate, Jojoba oil, liquid paraffin, the ethyl oleate.These oil are in a liquid state, do not have bad abnormal smells from the patient at normal temperatures.
The Oleum Vitis viniferae that the present invention selects for use is a seed of Fructus Vitis viniferae via refining the forming of the five-star mode of colding pressing, and Oleum Vitis viniferae has the characteristic of Nantural non-toxic, and the Main Ingredients and Appearance of Oleum Vitis viniferae is linoleic acid and procyanidin, and linoleic acid content reaches more than 70%.Can protect the collagen protein in the skin, improve venous engorgement and edema, the destruction of prevention melanin deposition and collagen fiber and elastic fiber makes skin keep due elasticity and tension force.
The Radix Oenotherae erythrosepalae oil that the present invention selects for use mainly is from evening primrose seed; Through low temperature pressing or subcritical low-temperature extraction (the brilliant magnificent oil engineering company limited patented technology in Anyang); Natural Radix Oenotherae erythrosepalae oil is faint yellow; Contain 90% unsaturated fatty acid approximately, that wherein content is maximum is the linoleic acid (Linoleic Acid is called for short LA) of content about 70% and about 7～10% GLA.Can promote the self-sow of estrogen, let hypogenetic breast increase fast, the effect of enlarging the bosom.
The Cananga odorata quintessence oil that the present invention selects for use; Be a kind of extract that comes from the plant Cananga odorata, this material, colourless or yellow; Liquid shape, limpid and odd perfume (or spice) and thick and heavy; Have anti-melancholy, antibiotic, promote the sexual maturity, bring high blood pressure down, effect such as calmness, it is extremely valuable in order to the problem of nursing one's health reproductive system being held in high repute aspect the balance hormone.Another famous use rule is to be used to keep the point of breast to endure elasticity.
The sage oil that the present invention selects for use is the quintessence oil from clary leaf and alabastrum distillation acquisition.The former Europe of being born in of this medical herbs, owing to have good medical value, and health is had numerous benefits, now in widely plantation all over the world.It has the hormonal characteristic of balance, can stimulate female estrogen active, has the effect of the U.S. breast of breast enlargement.
The rose oil that the present invention selects for use is called as " after the quintessence oil ", has the antiallergic sense, preserves moisture, U.S. breast, eliminates the effect of black eye, wrinkle, striae gravidarum.
The present invention select for use will more than several kinds meticulously organically combine and be prepared into nano-emulsion, improved its therapeutic effect greatly.
Another object of the present invention provides the method for preparing of oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation, and step is following:
1) preparation of surfactant phase takes by weighing surfactant and cosurfactant by formula proportion and carries out compositely, stirs.
2) one or more oil are selected in the preparation of oil phase, regulate the ratio of itself and mixed surfactant.
3) add various active component by formula proportion; Add surfactant, cosurfactant and oil phase again; Stirring and evenly mixing fully stirs at 20 ℃～25 ℃ slow adding distil waters, until forming clear, viscosity is little and has mobile xanchromatic O/W type nanometer emulsion;
The present invention detects through transmission electron microscope, and droplet diameter distribution is at 10nm～100nm, and outward appearance is a yellow transparent liquid, has good stability:
1, ageing stability
Ageing stability is meant when nanometer emulsion oral liquid is preserved under room temperature nature change condition, and outward appearance prolongs and the degree that changes in time.This compound grape-seed oil nanometer emulsion is transparent lastingly, does not find muddy or deposition, explains that then ageing stability is good.This is an important indicator estimating nanometer emulsion oral liquid.
2, heat storage stability
This compound grape-seed oil nanometer emulsion is placed test tube, and sealing places 37 ℃ of constant water bath box to store 14 days, this liquid heat storage back appearance transparent.
3, anti-freeze-stable property
With this compound grape-seed oil nanometer emulsion in refrigerator-4 ℃ preserve a week after.Return to room temperature.If nanometer emulsion oral liquid becomes solids at-4 ℃, return to room temperature, return to transparently, and it is transparent to place all continued, thinks that then freezing-resistance is good.
4, accelerated stability
This compound grape-seed oil nanometer emulsion is placed test tube, and sealing under the rotating speed of 15000r/min centrifugal 2 minutes, does not have layering, still clear.
Compound grape-seed oil nanometer emulsion breast enlargement preparation of the present invention cooperates scientific and reasonable massage manipulation to can be good at skin permeation; Get in the cell of breast tissue; The respiratory function of irritation cell and activation capability reach conditioning and rebuild, improve the effect that chest is sagging, promote, increase the breast line.And can moisten skin care, make the more pale delicacy of skin.Method for using is for dripping an amount of quintessence oil in the palm of the hand, and rubbing is evenly pointed with both hands, and circle is lived the The entire breast surrounding tissue; The each stop for 3 seconds, both hands open, and push by the cleavage place is down parallel respectively; Until breast is peripheral, do the massage of 8 fonts at two colpus, each action repetition 20 times.
Compound grape-seed oil nanometer emulsion breast enlargement preparation of the present invention compared with prior art, has the following advantages:
1) thermodynamic stability is high.Operation is fairly simple during preparation, not phase-splitting, do not precipitate, and bin stability improves;
2) light transmission is good, and any inhomogeneities or sedimentary existence are prone to come to light, and sensible quality improves;
3) antiseptic property improves, because decentralized photo liquid is smaller, can prevent the intrusion of antibacterial, increases the dissolubility of some effective ingredient simultaneously;
4) have good solubilization, can effectively improve the dissolubility of insoluble drug;
5) method technology is simple, is fit to large-scale production.
Below the embodiment that provides through the inventor method for preparing of coming further to set forth compound grape-seed oil nanometer emulsion breast enlargement preparation of the present invention.
The specific embodiment
Test Example 1The breast enlargement effect comparison test of compound grape-seed oil nanometer emulsion breast enlargement preparation and other drug
60 schoolgirl's voluntary participation breast enlargement tests that chest is flat in various degree, the age, trial edition invention breast enlargement formulation method was: before everyone sleeps every night between 20～25 years old; Drip an amount of essence oil nanometer breast in the palm of the hand, rubbing is evenly pointed with both hands; Circle is lived the The entire breast surrounding tissue, stops for 3 seconds at every turn, and both hands open; Push by the cleavage place is down parallel respectively,, do the massage of 8 fonts at two colpus until breast is peripheral; Each action repetition 20 times continues two months, checks at least weekly simultaneously once to have or not whole body and local untoward reaction with understanding.By following canonical statistics result: chest has increase and strong being regarded as effectively in various degree; Being regarded as that chest does not change is invalid.60 experimenter's trial edition products all have no adverse reaction after two months as a result, and safety is good.Medicine as a comparison is compound grape-seed oil, pretty good charm cream.Last statistical result is as shown in table 1:
Table 1. compound grape-seed oil nanometer emulsion breast enlargement preparation and the test of other drug breast enlargement effect comparison
Result of the test shows that the breast enlargement effect of compound grape-seed oil nanometer emulsion obviously is better than other two kinds of medicines.
Below the embodiment that provides through the inventor method for preparing of coming further to set forth compound grape-seed oil nanometer emulsion breast enlargement preparation of the present invention.
Embodiment 1Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Oil and surfactant, cosurfactant through calculating HLB value is selected are confirmed optimal proportion according to the rule drafting pseudo-ternary phase diagram of 9:1～1:9.Accurately take by weighing tween 80 2.5g, ethanol 0.2g, isopropyl myristate 0.1g, Oleum Vitis viniferae 0.2g; Rose oil 0.01g, sage oil 0.01g, fragrant cananga caul-fat 0.01g, Radix Oenotherae erythrosepalae oil 0.01g; Under 25 ℃ of room temperature conditions, manually stir with its abundant mix homogeneously, then to wherein slowly adding distilled water; Manually stir on adding distil water limit, limit, and the system viscosity is less during beginning, along with the increase of the distillation water yield; It is sticky that system can become, and this moment, liquid crystal state or water-in-oil type nanoemulsion may appear in system, continues to drip and constantly stir; Unexpected when thinning when system, what produced this moment promptly is stable yellow transparent oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation, and its each component gross weight is 10g.
Embodiment 2Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
RH-40 3.2g, glycerin 1.0g, Jojoba oil 0.4g, Oleum Vitis viniferae 0.01g, rose oil 0.1g, sage oil 0.12g, fragrant cananga caul-fat 0.15g, Radix Oenotherae erythrosepalae oil 0.1g, distilled water 4.92g;
Embodiment 3Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 2.7g, 1,3 butylene glycol 0.9g, ethyl oleate 0.2g, Oleum Vitis viniferae 0.2g, rose oil 0.15g, sage oil 0.1g, fragrant cananga caul-fat 0.1g, Radix Oenotherae erythrosepalae oil 0.2g, distilled water 5.45g;
Embodiment 4Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 2.25g, EL-40 0.75g, ethanol 1.5g, liquid paraffin 0.15g, Oleum Vitis viniferae 0.4g, rose oil 0.05g, sage oil 0.15g, fragrant cananga caul-fat 0.05g, Radix Oenotherae erythrosepalae oil 0.1g, distilled water 4.6g;
Embodiment 5Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 3.5g, 1,2-propylene glycol 0.2g, glycerin 0.2g, isopropyl myristate 0.2g, Oleum Vitis viniferae 0.3g, rose oil 0.2g, sage oil 0.2g, fragrant cananga caul-fat 0.05g, Radix Oenotherae erythrosepalae oil 0.15g,
Distilled water 5.0g;
Embodiment 6Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 2.0g, ethanol 1.0g, 1,2-propylene glycol 0.2g, isopropyl myristate 0.2g, Oleum Vitis viniferae 0.1g, rose oil 0.05g, sage oil 0.05g, fragrant cananga caul-fat 0.05g, Radix Oenotherae erythrosepalae oil 0.05g, distilled water 6.3g;
Embodiment 7Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
RH-40 3.0g, ethanol 0.6g, isopropyl myristate 0.1g, Jojoba oil 0.2g, Oleum Vitis viniferae 0.5g, rose oil 0.1g, sage oil 0.05g, fragrant cananga caul-fat 0.05g, Radix Oenotherae erythrosepalae oil 0.05g, distilled water 5.35g;
Embodiment 8Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 3.4g, ethanol 0.5g, Jojoba oil 0.3g, Oleum Vitis viniferae 0.3g, rose oil 0.3g,
Sage oil 0.05g, fragrant cananga caul-fat 0.1g, Radix Oenotherae erythrosepalae oil 0.05g, distilled water 5.0g;
Embodiment 9Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 3.0g, ethanol 0.6g, isopropyl myristate 0.4g, Oleum Vitis viniferae 0.2g, rose oil 0.1g, sage oil 0.3g, fragrant cananga caul-fat 0.1g, Radix Oenotherae erythrosepalae oil 0.1g, distilled water 5.2g;
Embodiment 10Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 2.8g, ethanol 0.4g, ethyl oleate 0.4g, Oleum Vitis viniferae 0.3g, rose oil 0.1g, sage oil 0.1g, fragrant cananga caul-fat 0.2g, Radix Oenotherae erythrosepalae oil 0.2g, distilled water 5.5g.
Embodiment 11Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
RH-40 3.0g, ethanol 1.5g, isopropyl myristate 0.5g, Oleum Vitis viniferae 0.2g, rose oil 0.1g, sage oil 0.1g, fragrant cananga caul-fat 0.05g, Radix Oenotherae erythrosepalae oil 0.05g, distilled water 4.5g.
Embodiment 12Oil-in-water type compound Oleum Vitis viniferae nano-emulsion
Tween 80 3.0g, ethanol 0.6g, isopropyl myristate 0.4g, Oleum Vitis viniferae 0.3g, rose oil 0.15g, sage oil 0.15g, Cananga odorata oil 0.1g, Radix Oenotherae erythrosepalae oil 0.1g, distilled water 5.2g.
Claims (5)
1. an oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation is characterized in that, is made up of following raw materials by weight percentage
Surfactant 20%～35%
Cosurfactant 2%～15%
Oil phase 1%～5%
Oleum Vitis viniferae 0.1%～5%
Rose oil 0.1%～3%
Sage oil 0.1%～3%
Cananga odorata oil 0.1%～2%
Radix Oenotherae erythrosepalae oil 0.1%～2%
Surplus is a distilled water, and the mass percent sum of above-mentioned raw materials is 100%;
Described surfactant is the mixture of any or several kinds among RH-40, tween 80 and the EL-40;
Described cosurfactant is an ethanol, 1, any in 2-propylene glycol, glycerin, the 1,3 butylene glycol or several kinds of mixture;
Said oil is the mixture of any or several kinds in isopropyl myristate, Jojoba oil, liquid paraffin, the ethyl oleate.
2. a kind of oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation according to claim 1, wherein the mass percent of each raw material is:
Surfactant 25%～32%
Cosurfactant 4%～10%
Oil phase 2%～4%
Oleum Vitis viniferae 0.1%～4%
Rose oil 0.1%～2%
Sage oil 0.1%～2%
Cananga odorata oil 0.1%～1.5%
Radix Oenotherae erythrosepalae oil 0.1%～1.5%
Surplus is a distilled water, and the mass percent sum of above-mentioned raw materials is 100%.
3. a kind of oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation according to claim 1, wherein the percentage by weight of each raw material is:
Tween-80 30%, ethanol 6%, isopropyl myristate 4%, Oleum Vitis viniferae 3%, rose oil 1.5%, sage oil 1.5%, Cananga odorata oil 1%, Radix Oenotherae erythrosepalae oil 1%, distilled water 52%.
4. a kind of oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement preparation according to claim 1 is characterized in that the liquid-drop diameter size is between 10～100nm.
5. the described a kind of oil-in-water type compound Oleum Vitis viniferae nano-emulsion breast enlargement formulation preparation method of claim 1 is characterized in that, may further comprise the steps:
1) preparation of surfactant phase takes by weighing surfactant by formula proportion and cosurfactant is re-dubbed mixed surfactant, stirs;
2) one or more oil are selected in the preparation of oil phase, transfer the ratio of itself and mixed surfactant;
3) add various active component by formula proportion; Add surfactant, cosurfactant and oil phase again; Stirring and evenly mixing fully stirs at 20 ℃～25 ℃ slow adding distil waters, until forming clear, viscosity is little and has mobile xanchromatic O/W type nanometer emulsion.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078822A (en) * | 2015-08-14 | 2015-11-25 | 广东艾圣日用化学品有限公司 | Breast enlarging composition and preparation method thereof |
| CN105411014A (en) * | 2015-12-18 | 2016-03-23 | 李芊墨 | Multifunctional professional adjustable health care breast beautifying underwear |
| CN106176433A (en) * | 2016-08-25 | 2016-12-07 | 原林 | A kind of bust treatment compositions and preparation technology thereof |
| CN106420448A (en) * | 2016-09-25 | 2017-02-22 | 安徽旺润生物科技有限公司 | Breast enlargement and enhancement cream |
| CN106798359A (en) * | 2017-02-28 | 2017-06-06 | 上海芊墨生物科技有限公司 | A kind of multi-functional major adjusting type health care U.S. rounding under garment |
| CN106821977A (en) * | 2017-01-22 | 2017-06-13 | 福建医科大学 | Tea oil nanoemulsion and preparation method thereof |
-
2012
- 2012-02-19 CN CN2012100365868A patent/CN102552565A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078822A (en) * | 2015-08-14 | 2015-11-25 | 广东艾圣日用化学品有限公司 | Breast enlarging composition and preparation method thereof |
| CN105411014A (en) * | 2015-12-18 | 2016-03-23 | 李芊墨 | Multifunctional professional adjustable health care breast beautifying underwear |
| CN106176433A (en) * | 2016-08-25 | 2016-12-07 | 原林 | A kind of bust treatment compositions and preparation technology thereof |
| CN106420448A (en) * | 2016-09-25 | 2017-02-22 | 安徽旺润生物科技有限公司 | Breast enlargement and enhancement cream |
| CN106821977A (en) * | 2017-01-22 | 2017-06-13 | 福建医科大学 | Tea oil nanoemulsion and preparation method thereof |
| CN106798359A (en) * | 2017-02-28 | 2017-06-06 | 上海芊墨生物科技有限公司 | A kind of multi-functional major adjusting type health care U.S. rounding under garment |
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Application publication date: 20120711 |